Hydrology and Water Quality of the Grand Portage Reservation, Northeastern Minnesota, 1991-2000

Mounds View, M.N.: U.S. Geological SurveyThis is a technical geo-hydrologic study of water resources on the Grand Portage Reservation. There are few references to human uses of water resources, or to anthropogenic factors. The abstract with key points are extracted and reproduced below. Abstract: “The Grand Portage Reservation is located in northeastern Cook County, Minnesota at the boundary between Minnesota, USA, and Ontario, Canada. Between 1991 and 2000 the U.S. Geological Survey conducted a series of studies, with the cooperation with Grand Portage Band of Chippewa, to describe the water resources of the Grand Portage Reservation. Ground water moves primarily through fractures in the bedrock, probably in three ground-water systems: local, regional, and deep. Lake Superior is thought to be the discharge point for brines in the deep ground-water flow system. The watersheds in the Grand Portage Reservation are small and steep; consequently streams in the Grand Portage Reservation tend to be flashy. Lake stages rise and fall with rainfall. The pH of water in the Reservation is generally alkaline (pH greater than 7.0). The alkalinity of water in the Reservation is low. Concentrations of major ions are much greater in ground water than in spring water and surface water. The ionic composition of water in the Reservation differs depending upon the source of the water. Water from 11 of the 20 wells sampled are a calcium-sodium-chloride type. Water from wells GW-2, GW-7, and GW-11 had much greater specific conductance concentrations of major ions compared to the other wells. Some spring water (SP-1, SP-3, SP-4, SP-6, and SP-8) is calcium-bicarbonate type like surface water, whereas other spring water (SP-5 and SP-7) is similar to the calcium-sodium-chloride type occurring in samples from about one-half the wells. The major chemical constituents in surface water are bicarbonate, calcium, and magnesium. Measured tritium and sulfur hexafluoride (SF6) concentrations in water samples from springs and wells were used to determine the recharge age of the sampled water. The recharge ages of two of the wells sampled for tritium are before 1953. The recharge ages of the remaining 10 samples for tritium are probably after 1970. The recharge ages of seven SF6 samples were between 1973 and 1998.

Plasticity, crack initiation and defect resistance in alkali-borosilicate glasses: From normal to anomalous behavior

We provide a comprehensive description of the defect tolerance of sodium-borosilicate glasses upon sharp contact loading. This is motivated by the key role which is taken by this particular glass system in a wide variety of applications, ranging from electronic substrates, display covers and substrates for biomedical imaging and sensing to, e.g., radioactive waste vitrification. The present report covers the mechanical properties of glasses in the Na2O–B2O3–SiO2 ternary over the broad range of compositions from pure SiO2 to binary sodium-borates, and crossing the regions of various commercially relevant specialty borosilicate glasses, such as the multi-component Duran-, Pyrex- and BK7-type compositions and typical soda-lime silicate glasses, which are also included in this study. In terms of structure, the considered glasses may be separated into two groups, that is, one series which contains only bridging oxygen atoms, and another series which is designed with an increasing number of non-bridging oxygen ions. Elastic moduli, Poisson ratio, hardness as well as creep and crack resistance were evaluated, as well as the contribution of densification to the overall amount of indentation deformation. Correlations between the mechanical properties and structural characteristics of near- and mid-range order are discussed, from which we obtain a mechanistic view at the molecular reactions which govern the overall deformation reaction and, ultimately, contact cracking

The Effect of Varying Illumination on Distance Perception of Objects Subtending

The problem relates to the effect of distance judgment under conditions of semi-scotopic vision. The levels of illumination ranged between .01 and 1.30 foot candles. Two series of experiments are reported. The first series used 16 subjects with illumination levels ranging between .04 and 1.30 foot candles. The second series used seven subjects between the ranges of .01 and .04 foot candles. Time and errors were used as the criteria of performance. Both showed considerable variation throughout the series but greatest effects are noted below .03 foot candles. The time for setting varied more than the error score. Differential settings for colored test objects are given

Application of Large-Scale Parentage Analysis for Investigating Natal Dispersal in Highly Vagile Vertebrates: A Case Study of American Black Bears (\u3ci\u3eUrsus americanus\u3c/i\u3e)

Understanding the factors that affect dispersal is a fundamental question in ecology and conservation biology, particularly as populations are faced with increasing anthropogenic impacts. Here we collected georeferenced genetic samples (n=2,540) from three generations of black bears (Ursus americanus) harvested in a large (47,739 km2), geographically isolated population and used parentage analysis to identify mother-offspring dyads (n=337). We quantified the effects of sex, age, habitat type and suitability, and local harvest density at the natal and settlement sites on the probability of natal dispersal, and on dispersal distances. Dispersal was male-biased (76% of males dispersed) but a small proportion (21%) of females also dispersed, and female dispersal distances (mean ± SE = 48.9±7.7 km) were comparable to male dispersal distances (59.0±3.2 km). Dispersal probabilities and dispersal distances were greatest for bears in areas with high habitat suitability and low harvest density. The inverse relationship between dispersal and harvest density in black bears suggests that 1) intensive harvest promotes restricted dispersal, or 2) high black bear population density decreases the propensity to disperse. Multigenerational genetic data collected over large landscape scales can be a powerful means of characterizing dispersal patterns and causal associations with demographic and landscape features in wild populations of elusive and wide-ranging species

Prevalence and correlates of antipsychotic polypharmacy in children and adolescents receiving antipsychotic treatment*

Antipsychotic polypharmacy (APP), which is common in adults with psychotic disorders, is of unproven efficacy and raises safety concerns. Although youth are increasingly prescribed antipsychotics, little is known about APP in this population. We performed a systematic PubMed search (last update 26 January 2013) of studies reporting the prevalence of APP in antipsychotic-treated youth. Summary statistics and statistical tests were calculated at the study level and not weighted by sample size. Fifteen studies (n=58041, range 68-23183) reported on APP in youth [mean age=13.4 +/- 1.7 yr, 67.1 +/- 10.2% male, 77.9 +/- 27.4% treated with second-generation antipsychotics (SGAs)]. Data collected in these studies covered 1993-2008. The most common diagnoses were attention-deficit hyperactivity disorder (ADHD; 39.9 +/- 23.5%) and conduct disorder/oppositional defiant disorder (CD/ODD; 33.6 +/- 24.8). In studies including predominantly children (mean age=yr, N=5), the most common diagnosis were ADHD (50.6 +/- 25.4%) and CD/ODD (39.5 +/- 27.5%); while in studies with predominantly adolescents (mean age=13yr, N=7) the most common diagnoses were schizophrenia-spectrum disorders (28.6 +/- 23.8%), anxiety disorders (26.9 +/- 14.9%) and bipolar-spectrum disorders (26.6 +/- 7.0%), followed closely by CD/ODD (25.8 +/- 17.7). The prevalence of APP among antipsychotic-treated youth was 9.6 +/- 7.2% (5.9 +/- 4.5% in child studies, 12.0 +/- 7.9% in adolescent studies, p=0.15). Higher prevalence of APP was correlated with a bipolar disorder or schizophrenia diagnosis (p=0.019) and APP involving SGA+SGA combinations (p=0.0027). No correlation was found with APP definition [1d (N=10) vs. \u3e30-90d (N=5), p=0.88]. Despite lacking safety and efficacy data, APP in youth is not uncommon, even in samples predominantly consisting of non-psychotic patients. The duration, clinical motivations and effectiveness of this practice require further study

Model simulations of atmospheric methane (1997-2016) and their evaluation using NOAA and AGAGE surface and IAGOS-CARIBIC aircraft observations

Methane (CH4) is an important greenhouse gas, and its atmospheric budget is determined by interacting sources and sinks in a dynamic global environment. Methane observations indicate that after almost a decade of stagnation, from 2006, a sudden and continuing global mixing ratio increase took place. We applied a general circulation model to simulate the global atmospheric budget, variability, and trends of methane for the period 1997–2016. Using interannually constant CH4 a priori emissions from 11 biogenic and fossil source categories, the model results are compared with observations from 17 Advanced Global Atmospheric Gases Experiment (AGAGE) and National Oceanic and Atmospheric Administration (NOAA) surface stations and intercontinental Civil Aircraft for the Regular observation of the atmosphere Based on an Instrumented Container (CARIBIC) flights, with > 4800 CH4 samples, gathered on > 320 flights in the upper troposphere and lowermost stratosphere. Based on a simple optimization procedure, methane emission categories have been scaled to reduce discrepancies with the observational data for the period 1997–2006. With this approach, the all-station mean dry air mole fraction of 1780 nmol mol−1 could be improved from an a priori root mean square deviation (RMSD) of 1.31 % to just 0.61 %, associated with a coefficient of determination (R2) of 0.79. The simulated a priori interhemispheric difference of 143.12 nmol mol−1 was improved to 131.28 nmol mol−1, which matched the observations quite well (130.82 nmol mol−1). Analogously, aircraft measurements were reproduced well, with a global RMSD of 1.1 % for the measurements before 2007, with even better results on a regional level (e.g., over India, with an RMSD of 0.98 % and R2=0.65). With regard to emission optimization, this implied a 30.2 Tg CH4 yr−1 reduction in predominantly fossil-fuel-related emissions and a 28.7 Tg CH4 yr−1 increase of biogenic sources. With the same methodology, the CH4 growth that started in 2007 and continued almost linearly through 2013 was investigated, exploring the contributions by four potential causes, namely biogenic emissions from tropical wetlands, from agriculture including ruminant animals, and from rice cultivation, and anthropogenic emissions (fossil fuel sources, e.g., shale gas fracking) in North America. The optimization procedure adopted in this work showed that an increase in emissions from shale gas (7.67 Tg yr−1), rice cultivation (7.15 Tg yr−1), and tropical wetlands (0.58 Tg yr−1) for the period 2006–2013 leads to an optimal agreement (i.e., lowest RMSD) between model results and observations

Psychometric Properties of the Wisconsin Schizotypy Scales in an Undergraduate Sample: Classical Test Theory, Item Response Theory, and Differential Item Functioning

The Wisconsin Schizotypy Scales are widely used for assessing schizotypy in nonclinical and clinical samples. However, they were developed using classical test theory (CTT) and have not had their psychometric properties examined with more sophisticated measurement models. The present study employed item response theory (IRT) as well as traditional CTT to examine psychometric properties of four of the schizotypy scales on the item and scale level, using a large sample of undergraduate students (n?=?6,137). In addition, we investigated differential item functioning (DIF) for sex and ethnicity. The analyses revealed many strengths of the four scales, but some items had low discrimination values and many items had high DIF. The results offer useful guidance for applied users and for future development of these scales. The items for the Wisconsin Schizotypy Scales are available from Thomas R. Kwapil

Search for quarks in cosmic rays with the Leeds cloud chamber

The central regions of cosmic-ray air showers near sea level have been studied with the Leeds cloud chamber for the possible occurrence of low-ionizing tracks. The average energy of the primary particles was a few times 106 GeV. Our current results give an upper limit to the "flux" of quarks of 1.2 x 10-11 cm-2 sec-1 sr-1 at a 90% confidence level. A simple model is used to obtain an upper limit to the production cross section versus quark mass.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21994/1/0000406.pd

Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers

Recent studies have shown that membrane proteins can be efficiently synthesized in vitro before spontaneously inserting into soluble nanoscale lipid bilayers called nanodiscs (NDs). In this paper, we present experimental details that allow a combination of in vitro translation of ion channels into commercially available NDs followed by their direct reconstitution from these nanobilayers into standard bilayer setups for electrophysiological characterization. We present data showing that two model K+ channels, Kcv and KcsA, as well as a recently discovered dual-topology F-channel, Fluc, can be reliably reconstituted from different types of NDs into bilayers without contamination from the in vitro translation cocktail. The functional properties of Kcv and KcsA were characterized electrophysiologically and exhibited sensitivity to the lipid composition of the target DPhPC bilayer, suggesting that the channel proteins were fully exposed to the target membrane and were no longer surrounded by the lipid/protein scaffold. The single-channel properties of the three tested channels are compatible with studies from recordings of the same proteins in other expression systems. Altogether, the data show that synthesis of ion channels into NDs and their subsequent reconstitution into conventional bilayers provide a fast and reliable method for functional analysis of ion channels