19 research outputs found
An evaluation of family physicians' educational needs and experiences in health promotion and disease prevention in Poland and Lithuania - a qualitative study
Reikšminiai žodžiai: Ligų prevencija; Sveikatos stiprinimas; Šeimos gydytojai; Šeimos gydytojų rengimas; Šeimos gydytojų švietimo poreikiai; Disease prevention; Family physicians; Family physicians educational needs; Health promotion; Training of family physician
An insertional mutagenesis programme with an enhancer trap for the identification and tagging of genes involved in abiotic stress tolerance in the tomato wild-related species Solanum pennellii
Salinity and drought have a huge impact on agriculture since there are few areas free of these abiotic stresses and the problem continues to increase. In tomato, the most important horticultural crop worldwide, there are accessions of wild-related species with a high degree of tolerance to salinity and drought. Thus, the finding of insertional mutants with other tolerance levels could lead to the identification and tagging of key genes responsible for abiotic stress tolerance. To this end, we are performing an insertional mutagenesis programme with an enhancer trap in the tomato wild-related species Solanum pennellii. First, we developed an efficient transformation method which has allowed us to generate more than 2,000 T-DNA lines. Next, the collection of S. pennelli T0 lines has been screened in saline or drought conditions and several presumptive mutants have been selected for their salt and drought sensitivity. Moreover, T-DNA lines with expression of the reporter uidA gene in specific organs, such as vascular bundles, trichomes and stomata, which may play key roles in processes related to abiotic stress tolerance, have been identified. Finally, the growth of T-DNA lines in control conditions allowed us the identification of different development mutants. Taking into account that progenies from the lines are being obtained and that the collection of T-DNA lines is going to enlarge progressively due to the high transformation efficiency achieved, there are great possibilities for identifying key genes involved in different tolerance mechanisms to salinity and drought
Clinical variants of mycosis fungoides in a cohort
Introduction: Mycosis fungoides (MF) is the most common primary skin T-cell lymphoma, which is characterized for a heterogeneous clinical expressivity. Objective: To report clinical variants and sociodemographic characteristics in patients with MF under the care of a dermatological hospital. Methods: 290 patients with MF clinical and histopathological diagnosis attended to over the course of 11 years were included. Sociodemographic description of patients was made, who were classified according to clinical and histopathological variants. Results: MF was recorded in 57.9 % of women and 42 % of men. The most common clinical variant was the classic type in 46.2 %; dyschromic variants accounted for 35.2 %, out of which hypopigmented MF was the most representative (17.6 %); poikilodermatous MF accounted for 4.1 %, and folliculotropic, for 3.1%. The papular variant occurred in six patients (2.1 %), the single-plaque variety in three (1%), and the ichthyosiform, syringotropic and granulomatous slack skin varieties occurred in one patient each. The granulomatous variant was found in 0.7 %, and 1.4 % had erythroderma. Conclusions: The most common MF clinical variant was classic plaque stage, followed by dyschromic variants. Other clinical variants accounted for 18.6 %
Calidad metodológica de los ensayos clínicos de cicatrices queloides
Antecedentes: Existe heterogeneidad en el diseño de los ensayos clínicos (EC) para el tratamiento de cicatrices queloides que compromete la validez de sus resultados. Objetivo: Evaluar la calidad metodológica de los EC publicados sobre cicatrices queloides, principalmente las medidas de eficacia utilizadas. Método: Se analizaron los EC publicados sobre tratamientos para cicatrices queloides y se evaluó su calidad metodológica siguiendo los lineamientos CONSORT y el riesgo de sesgo según la herramienta de Cochrane. Se identificaron todas las medidas de eficacia utilizadas en los EC. Resultados: Se incluyeron 52 artículos, de los cuales solo en el 3.84% se mencionan los cambios importantes en la metodología después de iniciar el reclutamiento de los pacientes. El 59.6% de los EC fueron evaluados con alto riesgo de sesgo de realización por errores en el cegamiento del equipo de investigación. La variable de respuesta más frecuente fue la altura o grosor de las cicatrices. Conclusiones: Se recomienda que en los EC de cicatrices queloides se excluya a los participantes con cicatrices hipertróficas, y que la variable de resultado principal sea la altura de la cicatriz. También deben medirse el dolor y la calidad de vida de los pacientes
FXTAS in an unmethylated mosaic male with fragile X syndrome from Chile
© 2013 John Wiley & Sons A/S. Carriers of an FMR1 premutation allele (55-200 CGG repeats) often develop the neurodegenerative disorders, fragile X-associated tremor/ataxia syndrome (FXTAS). Neurological signs of FXTAS, parkinsonism and rapid onset of cognitive decline have not been reported in individuals with an unmethylated full mutation (FM). Here, we report a Chilean family affected with FXS, inherited from a parent carrier of an FMR1 unmethylated full mosaic allele, who presented with a fast progressing FXTAS. This case suggests that the definition of FXTAS may need to be broadened to not only include those with a premutation but also those with an expanded allele in FM range with a lack of methylation leading to elevated FMR1-mRNA expression levels and subsequent RNA toxicity
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FXTAS in an unmethylated mosaic male with fragile X syndrome from Chile.
Carriers of an FMR1 premutation allele (55-200 CGG repeats) often develop the neurodegenerative disorders, fragile X-associated tremor/ataxia syndrome (FXTAS). Neurological signs of FXTAS, parkinsonism and rapid onset of cognitive decline have not been reported in individuals with an unmethylated full mutation (FM). Here, we report a Chilean family affected with FXS, inherited from a parent carrier of an FMR1 unmethylated full mosaic allele, who presented with a fast progressing FXTAS. This case suggests that the definition of FXTAS may need to be broadened to not only include those with a premutation but also those with an expanded allele in FM range with a lack of methylation leading to elevated FMR1-mRNA expression levels and subsequent RNA toxicity
313 CARDIOTROPHIN-1 (CT-1) PLAYS A KEY ROLE IN ENHANCING ANTIAPOPTOTIC DEFENSES AND MAINTAINING MITOCHONDRIAL FUNCTION DURING LIVER REGENERATION
Avaliação das competências de enfermeiras para a promoção em saúde durante atendimentos pediátricos em unidade de emergência
Anales de Edafología y Agrobiología Tomo 42 Número 3-4
Suelos. Las tierras pardo ácidas sobre granodioritas de la zona nor-oriental del macizo de Montseny, por J. Bech, A. Heretery R. Vallejo.-- Morfología y propiedades químicas de suelos forestales del Norte de Marruecos. l. Suelos bajo A bies maroccana, por María S. Marín, R. Ca banas, L. Corral y G. Paneque.-- Morfología y propiedades químicas de suelos forestales del Norte de Marruecos. II . Suelos bajo Cedrus.atlantica, por María S. Marín, L. Corral y G. Paneque.-- Suelos de la zona húmeda española. XI. Contribución al estudio de los suelos hidromorfos de Galicia. 2. Suelos continentales, por Leiros de la Peña, M. a C. y Guitian Ojea, F.-- The compu tation of the cation exchange capacity of soils from clay and organic matter content, por L. L. Somani.-- An investigation on the carbón content of soil organic matter, for L. L. Somani and S. N. Saxena.-- Retención de parathion en bentonitas homoionicas. l. Cinética del proceso, por E. González Pradas, J. de D. López González, F. del Rey Bueno y C. Valenzuela Calahorro.-- Niveles de influencia de la vegetación en los horizontes superficiales de los suelos, por Hoyos de Castro, A., Remando Costa, J., Egido Rodríguez, J. A. y De .la Cruz Caravaca, M. T.-- Estudio de la superficie y de la textura de bentonitas homoiónicas. l. Superficie específica y porosidad, por E. González-Pradas, J. D. López-González, F. del Rey Bueno y C. Valenzuela Calahorra.—Fertilidad del suelo. Mineralization of phosphorus under the influence of decomposing organic materials in sorne soils of Rajasthan, for L. L. Somani.-- lnfluence of the soil fertility factors on the P absorption of Rye-Grass grown in saline soils, for Benigna Eleizalde, M. Fernández and P. Díaz.-- Adición de residuos vegetales a suelos calizos. V. Influencia sobre el desarrollo vegetal, por J. Cegarra, T. Hemández y F. Costa.-- Adición de residuos vegetales a suelos calizos. VI. Influencia sobre la dinámica del manganeso en el suelo y respuesta de cultivos, por T. Hernández, J. Cegarra, A. Lax y F. Costa.—Fisiología Vegetal y Nutrición.-- Influencia de las características de las protecciones de plástico en el cultivo semiforzado del tomate. l. Producción y precocidad, por A. A. Contreras, A. Cerdá y F. Santa Cruz.-- Influencia de las características de las protecciones de plástico en el cultivo semiforzado del tomate. II. Composición mineral (N .P .K.), por A. A. Contreras, A. Cerdá y M. Moreno. Influencia de las características de las protecciones de plástico en el cultivo semiforzado del tomate. 111. Composición mineral (Ca, Mg, Na, Fe, Mn, Cu, Zn), por A. Contreras, A. Cerdá y M. C. Bolarin.-- Influencia de los elementos alcalinos sobre el crecimiento y niveles de pigmentos cloroplásticos en plantas de Nicotiana Rústica, L., por Carlos Codina Mahrer, Carmen Morales Pujol y Manuel Serrano García.-- Influencia de la aplicación de Edta-Fe y Arcilla-Fe en judía (Phaseolus vulgaris, L.) l. Efecto sobre el crecimiento, por l. Agüi, M. Gómez, T. Palma y M. A. Skrabonja.-- Necesidad de agua de cultivos determinada con lisimetros y estimada con ecuaciones empíricas, por Donnari M. A., Mormeneo, A. l. y Rosell, R. A.-- Notas.-- BibliografíaPeer reviewe