Towards improving resilience of cities: an optimisation approach to minimising vulnerability to disruption due to natural disasters under budgetary constraints

In recent years, climate change emerged as a dominant concern to many parts of the world bringing in huge economic losses disturbing normal business/life. In particular cities are suffering from floods affecting land based transportation systems in a significant manner more frequently than ever. Many local authorities facing funding cuts are suffering from limited budgets and they are put under even higher pressure when looking for resources to recover the damaged networks. The agencies involved with post-disaster reconstruction too struggle to prioritise the network links to recover. This paper addresses the problem of road maintenance/development with the aim of improving resilience of the network by formulating the problem as a mathematical model that minimises the vulnerability to disruption due to natural incidents under budgetary constraints. This paper extends the critical link analysis from a single link being disrupted to the case of multiple links, and for the first time proposes an objective function involving a measure of vulnerability to minimise. Metaheuristic Simulated Annealing method is used to reach near global optimal solution for a real-life network with large demand. A segment of the City of York in England has been used to illustrate the principles involved. Numerical experiments indicate that Simulated Annealing based optimisation method outperforms the ‘volume-priority’ heuristic approach, returning higher value for money spent. The proposed approach spreads the benefits across wider population by including more number of links in the priority list while reducing the vulnerability to disruption

Evaluation of the System of Dispensation of Drugs in Intrahospital Services, of a Health Unit of Riobamba

Introduction: In Ecuador, many health institutions have not yet migrated to the Unit Dose Dispensation / Distribution System for Medications, which ensures the correct, safe and rational use of medications. Objective: The medication dispensing process in a Riobamba health unit was evaluated as part of the service quality improvement process. Methodology: Information was collected during three months of investigation, from the in-hospital services of hospitalization, intensive care unit, operating room and emergency. The instruments used for the evaluation corresponded to medical prescriptions, medication and medical device request sheets, medication return record sheets and labeling of boxes. Results: In the medical prescriptions as in the record sheets for the return of evaluated drugs, the main drawback was presented in the writing of the pharmaceutical form and the absence of mandatory data for the identification of the patient. In the total of the registers for the return of medications, the absence of the reason for the return of the medications was identified. The medication dispensing process was considered a critical point within the evaluation, since throughout the review period it was observed that the boxes did not have the minimum required labeling, for the correct identification of the patient. Conclusion: It was concluded that the dispensing system presented critical flaws, such as: deficiencies in the supply of medications, dispensing errors, lack of pharmacotherapeutic follow-up and little participation of the pharmaceutical professional. Keywords: dispensing, medication, medication error. Resumen Introducción: En Ecuador, muchas instituciones de salud aún no migran al Sistema de Dispensación/Distribución de Medicamentos por Dosis Unitaria, el cual asegura la correcta, segura y racional utilización de los medicamentos. Objetivo: Se evaluó el proceso de dispensación de medicamentos en una unidad de salud de Riobamba, como parte del proceso de mejoramiento en la calidad del servicio. Metodología: Se recolectó información durante tres meses de investigación, de los servicios de intrahospitalarios de hospitalización, unidad de cuidados intensivos, quirófano y emergencia. Los instrumentos utilizados para la evaluación correspondieron a recetas médicas, hojas de requerimiento de medicamentos y dispositivos médicos, hojas de registro de devolución de medicación y rotulación de cajetines. Resultados: En las recetas médicas como en las hojas de registro de devolución de medicamentos evaluadas, el principal inconveniente se presentó en la escritura de la forma farmacéutica y la ausencia de datos obligatorios para identificación del paciente. En el total de los registros de devolución de medicamentos, se identificó la inexistencia del motivo de la devolución de los medicamentos. El proceso de dispensación de medicación, se consideró un punto crítico dentro de la evaluación, ya que durante todo el período de revisión se observó que los cajetines no contaban con la rotulación mínima requerida, para la identificación correcta del paciente. Conclusión: Se concluyó que el sistema de dispensación presentaba fallas críticas, tales como: deficiencias en el suministro de medicamentos, errores de dispensación, falta de seguimiento farmacoterapéutico y la poca participación del profesional farmacéutico. Palabras clave: dispensación, medicamentos, error de medicación

ACERCA DEL DIAGNÓSTICO PSICOPEDAGÓGICO DEL ESCOLAR

Diferenciar la atención de los escolares en dependencia de sus necesidades y posibilidades para potenciar su desarrollo, constituye una prioridad del sistema educativo cubano por lo que el diagnóstico constituye un instrumento valioso para orientar el trabajo del maestro con objetividad y precisión. Después de analizar  los diferentes criterios existentes en la literatura sobre el tema este trabajo hace referencia a la definición aportada por diferentes autores sobre diagnóstico, se hace un análisis de las semejanzas y diferencias y se saca las inferencias sobre aquellos elementos comunes que se aprecian con el fin de ofrecer información  comprensible sobre el tema. Para lo que se realizó una amplia revisión bibliográfica que incluyó autores clásicos y contemporáneos, determinando que el diagnóstico como categoría psicológica tiene gran importancia

Importancia de la visualización digital en el aprendizaje de las proyecciones ortogonales

Objetivos generales: • Determinar la importancia de la visualización digital en el aprendizaje de las proyecciones ortogonales. • Diseñar una propuesta de fácil proyección y comprensión para los participantes en los cursos. Objetivos específicos: • Definir los conceptos de visualización digital en el aprendizaje de las proyecciones ortogonales. • Aplicar instrumentos que permitan obtener información referente a visualización digital en el aprendizaje de las proyecciones ortogonales. • Analizar la información obtenida mediante la aplicación de instrumentos referente visualización digital en el aprendizaje de las proyecciones ortogonales. • Comprobar la necesidad de una herramienta digital para facilitar el aprendizaje de las proyecciones ortogonale

Retrospective analysis of therapeutic response obtained with enteral and parenteral iron in adults with iron deficiency anaemia

AbstractBackgroundFew studies compare the therapeutic efficacy of different iron deficiency anaemia treatments.AimEvaluate the therapeutic response of the most common iron preparations.Material and methodsRetrospective, observational-analytical study based on medical records from the Haematology Department, conducted from March to October 2014, including 121 adults with ferropenic anaemia and 3-month follow-up. Patients with comorbidities or pregnancy were excluded.Results85.8% were women (n=103) and 14% men (n=17), with a mean age of 42 (16–83) years. Seventy patients (58.3%) started with oral administration; the rest received intravenous iron. Efficacy was similar among all the iron preparations, with no significant differences (p>0.05). Iron sucrose was most effective in rapidly replenishing body iron stores.ConclusionsDespite comparable efficacy among treatments, ferrous fumarate had the lowest treatment failure and was the therapy of choice

Unexplained changes on a psychiatric pregnancy study.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Cartas al EditorRevisión por pare

Anaerobic Speed Reserve, Sprint Force–Velocity Profile, Kinematic Characteristics, and Jump Ability among Elite Male Speed-and Endurance-Adapted Milers

This study aimed to compare sprint, jump performance, and sprint mechanical variables between endurance-adapted milers (EAM, specialized in 1500–3000-m) and speed-adapted milers (SAM, specialized in 800–1500 m) and to examine the relationships between maximal sprint speed (MSS), anaerobic speed reserve (ASR), sprint, jump performance, and sprint mechanical characteristics of elite middle-distance runners. Fifteen participants (8 EAM; 7 SAM) were evaluated to obtain their maximal aerobic speed, sprint mechanical characteristics (force–velocity profile and kinematic variables), jump, and sprint performance. SAM displayed greater MSS, ASR, horizontal jump, sprint performance, and mechanical ability than EAM (p < 0.05). SAM also showed higher stiffness in the 40-m sprint (p = 0.026) and a higher ratio of horizontal-to-resultant force (RF) at 10 m (p = 0.003) and RFpeak (p = 0.024). MSS and ASR correlated with horizontal (r = 0.76) and vertical (r = 0.64) jumps, all sprint split times (r ≤ −0.85), stiffness (r = 0.86), and mechanical characteristics (r ≥ 0.56) during the 100-m sprint, and physical qualities during acceleration (r ≥ 0.66) and sprint mechanical effectiveness from the force–velocity profile (r ≥ 0.69). Season-best times in the 800 m were significantly correlated with MSS (r = −0.86). Sprint ability has a crucial relevance in middle-distance runners’ performance, especially for SA

Synthesis of Batrachochytrium dendrobatidis infection in South America: amphibian species under risk and areas to focus research and disease mitigation

Amphibian chytridiomycosis, caused by Batrachochytrium dendrobatidis (Bd), has been recognized as the infectious disease causing the most catastrophic loss of biodiversity known to science, with South America being the most impacted region. We tested whether Bd prevalence is distributed among host taxonomy, ecoregion, conservation status and habitat preference in South America. Here we provide a synthesis on the extent of Bd infection across South America based on 21 648 molecular diagnostic assays, roles of certain species in the epidemiology of Bd and explore its association with the reported amphibian catastrophic declines in the region. We show that Bd is widespread, with a continental prevalence of 23.2%. Its occurrence in the region shows a phylogenetic signal and the probability of infection is determined by ecoregion, preferred habitat and extinction risk hosts' traits. The taxa exhibiting highest Bd occurrence were mostly aquatic amphibians, including Ranidae, Telmatobiidae, Hylodidae, Calyptocephalellidae and Pipidae. Surprisingly, families exhibiting unusually low Bd prevalence included species in which lethal chytridiomycosis and population declines have been described (genera Atelopus, Rhinoderma and Eleutherodactylus). Higher than expected prevalence of Bd occurred mainly in amphibians living in association with mountain environments in the Andes and Atlantic forests, reflecting highly favourable Bd habitats in these areas. Invasive amphibian species (e.g. Lithobates catesbeianus and Xenopus laevis) exhibited high Bd prevalence; thus we suggest using these as sentinels to understand their potential role as reservoirs, vectors or spreaders of Bd that can be subjected to management. Our results guide on the prioritization of conservation actions to prevent further biodiversity loss due to chytridiomycosis in the world's most amphibian diverse region

Xenopus laevis and Emerging Amphibian Pathogens in Chile

Amphibians face an extinction crisis with no precedence. Two emerging infectious diseases, ranaviral disease caused by viruses within the genus Ranavirus and chytridiomycosis due to Batrachochytrium dendrobatidis (Bd), have been linked with amphibian mass mortalities and population declines in many regions of the globe. The African clawed frog (Xenopus laevis) has been indicated as a vector for the spread of these pathogens. Since the 1970s, this species has been invasive in central Chile. We collected X. laevis and dead native amphibians in Chile between 2011 and 2013. We conducted post-mortem examinations and molecular tests for Ranavirus and Bd. Eight of 187 individuals (4.3 %) tested positive for Ranavirus: seven X. laevis and a giant Chilean frog (Calyptocephallela gayi). All positive cases were from the original area of X. laevis invasion. Bd was found to be more prevalent (14.4 %) and widespread than Ranavirus, and all X. laevis Bd-positive animals presented low to moderate levels of infection. Sequencing of a partial Ranavirus gene revealed 100 % sequence identity with Frog Virus 3. This is the first report of Ranavirus in Chile, and these preliminary results are consistent with a role for X. laevis as an infection reservoir for both Ranavirus and Bd

Chytridiomycosis outbreak in a Chilean giant frog (Calyptocephalella gayi) captive breeding program: genomic characterization and pathological findings

Emerging infectious diseases in wildlife are increasingly associated with animal mortality and species declines, but their source and genetic characterization often remains elusive. Amphibian chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has been associated with catastrophic and well-documented amphibian population declines and extinctions at the global scale. We used histology and whole-genome sequencing to describe the lesions caused by, and the genetic variability of, two Bd isolates obtained from a mass mortality event in a captive population of the threatened Chilean giant frog (Calyptocephalella gayi). This was the first time an association between Bd and high mortality had been detected in this charismatic and declining frog species. Pathological examinations revealed that 30 dead metamorphosed frogs presented agnathia or brachygnathia, a condition that is reported for the first time in association with chytridiomycosis. Phylogenomic analyses revealed that Bd isolates (PA1 and PA2) from captive C. gayi group with other Bd isolates (AVS2, AVS4, and AVS7) forming a single highly supported Chilean Bd clade within the global panzootic lineage of Bd (BdGPL). These findings are important to inform the strengthening of biosecurity measures to prevent the impacts of chytridiomycosis in captive breeding programs elsewhere