780 research outputs found
High-resolution spatial mapping of a superconducting NbN wire using single-electron detection
Superconducting NbN wires have recently received attention as detectors for
visible and infrared photons. We present experiments in which we use a NbN wire
for high-efficiency (40 %) detection of single electrons with keV energy. We
use the beam of a scanning electron microscope as a focussed, stable, and
calibrated electron source. Scanning the beam over the surface of the wire
provides a map of the detection efficiency. This map shows features as small as
150 nm, revealing wire inhomogeneities. The intrinsic resolution of this
mapping method, superior to optical methods, provides the basis of a
characterization tool relevant for photon detectors.Comment: 2009 IEEE Toronto International Conference, Science and Technology
for Humanity (TIC-STH
Magnetic structure of free cobalt clusters studied with Stern-Gerlach deflection experiments
We have studied the magnetic properties of free cobalt clusters in two
semi-independent Stern-Gerlach deflection experiments at temperatures between
60 and 307 K. We find that clusters consisting of 13 to 200 cobalt atoms
exhibit behavior that is entirely consistent with superparamagnetism, though
complicated by finite-system fluctuations in cluster temperature. By fitting
the data to the Langevin function, we report magnetic moments per atom for each
cobalt cluster size and compare the results of our two measurements and all
those performed previously. In addition to a gradual decrease in moment per
atom with increasing size, there are oscillations that appear to be caused by
geometrical shell structure. We discuss our observations in light of the two
competing models for Langevin-like magnetization behavior in free clusters,
superparamagnetism and adiabatic magnetization, and conclude that the evidence
strongly supports the superparamagnetic model
Connections between Classical and Parametric Network Entropies
This paper explores relationships between classical and parametric measures of graph (or network) complexity. Classical measures are based on vertex decompositions induced by equivalence relations. Parametric measures, on the other hand, are constructed by using information functions to assign probabilities to the vertices. The inequalities established in this paper relating classical and parametric measures lay a foundation for systematic classification of entropy-based measures of graph complexity
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Fusion reactor design studies
This progress report will give a detailed breakdown of the work accomplished for ARIES-III during the contract period, November 1, 1990 to October 31, 1991. The areas of effort discussed are: Neutronics; First-Wall; Shield; Safety; Systems; Startup and Shutdown; Energy Conversion; Ripple Loss; and Fuel Resources
Integrative Network Biology: Graph Prototyping for Co-Expression Cancer Networks
Network-based analysis has been proven useful in biologically-oriented areas, e.g., to explore the dynamics and complexity of biological networks. Investigating a set of networks allows deriving general knowledge about the underlying topological and functional properties. The integrative analysis of networks typically combines networks from different studies that investigate the same or similar research questions. In order to perform an integrative analysis it is often necessary to compare the properties of matching edges across the data set. This identification of common edges is often burdensome and computational intensive. Here, we present an approach that is different from inferring a new network based on common features. Instead, we select one network as a graph prototype, which then represents a set of comparable network objects, as it has the least average distance to all other networks in the same set. We demonstrate the usefulness of the graph prototyping approach on a set of prostate cancer networks and a set of corresponding benign networks. We further show that the distances within the cancer group and the benign group are statistically different depending on the utilized distance measure
Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus - associated hepatocellular carcinoma.
Background: The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC)
remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by studying multiple areas of the same liver from patients with HCC.
Methods: We compared the gene signature of whole liver tissue (WLT) versus laser capture-microdissected (LCM)
hepatocytes along with the intrahepatic expression of HBV. Gene expression profiling was performed on up to 17 WLT specimens obtained at various distances from the tumor center from individual livers of 11 patients with HCC and on selected LCM samples. HBV markers in liver and serum were determined by real-time polymerase chain reaction (PCR)and confocal immunofluorescence.
Results: Analysis of 5 areas of the liver showed a sharp change in gene expression between the immediate perilesional area and tumor periphery that correlated with a significant decrease in the intrahepatic expression of HB surface antigen (HBsAg). The tumor was characterized by a large preponderance of down-regulated genes, mostly involved in the
metabolism of lipids and fatty acids, glucose, amino acids and drugs, with down-regulation of pathways involved in the activation of PXR/RXR and PPARα/RXRα nuclear receptors, comprising PGC-1α and FOXO1, two key regulators
critically involved not only in the metabolic functions of the liver but also in the life cycle of HBV, acting as essential transcription factors for viral gene expression. These findings were confirmed by gene expression of microdissected
hepatocytes. Moreover, LCM of malignant hepatocytes also revealed up-regulation of unique genes associated with
cancer and signaling Pathways, including two novel HCC-associated cancer testis antigen genes, NUF2 and TTK.
Conclusions: Integrated gene expression profiling of whole liver tissue with that of microdissected hepatocytes
demonstrated that HBV-associated HCC is characterized by a metabolism switch-off and by a significant reduction in
HBsAg. LCM proved to be a critical tool to validate gene signatures associated with HCC and to identify genes that may play a role in hepatocarcinogenesis, opening new perspectives for the discovery of novel diagnostic markers and therapeutic targets
Comparing biological information contained in mRNA and non-coding RNAs for classification of lung cancer patients
Photodetection of propagating quantum microwaves in circuit QED
We develop the theory of a metamaterial composed of an array of discrete
quantum absorbers inside a one-dimensional waveguide that implements a
high-efficiency microwave photon detector. A basic design consists of a few
metastable superconducting nanocircuits spread inside and coupled to a
one-dimensional waveguide in a circuit QED setup. The arrival of a {\it
propagating} quantum microwave field induces an irreversible change in the
population of the internal levels of the absorbers, due to a selective
absorption of photon excitations. This design is studied using a formal but
simple quantum field theory, which allows us to evaluate the single-photon
absorption efficiency for one and many absorber setups. As an example, we
consider a particular design that combines a coplanar coaxial waveguide with
superconducting phase qubits, a natural but not exclusive playground for
experimental implementations. This work and a possible experimental realization
may stimulate the possible arrival of "all-optical" quantum information
processing with propagating quantum microwaves, where a microwave photodetector
could play a key role.Comment: 27 pages, submitted to Physica Scripta for Nobel Symposium on "Qubits
for Quantum Information", 200
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