Ionization disequilibrium in K- and L-shell ions

Producción CientíficaTime-gated Sc K-shell and Ge L-shell spectra are presented from a range of characterized thermodynamic states spanning ion densities of 1e19-1e20cm-3 and plasma temperatures around 2000eV. For the higher densities studied and temperatures from 1000 to 3000 eV, the Sc and Ge x-ray emission spectra are consistent with steady-state calculations from the modern atomic kinetics model SCRAM. At the lower ion densities achieved through plasma expansion, however, the model calculations require a higher plasma temperature to reproduce the observed Ge spectrum. We attribute this to ionization disequilibrium of the Sc because the ionization time scales exceed the hydrodynamic timescale when the inferred temperatures diverge.This work has been supported by the Research Grant No. PID2019-108764RB-I00 from the Spanish Ministry of Science and Innovation

X-ray Astronomy in the Laboratory with a Miniature Compact Object Produced by Laser-Driven Implosion

Laboratory spectroscopy of non-thermal equilibrium plasmas photoionized by intense radiation is a key to understanding compact objects, such as black holes, based on astronomical observations. This paper describes an experiment to study photoionizing plasmas in laboratory under well-defined and genuine conditions. Photoionized plasma is here generated using a 0.5-keV Planckian x-ray source created by means of a laser-driven implosion. The measured x-ray spectrum from the photoionized silicon plasma resembles those observed from the binary stars Cygnus X-3 and Vela X-1 with the Chandra x-ray satellite. This demonstrates that an extreme radiation field was produced in the laboratory, however, the theoretical interpretation of the laboratory spectrum significantly contradicts the generally accepted explanations in x-ray astronomy. This model experiment offers a novel test bed for validation and verification of computational codes used in x-ray astronomy.Comment: 5 pages, 4 figures are included. This is the original submitted version of the manuscript to be published in Nature Physic

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive

Radiation Science Using Z-Pinch X-Rays

Present-day Z-pinch experiments generate 200 TW peak power, 5–10 ns duration x-ray bursts that provide new possibilities to advance radiation science. The experiments support both the underlying atomic and plasma physics, as well as inertial confinement fusion and astrophysics applications. A typical configuration consists of a sample located 1–10 cm away from the pinch, where it is heated to 10–100 eV temperatures by the pinch radiation. The spectrally-resolved sample-plasma absorption is measured by aiming x-ray spectrographs through the sample at the pinch. The pinch plasma thus both heats the sample and serves as a backlighter. Opacitymeasurements with this source are promising because of the large sample size, the relatively long radiation duration, and the possibility to measureopacities at temperatures above 100 eV. Initial opacity experiments are under way with CH-tamped NaBr foil samples. The Na serves as a thermometer and absorption spectra are recorded to determine the opacity of Br with a partially-filled M-shell. The large sample size and brightness of the Z pinch as a backlighter are also exploited in a novel method measuring re-emission from radiation-heated gold plasmas. The method uses a CH-tamped layered foil with Al+MgF2 facing the radiationsource. A gold backing layer that covers a portion of the foil absorbs radiation from the source and provides re-emission that further heats the Al+MgF2. The Al and Mg heating is measured using space-resolved Kα absorption spectroscopy and the difference between the two regions enables a determination of the gold re-emission. Measurements are also performed at lower densities where photoionization is expected to dominate over collisions. Absorption spectra have been obtained for both Ne-like Fe and He-like Ne, confirming production of the relevant charge states needed to benchmark atomic kinetics models. Refinement of the methods described here is in progress to address multiple issues for radiation science

Developing the Physics Basis of Fast Ignition Experiments at Future Large Fusion-class lasers

The Fast Ignition (FI) concept for Inertial Confinement Fusion (ICF) has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy (IFE) reactors. FI differs from conventional 'central hot spot' (CHS) target ignition by using one driver (laser, heavy ion beam or Z-pinch) to create a dense fuel and a separate ultra-short, ultra-intense laser beam to ignite the dense core. FI targets can burn with {approx} 3X lower density fuel than CHS targets, resulting in (all other things being equal) lower required compression energy, relaxed drive symmetry, relaxed target smoothness tolerances, and, importantly, higher gain. The short, intense ignition pulse that drives this process interacts with extremely high energy density plasmas; the physics that controls this interaction is only now becoming accessible in the lab, and is still not well understood. The attraction of obtaining higher gains in smaller facilities has led to a worldwide explosion of effort in the studies of FI. In particular, two new US facilities to be completed in 2009/2010, OMEGA/OMEGA EP and NIF-ARC (as well as others overseas) will include FI investigations as part of their program. These new facilities will be able to approach FI conditions much more closely than heretofore using direct drive (dd) for OMEGA/OMEGA EP and indirect drive (id) for NIF-ARC. This LDRD has provided the physics basis for the development of the detailed design for integrated Fast ignition experiments on these facilities on the 2010/2011 timescale. A strategic initiative LDRD has now been formed to carry out integrated experiments using NIF ARC beams to heat a full scale FI assembled core by the end of 2010

Modelling, Design And Diagnostics For A Photoionised Plasma Experiment

Photoionised plasmas are common in astrophysical environments and new high resolution spectra from such sources have been recorded in recent years by the Chandra and XMM-Newton satellites. These provide a wealth of spectroscopic information and have motivated recent efforts aimed at obtaining a detailed understanding of the atomic-kinetic and radiative characteristics of photoionised plasmas. The Z-pinch facility at the Sandia National Laboratories is the most powerful terrestrial source of X-rays and provides an opportunity to produce photoionised plasmas in a well characterised radiation environment. We present modelling work and experimental design considerations for a forthcoming experiment at Sandia in which X-rays from a collapsing Z-pinch will be used to photoionise low density neon contained in a gas cell. View factor calculations were used to evaluate the radiation environment at the gas cell; the hydrodynamic characteristics of the gas cell were examined using the Helios-CR code, in particular looking at the heating, temperature and ionisation of the neon and the absorption of radiation. Emission and absorption spectra were also computed, giving estimates of spectra likely to be observed experimentally

Molecular evidence of Ebola Reston virus infection in Philippine bats

Background: In 2008-09, evidence of Reston ebolavirus (RESTV) infection was found in domestic pigs and pig workers in the Philippines. With species of bats having been shown to be the cryptic reservoir of filoviruses elsewhere, the Philippine government, in conjunction with the Food and Agriculture Organization of the United Nations, assembled a multi-disciplinary and multi-institutional team to investigate Philippine bats as the possible reservoir of RESTV. Methods: The team undertook surveillance of bat populations at multiple locations during 2010 using both serology and molecular assays. Results: A total of 464 bats from 21 species were sampled. We found both molecular and serologic evidence of RESTV infection in multiple bat species. RNA was detected with quantitative PCR (qPCR) in oropharyngeal swabs taken from Miniopterus schreibersii, with three samples yielding a product on conventional hemi-nested PCR whose sequences differed from a Philippine pig isolate by a single nucleotide. Uncorroborated qPCR detections may indicate RESTV nucleic acid in several additional bat species (M. australis, C. brachyotis and Ch. plicata). We also detected anti-RESTV antibodies in three bats (Acerodon jubatus) using both Western blot and ELISA. Conclusions: The findings suggest that ebolavirus infection is taxonomically widespread in Philippine bats, but the evident low prevalence and low viral load warrants expanded surveillance to elaborate the findings, and more broadly, to determine the taxonomic and geographic occurrence of ebolaviruses in bats in the region. © 2015 Jayme et al

Promotion of Hendra virus replication by microRNA 146a

Hendra virus is a highly pathogenic zoonotic paramyxovirus in the genus Henipavirus. Thirty-nine outbreaks of Hendra virus have been reported since its initial identification in Queensland, Australia, resulting in seven human infections and four fatalities. Little is known about cellular host factors impacting Hendra virus replication. In this work, we demonstrate that Hendra virus makes use of a microRNA (miRNA) designated miR-146a, an NF-κB-responsive miRNA upregulated by several innate immune ligands, to favor its replication. miR-146a is elevated in the blood of ferrets and horses infected with Hendra virus and is upregulated by Hendra virus in human cells in vitro. Blocking miR-146a reduces Hendra virus replication in vitro, suggesting a role for this miRNA in Hendra virus replication. In silico analysis of miR-146a targets identified ring finger protein (RNF)11, a member of the A20 ubiquitin editing complex that negatively regulates NF-κB activity, as a novel component of Hendra virus replication. RNA interference-mediated silencing of RNF11 promotes Hendra virus replication in vitro, suggesting that increased NF-κB activity aids Hendra virus replication. Furthermore, overexpression of the IκB superrepressor inhibits Hendra virus replication. These studies are the first to demonstrate a host miRNA response to Hendra virus infection and suggest an important role for host miRNAs in Hendra virus disease

Long Duration Backlighter Experiments at Omega

We have successfully demonstrated a 7.5 ns-duration pinhole-apertured backlighter at the Omega laser facility. Pinhole-apertured point-projection backlighting for 8 ns will be useful for imaging evolving features in experiments at the National Ignition Facility. The backlighter consisted of a 20 {micro}m diameter pinhole in a 75 {micro}m thick Ta substrate separated from a Zn emitter (9 keV) by a 400 {micro}m thick high-density carbon piece. The carbon prevented the shock from the laser-driven surface from reaching the substrate before 8 ns and helped minimize x-ray ablation of the pinhole substrate. Grid wires in x-ray framing camera images of a gold grid have a source-limited resolution significantly smaller than the pinhole diameter due to the high aspect ratio of the pinhole, but do not become much smaller at late times

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

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