250 research outputs found
(R1884) Motion of Variable Mass Body in the Seventh-Degree Henon-Heiles System
The goal of this paper is to reveal numerically the generalized Henon-Heiles system, that is, in the seventh-degree potential function where the smallest body mass varies. Utilizing the seventh degree potential function, we determine the equations of motion for the variable mass generalized Henon-Heiles system. Then we perform the graphical works such as locations of parking points, allowed regions of motion, and attracting domain basins. Lastly, using the Meshcherskii space transformations, we investigate stability states for these parking points
Evolving Lorentzian Wormholes
Evolving Lorentzian wormholes with the required matter satisfying the Energy
conditions are discussed. Several different scale factors are used and the
corresponding consequences derived. The effect of extra, decaying (in time)
compact dimensions present in the wormhole metric is also explored and certain
interesting conclusions are derived for the cases of exponential and
Kaluza--Klein inflation.Comment: 10 pages( RevTex, Twocolumn format), Two figures available on request
from the first author. transmission errors corrected
Management of non-visualization following dynamic sentinel lymph node biopsy for squamous cell carcinoma of the penis
Objectives:
To review the management and clinical outcomes of uni- or bilateral non-visualization of inguinal lymph nodes during dynamic sentinel lymph node biopsy (DSNB) in patients diagnosed with penile cancer and clinically impalpable inguinal lymph nodes (cN0), and to develop an algorithm for the management of patients in which non-visualization occurs.
Patients and Methods:
This is a retrospective observational study over a period of 4 years, comprising 166 patients with penile squamous cell carcinoma undergoing DSNB and followed up for a minimum of 6 months. All cases diagnosed with uni- or bilateral non-visualization of sentinel nodes in this cohort were identified from a penile cancer database. The management of the inguinal lymph nodes after non-visualization and the oncological outcomes including local and regional recurrence rates were documented.
Results:
Out of 166 consecutive patients undergoing DSNB, 20 patients (12%) had unilateral non-visualization after injection of intradermal 99mTc. Of these 20 patients, seven underwent repeat DSNB at a later date, with six having successful visualization. One patient had persistent non-visualization and proceeded to a superficial modified inguinal lymphadenectomy (SML). None of these patients experienced recurrence at follow-up. A further seven patients underwent modified SML with on-table frozen-section analysis of the lymph node packet; none of these patients were found to have micrometastatic disease in the inguinal lymph nodes, although one patient developed metastatic inguinal node disease at a later date. Six patients elected to undergo clinical surveillance and have remained disease-free.
Conclusion:
Patients with impalpable inguinal lymph nodes undergoing DSNB with ≥G2 T1 disease should ideally have bilateral visualization of the sentinel lymph nodes, reflecting the drainage pattern from the primary tumour. In the present series, 12% of patients were found to have unilateral non-visualization after DSNB. Among patients offered a repeat DSNB at a later date, localizing the sentinel node was successful in 86% of cases. Patients with favourable histological characteristics can be placed on clinical surveillance. Those with high-risk disease can be offered a repeat DSNB procedure on the proviso that SML may be carried out if there is repeated non-visualization. Larger cohorts are required to validate this proposed algorithm
Accelerating Universe from an Evolving Lambda in Higher Dimension
We find exact solutions in five dimensional inhomogeneous matter dominated
model with a varying cosmological constant. Adjusting arbitrary constants of
integration one can also achieve acceleration in our model. Aside from an
initial singularity our spacetime is regular everywhere including the centre of
the inhomogeneous distribution. We also study the analogous homogeneous
universe in (4+d) dimensions. Here an initially decelerating model is found to
give late acceleration in conformity with the current observational demands. We
also find that both anisotropy and number of dimensions have a role to play in
determining the time of flip, in fact the flip is delayed in multidimensional
models. Some astrophysical parameters like the age, luminosity distance etc are
also calculated and the influence of extra dimensions is briefly discussed.
Interestingly our model yields a larger age of the universe compared to many
other quintessential models.Comment: 18 pages, 9 figure
Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma
SC was funded by fellowships from NIHR and Cancer Research UK. IK was
funded by the UCLH Experimental Cancer Centre and UCLH NIHR Biomedical
Research Centre. TP was funded by grants from Cancer Research UK (the
Experimental Cancer Medicine Centre). MG was funded by grants from
Cancer Research UK, Prostate Cancer UK, the Prostate Cancer Foundation,
the Schottlander Research Charitable Trust, the Royal Marsden NIHR
Biomedical Research Centre for Cancer and the Wellcome Trust (grant
number: 105104/Z/14/Z
Dilaton Contributions to the Cosmic Gravitational Wave Background
We consider the cosmological amplification of a metric perturbation
propagating in a higher-dimensional Brans-Dicke background, including a non
trivial dilaton evolution. We discuss the properties of the spectral energy
density of the produced gravitons (as well as of the associated squeezing
parameter), and we show that the present observational bounds on the graviton
spectrum provide significant information on the dynamical evolution of the
early universe.Comment: 26 pages, plain tex (to appear in Phys.Rev.D, 1 fig available from
the authors upon req.
The trace left by signature-change-induced compactification
Recently, it has been shown that an infinite succession of classical
signature changes (''signature oscillations'') can compactify and stabilize
internal dimensions, and simultaneously leads, after a coarse graining type of
average procedure, to an effective (''physical'') space-time geometry
displaying the usual Lorentzian metric signature. Here, we consider a minimally
coupled scalar field on such an oscillating background and study its effective
dynamics. It turns out that the resulting field equation in four dimensions
contains a coupling to some non-metric structure, the imprint of the
''microscopic'' signature oscillations on the effective properties of matter.
In a multidimensional FRW model, this structure is identical to a massive
scalar field evolving in its homogeneous mode.Comment: 15 pages, LaTeX, no figure
GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.
Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour (pNET) at the age of 10 years and had subtotal parathyroidectomy due to primary hyperparathyroidism at the age of 15 years. He was found to have significantly elevated serum IGF-1, GH, GHRH and calcitonin levels. Pituitary MRI showed an overall bulky gland with a 3 mm hypoechoic area. Abdominal MRI showed a 27 mm mass in the head of the pancreas and a 6 mm lesion in the tail. Lanreotide-Autogel 120 mg/month reduced GHRH by 45% and IGF-1 by 20%. Following pancreaticoduodenectomy, four NETs were identified with positive GHRH and calcitonin staining and Ki-67 index of 2% in the largest lesion. The pancreas tail lesion was not removed. Post-operatively, GHRH and calcitonin levels were undetectable, IGF-1 levels normalised and GH suppressed normally on glucose challenge. Post-operative fasting glucose and HbA1c levels have remained normal at the last check-up. While adolescent-onset cases of GHRH-secreting pNETs have been described, to the best of our knowledge, this is the first reported case of ectopic GHRH in a paediatric setting leading to gigantism in a patient with MEN1. Our case highlights the importance of distinguishing between pituitary and ectopic causes of gigantism, especially in the setting of MEN1, where paediatric somatotroph adenomas causing gigantism are extremely rare. Learning points: It is important to diagnose gigantism and its underlying cause (pituitary vs ectopic) early in order to prevent further growth and avoid unnecessary pituitary surgery. The most common primary tumour sites in ectopic acromegaly include the lung (53%) and the pancreas (34%) (1): 76% of patients with a pNET secreting GHRH showed a MEN1 mutation (1). Plasma GHRH testing is readily available in international laboratories and can be a useful diagnostic tool in distinguishing between pituitary acromegaly mediated by GH and ectopic acromegaly mediated by GHRH. Positive GHRH immunostaining in the NET tissue confirms the diagnosis. Distinguishing between pituitary (somatotroph) hyperplasia secondary to ectopic GHRH and pituitary adenoma is difficult and requires specialist neuroradiology input and consideration, especially in the MEN1 setting. It is important to note that the vast majority of GHRH-secreting tumours (lung, pancreas, phaeochromocytoma) are expected to be visible on cross-sectional imaging (median diameter 55 mm) (1). Therefore, we suggest that a chest X-ray and an abdominal ultrasound checking the adrenal glands and the pancreas should be included in the routine work-up of newly diagnosed acromegaly patients
M-theory resolution of four-dimensional cosmological singularities via U-duality
We consider cosmological solutions of string and M-theory compactified to
four dimensions by giving a general prescription to construct four-dimensional
modular cosmologies with two commuting Killing vectors from vacuum solutions.
By lifting these solutions to higher dimensions we analyze the existence of
cosmological singularities and find that, in the case of non-closed
Friedmann-Robertson-Walker universes, singularities can be removed from the
higher-dimensional model when only one of the extra dimensions is time-varying.
By studying the moduli space of compactifications of M-theory resulting in
homogeneous cosmologies in four dimensions we show that U-duality
transformations map singular cosmologies into non-singular ones.Comment: 21 pages, harvmac. No figures. Minor changes. Typos corrected, a
footnote added in Sec. 3 and two words added to the title. Final version to
appear in Nuclear Physics
Dynamical Compactification, Standard Cosmology and the Accelerating Universe
A cosmological model based on Kaluza-Klein theory is studied. A metric, in
which the scale factor of the compact space evolves as an inverse power of the
radius of the observable universe, is constructed. The
Freedmann-Robertson-Walker equations of standard four-dimensional cosmology are
obtained precisely. The pressure in our universe is an effective pressure
expressed in terms of the components of the higher dimensional energy-momentum
tensor. In particular, this effective pressure could be negative and might
therefore explain the acceleration of our present universe. A special feature
of this model is that, for a suitable choice of the parameters of the metric,
the higher dimensional gravitational coupling constant could be negative.Comment: 11 pages, uses revte
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