1,650 research outputs found
Classification of Lie bialgebras over current algebras
In the present paper we present a classification of Lie bialgebra structures
on Lie algebras of type g[[u]] and g[u], where g is a simple finite dimensional
Lie algebra.Comment: 26 page
Migration Flows and Intra-Industry Trade Adjustments.
In this paper we analyse the link between trade and migration. Focusing in the experience of Spain, we relate a marginal index of intra-industry trade with the stock of foreign workers - classified according to their country of origin and their situation in the Spanish labour market. We focus on the possibility that existing networks of foreign workers and their connections with their countries of origin could stimulate trade with the host country. Our results show a significant impact of the number of immigrants with work permits on intra-industry trade adjustment. However, this impact being positive or negative depends on whether foreign workers are employees or self-employed, the duration of the work permits and the type of job they occupy.migration, intra-industry trade, networks.
Prediction-based classification for longitudinal biomarkers
Assessment of circulating CD4 count change over time in HIV-infected subjects
on antiretroviral therapy (ART) is a central component of disease monitoring.
The increasing number of HIV-infected subjects starting therapy and the limited
capacity to support CD4 count testing within resource-limited settings have
fueled interest in identifying correlates of CD4 count change such as total
lymphocyte count, among others. The application of modeling techniques will be
essential to this endeavor due to the typically nonlinear CD4 trajectory over
time and the multiple input variables necessary for capturing CD4 variability.
We propose a prediction-based classification approach that involves first stage
modeling and subsequent classification based on clinically meaningful
thresholds. This approach draws on existing analytical methods described in the
receiver operating characteristic curve literature while presenting an
extension for handling a continuous outcome. Application of this method to an
independent test sample results in greater than 98% positive predictive value
for CD4 count change. The prediction algorithm is derived based on a cohort of
HIV-1 infected individuals from the Royal Free Hospital, London who
were followed for up to three years from initiation of ART. A test sample
comprised of individuals from Philadelphia and followed for a similar
length of time is used for validation. Results suggest that this approach may
be a useful tool for prioritizing limited laboratory resources for CD4 testing
after subjects start antiretroviral therapy.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS326 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is the etiological agent of one of the
most important swine diseases with a significant economic burden worldwide. Unfortunately, available
vaccines are partially effective highlighting the need of novel approaches. Previously, antigenic viral
proteins were described in serum-derived extracellular vesicles (EVs) from pigs previously infected with
PRRSV. Here, a targeted-pig trial was designed to determine the safety and immunogenicity of such
extracellular vesicles enriched fractions. Our results showed that immunizations with EV-enriched
fractions from convalescence animals in combination with montanide is safe and free of virus as
immunizations with up-to two milligrams of EV-enriched fractions did not induce clinical symptoms,
adverse effects and detectable viral replication. In addition, this vaccine formulation was able to elicit
specific humoral IgG immune response in vaccinated animals, albeit variably. Noticeably, sera from
vaccinated animals was diagnosed negative when tested for PRRSV using a commercial ELISA test;
thus, indicating that this new approach differentiates vaccinated from infected animals. Lastly, after
priming animals with EV-enriched fractions from sera of convalescence animals and boosting them with
synthetic viral peptides identified by mass spectrometry, a distinctive high and specific IFN-γ response
was elicited. Altogether, our data strongly suggest the use of serum EV-enriched fractions as a novel
vaccine strategy against PRRSV.Anti-CD9, Anti-CD63 and anti-CD81 antibodies were kindly donated by Francisco Sánchez-Madrid and Maria Yañez-Mo, Hospital de la Princesa, Madrid, Spain. The authors wish to particularly thank Glòria Abella for her collaboration in conducting the field study and to Marta Alcobé, Miriam Moron Font and Paula Crego Mendez for technical assistance. This study received support from Innovex Therapeutics S.L., Pinsos del Segre SA, Granja Casanyé, Grup de Sanejament Porci (GSP, Lleida, Spain) and the FEDER project (COMRDI16-1-0035-03). Sergio Montanter-Tarbes is an industrial doctorate awarded by the Government of Catalonia, Spain (No. 2014 DI 044). ISGlobal and IGTP are members of the CERCA Programme, Generalitat de Catalunya
Artroplastia total de tobillo
Presentamos un estudio retrospectivo de siete pacientes tratados con artroplastia
total de tobillo en el período 1978-1988, realizando una revisión bibliográfica
del tema. La serie la componen cinco hombres y dos mujeres con edades comprendidas
entre 41 y 72 años. Cinco pacientes estaban afectos de artrosis postraumática, uno de
artropatía gotosa y otro de espondilitis anquilopoyética. Los modelos protésicos utilizados
fueron Smith en cuatro ocasiones e I.C.L.H. en tres. El seguimiento medio ha sido
de once años, siendo evaluados según un sistema de puntuación creado por Mc Guire.
En tres pacientes se ha obtenido un resultado excelente, en dos bueno y los dos restantes
fueron reintervenidos realizándose una artrodesis.We have reported a retrospective study of seven patients with total ankle
arthroplasty perfomed between 1978-1988. We have reviewed series published in the
literature. There were five men and two women, the age range of this group was 41-72
years. Five of them suffered from posttraumatic arthrosis, one ankylosing spondylitis
and the last had gouty arthritis. Four patients recieved the Smith total ankle and three
the ICLH total ankle. The mean follow-up period was eleven years. Patients were evaluated
using a scoring system (Mc Guire et al). Three patients had an excellent result,
the result from two of them were good and the other two patients required revision
and arthrodesis
Does ratification of human-rights treaties have effects on population health?
Human-rights treaties indicate a country's commitment to human rights. Here, we assess whether ratification of human-rights treaties is associated with improved health and social indicators. Data for health (including HIV prevalence, and maternal, infant, and child [<5 years] mortalities) and social indicators (child labour, human development index, sex gap, and corruption index), gathered from 170 countries, showed no consistent associations between ratification of human-rights treaties and health or social outcomes. Established market economy states had consistently improved health compared with less wealthy settings, but this was not associated with treaty ratification. The status of treaty ratification alone is not a good indicator of the realisation of the right to health. We suggest the need for stringent requirements for ratification of treaties, improved accountability mechanisms to monitor compliance of states with treaty obligations, and financial assistance to support the realisation of the right to health
Un manojo documental de Bernardo de Balbuena: Práctica administrativa y construcción biográfica
This paper offers an annotated edition of a set of documents, almost all unpublished, related to some of the main biographical circumstances of Bernardo de Balbuena, which allows to do a reflection on the administrative context of selffashioning. © 2021 Servicio de Publicaciones de la Universidad de Navarra. All rights reserved
Accurate determination of dielectric properties in small, high-permittivity dielectric cylinders
We describe a method for performing cryogenic permittivity and loss tangent measurements of small (few mm), high-permittivity dielectric cylinders used in surface impedance measurement of superconductors. We combine the use of sapphire and PTFE supports to hold the dielectric under test and provide good thermal conductivity to the cold head. Additionally, the sapphire support is used to facilitate the measurement of the cavity's metal loss and the assessment of its contribution to the overall resonator loss.Authors wish to acknowledge the support provided by CERN under Grants FCC-GOV-CC-0072/KE3358 and FCC-GOV-CC-0210/KE4945. NT acknowledges MSCA-COFUND-2016-754397 for the PhD grant.Peer ReviewedPostprint (author's final draft
Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins
PRRSV is the etiological agent of one of the most important swine diseases with a significant economic burden
worldwide and limitations in vaccinology. Exosomes are 30–100 nm vesicles of endocytic origin. Remarkably, immunizations
with exosomes containing antigens from tumors or pathogens are capable of eliciting protective immune
responses, albeit variably, in cancer and infectious diseases. Here we describe the isolation, molecular composition
and immunogenicity of serum-derived exosomes from naïve animals, from PRRSV viremic animals and from animals
previously PRRSV infected but already free of viruses (non viremic). Exosomes were isolated through size exclusion
chromatography and characterized by different methodologies. Exosome-enriched fractions from naïve and natural
infected animals contained classical tetraspanin exosomal markers (CD63 and CD81) and high concentrations of
particles in the size-range of exosomes as detected by nanoparticle tracking analysis and cryo-TEM. NanoLC-MS/MS
was used to identify viral antigens associated to exosomes. PRRSV-proteins were detected in serum samples from
only viremic animals and from animals previously infected already free of viruses (non-viremic), but not in controls.
Moreover, immune sera from pigs previously exposed to PRRSV specifically reacted against exosomes purified from
non-viremic pig sera in a dose-dependent manner, a reactivity not detected when naïve sera was used in the assay. To
facilitate future studies, a scaling-up process was implemented. To the best of our knowledge, this is the first molecular
characterization of serum-derived exosomes from naïve pigs and pigs actively or previously infected with PRRSV.
The presence of antigenic viral proteins in serum-derived exosomes free of virus, suggest their use as a novel vaccine
approach against PRRSV.Anti‑ CD63 and anti‑ CD81 antibodies were kindly donated by Francisco Sánchez‑Madrid and Maria Yañez‑Mo, Hospital de la Princesa, Madrid, Spain. We thank Miriam Morón Font for technical assistance and Inés Lozano and Marta Monguió ‑Tortajada for valuable scientific discussions. SMT is supported by an Industrial PhD Fellowship from the government of Catalonia (AGAUR) as part of a collaborative agreement between INNOVEX THERAPEUTICS SL and the University of Lleida (Id No 2014 DI 044
Exosome based vaccines: pros and cons in the world of animal health
Due to the emergence of antibiotic resistance and new and more complex diseases that affect livestock animal health and food security, the control of epidemics has become a top priority worldwide. Vaccination represents the most important and cost‐effective measure to control infectious diseases in animal health, but it represents only 23% of the total global animal health market, highlighting the need to develop new vaccines. A recent strategy in animal health vaccination is the use of extracellular vesicles (EVs), lipid bilayer nanovesicles produced by almost all living cells, including both prokaryotes and eukaryotes. EVs have been evaluated as a prominent source of viral antigens to elicit specific immune responses and to develop new vaccination platforms as viruses and EVs share biogenesis pathways. Preliminary trials with lymphocytic choriomeningitis virus infection (LCMV), porcine reproductive and respiratory syndrome virus (PRRSV), and Marek's disease virus (MDV) have demonstrated that EVs have a role in the activation of cellular and antibody immune responses. Moreover, in parasitic diseases such as Eimeria (chickens) and Plasmodium yoelii (mice) protection has been achieved. Research into EVs is therefore opening an opportunity for new strategies to overcome old problems affecting food security, animal health, and emerging diseases. Here, we review different conventional approaches for vaccine design and compare them with examples of EV‐based vaccines that have already been tested in relation to animal health
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