Infants' mu suppression during the observation of real and mimicked goal-directed actions

Since their discovery in the early 1990s, mirror neurons have been proposed to be related to many social-communicative abilities, such as imitation. However, research into the early manifestations of the putative neural mirroring system and its role in early social development is still inconclusive. In the current EEG study, mu suppression, generally thought to reflect activity in neural mirroring systems was investigated in 18- to 30-month-olds during the observation of object manipulations as well as mimicked actions. EEG power data recorded from frontal, central, and parietal electrodes were analysed. As predicted, based on previous research, mu wave suppression was found over central electrodes during action observation and execution. In addition, a similar suppression was found during the observation of intransitive, mimicked hand movements. To a lesser extent, the results also showed mu suppression at parietal electrode sites, over all three conditions. Mu wave suppression during the observation of hand movements and during the execution of actions was significantly correlated with quality of imitation, but not with age or language level

Polder politics under pressure: the advisory roles of political scientists in the Netherlands

Political science in the Netherlands has a long tradition and a history of institutionalization. It developed as a broad discipline, together with public administration, and grew into separate research and education programmes. Does this segmented nature of political science appear in the external activities of those scholars concerned? Or is the overall consensus-style and neo-corporatist (‘polder’) advisory system in which political scientists are placed a more important determinant? What about developments in the policy advisory system itself, pressures on institutions and trends in the environment and their consequences for the supply and demand of scholarly political science advice? These are the central questions we examine in this chapter. We first present the development of the discipline in the country. Then we look at the main features and trends of the advisory system and the niche occupied by political scientists. As we will show on the basis of the survey results, political scientists in the Netherlands gauge their visibility and their social and political impact as relatively high, and a large majority of them engage in advisory activities. Our findings also highlight that the effects of the segmented structure of political science on the type of advisory role are relatively limited. The politics and administration of institutional chang

Does touch matter? The impact of stroking versus non-stroking maternal touch on cardio-respiratory processes in mothers and infants

The beneficial effects of touch in development were already observed in different types of skin-to-skin care. In the current study, we aimed at studying potential underlying mechanisms of these effects in terms of parasympatho-inhibitory regulation. We examined the specific impact of affective maternal stroking versus non-stroking touch on the cardio-respiration of both mothers and infants in terms of respiratory sinus arrhythmia (RSA). We compared a 3-min TOUCH PERIOD (stroking or non-stroking touch) with a baseline before (PRE-TOUCH) and after (POST-TOUCH) in 45 dyads (24 stroking/21 non-stroking touch) with infants aged 4–16 weeks. We registered mother-infant ECG, respiration and made video-recordings. We calculated RR-interval (RRI), respiration rate (fR) and (respiratory corrected) RSA and analyzed stroking mean velocity rate (MVR) of the mothers. ANOVA-tests showed a significant different impact on infants' respiratory corrected RSA of stroking touch (increase) versus non-stroking touch (decrease). Further, during and after stroking touch, RRI significantly increased whereas fR significantly decreased. Non-stroking touch had no significant impact on infants' RRI and fR. In the mothers, RRI significantly decreased and fR significantly increased during the TOUCH PERIOD. The mothers' MVR occurred within the range of 1–10 cm/s matching with the optimal afferent stimulation range of a particular class of cutaneous unmyelinated, low-threshold mechano-sensitive nerves, named c-tactile (CT) afferents. We suggest CT afferents to be the a potential missing link between the processing of affective touch and the development of physiological and emotional self-regulation. The results are discussed with regard to the potential role of CT afferents within the building of early self-regulation as part of a multisensory intuitive parenting system and the importance to respect this ecological context of an infant in research and clinical applications

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter.

Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI) in a total of 25 healthy crew members (mean age: 34 ± 11y; 7f). The pupil responses to different light stimuli were used to assess retinal sensitivity changes. Rest-activity cycles were continuously monitored by activity watches. Overall, our data showed increased pupil responses under scotopic (mainly rod-dependent), photopic (mainly L-/M-cone dependent) as well as bright-blue light (mainly melanopsin-dependent) conditions during the time without direct sunlight. Circadian rhythm analysis revealed a significant decay of intra-daily stability, indicating more fragmented rest-activity rhythms during the dark period. Sleep and wake times (as assessed from rest-activity recordings) were significantly delayed after the first month without sunlight (p < 0.05). Our results suggest that during long-term daylight deprivation, retinal sensitivity to blue light increases, whereas circadian rhythm stability decreases and sleep-wake timing is delayed

The knowledge behind Brexit. A bibliographic analysis of ex-ante policy appraisals on Brexit in the United Kingdom and the European Union

This is the final version. Available on open access from Taylor & Francis via the DOI in this recordIn this article we map and explain the sources of knowledge cited on 85 Brexit impact appraisals, 46 of which were formal impact assessments ordered and published by the European Parliament and 39 ‘sectoral reports’ ordered by the UK Government and released by the House of Commons Exiting the EU Committee. All reports were published between the day after the UK referendum and the year after the start of the UK-EU negotiations. We conducted a citation analysis of 3537 references and tested author push and policy sector pull hypotheses with non-parametric tests. Our findings highlight the epistemic function of the professional referent groups to which authors belong. Authors tend to generate information and cite sources that are congruent with their ‘home group’ in the departmental unit where they work, or their larger professional group, even in urgent high-salient risk situations like Brexit. Differences between policy sectors do not strongly matter

Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain

Identification of the molecular mechanisms governing sensory neuron subtype excitability is a key requisite for the development of treatments for somatic sensory disorders. Here, we show that the Na,K-ATPase modulator Fxyd2 is specifically required for setting the mechanosensitivity of Aδ-fiber low-threshold mechanoreceptors and sub-populations of C-fiber nociceptors, a role consistent with its restricted expression profile in the spinal somatosensory system. We also establish using the spared nerve injury model of neuropathic pain, that loss of Fxyd2 function, either constitutively in Fxyd2(-/-) mice or acutely in neuropathic rats, efficiently alleviates mechanical hypersensitivity induced by peripheral nerve lesions. The role of Fxyd2 in modulating Aδ- and C-fibers mechanosensitivity likely accounts for the anti-allodynic effect of Fxyd2 knockdown. Finally, we uncover the evolutionarily conserved restricted expression pattern of FXYD2 in human dorsal root ganglia, thus identifying this molecule as a potentially promising therapeutic target for peripheral neuropathic pain management

Neck–size Distributions of Through–pores in Polymer Membranes

AbstractThe capillary flow porometry (CFP) is generally used for measuring the bubble point pressure corresponding to largest through pore–size in the membrane. In present work, the CFP technique was used for developing a methodology for determination of the neck–size distributions in the synthetic membranes. It is important as the transport flux across the membrane is controlled by the neck size of through–pores. Therefore the average, maximum and minimum pore sizes and pore–size distribution in these membranes was determined by CFP and compared with different techniques like Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM) and Molecular Weight Cut–off (MWCO). For the MWCO method, the Stokes radius of solute poly(ethylene oxide) (PEO) was calculated using the method commonly used, and also confirmed by Dynamic Light Scattering (DLS)

Ice core evidence for a recent increase in snow accumulation in coastal Dronning Maud Land, East Antarctica

Abstract. Ice cores provide temporal records of snow accumulation, a crucial component of Antarctic mass balance. Coastal areas are particularly under-represented in such records, despite their relatively high and sensitive accumulation rates. Here we present records from a 120 m ice core drilled on Derwael Ice Rise, coastal Dronning Maud Land (DML), East Antarctica in 2012. We date the ice core bottom back to 1745 ± 2 AD. δ18O and δD stratigraphy is supplemented by discontinuous major ion profiles, and verified independently by electrical conductivity measurements (ECM) to detect volcanic horizons. The resulting annual layer history is combined with the core density profile to calculate accumulation history, corrected for the influence of ice deformation. The mean long-term accumulation is 0.425 ± 0.035 m water equivalent (w.e.) a−1 (average corrected value). Reconstructed annual accumulation rates show an increase from 1955 onward to a mean value of 0.61 ± 0.02 m w.e. a−1 between 1955 and 2012. This trend is compared to other reported accumulation data in Antarctica, generally showing a high spatial variability. Output of the fully coupled Community Earth System Model demonstrates that sea ice and atmospheric patterns largely explain the accumulation variability. This is the first and longest record from a coastal ice core in East Antarctica showing a steady increase during the 20th and 21st centuries, thereby supporting modelling predictions. </jats:p