A study on oxygen independent fitness (anaerobic capacity) in pre-collegiate boys of Vijayapur, North Karnataka, India

Background: The anaerobic capacity is a useful concept, its application during exercise testing should considerably increase the information gained regarding cardiovascular function in health and disease. The objective was to evaluate oxygen independent fitness (anaerobic capacity) in pre-collegiate boys (age group of 16-18 years) of Vijayapur, North Karnataka, India.Methods: Eighty seven young adolescent healthy pre-collegiate boys volunteered for this study. The following parameters were recorded: Physical anthropometric parameters: body surface area, body mass index, body fat percentage, Physiological parameters: Blood pressure, physical fitness index test and anaerobic fitness step test. Correlation analysis and Z tests were used to analyze the obtained data.Results: Physical anthropometric parameters of the subjects were found within normal range. Statistically significant exercise induced rise in blood pressure were observed in physical fitness step test. Anaerobic capacity was correlated with body surface area, body mass index, body fat percentage and pre and post exercise blood pressure. Physical fitness index was not correlated with anaerobic capacity.  Conclusions:The physical fitness index was in good category, normal physiological response to exercise but physical fitness index not correlated with anaerobic capacity. Anaerobic capacity was found within normal range in pre-collegiate boys of age 16-18 years in study area. Ideal body mass index may not be possible in this age group.

Occurrence of Equine West Nile VirusAmongHorses in Qatar :A Preliminary Investigation

West Nile Virus (WNV) is an emerging threat to public health authorities around the globe. WNV is maintained in ecosystems primarily in enzootic cycles involving mosquito vector and avian hosts, with epizootic spread to mammals including horses and humans. Outbreaks of WNV disease in mammals have been associated with significant losses. The factors that play roles in the evaluation of these outbreaks are not fully known and the disease has not been reported in Qatar. We carried out a study to determine the prevalence of exposure to WNV in the State of Qatar and identify the factors that are likely to associate with seroconverion

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in \u3ci\u3eDrosophila\u3c/i\u3e

Mitochondrial transcription, translation, and respiration require interactions between genes encoded in two distinct genomes, generating the potential for mutations in nuclear and mitochondrial genomes to interact epistatically and cause incompatibilities that decrease fitness. Mitochondrial-nuclear epistasis for fitness has been documented within and between populations and species of diverse taxa, but rarely has the genetic or mechanistic basis of these mitochondrial–nuclear interactions been elucidated, limiting our understanding of which genes harbor variants causing mitochondrial–nuclear disruption and of the pathways and processes that are impacted by mitochondrial–nuclear coevolution. Here we identify an amino acid polymorphism in the Drosophila melanogaster nuclear-encoded mitochondrial tyrosyl–tRNA synthetase that interacts epistatically with a polymorphism in the D. simulans mitochondrial-encoded tRNATyr to significantly delay development, compromise bristle formation, and decrease fecundity. The incompatible genotype specifically decreases the activities of oxidative phosphorylation complexes I, III, and IV that contain mitochondrial-encoded subunits. Combined with the identity of the interacting alleles, this pattern indicates that mitochondrial protein translation is affected by this interaction. Our findings suggest that interactions between mitochondrial tRNAs and their nuclear-encoded tRNA synthetases may be targets of compensatory molecular evolution. Human mitochondrial diseases are often genetically complex and variable in penetrance, and the mitochondrial–nuclear interaction we document provides a plausible mechanism to explain this complexity

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in \u3ci\u3eDrosophila\u3c/i\u3e

Mitochondrial transcription, translation, and respiration require interactions between genes encoded in two distinct genomes, generating the potential for mutations in nuclear and mitochondrial genomes to interact epistatically and cause incompatibilities that decrease fitness. Mitochondrial-nuclear epistasis for fitness has been documented within and between populations and species of diverse taxa, but rarely has the genetic or mechanistic basis of these mitochondrial–nuclear interactions been elucidated, limiting our understanding of which genes harbor variants causing mitochondrial–nuclear disruption and of the pathways and processes that are impacted by mitochondrial–nuclear coevolution. Here we identify an amino acid polymorphism in the Drosophila melanogaster nuclear-encoded mitochondrial tyrosyl–tRNA synthetase that interacts epistatically with a polymorphism in the D. simulans mitochondrial-encoded tRNATyr to significantly delay development, compromise bristle formation, and decrease fecundity. The incompatible genotype specifically decreases the activities of oxidative phosphorylation complexes I, III, and IV that contain mitochondrial-encoded subunits. Combined with the identity of the interacting alleles, this pattern indicates that mitochondrial protein translation is affected by this interaction. Our findings suggest that interactions between mitochondrial tRNAs and their nuclear-encoded tRNA synthetases may be targets of compensatory molecular evolution. Human mitochondrial diseases are often genetically complex and variable in penetrance, and the mitochondrial–nuclear interaction we document provides a plausible mechanism to explain this complexity

Shashthosheba: Dissecting Perception of Bangladeshi People towards Telemedicine Apps through the Lens of Features of the Apps

Bangladesh, a developing country with a large and dense population, has recently seen significant economic as well as technological developments. The growth of technology has resulted in a dramatic increase in the number of smartphone users in Bangladesh, and as such, mobile apps have become an increasingly important part of peoples' life, even encompassing healthcare services. However, the apps used in healthcare (telemedicine to be specific) in Bangladesh are yet to be studied from the perspective of their features as per the voices of the users as well as service providers. Therefore, in this study, we focus on the features of the telemedicine apps used in Bangladesh. First, we evaluated the present status of existing telemedicine apps in Bangladesh, as well as their benefits and drawbacks in the context of HCI. We analyzed publicly accessible reviews of several Bangladeshi telemedicine apps (N = 14) to evaluate the user impressions. Additionally, to ascertain the public opinion of these apps, we performed a survey in which the patients (N = 87) participated willingly. Our analysis of the collected opinions reveals what users experience, what they appreciate, and what they are concerned about when they use telemedicine apps. Additionally, our study demonstrates what users expect from telemedicine apps, independent of their past experience. Finally, we explore how to address the issues we discovered and how telemedicine may be used to effectively offer healthcare services throughout the country. To the best of our knowledge, this study is the first to analyze the perception of the people of Bangladesh towards telemedicine apps from the perspective of features of the apps.Comment: 12 page

Histomorphological study of mucormycosis in COVID-19 patients

Background: Mucormycosis is a rapidly progressive angioinvasive fungal infection which has a high rate of mortality and morbidity. Mucormycosis most commonly invades the nose and paranasal sinuses presenting as rhinosinusitis. We noted an upsurge in the number of patients affected with Mucormycosis during Covid-19 infection era. Aim: Our study aims to illustrate the histopathology of Mucormycosis in post-Covid-19 patients and also to study the fungal morphology by utilizing special stains. Materials and Methods: We prospectively analysed the histopathological findings of fungal elements in 260 different histopathological samples of mucormycosis in post-covid-19 patients. The clinical and histopathological findings were noted and tabulated. Statistical Analysis Used: The data collected was tabulated and coded in Microsoft excel. All the data of demographic and clinical characteristics were analysed by descriptive statistics and percentage. Tables and graphs were added wherever applicable. Results: Out of 260 cases analysed, most of the patients presented with periorbital swelling followed by headache and nasal block. Histopathologically, most of the cases showed chronic inflammatory reaction with wide areas of necrosis and granuloma formation. The fungal elements have been appreciated and sensitivity of different stains to appreciate the fungal structures have been compared.

Sandstone sample analysis and additional structural data from Jabal Rayah, a possible impact structure in Saudi Arabia

The ~ 5.5 km sized Jabal Rayah ring structure located at 28° 390 N/37° 120 E in Saudi-Arabia has been classified as a possible complex impact structure located in flat-lying-Paleozoic clastic sediments. Previous, detailed mapping showed that erosional processes led-to a relief inversion, with displaced, folded, and faulted blocks of Silurian to Early-Devonian strata, interpreted to form a ring syncline, now forming a topographically-outstanding, 150 m high ring crest. The drainage toward the center of the structure seems-controlled by a set of radial faults. This central part is eroded to the level of the-surrounding plateau and partially covered with gravel. Analysis of 28 Qusaiba Formation-sandstones showed that at the present outcrop level, the sediments seem devoid of shock-features. Measurement of fold axes in the central part of the structure shows radially-outward plunging fold axes, becoming steeper toward the center, and also fold axes of other-orientation, and folded folds. This fold axis pattern is interpreted as an upward-pointing,-kilometer-sized sheath fold. Assuming an impact scenario and using the present size of the-structure, the minimum central structural uplift is estimated at ~ 500 m, which is consistent-with Qusaiba Formation occupying the center of the ring structure

Influence of the Additives on Clouding of Non-Ionic Surfactant Triton X-114 Solutions: Evaluation of Thermodynamics at the CP

<div><p>In the present work, we report the influence of the additives (e.g., electrolytes, sugars, amino acids, vitamin, etc.) on the cloud point (CP) of non-ionic surfactant Triton X-114 in aqueous solutions. In the absence of any added additives, the CP of Triton X-114 showed a concentration dependent variation (i.e., the CP of pure Triton X-114 is concentration dependent). A decrease/increase in the CP values was observed with the addition of the additives. The results are discussed by taking into consideration the nature of the additives and their micellar growth. The clouding components release their solvated water and separate out from the solution. Therefore, the CP of an amphiphile can be considered as the limit of its solubility. We have evaluated the various thermodynamic parameters of the surfactant (Triton X-114) molecule at the CP in the absence and presence of the additives. Furthermore, for a better understanding of the mechanism of clouding of the surfactant + additive systems in water, dye solubilization studies also performed.</p></div