76 research outputs found
Why Constitutional Torts Deserve a Book of Their Own
Over thirty years ago, Marshall Shapo coined the term constitutional tort to denote a suit brought against an official, charging a constitutional violation and seeking damages.\u27 In the years since Shapo\u27s pathbreaking article, the number of such suits has grown exponentially.\u27 The suits have generated a host of new substantive and remedial issues, yet conventional casebooks on constitutional law and federal courts give little attention to the area. That Professor Shapiro had four books to include in his review of âCivil Rightsâ casebooks in the Seattle University Law Review is some indication of a demand for teaching materials currently unmet by federal courts and constitutional law casebook offerings. The premise of our book is that âconstitutional tortsâ present a sufficiently large and complex group of problems to warrant a casebook and a course of their own. We will first discuss why constitutional tort issues tend to receive inadequate attention in courses and casebooks on constitutional law and other civil rights topics. Then we will explain the pedagogic advantages of having a separate offering on constitutional torts
Flagellin delays spontaneous human neutrophil apoptosis
Neutrophils are short-lived cells that rapidly undergo apoptosis. However, their survival can be regulated by signals from the environment. Flagellin, the primary component of the bacterial flagella, is known to induce neutrophil activation. In this study we examined the ability of flagellin to modulate neutrophil apoptosis. Neutrophils cultured for 12 and 24 h in the presence of flagellin from Salmonella thyphimurim at concentrations found in pathological situations underwent a marked prevention of apoptosis. In contrast, Helicobacter pylori flagellin did not affect neutrophil survival, suggesting that Salmonella flagellin exerts the antiapoptotic effect by interacting with TLR5. The delaying in apoptosis mediated by Salmonella flagellin was coupled to higher expression levels of the antiapoptotic protein Mcl-1 and lower levels of activated caspase-3. Analysis of the signaling pathways indicated that Salmonella flagellin induced the activation of the p38 and ERK1/2 MAPK pathways as well as the PI3K/Akt pathway. Furthermore, it also stimulated IBα degradation and the phosphorylation of the p65 subunit, suggesting that Salmonella flagellin also triggers NF-B activation. Moreover, the pharmacological inhibition of ERK1/2 pathway and NF-B activation partially prevented the antiapoptotic effects exerted by flagellin. Finally, the apoptotic delaying effect exerted by flagellin was also evidenced when neutrophils were cultured with whole heat-killed S. thyphimurim. Both a wild-type and an aflagellate mutant S. thyphimurim strain promoted neutrophil survival; however, when cultured in low bacteria/neutrophil ratios, the flagellate bacteria showed a higher capacity to inhibit neutrophil apoptosis, although both strains showed a similar ability to induce neutrophil activation. Taken together, our results indicate that flagellin delays neutrophil apoptosis by a mechanism partially dependent on the activation of ERK1/2 MAPK and NF-B. The ability of flagellin to delay neutrophil apoptosis could contribute to perpetuate the inflammation during infections with flagellated bacteria.Facultad de Ciencias Exacta
On the probabilistic Cauchy theory for nonlinear dispersive PDEs
In this note, we review some of the recent developments in the well-posedness
theory of nonlinear dispersive partial differential equations with random
initial data.Comment: 26 pages. To appear in Landscapes of Time-Frequency Analysis, Appl.
Numer. Harmon. Ana
Energy dispersed large data wave maps in 2+1 dimensions
In this article we consider large data Wave-Maps from into
a compact Riemannian manifold , and we prove that regularity
and dispersive bounds persist as long as a certain type of bulk
(non-dispersive) concentration is absent. In a companion article we use these
results in order to establish a full regularity theory for large data
Wave-Maps.Comment: 89 page
Random data wave equations
Nowadays we have many methods allowing to exploit the regularising properties
of the linear part of a nonlinear dispersive equation (such as the KdV
equation, the nonlinear wave or the nonlinear Schroedinger equations) in order
to prove well-posedness in low regularity Sobolev spaces. By well-posedness in
low regularity Sobolev spaces we mean that less regularity than the one imposed
by the energy methods is required (the energy methods do not exploit the
dispersive properties of the linear part of the equation). In many cases these
methods to prove well-posedness in low regularity Sobolev spaces lead to
optimal results in terms of the regularity of the initial data. By optimal we
mean that if one requires slightly less regularity then the corresponding
Cauchy problem becomes ill-posed in the Hadamard sense. We call the Sobolev
spaces in which these ill-posedness results hold spaces of supercritical
regularity.
More recently, methods to prove probabilistic well-posedness in Sobolev
spaces of supercritical regularity were developed. More precisely, by
probabilistic well-posedness we mean that one endows the corresponding Sobolev
space of supercritical regularity with a non degenerate probability measure and
then one shows that almost surely with respect to this measure one can define a
(unique) global flow. However, in most of the cases when the methods to prove
probabilistic well-posedness apply, there is no information about the measure
transported by the flow. Very recently, a method to prove that the transported
measure is absolutely continuous with respect to the initial measure was
developed. In such a situation, we have a measure which is quasi-invariant
under the corresponding flow.
The aim of these lectures is to present all of the above described
developments in the context of the nonlinear wave equation.Comment: Lecture notes based on a course given at a CIME summer school in
August 201
Flagellin delays spontaneous human neutrophil apoptosis
Neutrophils are short-lived cells that rapidly undergo apoptosis. However, their survival can be regulated by signals from the environment. Flagellin, the primary component of the bacterial flagella, is known to induce neutrophil activation. In this study we examined the ability of flagellin to modulate neutrophil apoptosis. Neutrophils cultured for 12 and 24 h in the presence of flagellin from Salmonella thyphimurim at concentrations found in pathological situations underwent a marked prevention of apoptosis. In contrast, Helicobacter pylori flagellin did not affect neutrophil survival, suggesting that Salmonella flagellin exerts the antiapoptotic effect by interacting with TLR5. The delaying in apoptosis mediated by Salmonella flagellin was coupled to higher expression levels of the antiapoptotic protein Mcl-1 and lower levels of activated caspase-3. Analysis of the signaling pathways indicated that Salmonella flagellin induced the activation of the p38 and ERK1/2 MAPK pathways as well as the PI3K/Akt pathway. Furthermore, it also stimulated IBα degradation and the phosphorylation of the p65 subunit, suggesting that Salmonella flagellin also triggers NF-B activation. Moreover, the pharmacological inhibition of ERK1/2 pathway and NF-B activation partially prevented the antiapoptotic effects exerted by flagellin. Finally, the apoptotic delaying effect exerted by flagellin was also evidenced when neutrophils were cultured with whole heat-killed S. thyphimurim. Both a wild-type and an aflagellate mutant S. thyphimurim strain promoted neutrophil survival; however, when cultured in low bacteria/neutrophil ratios, the flagellate bacteria showed a higher capacity to inhibit neutrophil apoptosis, although both strains showed a similar ability to induce neutrophil activation. Taken together, our results indicate that flagellin delays neutrophil apoptosis by a mechanism partially dependent on the activation of ERK1/2 MAPK and NF-B. The ability of flagellin to delay neutrophil apoptosis could contribute to perpetuate the inflammation during infections with flagellated bacteria.Facultad de Ciencias Exacta
Reciprocal Interaction between Macrophages and T cells Stimulates IFN-Îł and MCP-1 Production in Ang II-induced Cardiac Inflammation and Fibrosis
Background: The inflammatory response plays a critical role in hypertension-induced cardiac remodeling. We aimed to study how interaction among inflammatory cells causes inflammatory responses in the process of hypertensive cardiac fibrosis. Methodology/Principal Findings: Infusion of angiotensin II (Ang II, 1500 ng/kg/min) in mice rapidly induced the expression of interferon c (IFN-c) and leukocytes infiltration into the heart. To determine the role of IFN-c on cardiac inflammation and remodeling, both wild-type (WT) and IFN-c-knockout (KO) mice were infused Ang II for 7 days, and were found an equal blood pressure increase. However, knockout of IFN-c prevented Ang II-induced: 1) infiltration of macrophages and T cells into cardiac tissue; 2) expression of tumor necrosis factor a and monocyte chemoattractant protein 1 (MCP-1), and 3) cardiac fibrosis, including the expression of a-smooth muscle actin and collagen I (all p,0.05). Cultured T cells or macrophages alone expressed very low level of IFN-c, however, co-culture of T cells and macrophages increased IFN-c expression by 19.860.95 folds (vs. WT macrophage, p,0.001) and 20.9 6 2.09 folds (vs. WT T cells, p,0.001). In vitro co-culture studies using T cells and macrophages from WT or IFN-c KO mice demonstrated that T cells were primary source for IFN-c production. Co-culture of WT macrophages with WT T cells, but not with IFN-c-knockout T cells, increased IFN-c production (p,0.01). Moreover, IFN-c produced by T cells amplified MCP-1 expression in macrophages and stimulated macrophag
Quasi-invariant Gaussian measures for the cubic fourth order nonlinear Schrödinger equation
We consider the cubic fourth order nonlinear Schr\"odinger equation on the
circle. In particular, we prove that the mean-zero Gaussian measures on Sobolev
spaces , , are quasi-invariant under the flow.Comment: 41 pages. To appear in Probab. Theory Related Field
Modulation Invariant Bilinear T(1) Theorem
We prove a T(1) theorem for bilinear singular integral operators (trilinear forms) with a one-dimensional modulation symmetry
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