Two‐step continuous production of monodisperse colloidal ellipsoids at rates of one gram per day

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141576/1/aic16009_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141576/2/aic16009.pd

Towards a resource-based habitat approach for spatial modelling of vector-borne disease risks

Given the veterinary and public health impact of vector-borne diseases, there is a clear need to assess the suitability of landscapes for the emergence and spread of these diseases. Current approaches for predicting disease risks neglect key features of the landscape as components of the functional habitat of vectors or hosts, and hence of the pathogen. Empirical–statistical methods do not explicitly incorporate biological mechanisms, whereas current mechanistic models are rarely spatially explicit; both methods ignore the way animals use the landscape (i.e. movement ecology). We argue that applying a functional concept for habitat, i.e. the resource-based habitat concept (RBHC), can solve these issues. The RBHC offers a framework to identify systematically the different ecological resources that are necessary for the completion of the transmission cycle and to relate these resources to (combinations of) landscape features and other environmental factors. The potential of the RBHC as a framework for identifying suitable habitats for vector-borne pathogens is explored and illustrated with the case of bluetongue virus, a midge-transmitted virus affecting ruminants. The concept facilitates the study of functional habitats of the interacting species (vectors as well as hosts) and provides new insight into spatial and temporal variation in transmission opportunities and exposure that ultimately determine disease risks. It may help to identify knowledge gaps and control options arising from changes in the spatial configuration of key resources across the landscape. The RBHC framework may act as a bridge between existing mechanistic and statistical modelling approaches

3D Gamma-ray and Neutron Mapping in Real-Time with the Localization and Mapping Platform from Unmanned Aerial Systems and Man-Portable Configurations

Nuclear Scene Data Fusion (SDF), implemented in the Localization and Mapping Platform (LAMP) fuses three-dimensional (3D), real-time volumetric reconstructions of radiation sources with contextual information (e.g. LIDAR, camera, etc.) derived from the environment around the detector system. This information, particularly when obtained in real time, may be transformative for applications, including directed search for lost or stolen sources, consequence management after the release of radioactive materials, or contamination avoidance in security-related or emergency response scenarios. 3D reconstructions enabled by SDF localize contamination or hotspots to specific areas or objects, providing higher resolution over larger areas than conventional 2D approaches, and enabling more efficient planning and response, particularly in complex 3D environments. In this work, we present the expansion of these gamma-ray mapping concepts to neutron source localization. Here we integrate LAMP with a custom $Cs_2LiLa(Br,Cl)_6:Ce$ (CLLBC) scintillator detector sensitive to both gamma-rays and neutrons, which we dub Neutron Gamma LAMP (NG-LAMP). NG-LAMP enables simultaneous neutron and gamma-ray mapping with high resolution gamma-ray spectroscopy. We demonstrate the ability to detect and localize surrogate Special Nuclear Materials (SNM) in real-time and in 3D based on neutron signatures alone, which is critical for the detection of heavily shielded SNM, when gamma-ray signatures are attenuated. In this work, we show for the first time the ability to localize, in 3D and realtime, a neutron source in the presence of a strong gamma-ray source, simultaneous and spectroscopic localization of three gamma-ray sources and a neutron source, and finally the localization of a surrogate SNM source based on neutron signatures alone, where gamma-ray data are consistent with background

Characterization of a Reverse-Phase Perfluorocarbon Emulsion for the Pulmonary Delivery of Tobramycin

Background: Aerosolized delivery of antibiotics is hindered by poor penetration within distal and plugged airways. Antibacterial perfluorocarbon ventilation (APV) is a proposed solution in which the lungs are partially or totally filled with perfluorocarbon (PFC) containing emulsified antibiotics. The purpose of this study was to evaluate emulsion stability and rheological, antibacterial, and pharmacokinetic characteristics. Methods: This study examined emulsion aqueous droplet diameter and number density over 24?hr and emulsion and neat PFC viscosity and surface tension. Additionally, Pseudomonas aeruginosa biofilm growth was measured after 2-hr exposure to emulsion with variable aqueous volume percentages (0.25, 1, and 2.5%) and aqueous tobramycin concentrations (Ca=0.4, 4, and 40?mg/mL). Lastly, the time course of serum and pulmonary tobramycin concentrations was evaluated following APV and conventional aerosolized delivery of tobramycin in rats. Results: The initial aqueous droplet diameter averaged 1.9±0.2??m with little change over time. Initial aqueous droplet number density averaged 3.5±1.7?109 droplets/mL with a significant (p<0.01) decrease over time. Emulsion and PFC viscosity were not significantly different, averaging 1.22±0.03?10?3 Pa·sec. The surface tensions of PFC and emulsion were 15.0±0.1?10?3 and 14.6±0.6?10?3 N/m, respectively, and the aqueous interfacial tensions were 46.7±0.3?10?3 and 26.9±11.0?10?3 N/m (p<0.01), respectively. Biofilm growth decreased markedly with increasing Ca and, to a lesser extent, aqueous volume percentage. Tobramycin delivered via APV yielded 2.5 and 10 times larger pulmonary concentrations at 1 and 4?hr post delivery, respectively, and significantly (p<0.05) lower serum concentrations compared with aerosolized delivery. Conclusions: The emulsion is bactericidal, retains the rheology necessary for pulmonary delivery, is sufficiently stable for this application, and results in increased pulmonary retention of the antibiotic.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140105/1/jamp.2013.1058.pd

Personalised therapy in follicular lymphoma - is the dial turning?

Follicular lymphoma is the most common indolent lymphoma accounting for approximately 20%–25% of all new non-Hodgkin lymphoma diagnoses in western countries. Whilst outcomes are mostly favorable, the spectrum of clinical phenotypes includes high-risk groups with significantly inferior outcomes. This review discusses recent updates in risk stratification and treatment approaches from upfront treatment for limited and advanced stage follicular lymphoma to the growing options for relapsed, refractory disease with perspectives on how to approach this from a personalized lens. Notable gaps remain on how one can precisely and prospectively select optimal treatment for patients based on varying risks, with an anticipation that an increased understanding of the biology of these different phenotypes and increasing refinement of imaging- and biomarker-based tools will, in time, allow these gaps to be closed

Efficacy and safety of dasatinib vs. Imatinib in Latin american subpopulation from the dasision trial in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP)

sem informação100120th Congress of European-Hematology-Associationsem informaçã

Morphological Composition of z~0.4 groups: The site of S0 formation

The low redshift Universe (z<~0.5) is not a dull place. Processes leading to the suppression of star formation and morphological transformation are prevalent: this is particularly evident in the dramatic upturn in the fraction of S0-type galaxies in clusters. However, until now, the process and environment of formation has remained unidentified. We present a HST-based morphological analysis of galaxies in the redshift-space selected group and field environments at z~0.4. Groups contain a much higher fraction of S0s at fixed luminosity than the lower density field, with >99.999% confidence. Indeed the S0 fraction in groups is at least as high as in z~0.4 clusters and X-ray selected groups, which have more luminous Intra Group Medium (IGM). An 97% confident excess of S0s at >=0.3Mpc from the group centre at fixed luminosity, tells us that formation is not restricted to, and possibly even avoids, the group cores. Interactions with a bright X-ray emitting IGM cannot be important for the formation of the majority of S0s in the Universe. In contrast to S0s, the fraction of elliptical galaxies in groups at fixed luminosity is similar to the field, whilst the brightest ellipticals are strongly enhanced towards the group centres (>99.999% confidence within 0.3Mpc). We conclude that the group and sub-group environments must be dominant for the formation of S0 galaxies, and that minor mergers, galaxy harassment and tidal interactions are the most likely responsible mechanisms. This has implications not only for the inferred pre-processing of cluster galaxies, but also for the global morphological and star formation budget of galaxies: as hierarchical clustering progresses, more galaxies will be subject to these transformations as they enter the group environment.Comment: 13 pages, 6 figures. Accepted for publication in Ap

The Massive Star Content of NGC 3603

We investigate the massive star content of NGC 3603, the closest known giant H II region. We have obtained spectra of 26 stars in the central cluster using the Baade 6.5-m telescope (Magellan I). Of these 26 stars, 16 had no previous spectroscopy. We also obtained photometry of all of the stars with previous or new spectroscopy, primarily using archival HST ACS/HRC images. We use these data to derive an improved distance to the cluster, and to construct an H-R diagram for discussing the masses and ages of the massive star content of this cluster.Comment: Accepted by the Astronomical Journal. This revision updates the coordinates in Table 1 by (-0.18sec, +0.2") to place them on the UCAC2 syste