Does the paucity of elastic fibres contribute to the process of keloidogenesis?

Introduction: Keloids are a prototype of excessive wound healing. Keloid fibroblasts generate traction force, which deforms and realigns the collagen network during migration. Cells move bidirectionally along aligned fibres resulting in nonuniform cell distribution. This and the anisotropic collagen properties displayed in keloids, may be governed by traction force. Excessive traction force (>elastic limit), causes permanent deformations. As recovery from deformational forces is attained mainly by elastic recoil, we hypothesised that in keloids the elastic limit is decreased by reduced numbers of dermal elastic fibres, leading to permanent plastic deformation of dermal tissue by traction force. Objective: To quantitate and compare the elastic fibre content of keloids and non-lesional skin Methods: Sections of keloids and non-lesional skin from 32 patients were stained with elastic Van Gieson. The elastic fibre content was histomorphometrically quantified and the mean (± SEM) percentage area of elastic fibres in lesional and non-lesional skin was compared. Results: Elastic fibres at the border of keloids were increased whereas internally they were minimal or absent. Statistical analysis (Wilcoxon signed ranks test) showed significant differences (p < 0.05) in elastic fibre content between non-lesional dermis and keloids. Conclusions: The lack of elastic fibres in keloids decreases the elastic limit, leading to effects of excessive deformational force. These include compression and stiffening of tissue, increased mitogenesis and cell contractility, modified DNA and protein synthesis and increased collagen biosynthesis. The manifestation of these effects in keloids, supports the hypothesis that decreased elasticity in keloids promotes permanent dermal deformation by traction forces. Keywords: Elastic fibres; wound healing fibroblasts; deformation forces; histomorphometric analysis.Running title: Comparative histomorphometric analysis of elastic fibres in lesional and non-lesional skin of patients with keloid

Processing of Discard Tailings and Non-conventional raw Materials using efficient upgrading Processes

At Russian alluvial deposits , precious metals are nor-mally recovered with the aid of simple ore dressing units, such as washing slices.Particles of precious metals with a size of less than 100 um are not recovered by this method. Centrifugal apparatus and processing technology have been developed for recovery of fine and ultra fine particles of precious metals ensuring recoveries of up to 90-97% and producing a product containing 1-2% Au. This technology is environmentally sound and does not impose any nega-tive impact on the ambient environment. The tailings generated by a DM-250 dredge have a gold content front 0.5 to 1.5 g/t, of which about 85% has it particle size, of less than 50 um. The use of proposed centrifugal equipment at an alluvial operation for processing of dredge tailings made it possible to produce concentrate with a gold content of 1.1 kg /tat with a gold recovery of 92.7%

The mathematical model of the law on the correlation of unique competencies with the emergence of new consumer markets

The article deals with the applied aspects of assessing the influence degree of unique competencies on the process of creating innovative technologies and forming new consumer markets. It also builds the economic model, which demonstrates the presence of this correlation. Paper formulates the law on spiral dependence of the competences level on the emergence of new markets. The authors proposed mathematical instruments based on simulation modeling, which confirms the objectivity of the derived law.peer-reviewe

Assessment of the Orion-SLS Interface Management Process in Achieving the EIA 731.1 Systems Engineering Capability Model Generic Practices Level 3 Criteria

NASA is currently developing the next generation crewed spacecraft and launch vehicle for exploration beyond earth orbit including returning to the Moon and making the transit to Mars. Managing the design integration of major hardware elements of a space transportation system is critical for overcoming both the technical and programmatic challenges in taking a complex system from concept to space operations. An established method of accomplishing this is formal interface management. In this paper we set forth an argument that the interface management process implemented by NASA between the Orion Multi-Purpose Crew Vehicle (MPCV) and the Space Launch System (SLS) achieves the Level 3 tier of the EIA 731.1 System Engineering Capability Model (SECM) for Generic Practices. We describe the relevant NASA systems and associated organizations, and define the EIA SECM Level 3 Generic Practices. We then provide evidence for our compliance with those practices. This evidence includes discussions of: NASA Systems Engineering Interface (SE) Management standard process and best practices; the tailoring of that process for implementation on the Orion to SLS interface; changes made over time to improve the tailored process, and; the opportunities to take the resulting lessons learned and propose improvements to our institutional processes and best practices. We compare this evidence against the practices to form the rationale for the declared SECM maturity level

Learning in Partnership: Leadership as a Cornerstone for Interprofessional Education Between GPs and Community Pharmacists

Objective: Interprofessional education (IPE), defined as ‘Occasions where two or more professions learn with, from and about each other to improved collaboration and the quality of care’ (Barr, 2002), is vital for development of new NHS models of patient care. This project aimed to develop and evaluate an IPE programme to encourage the development of networks of Community Pharmacists and GPs, and to deepen understanding of each other’s NHS contracts and their role in helping achieve better patient outcomes. / Design: Leadership training provided common ground for IPE with GPs and community pharmacists. Five pairs of GPs and community pharmacists, recruited from London and the South East, attended an initial project induction event and five half-day sessions focussing on leadership training based on the Healthcare Leadership Model (NHS Leadership Academy, 2013). The pairs then spent four half day placements in each other’s practice. As an outcome of these activities, each pair was required to jointly undertake, write up and present a Quality Improvement Project (QIP). The leadership training was evaluated using a questionnaire containing open questions developed from previously used questionnaires. Responses were scrutinised to identify and frequency-count themes. / Results: Eight responses were received. Ten overarching themes emerged. The most frequent themes were ‘developing understanding’ and ‘collaborative working’, as illustrated by the following quotes: ‘I have a new found respect for Doctors now and realise we are in the same boat.’ ‘We can work together to achieve a common goal.’ / Conclusion: The focus on leadership training enabled pharmacists and GPs to learn from, with and about each other through the identification of similar challenges and issues. This provided a strong basis to develop interprofessional communication and collaborative working to improve the patient journey

EVALUASI TINGKAT PENERANGAN JALAN UMUM (PJU) DI KOTA GORONTALO (Studi Kasus : Ruas Jalan Prof. Dr. Jhon Katili)

ABSTRAK Utilitas publik terdiri dari listrik, telekomunikasi, jaringan air bersih, sanitasi/air limbah, persampahan dan jaringan gas. Penerangan jalan umum (PJU) merupakan salah satu bagian utilitas publik  yang harus disediakan oleh pemerintah kota/kabupaten, untuk dapat menyediakan dan merawat penerangan jalan umum yang  telah ada pemerintah menarik dana dari masyarakat melalui pajak yang  dibayarkan setiap bulan bersamaan dengan rekening listrik kepada PT. PLN (Persero). Penelitian ini dimaksudkan untuk mengidentifikasi intensitas cahaya dan tingkat Penerangan Jalan Umum (PJU) di ruas jalan Prof. Dr. Jhon A. Katili, analisis data dalam penelitian ini menggunakan analisis kuantitatif dengan cara pengumpulan data yang berhubungan dengan Penerangan Jalan Umum (PJU). Dalam perhitungan intensitas pencahayaan (lux) penerangan jalan umum, digunakan alat bantu ukur Digital Lux Meter, model LX-1010B. Lokasi penelitian dilakukan yakni di sepanjang ruas jalan Prof. Dr. Jhon A. Katili, mengukur lebar jalan dan klasifikasi kelas jalan, kemudian mengukur jarak antar lampu jalan. Selain itu, penelitian itu juga meliputi tingkat Penerangan Jalan Umum (PJU) di ruas jalan Prof. Dr. Jhon A. Katili. Dilakukan cara : (1) survey/mengukur intensitas cahaya pada lampu jalan Penerangan Jalan Umum (PJU), mengklasifikasikan kelas jalan, mengukur lebar jalan, kondisi jalan, kondisi sekitar dan kendaraan yang ada serta jarak antar lampu (2) analisis data hasil survey/pengukuran di lapangan dengan menggunakan standar pencahayaan yang telah ditetapkan oleh Pemerintah sesuai dengan Standar Nasional Indonesia (SNI) 04-6262-2000 tentang rekomendasi untuk pencahayaan jalan bagi kendaraan bermotor dan pejalan kaki.Dari hasil analisis data diperoleh bahwa intensitaspencahayaan PJU pada ruas jalan Prof. Dr. Jhon A. Katili cenderung memiliki intensitaspencahayaandi bawah standar. 13 buah lampu PJU memiliki kriteria persentase dibawah standar 54%, sesuai standar 38%, dan diatas standar 8%. Intensitaspencahayaan tidak merata pada masing-masing PJU. Untuk PJU 1 yang terletak pada perempatan jalan dan terdapat lampu lalu lintas, batasan intensitas pencahayaan (iluminansi) dan luminansi pada rambu-rambu lalu lintas yangdipasang berdekatan dengan lampu penerangan jalan atau papan reklame bertujuan agar lebih menarik perhatian bagi pengguna jalan.   Kata Kunci : Intensitas Cahaya, Klasifikasi Jalan, Penerangan Jalan Umum (PJU

Extraction processing of concentrated solutions of uranyl nitrate with high impurities content

Process flowsheet of recycling uranium concentrated solutions with its purification from insoluble impurities of iron, silicon, molybdenum, calcium oxides and hydroxides and soluble impurities with application of centrifugal extractors cascade has been developed and suggested for commercial introduction. The process was carried out at extractant saturation (30 % tributyl phosphate in hydrocarbon diluent) in extraction assembly lower than a limiting level (85...95 g/l) and in wash assembly - at limiting saturation (up to 120 g/l). As a result the waste uranium content in water-tail solutions 0,01...0,04 g/l and minimal content of impurities in re-extractors is provide

'Sample-in, answer-out'? Evaluation and comprehensive analysis of the Unyvero P50 pneumonia assay

This study aimed to evaluate the performance of the Unyvero P50 pneumonia assay, the first ‘sample-in, answer-out’ system for rapid identification of pathogens and antibiotic resistance markers directly from clinical specimens. Overall, Unyvero P50 displayed very good sensitivity (>95%); however, specificity was low (33%) mainly because 40% of the specimens were reported as normal flora. Specifically, one or more pathogens were identified in 28 of them. From a detailed analysis of 42 specimens selected at random, 76% of the additionally reported pathogens were confirmed present in primary specimens. Detection of selected resistance markers was compared to routine phenotypic susceptibility testing, supplemented with Checkpoints microarray system, PCR and sequencing. Concordance was mixed, primarily due to issues with panel’s choice of markers and detection of some intrinsic beta-lactamases. Finally, we offer a critical analysis of the assay’s microbial panel and resistance markers and provide suggestions for improvement