Discovery of High-Latitude CO in a HI Supershell in NGC 5775

We report the discovery of very high latitude molecular gas in the edge-on spiral galaxy, NGC 5775. Emission from both the J=1-0 and 2-1 lines of 12CO is detected up to 4.8 kpc away from the mid-plane of the galaxy. NGC 5775 is known to host a number of HI supershells. The association of the molecular gas M(H2,F2) = 3.1x10^7 solar masses reported here with one of the HI supershells (labeled F2) is clear, which suggests that molecular gas may have survived the process which originally formed the supershell. Alternatively, part of the gas could have been formed in situ at high latitude from shock-compression of pre-existing HI gas. The CO J=2-1/J=1-0 line ratio of 0.34+-40% is significantly lower than unity, which suggests that the gas is excited subthermally, with gas density a few times 100 cubic cm. The molecular gas is likely in the form of cloudlets which are confined by magnetic and cosmic rays pressure. The potential energy of the gas at high latitude is found to be 2x10^56 ergs and the total (HI + H2) kinetic energy is 9x10^53 ergs. Based on the energetics of the supershell, we suggest that most of the energy in the supershell is in the form of potential energy and that the supershell is on the verge of falling and returning the gas to the disk of the galaxy.Comment: Accept by ApJL, 4 pages, 3 ps figure

NUGA: the IRAM survey of AGN spiral hosts

The NUclei of GAlaxies (NUGA) project is a combined effort to carry out a high-resolution (<1'') interferometer CO survey of a sample of 12 nearby AGN spiral hosts, using the IRAM array. We map the distribution and dynamics of molecular gas in the inner 1 kpc of the nuclei with resolutions of 10-50 pc, and study the mechanisms for gas fueling of the different low-luminosity AGN. First results show evidence for the occurrence of strong m=1 gas instabilities in Seyferts. NUGA maps allow us to address the origin/nature of m=1 modes and their link with m=2 modes and acoustic instabilities, present in other targets.Comment: 1 gzipped tar file containing 1 Latex file + 3 eps figures. Proceedings of ''Active Galactic Nuclei: from Central Engine to Host Galaxy'', meeting held in Meudon, France, July 23-27, 2002, Eds.: S. Collin, F. Combes and I. Shlosman. To be published in ASP Conference Serie

Remote Controlling and Monitoring of Safety Devices Using Web-Interface Embedded Systems

To date, access control systems have been hardware-based platforms, where software and hardware parts were uncoupled into different systems. The Department of Electronic Technology in the University of Seville, together with ISIS Engineering, have developed an innovative embedded system that provides all needed functions for controlling and monitoring remote access control systems through a built-in web interface. The design provides a monolithic structure, independence from outer systems, easiness in management and maintenance, conformation to the highest standards in security, and straightforward adaptability to applications other than the original one. We have accomplished it by using an extremely reduced Linux kernel and developing web and purpose- specific logic under software technologies with an optimal resource use.Ministerio de Ciencia y Tecnología TEC2006-0843

Closing the dark photon window to thermal dark matter

The nature of dark matter remains a central question in particle physics, cosmology, and astrophysics. The prevailing hypothesis postulates that dark matter consists of particles that interact only weakly with Standard Model particles. However, the knowledge of dark matter properties beyond these interactions is limited. This study explores a scenario involving a dark photon as a mediator between dark matter and the Standard Model, akin to the photon's role in electromagnetism. Recent cosmological and experimental evidence impose constraints on this scenario, focusing on results from direct detection experiments such as PICO-60, XENON-1T, and PANDAX-4T. The results reveal severe constraints, effectively closing the window for laboratory searches for dark photons as mediators between the Standard Model and the dark sector (dark electrons) in the secluded dark matter scenario. The findings underscore the need for alternative explanations and offer fresh perspectives on the ongoing quest to understand dark matter and its interactions since they are nearly independent of the dark electron fraction content for the total dark matter. This analysis significantly narrows down the parameter space for thermal dark matter scenarios involving a dark photon portal, reinforcing the urgency of exploring alternative models and designing new experiments to unravel the mysteries surrounding the nature of dark matter.Comment: 11 pages, 5 figure

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Background Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix by hepatic stellate cell-derived myofibroblasts. Whereas nucleotide sequence variations have been extensively studied in liver fibrosis, the role of copy number variations (CNV) in which genes exist in abnormal numbers of copies (mostly due to duplication or deletion) has had limited exploration. Methods The impact of the XPO4 CNV on histological liver damage was examined in a cohort comprised 646 Caucasian patients with biopsy-proven MAFLD and 170 healthy controls. XPO4 expression was modulated and function was examined in human and animal models. Findings Here we demonstrate in a cohort of 816 subjects, 646 with biopsy-proven metabolic associated liver disease (MAFLD) and 170 controls, that duplication in the exportin 4 (XPO4) CNV is associated with the severity of liver fibrosis. Functionally, this occurs via reduced expression of hepatic XPO4 that maintains sustained activation of SMAD3/SMAD4 and promotes TGF-β1-mediated HSC activation and fibrosis. This effect was mediated through termination of nuclear SMAD3 signalling. XPO4 demonstrated preferential binding to SMAD3 compared to other SMADs and led to reduced SMAD3-mediated responses as shown by attenuation of TGFβ1 induced SMAD transcriptional activity, reductions in the recruitment of SMAD3 to target gene promoters following TGF-β1, as well as attenuation of SMAD3 phosphorylation and disturbed SMAD3/SMAD4 complex formation. Interpretation We conclude that a CNV in XPO4 is a critical mediator of fibrosis severity and can be exploited as a therapeutic target for liver fibrosis

Molecular Gas in NUclei of GAlaxies (NUGA) I.The counter-rotating LINER NGC4826

We present new high-resolution observations of the nucleus of the counter-rotating LINER NGC4826, made in the J=1-0 and J=2-1 lines of 12CO with the IRAM Plateau de Bure mm-interferometer(PdBI).The CO maps, which achieve 0.8''(16pc) resolution in the 2-1 line, fully resolve an inner molecular gas disk which is truncated at an outer radius of 700pc. The total molecular gas mass is distributed in a lopsided nuclear disk of 40pc radius and two one-arm spirals, which develop at different radii in the disk. The distribution and kinematics of molecular gas in the inner 1kpc of NGC4826 show the prevalence of different types of m=1 perturbations in the gas. Although dominated by rotation, the gas kinematics are perturbed by streaming motions related to the m=1 instabilities. The non-circular motions associated with the inner m=1 perturbations agree qualitatively with the pattern expected for a trailing wave developed outside corotation ('fast' wave). In contrast, the streaming motions in the outer m=1 spiral are better explained by a 'slow' wave. A paradoxical consequence is that the inner m=1 perturbations would not favour AGN feeding. An independent confirmation that the AGN is not being generously fueled at present is found in the low values of the gravitational torques exerted by the stellar potential for R<530pc. The distribution of star formation in the disk of NGC4826 is also strongly asymmetrical. Massive star formation is still vigorous, fed by the significant molecular gas reservoir at R<700pc. There is supporting evidence for a recent large mass inflow episode in NGC4826. These observations have been made in the context of the NUclei of GAlaxies (NUGA) project, aimed at the study of the different mechanisms for gas fueling of AGN.Comment: A&A, 2003, Paper accepted (04/06/03). For a full-resolution version of this paper see http://www.oan.es/preprint

A Parenting Program to Reduce Disruptive Behavior in Hispanic Children with Acquired Brain Injury: A Randomized Controlled Trial Conducted in Mexico

Children with acquired brain injury (ABI) are at risk of impairments in self-regulation and disruptive behavior. We aimed to investigate the effectiveness of the Signposts program to reduce disruptive behavior and improve self-regulation in Hispanic children with ABI, and reduce parental stress and improve parenting practices. Using a randomized controlled trial design, we assigned children (n = 71) and their parents to Signposts or generic telephone support. Blinded assessors conducted assessments at pre-intervention, immediately post-intervention, and at 3 months post-intervention. Signposts was effective in reducing dysfunctional parenting practices. Further, when analyzing participants at risk of behavioral disturbance (n = 46), Signposts was effective in reducing child disruptive behavior in the home environment and emotional self-regulation. No differences were found for parental stress, parent sense of competence, child disruptive behaviors at school, and child cognitive and behavioral selfregulation. The reduction in disruptive behavior was associated with the implementation of authoritative parenting practices (external regulation), and not as

Parenting and the dysregulation profile predict executive functioning in children with acquired brain injury

Background: Children with acquired brain injury (ABI) present with high rates of psychological disorders commonly accompanied by deficits in hot and cold executive functions (EFs). Impairments in EFs have been reported to precede mental health problems. Moreover, children who are vulnerable to developing mental health problems in adulthood frequently present with a dysregulation profile in childhood, characterized by impairments in cognitive, behavioral and emotional regulation. Objective: To identify profiles of behaviors associated with impairment in hot and cold EFs and compare injury factors, envi