A Novel QAM Technique for High Order QAM Signaling

The paper proposes a novel spread quadrature amplitude modulation (S-QAM) technique with high SNR improvement for high-order QAM channels. Simulated and experimental bit error rate (BER) performance analyses of the proposed technique in blind and non-blind equalizers are obtained by using single carrier (SC) WiMAX (IEEE 802.16-2004) radio. Instead of using any one particular type of channel profile, this study concentrates on true frequency selective Rayleigh fading channels in the real-time WiMAX radio environment around 3.5 GHz. The Constant Modulus Algorithm (CMA) blind equalizer has been compared with the popular non-blind equalizers, Recursive Least Squares (RLS) and Least Mean Squares (LMS) algorithm, as benchmarks. It has been proven in experimental and simulated channels that CMA blind equalizer, using the proposed technique, can be considered as a low complexity, spectrum efficient and high performance time domain equalizations to be embedded in a transceiver for the next generation communications. Furthermore the proposed technique has also reduced approximately till 5 dB and 7.5 dB performance differences between non-blind and blind equalizers for 16-QAM and 64-QAM, respectively. The simulation results have demonstrated that the simulated and experimental studies of the proposed technique are compatible with each other and extremely satisfying

Are cascading flows stable?

The stability of flows cascading down slopes as dense inclined plumes is examined, with particular reference to flows observed in Lake Geneva during winter periods of severe cooling. A previous conjecture by Turner that the flow may be in a state of marginal stability is confirmed: the observed mean velocity and density profiles are unstable to Kelvin-Helmholtz instability, but only marginally so; the growth rates of the most unstable small disturbances to the cascading flow in Lake Geneva are small, with e-folding periods of about 2 h. A reduction in the maximum velocity by about 20% is required to stabilize the flow. The possibility that stationary hydraulic jumps may occur in the observed flow is also considered. Several plausible flow states downstream of transitions are examined, allowing for mixing and density changes to occur, ranging from one that preserves the shape of the density and velocity profiles to one in which, as a consequence of mixing, the velocity and density become uniform in depth within the cascading flow. Neither of these extreme states is found to conserve the fluxes of volume, mass and momentum through a transition in which the energy flux does not increase, and to be unique or ‘stable' in the sense that no further transition is possible to a similar flow state without more entrainment. Stable transitions to intermediate downstream flows that conserve flow properties and reduce energy flux are, however, found, although the smallest value of the flow parameter, Fr≡ Umax2/gΔ h (where Umax is the maximum flow speed, g is the acceleration due to gravity, Δ is a fractional density difference within the flow and h is the flow thickness) at which transitions may occur is only slightly less than that of the cascading flow in Lake Geneva. In this sense, the observed flow is marginally unstable to a finite-amplitude transition or hydraulic jump. Velocity and density profiles of possible flows downstream of a transition are found. The amplitudes of possible transitions and the flux of water entrained from the ambient overlying water mass are limited to narrow range

Transcranial Electric Stimulation Entrains Cortical Neuronal Populations in Rats

Low intensity electric fields have been suggested to affect the ongoing neuronal activity in vitro and in human studies. However, the physiological mechanism of how weak electrical fields affect and interact with intact brain activity is not well understood. We performed in vivo extracellular and intracellular recordings from the neocortex and hippocampus of anesthetized rats and extracellular recordings in behaving rats. Electric fields were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz) via electrodes placed on the surface of the skull or the dura. Transcranial electric stimulation (TES) reliably entrained neurons in widespread cortical areas, including the hippocampus. The percentage of TES phase-locked neurons increased with stimulus intensity and depended on the behavioral state of the animal. TES-induced voltage gradient, as low as 1 mV/mm at the recording sites, was sufficient to phase-bias neuronal spiking. Intracellular recordings showed that both spiking and subthreshold activity were under the combined influence of TES forced fields and network activity. We suggest that TES in chronic preparations may be used for experimental and therapeutic control of brain activity

Effect of Composition on the Spontaneous Emission Probabilities, simulated Emission Cross Sections and Local Environment of Tm+3, in Teo2-Wo3 Glass'

Cataloged from PDF version of article.Effect of composition on the structure, spontaneous and stimulated emission probabilities of various 1.0 mol% Tm2O3 doped (1 - x)TeO2 + (x)WO3 glasses were investigated using Raman spectroscopy, ultraviolet-visible-near-infrared (UV/VIS/NIR) absorption and luminescence measurements. Absorption measurements in the UV/VIS/NIR region were used to determine spontaneous emission probabilities for the 4f-4f transitions of Tm3+ ions. Six absorption bands corresponding to the absorption of the (1)G(4), F-3(2), F-3(3) and F-3(4), H-3(5) and H-3(4) levels from the H-3(6) ground level were observed. Integrated absorption cross-section of each band except that of H-3(5) level was found to vary with the glass composition. Luminescence spectra of the samples were measured upon 457.9 nm excitation. Three emission bands centered at 476 nm ((1)G(4) --> H-3(6) transition), 651 nm ((1)G(4) --> H-3(4) transition) and 800 nm ((1)G(4) --> H-3(5) transition) were observed. Spontaneous emission cross-sections together with the luminescence spectra measured upon 457.9 nm excitation were used to determine the stimulated emission cross-sections of these emissions. The effect of glass composition on the Judd-Ofelt parameters and therefore on the spontaneous and the stimulated emission cross-sections for the metastable levels of Tm3+ ions were discussed in detail. The effect of temperature on the stimulated emission cross-sections for the emissions observed upon 457.9 nm excitation was also discussed. (C) 2002 Elsevier Science B.V. All rights reserved

Comparison of emotional approaches of medical doctors against COVID-19 pandemic: Eastern and Western Mediterranean countries

Background: Pandemics are states of disease that occur worldwide and sharply increase in populations. It causes life events which trigger anxiety, depression, anger, sleep deprivation, emotional distress and stress. World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, pointing to the over 118,000 cases in over 110 countries. Many healthcare workers became ill during the pandemic and some among them died. In this study, we aimed to evaluate and compare level of stress against COVID-19 pandemic among doctors from Turkey and Italy. Methods: This research is a cross-sectional study in which Perceived Stress Scale (PSS-10) and Secondary Traumatic Stress Scale (STSS) are administered online via social networks. All data collection tools were delivered to individuals between 1 and 15 June 2020 and filled in online with Google Forms application. In total, 618 individuals were included in this study and all of them were medical doctors. Results: Higher PS and STS levels were found related to female gender, being married, working in pandemic hospital and older ages. Stress levels were found statistically higher in Turkish doctors when compared to Italian doctors for both stress scales (Turkish/Italian PSS:20.18 ± 7.90/ 19.35 ± 6.71, STSS: 44.19 ± 13.29/ 38.83 ± 13.74). Conclusion: The number of doctors per 1000 of population is lower and per capita visits to a physician are higher in Turkey when compared to Italy. Besides pandemic, these heavier working conditions, increased weekly working hours can cause stress for Turkish doctors. Reporting information such this study is important and international collaborations are essential to plan future prevention strategies. We need to strengthen international ties and build more international collaborations rather than staying within our national silos. Additionally, interventions to promote mental well-being in health care professionals exposed to COVID-19 need to be immediately implemented

Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

Drug resistance is caused by mutations that change the balance of recognition favoring substrate cleavage over inhibitor binding. Here, a structural dynamics perspective of the regained wild-type functioning in mutant HIV-1 proteases with coevolution of the natural substrates is provided. The collective dynamics of mutant structures of the protease bound to p1-p6 and NC-p1 substrates are assessed using the Anisotropic Network Model (ANM). The drug-induced protease mutations perturb the mechanistically crucial hinge axes that involve key sites for substrate binding and dimerization and mainly coordinate the intrinsic dynamics. Yet with substrate coevolution, while the wild-type dynamic behavior is restored in both p1-p6 ((LP) (1\u27F)p1-p6D30N/N88D) and NC-p1 ((AP) (2) (V)NC-p1V82A) bound proteases, the dynamic behavior of the NC-p1 bound protease variants (NC-p1V82A and (AP) (2) (V)NC-p1V82A) rather resemble those of the proteases bound to the other substrates, which is consistent with experimental studies. The orientational variations of residue fluctuations along the hinge axes in mutant structures justify the existence of coevolution in p1-p6 and NC-p1 substrates, that is, the dynamic behavior of hinge residues should contribute to the interdependent nature of substrate recognition. Overall, this study aids in the understanding of the structural dynamics basis of drug resistance and evolutionary optimization in the HIV-1 protease system

Effect of twine thickness on selectivity of gillnets for bogue, Boops boops,in Turkish waters

To investigate the effect of twine thickness on the selectivity of multifilament gillnet targeting bogue,Boops boops L., four different stations were sampled between March and November 2008 in the northern Aegean Sea. Gillnets with 22, 23, and 25 mm nominal mesh size (bar length) each having two different twine thicknesses (approximately 0.45 mm and 0.54 mm ∅) were applied for this purpose. The deviances from the SELECT method revealed that lognormal models provided the best fits for both of the twine thicknesses. Results from the two-way ANOVA analyses revealed that the mean total lengths increased with the mesh size (F = 87.36; df = 2; P < 0.0001) and decreased with the twine thickness (F = 46.12; df = 1; P < 0.0001). The 22 mm mesh size net (0.45 mm ∅) captured significantly larger fish than the 23 mm mesh size net (0.54 mm ∅) probably due to the higher elasticity and flexibility of the thinner twine. Thus, fisheries managers should take into consideration the twine thickness while advising mesh size regulations in gillnet fisheries

Determination of normal splenic volume in relation to age, gender and body habitus: a stereological study on computed tomography

Background: The aim of this study is to assess and document the dimensions of the normal spleen measured on computed tomography (CT) images with the normal splenic volume measured by Cavalieri principle on CT images and thereby serve as a baseline for comparison in cases of splenomegaly using abdominal CT. To investigate the relationship between these changes and body mass index, gender, abdominal diameters.Materials and methods: We retrospectively reviewed abdominal CT examinations of 212 adults between the ages of 20 and 88 years. There were seven groups of patients. The spleen volume (SV) measurements using abdominal CT images of each patient on the Image Information Systems were performed with Cavalieri principle.Results: The mean SV and splenic length (SL), width (SW), and thickness (ST) for the total study population of 212 patients was 198 ± 88 cm3, 9.96 ± 2.1 cm, 8.87 ±± 1.6 cm and 4.58 ± 0.8 cm, respectively. There was a strong correlation between SV and ST (r = 0.752, p &lt; 0.001), SL (r = 0.735, p &lt; 0.001), SW (r = 0.681,p &lt; 0.001) mean values of total study population. Comparison between mean splenic dimension parameters for males and females showed a statistically significant difference (p = 0.032 for SV, p = 0.04 for ST) but no statistically significant difference with SL and SW. Also there was a positive correlation between SV and body height, sagittal abdominal diameter and transvers abdominal diameter in mean of total groups and female groups, there was no correlation in males.Conclusions: The normal reference ranges for SV and size given in this study canserve as a standard to judge whether splenomegaly is present in patients

HIV-1 protease-substrate coevolution in nelfinavir resistance

Resistance to various human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) challenges the effectiveness of therapies in treating HIV-1-infected individuals and AIDS patients. The virus accumulates mutations within the protease (PR) that render the PIs less potent. Occasionally, Gag sequences also coevolve with mutations at PR cleavage sites contributing to drug resistance. In this study, we investigated the structural basis of coevolution of the p1-p6 cleavage site with the nelfinavir (NFV) resistance D30N/N88D protease mutations by determining crystal structures of wild-type and NFV-resistant HIV-1 protease in complex with p1-p6 substrate peptide variants with L449F and/or S451N. Alterations of residue 30\u27s interaction with the substrate are compensated by the coevolving L449F and S451N cleavage site mutations. This interdependency in the PR-p1-p6 interactions enhances intermolecular contacts and reinforces the overall fit of the substrate within the substrate envelope, likely enabling coevolution to sustain substrate recognition and cleavage in the presence of PR resistance mutations. IMPORTANCE: Resistance to human immunodeficiency virus type 1 (HIV-1) protease inhibitors challenges the effectiveness of therapies in treating HIV-1-infected individuals and AIDS patients. Mutations in HIV-1 protease selected under the pressure of protease inhibitors render the inhibitors less potent. Occasionally, Gag sequences also mutate and coevolve with protease, contributing to maintenance of viral fitness and to drug resistance. In this study, we investigated the structural basis of coevolution at the Gag p1-p6 cleavage site with the nelfinavir (NFV) resistance D30N/N88D protease mutations. Our structural analysis reveals the interdependency of protease-substrate interactions and how coevolution may restore substrate recognition and cleavage in the presence of protease drug resistance mutations