A Unique Surgical Model for Studying the Physiology of Gastrin: Gastrocystoplasty and Fundectomy

Gastrin is well known as a gastric acid secreting agent and trophic factor, but the complexity and plasticity of the mechanisms behind its effects need elucidation. For instance, whether the effects depend on vagal innervation is still an open question. In the present report, we describe in technical detail a rat model of gastrocystoplasty and fundectomy with the hope that it will provide an additional tool in gastrin research and an example of experimental surgery

Cotensor Coalgebras in Monoidal Categories

We introduce the concept of cotensor coalgebra for a given bicomodule over a coalgebra in an abelian monoidal category. Under some further conditions we show that such a cotensor coalgebra exists and satisfies a meaningful universal property. We prove that this coalgebra is formally smooth whenever the comodule is relative injective and the coalgebra itself is formally smooth

Recollements of Module Categories

We establish a correspondence between recollements of abelian categories up to equivalence and certain TTF-triples. For a module category we show, moreover, a correspondence with idempotent ideals, recovering a theorem of Jans. Furthermore, we show that a recollement whose terms are module categories is equivalent to one induced by an idempotent element, thus answering a question by Kuhn.Comment: Comments are welcom

Tyrosine hydroxylase activity in the endocrine pancreas: changes induced by short-term dietary manipulation

BACKGROUND: Tyrosine hydroxylase (TH) activity and its possible participation in the control of insulin secretion were studied in pancreatic islets of adult Wistar rats fed a standard commercial diet (SD) or carbohydrates alone (CHD) for one week. TH activity, norepinephrine (NE) content, and glucose-induced insulin secretion were assessed. Blood glucose and insulin levels were measured at the time of sacrifice. RESULTS: CHD rats had significantly higher blood glucose and lower insulin levels than SD rats (114.5 ± 6.7 vs 80.7 ± 7.25 mg/dl, p < 0.001; 20.25 ± 2.45 vs 42.5 ± 4.99 μU/ml, p < 0.01, respectively). Whereas TH activity was significantly higher in CHD isolated islets (600 ± 60 vs 330 ± 40 pmol/mg protein/h; p < 0.001), NE content was significantly lower (18 ± 1 vs 31 ± 5 pmol/mg protein), suggesting that TH activity would be inhibited by the end-products of catecholamines (CAs) biosynthetic pathway. A similar TH activity was found in control and solarectomized rats (330 ± 40 vs 300 ± 80 pmol/mg protein/h), suggesting an endogenous rather than a neural origin of TH activity. CHD islets released significantly less insulin in response to glucose than SD islets (7.4 ± 0.9 vs 11.4 ± 1.1 ng/islet/h; p < 0.02). CONCLUSIONS: TH activity is present in islet cells; dietary manipulation simultaneously induces an increase in this activity together with a decrease in glucose-induced insulin secretion in rat islets. TH activity – and the consequent endogenous CAs turnover – would participate in the paracrine control of insulin secretion

Lifting and restricting recollement data

We study the problem of lifting and restricting TTF triples (equivalently, recollement data) for a certain wide type of triangulated categories. This, together with the parametrizations of TTF triples given in "Parametrizing recollement data", allows us to show that many well-known recollements of right bounded derived categories of algebras are restrictions of recollements in the unbounded level, and leads to criteria to detect recollements of general right bounded derived categories. In particular, we give in Theorem 1 necessary and sufficient conditions for a 'right bounded' derived category of a differential graded(=dg) category to be a recollement of 'right bounded' derived categories of dg categories. In Theorem 2 we consider the particular case in which those dg categories are just ordinary algebras.Comment: 29 page

User Review Sites as a Resource for Large-Scale Sociolinguistic Studies

Sociolinguistic studies investigate the relation between language and extra-linguistic variables. This requires both representative text data and the associated socio-economic meta-data of the subjects. Traditionally, sociolinguistic studies use small samples of hand-curated data and meta-data. This can lead to exaggerated or false conclusions. Us-ing social media data offers a large-scale source of language data, but usually lacks reliable socio-economic meta-data. Our research aims to remedy both problems by exploring a large new data source, international review websites with user profiles. They provide more text data than manually collected studies, and more meta-data than most available social media text. We describe the data and present vari-ous pilot studies, illustrating the usefulness of this resource for sociolinguistic studies. Our approach can help gener-ate new research hypotheses based on data-driven findings across several countries and languages

Meaning and Dialogue Coherence: A Proof-theoretic Investigation

This paper presents a novel proof-theoretic account of dialogue coherence. It focuses on an abstract class of cooperative information-oriented dialogues and describes how their structure can be accounted for in terms of a multi-agent hybrid inference system that combines natural deduction with information transfer and observation. We show how certain dialogue structures arise out of the interplay between the inferential roles of logical connectives (i.e., sentence semantics), a rule for transferring information between agents, and a rule for information flow between agents and their environment. The order of explanation is opposite in direction to that adopted in game-theoretic semantics, where sentence semantics (or a notion of valid inference) is derived from winning dialogue strategies. That approach and the current one may, however, be reconcilable, since we focus on cooperative dialogue, whereas the game-theoretic tradition concentrates on adversarial dialogue

Determination of the basin of attraction of a periodic orbit in two dimensions using meshless collocation

A contraction metric for an autonomous ordinary differential equation is a Riemannian metric such that the distance between adjacent solutions contracts over time. A contraction metric can be used to determine the basin of attraction of a periodic orbit without requiring information about its position or stability. Moreover, it is robust to small perturbations of the system. In two-dimensional systems, a contraction metric can be characterised by a scalar-valued function. In [9], the function was constructed as solution of a first-order linear Partial Differential Equation (PDE), and numerically constructed using meshless collocation. However, information about the periodic orbit was required, which needed to be approximated. In this paper, we overcome this requirement by studying a second-order PDE, which does not require any information about the periodic orbit. We show that the second-order PDE has a solution, which defines a contraction metric. We use meshless collocation to approximate the solution and prove error estimates. In particular, we show that the approximation itself is a contraction metric, if the collocation points are dense enough. The method is applied to two examples

A Q-methodology study of flare help-seeking behaviours and different experiences of daily life in rheumatoid arthritis

© 2014 Lin et al.; licensee BioMed Central Ltd. Background: Previous studies have not addressed rheumatoid arthritis (RA) patients' help-seeking behaviours for RA flares, and only one small qualitative study has addressed how patients experience daily life on current treatment regimes. Thus, this study aims to identify clusters of opinion related to RA patients' experiences of daily life on current treatments, and their help-seeking behaviours for RA flares. Methods: Using Q-methodology (a methodology using qualitative and quantitative methods to sort people according to subjective experience), two separate studies were conducted with the same sample of RA patients (mean age 55, 73% female). Thirty participants sorted 39 statements about daily life (Q-study 1) and 29 participants separately sorted 23 statements about flare help-seeking (Q-study 2). Data were examined using Q-factor analysis. Results: Daily life with RA (Q-study 1): Three factors relating to the experience of living with RA were extracted and explained. Patients belonging to Factor A (mean age 62, 86% female) use effective self-management techniques to control the daily impact of RA. Those in Factor B (mean age 55, 75% male) struggle to self-manage and cope. Whilst patients in Factor C (mean age 42, 100% female) prioritise life responsibilities over their RA, reporting less impact. Flare help-seeking (Q-study 2): Two factors explaining the experience of flare help-seeking (unrelated to the factors from Q-study 1) were extracted and explained. Factor X (68.8% on biologics) reported seeking help quickly, believing the medical team is there to help. Factor Y (0% on biologics) delay help-seeking, concerned about wasting the rheumatologist's time, believing they should manage alone. All participants agreed they sought help due to intense pain and persistent, unmanageable symptoms. Conclusions: Patients with different characteristics appear to manage RA life in different ways and men may struggle more than women. Whilst all patients are prompted to seek help by persistent, unmanageable symptoms, some delay help-seeking. Further research is needed to quantify the severity of daily symptoms, the level of symptoms needed for patients to define themselves as in flare and to understand the support needs of RA men

Self-reported frequency of swearing in English: do situational, psychological and sociobiographical variables have similar effects on first and foreign language users?

An analysis of data collected from 2347 users of English on their self-reported swearing behaviour in English revealed significant higher values for the 1159 native English (L1) users than for the 1165 English foreign language (LX) users. Parallel analyses on the data of the L1 and LX users revealed that the interlocutor effect was slightly stronger among L1 users. Swearing was reported to be most frequent in interactions with friends, when alone, followed by interactions with family members, colleagues and strangers. Participants scoring high on Psychoticism, Extraversion and Neuroticism reported significantly more swearing in English. Extraversion and Neuroticism had the strongest effects on LX users’ self-reported swearing with friends and alone while Psychoticism and Neuroticism had the strongest effects on L1 users’ self-reported swearing with strangers and with friends. The effects of sociobiographical variables (education level, age group, gender) were broadly similar among L1 and LX users but were significant in more categories of interlocutors for the L1 users. It is argued that the weaker effect of situational, psychological and sociobiographical variables on self-reported frequency of swearing among LX users of English could be linked to larger heterogeneity in their history of learning, socialisation, proficiency and use of English