Ultrastructural changes in renal parenchyma with renal cell carcinoma

Pasichnyk S., Stakhovsky O., Gozhenko A., Pasichnyk M., Voronina O. Ultrastructural changes in renal parenchyma with renal cell carcinoma. Journal of Education, Health and Sport. 2018;8(6):446-451. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1495561 http://ojs.ukw.edu.pl/index.php/johs/article/view/6319 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.06.2018. Revised: 12.06.2018. Accepted: 29.06.2018. Ultrastructural changes in renal parenchyma with renal cell carcinoma S. Pasichnyk1, O. Stakhovsky2, A. Gozhenko3, M. Pasichnyk1, O. Voronina4 1Lviv National Medical University named after Danylo Halytsky, Lviv, Ukraine Department of urology FPGE 2National Cancer Institute, Kiyv 3Ukrainian Research Institute of Transport Medicine of Ministry of Health of Ukraine, Odessa 4NSC Institute of Biology and Medicine, Kiyv Abstract In recent years, there has been a significant increase in incidence of the renal cell carcinoma (RCC). In the structure of cancer, this pathology is on 10th place. The surgical treatment is the most radical and most effective method of management of this disease. Currently renal resection has become a desirable alternative to radical nephrectomy for tumors of the T1 stage [6, 7, 8, 9]. Nephron-sparing interventions, compared to radical nephrectomy, showed an equivalent cancer outcome in tumors < 4 cm in diameter [1, 10]. However, there is an opinion [2] that in the intact part of the organ due to an increased functional load various pathomorphological changes may occur [3, 4 ,7]. Although, it is believed that in this cohort of patients there are no pathomorphological changes and only in rare cases, distant functional changes can be observed [5, 2]. Key words: renal cell carcinoma, nephron, nephrectomy, nephron-sparing surger

Interaction between creatinine and sulfonated derivatives of cobalt phthalocyanine

© 2017Sulfonated derivatives of cobalt phthalocyanine strongly fix the creatinine (2-amino-1-methyl-1H-imidazol-4-ol) thus forming ordered dimeric structures. Such bonding may be used to create materials for sorption of creatinine from the solutions and to form direct liquid-phase systems based on metal phthalocyanines

Gender features of depressive disorders in women

The authors give the data available in the literature and the results of their investigations of the gender features of depressive disorders in women. They analyze the results of studies relating to gender differences in the neurohormonal system from the embryonic period, as well as those in the lateralization of neuromorphofunctional provision of emotions. Based on their clinical observations, the authors discuss the varying roles of menopause in the etiopathogenesis of climacteric, psychogenic, and endogenous depression; in these forms of depression, menopause may be a cause, ground, or trigger, respectively. The influence of endocrine and sociopsychological factors on the development of postpartum depression is considered. The authors unveil the diagnostic and predictive value of premenopausal syndrome with depressive disorders at different stages of a depressive episode: the prediction of depression when depressive symptoms appear in the premenopausal period, as well as the reduction of premenopausal depressive disorders as evidence of intermission. Based on the data available in the literature, the authors consider the clinical features of depression in women: earlier onset; more frequent depressive episodes; greater presentation of atypical symptoms (anxiety, fatigue, increased appetite, weight gain, hypersomnia, and signs of somatization), as well as rarer suicidal tendencies as comparedto men. It is concluded that the gender features of depression in women are due to the whole complex of gender factors, such as neurophysiological, neuroendocrine, and sociopsychological ones

Immune status of the lupus-test positive patients

Розглянуто зміни показників імунного статусу пацієнтів, позитивних за люпус-тестом. Охарактеризовано експресію деяких рецепторів на поверхні лімфоцитів периферійної крові. Розраховано кореляцію для показників тесту відновлення тетразолію нітросинього та рівня експресії CD95-рецептора (рецептора апоптозу). Розглянуто зміни показників імунного статусу пацієнтів, позитивних за люпус-тестом. Охарактеризовано експресію деяких рецепторів на поверхні лімфоцитів периферійної крові. Розраховано кореляцію для показників тесту відновлення тетразолію нітросинього та рівня експресії CD95-рецептора (рецептора апоптозу). Changes in immune status of the lupus-test positive patients are presented. The expression of some lymphocytic surface receptors in the peripheral blood is characterised. Correlation between the NST-test index and the level of CD95-receptor expression (apoptosis receptor) was calculated.

Clinical Analysis of Late Age Somatoform Algic Disorder Case Following with Pain in Maxillofacial Area: Example of Dental Treatment Groundlessness

Case of somatoform algic disorder with pain in maxillofacial region is described on a 58 years old patient. The patient have been observed by different specialists and underwent numerous medical examinations which led as a result to groundless medical manipulations such as several teeth extirpation, removal of previously mounted metalloceramic constructions.Latest observations show that there is a link between age and pain localization rate at mouth area as well as changes in hypochondriac experience to the increase of supervaluable generations. Thus condition described becomes a disorder which is hard to diagnose and a social problem concerning early diagnostics and treatment. With time and increase of life expectancy as well as increase of assortment and affordability of dental procedures problem of somatoform algic disorder diagnostics in late age becomes more urgent. Clinical case illustrates accumulated practical experience of late age somatoform disorders treatment by combinations of antidepressants and small doses of antipsychotics. Ethiopathogenesis of this condition assessed as nociceptive, neuropathologic and then as psychogenic pain is still to be investigated. Late diagnostics in this case points to a necessity of multidisciplinary approach to such patients’ treatment in order to develop criteria to apply in practice for diagnostic mechanisms optimization and pharmacologic effect on early disorder stages

The proresilients in multimodal programmes for the prevention of premature ageing

To study the properties of the proresilients in multimodal programs for the prevention of premature agein

Magnesium Preparations in Psychiatry, Addiction Medicine, Neurology and General Medicine (Part I. History)

The use of magnesium preparations in medicine has a long history. According to some sources, first attempts by humans to consume magnesium- and calcium-rich minerals orally, presumably for medicinal purposes, could have occurred even in prehistoric times. First attempts to use natural magnesium-calcium alkaline materials to increase the bioavailability of the alkaloids of some psychoactive plants, such as betel, tobacco, and coca, also date back to prehistoric times.Later, several ancient authors, in particular, Hippocrates II, Claudius Galen and Soran of Ephesus, have described the profound laxative effect of sea salt and of crushed dolomite, as well as a positive effect on the psyche of drinking mineral waters from sources that were found by modern scientists to be rich in magnesium, lithium and bromine. The laxative effect of mineral waters from some sources rich in magnesium, or of salts that were extracted from such sources was known in the Middle Ages. Later, Paracelsus discovered that these salts could be useful not only as a laxative, but also as a sedative.In 1707, Massimiliano Valentini first obtained magnesium oxide, which immediately found its use in medicine, as an antacid, as a mild laxative and skin powder. In 1926, Jacques Leroy was the first to prove the vital importance of magnesium for the physiology of animals.In this article, we thoroughly review the history of the medicinal use of magnesium preparations and the history of studies of biological role of magnesium, from antiquity to modern times

СУЧАСНІ АСПЕКТИ АНТИКРИЗОВОГО ФІНАНСОВОГО УПРАВЛІННЯ ПРОМИСЛОВИМИ ПІДПРИЄМСТВАМИ

The article studies existing methods of anti-crisis financial management of industrial enterprises and developed methodological support to assessment of the level of anti-crisis financial management. Provided that industry is one of the leading industries in national economy of Ukraine. All conversions that occur in industrial plants always lead to significant changes in the socio-economic situation of the country. The author’s definition anti-crisis financial management of industrial enterprise at which you want to understand the complex system of actions aimed at preventing or eliminating the negative phenomena for commercial and business activities. The algorithm of crisis financial management, which allows the development of a system crisis financial management of industrial enterprise to consider the impact of external and internal factors of the environment in which operates an industrial enterprise, with the aim prompt identification of threats to prevent or troubleshoot to prevent, or overcoming the crisis. Noted that an important role in the financial crisis management play the financial risks that occur throughout the entire production cycle. The developed methodological support of anti-crisis financial management, which is an estimate of the influence of groups of indicators for the deployment of crisis on the industrial enterprise.. It is concluded that the use of the proposed methodological support of anti-crisis financial management of industrial enterprises allows to reduce the likelihood of crisis situations and significantly reduce the size of the potential loss. That is, it application gain the opportunity for industrial enterprises to respond quickly to the emergence of the crisis and to consider all types of financial risk in the implementation industrial and commercial activities.Досліджено наявні&nbsp;методики антикризового фінансового управління промисловими підприємствами і розроблено методичне забезпечення до оцінки рівня антикризового фінансового управління підприємством. Зазначено, що промисловість є однією з провідних галузей у національному господарстві України. Усі перетворення, які відбуваються на промислових підприємствах, завжди призводять до суттєвих змін у соціально-економічному становищі країни. Надано авторське визначення антикризового фінансового управління промисловим підприємством, під яким слід розуміти комплексну систему дій, спрямованих на запобігання або усунення негативних явищ для комерційної діяльності та бізнесу. Розроблено алгоритм антикризового фінансового управління, який дає можливість при розробленні системи антикризового фінансового управління промисловим підприємством ураховувати вплив зовнішніх і внутрішніх факторів середовища, у якому функціонує промислове підприємство, з метою своєчасного визначення загроз для їх попередження або усунення з ціллю недопущення чи подолання кризи. Зазначено, що важливу роль в антикризовому фінансовому управлінні відіграють фінансові ризики, які мають місце протягом усього виробничого циклу. Розроблено методичне забезпечення антикризового фінансового управління, яке являє собою оцінку впливу груп показників на розгортання кризових явищ на промисловому підприємстві. Зроблено висновок, що використання запропонованого методичного забезпечення антикризового фінансового управління промисловими підприємствами дозволяє знизити ймовірність виникнення кризових ситуацій та значно зменшити розмір можливого збитку. Тобто його застосування надасть можливість промисловим підприємствам швидко реагувати на виникнення кризових явищ і враховувати всі види фінансових ризиків при здійсненні виробничо-господарської та комерційної діяльності