Improving efficiency of pig feed manufacturing and application of additives

The project has demonstrated that processed feeds with similar ingredient mixtures differ widely between mills in throughput, energy use, pellet hardness and durability and nutritional quality for growing pigs. Preparation of grains before mixing, specific ingredients and additives used as well as the physical structure of the processing units all affect the cost of manufacture and physical and nutritional quality of the finished product

How to write a successful grant application: guidance provided by the European Society of Clinical Pharmacy.

Considering a rejection rate of 80–90%, the preparation of a research grant is often considered a daunting task since it is resource intensive and there is no guarantee of success, even for seasoned researchers. This commentary provides a summary of the key points a researcher needs to consider when writing a research grant proposal, outlining: (1) how to conceptualise the research idea; (2) how to find the right funding call; (3) the importance of planning; (4) how to write; (5) what to write, and (6) key questions for reflection during preparation. It attempts to explain the difficulties associated with finding calls in clinical pharmacy and advanced pharmacy practice, and how to overcome them. The commentary aims to assist all pharmacy practice and health services research colleagues new to the grant application process, as well as experienced researchers striving to improve their grant review scores. The guidance in this paper is part of ESCP’s commitment to stimulate "innovative and high-quality research in all areas of clinical pharmacy"

Writing a manuscript for publication in a peer-reviewed scientific journal:Guidance from the European Society of Clinical Pharmacy

Publishing in reputable peer-reviewed journals is an integral step of the clinical pharmacy research process, allowing for knowledge transfer and advancement in clinical pharmacy practice. Writing a manuscript for publication in a journal requires several careful considerations to ensure that research findings are communicated to the satisfaction of editors and reviewers, and effectively to the readers. This commentary provides a summary of the main points to consider, outlining how to: (1) select a suitable journal, (2) tailor the manuscript for the journal readership, (3) organise the content of the manuscript in line with the journal’s guidelines, and (4) manage feedback from the peer review process. This commentary reviews the steps of the writing process, identifies common pitfalls, and proposes ways to overcome them. It aims to assist both novice and established researchers in the field of clinical pharmacy to enhance the quality of writing in a research paper to maximise impact

Scope, content and quality of clinical pharmacy practice guidelines:a systematic review

Background Guidelines for pharmacy practitioners regarding various clinical pharmacy activities have been published ina number of countries. There is a need to review the guidelines and identify the scope of activities covered as a prelude todeveloping internationally acceptable common guidelines.Aim To review the scope of clinical pharmacy guidelines and assess the extent to which these guidelines conform to qualitystandards as per the AGREE II instrument.Method Medline, Embase, Guideline Central, International Pharmaceutical Abstracts, Google Scholar and Google (for greyliterature) were searched for the period 2010 to January 2023. Guidelines which focused on any health care setting and anyclinical pharmacy activity were included. Data were extracted and quality assessed independently by two reviewers usingthe English version of the AGREE II instrument.Results Thirty-eight guidelines were included, mostly originating from Australia (n = 10), Ireland (n = 8), UK (n = 7) andUSA (n = 5). Areas covered included medication reconciliation, medicines optimisation, medication management and transi-tion of care. As per the AGREE II assessment, the highest score was obtained for the scope and purpose domain and the low-est score for rigour of development, mainly due to non-consideration of literature/evidence to inform guideline development.Conclusion Clinical pharmacy guidelines development processes need to focus on all quality domains and should take asystematic approach to guideline development. Guidelines need to further emphasise person-centred care and clinical com-munication. There is a scope to harmonise the guidelines internationally considering the diverse practices, standards and legislations across different geographie

Scope, content and quality of clinical pharmacy practice guidelines:a systematic review

Background Guidelines for pharmacy practitioners regarding various clinical pharmacy activities have been published ina number of countries. There is a need to review the guidelines and identify the scope of activities covered as a prelude todeveloping internationally acceptable common guidelines.Aim To review the scope of clinical pharmacy guidelines and assess the extent to which these guidelines conform to qualitystandards as per the AGREE II instrument.Method Medline, Embase, Guideline Central, International Pharmaceutical Abstracts, Google Scholar and Google (for greyliterature) were searched for the period 2010 to January 2023. Guidelines which focused on any health care setting and anyclinical pharmacy activity were included. Data were extracted and quality assessed independently by two reviewers usingthe English version of the AGREE II instrument.Results Thirty-eight guidelines were included, mostly originating from Australia (n = 10), Ireland (n = 8), UK (n = 7) andUSA (n = 5). Areas covered included medication reconciliation, medicines optimisation, medication management and transi-tion of care. As per the AGREE II assessment, the highest score was obtained for the scope and purpose domain and the low-est score for rigour of development, mainly due to non-consideration of literature/evidence to inform guideline development.Conclusion Clinical pharmacy guidelines development processes need to focus on all quality domains and should take asystematic approach to guideline development. Guidelines need to further emphasise person-centred care and clinical com-munication. There is a scope to harmonise the guidelines internationally considering the diverse practices, standards and legislations across different geographie

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study.

BACKGROUND: There is little current consensus regarding the route or duration of antibiotic treatment for acute osteomyelitis (OM) and septic arthritis (SA) in children. OBJECTIVE: To assess the overall feasibility and inform the design of a future randomised controlled trial (RCT) to reduce the duration of intravenous (i.v.) antibiotic use in paediatric OM and SA. DESIGN: (1) A prospective service evaluation (cohort study) to determine the current disease spectrum and UK clinical practice in paediatric OM/SA; (2) a prospective cohort substudy to assess the use of targeted polymerase chain reaction (PCR) in diagnosing paediatric OM/SA; (3) a qualitative study to explore families' views and experiences of OM/SA; and (4) the development of a core outcome set via a systematic review of literature, Delphi clinician survey and stakeholder consensus meeting. SETTING: Forty-four UK secondary and tertiary UK centres (service evaluation). PARTICIPANTS: Children with OM/SA. INTERVENTIONS: PCR diagnostics were compared with culture as standard of care. Semistructured interviews were used in the qualitative study. RESULTS: Data were obtained on 313 cases of OM/SA, of which 218 (61.2%) were defined as simple disease and 95 (26.7%) were defined as complex disease. The epidemiology of paediatric OM/SA in this study was consistent with existing European data. Children who met oral switch criteria less than 7 days from starting i.v. antibiotics were less likely to experience treatment failure (9.6%) than children who met oral switch criteria after 7 days of i.v. therapy (16.1% when switch was between 1 and 2 weeks; 18.2% when switch was > 2 weeks). In 24 out of 32 simple cases (75%) and 8 out of 12 complex cases (67%) in which the targeted PCR was used, a pathogen was detected. The qualitative study demonstrated the importance to parents and children of consideration of short- and long-term outcomes meaningful to families themselves. The consensus meeting agreed on the following outcomes: rehospitalisation or recurrence of symptoms while on oral antibiotics, recurrence of infection, disability at follow-up, symptom free at 1 year, limb shortening or deformity, chronic OM or arthritis, amputation or fasciotomy, death, need for paediatric intensive care, and line infection. Oral switch criteria were identified, including resolution of fever for ≥ 48 hours, tolerating oral food and medicines, and pain improvement. LIMITATIONS: Data were collected in a 6-month period, which might not have been representative, and follow-up data for long-term complications are limited. CONCLUSIONS: A future RCT would need to recruit from all tertiary and most secondary UK hospitals. Clinicians have implemented early oral switch for selected patients with simple disease without formal clinical trial evidence of safety. However, the current criteria by which decisions to make the oral switch are made are not clearly established or evidence based. FUTURE WORK: A RCT in simple OM and SA comparing shorter- or longer-course i.v. therapy is feasible in children randomised after oral switch criteria are met after 7 days of i.v. therapy, excluding children meeting oral switch criteria in the first week of i.v. therapy. This study design meets clinician preferences and addresses parental concerns not to randomise prior to oral switch criteria being met. FUNDING: The National Institute for Health Research Health Technology Assessment programme

Connecting the dots in pharmacy education: The FIP International Pharmaceutical Federation Global Competency Framework for Educators and Trainers in Pharmacy (FIP-GCFE)

The FIP (International Pharmaceutical Federation) Global Competency Framework for Educators and Trainers in Pharmacy (FIP-GCFE) is an ongoing project of the Academic Pharmacy Section of FIP in cooperation and collaboration with Sections, Special Interest Groups and Working Groups across the Federation. It was developed by a group of experts in pharmaceutical education to enable and promote the continuing professional development of pharmacists and pharmaceutical scientists who plan to advance their competence as educators and trainers in pharmacy and the pharmaceutical sciences, whether in a formal or informal context, and at all levels of education and professional development. The FIP-GCFE will be an essential resource for multiple stakeholders including individual educators, faculties of pharmacy, and accreditation agencies. This article presents the introductory text of the GCFE first version, connecting previously launched concepts and tools and explaining the integration with all other FIP workforce support frameworks, to provide a holistic approach to global workforce development

Staff experiences of working in a Sexual Assault Referral Centre: the impacts and emotional tolls of working with traumatised people

This study considers the impacts on staff of supporting people who have reported sexual violence and attend a Sexual Assault Referral Centre (SARC). This paper focuses on the staff’s perspectives of the stresses and emotional tolls they experience including the coping mechanisms they utilise. Semi- structured interviews were conducted with 12 staff, and a focus group was held with a further four staff of a SARC. The data were examined using thematic analysis. Findings indicated that staff experienced positive emotions connected to the meaningfulness of the work and team spirit as well as a range of unpleasant emotions. Staff also reported emotional numbing, in connection to the specificity, volume and sometimes unpredictable nature of the work. Coping mechanisms used by staff focused on the supportive connection to family, nature, and other team members; the value of clinical supervision; and the avoidance of topics related to work