A flat compound piezoelectric actuator of a type “a shaking beam”

It is investigated piezoelectric actuator, consisting of two flat converters of longitudinal fluctuations which ends are close by the hence – « a shaking beam ». Also is resulted the principle of work actuator in quality stator of the motor, and also as the ultrasonic concentrator of fluctuations. Additionally is made research of it actuator with the help of programs computer modeling. And is carried out optimization of the sizes driver hence actuator. Theoretical researches are confirmed experimentally, with the help of the precision laser equipmen

Biomechanical characteristics of the metatarsal part of the foot in swimmers in walking

Objective: to investigate the characteristics of the distribution of pressure under the foot during walking in swimmers of various ages and experience.Materials and methods. The study involved swimmers aged 11.4 ± 1.9 years, of both sexes, with at least 4 years of training experience (n = 23) and masters of sports in swimming, 19.3 ± 1.5 years old with 12.2 ± 1.3 years of experience (n = 23). The study used a podometric footscan® platform from RSscan company. Kinematic and dynamic parameters of pressure under the foot during natural walking were recorded. The focus was on the indicators of contact with the support in the zones of the metatarsal part of the foot. The peak pressure value in each metatarsal zone and the time to reach it were taken into account.Results. In the course of the study, the order in which the maximum pressure under the metatarsal zones manifests was understood, which appeared in a sequence: fifth, fourth, first, third and second metatarsal zones. It was found that in young athletes the transverse arch of the foot during walking undergoes a relatively greater load than in older athletes. Moreover, relatively high values were noted in the zones of the second and third metatarsals in both age groups.Conclusions: the swimmer’s foot experiences a significant professional transformation associated with specific sports activities, which dictates the need to introduce certain preventive and corrective measures into sports training

A flat compound piezoelectric actuator of a type “a shaking beam”

It is investigated piezoelectric actuator, consisting of two flat converters of longitudinal fluctuations which ends are close by the hence – « a shaking beam ». Also is resulted the principle of work actuator in quality stator of the motor, and also as the ultrasonic concentrator of fluctuations. Additionally is made research of it actuator with the help of programs computer modeling. And is carried out optimization of the sizes driver hence actuator. Theoretical researches are confirmed experimentally, with the help of the precision laser equipmen

A flat compound piezoelectric actuator of a type “a shaking beam”

It is investigated piezoelectric actuator, consisting of two flat converters of longitudinal fluctuations which ends are close by the hence – « a shaking beam ». Also is resulted the principle of work actuator in quality stator of the motor, and also as the ultrasonic concentrator of fluctuations. Additionally is made research of it actuator with the help of programs computer modeling. And is carried out optimization of the sizes driver hence actuator. Theoretical researches are confirmed experimentally, with the help of the precision laser equipmen

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin

Cysteine cathepsins often contribute to cancer progression due to their overexpression in the tumour microenvironment and therefore present attractive targets for non-invasive diagnostic imaging. However, the development of highly selective and versatile small molecule probes for cathepsins has been challenging. Here, we targeted tumour-associated cathepsin B using designed ankyrin repeat proteins (DARPins). The selective DARPin 8h6 inhibited cathepsin B with picomolar affinity (Ki = 35 pM) by binding to a site with low structural conservation in cathepsins, as revealed by the X-ray structure of the complex. DARPin 8h6 blocked cathepsin B activity in tumours ex vivo and was successfully applied in in vivo optical imaging in two mouse breast cancer models, in which cathepsin B was bound to the cell membrane or secreted to the extracellular milieu by tumour and stromal cells. Our approach validates cathepsin B as a promising diagnostic and theranostic target in cancer and other inflammation-associated diseases

On Possibility of Asteroids Taxonomy Classification Based on Multicolor Photometry in the LYRA-B Space Experiment

Possibility of carrying out of asteroids taxonomy classification has been analyzed based on the LYRA-B space experiment data about multicolor photometry in 10 spectral bands in the range from 175 to 1050 nm. Estimations of integral fluxes have obtained for the bands which overlapped with the range of the Bus-DeMeo taxonomy that is from 450 to 2450 nm. Drew a conclusion that the multicolor photometry data allow to carry out of asteroids taxonomy classification for main spectral classes.Анализируется возможность проведения таксономической классификации астероидов на основе данных космического эксперимента «Лира-Б» о многоцветной фотометрии в 10 полосах в диапазоне от 175 до 1 050 нм. Получены оценки интегральных потоков в полосах, перекрывающихся с диапазоном, применяемым в таксономии Бас-ДеМео от 450 до 2 450 нм. Сделан вывод, что данные многоцветной фотометрии позволят выполнить таксономическую классификацию астероидов для основных спектральных классов.Работа выполнена при поддержке постановления №211 Правительства Российской Федерации (контракт №02.A03.21.0006) и Министерства образования и науки Российской Федерации (базовая часть государственного задания, РК № AAAA–A17–117030310283–7)

Correctability of thyroid dysfunction by interm ittent hypobaric hypoxia

The work is devoted to studying the effect of intermittent hypobaric hypoxia on thyroid dysfunction. Simulation of thyroid dysfunction by oral introduction of levothyroxine sodium in a dose of 50 mg/kg body weight of the animal is accompanied by an increase in the concentration thyroid hormones and decreased levels of TSH in the blood, decrease blood supply to the thyroid gland and the structural changes, characteristic of reducing its functional activity. The use of intermittent hypobaric hypoxia reduces recovery time of hormonal imbalance in the pituitary gland-thyroid gland, structural, functional and microvascular disturbances in the thyroid gland.Работа посвящена изучению влияния прерывистой гипобарической гипоксии натиреоидную дисфункцию. Моделирование тиреоидной дисфункции путем перорального введения левотироксина натрия в дозе 50 мкг/кг массы тела животного сопровождается увеличением концентрации тиреоидных гормонов и снижением уровня ТТГ в крови, уменьшением кровоснабжения щитовидной железы и структурными изменениями, характерными для понижения её функциональной активности. Применение прерывистой гипобарической гипоксии сокращает сроки восстановления гормонального дисбаланса в системе гипофиз-щитовидная железа, структурно-функциональных и микрососудистых наррений в щитовидной железе

The possibility to decrease biological activity of chrysotile-asbestos

The paper presents a study of natural chrysotile and 15 samples modified using different temperature and pressure. The morphology, dimensions, chemical composition, crystalline structure, and technologic characteristics of the samples studied were similar. The numbers of negatively charged centers on the surface of fibers were about the same in all the samples. In two modified asbestos samples the number of positively charged centers was less than in the native one. In these samples the energy of interaction of charged centers with macromolecules of rodamin and eozin was also less than in the sample of natural chrysotile. It directly correlated with cytotoxicity and mutagenicity of them. The principal possibility to decrease the biological activity of asbestos has been discussed