Mining structured Petri nets for the visualization of process behavior

Visualization is essential for understanding the models obtained by process mining. Clear and efficient visual representations make the embedded information more accessible and analyzable. This work presents a novel approach for generating process models with structural properties that induce visually friendly layouts. Rather than generating a single model that captures all behaviors, a set of Petri net models is delivered, each one covering a subset of traces of the log. The models are mined by extracting slices of labelled transition systems with specific properties from the complete state space produced by the process logs. In most cases, few Petri nets are sufficient to cover a significant part of the behavior produced by the log.Peer ReviewedPostprint (author's final draft

Histiotus magellanicus (Chiroptera: Vespertilionidae) is not restricted to Subantarctic forests: first record for the Coastal Maulino Forest in central Chile

Te southern Big-Eared Brown Bat, Histiotus magellanicus, is a poorly known vespertilionid occurring only in southern Chile and Argentina, where it appears to be restricted to Valdivian Temperate Forests and Magellanic Subpolar Forests. Here we report the frst record of H. magellanicus in the Maulino Temperate Forest of central Chile, a Mediterranean-climate ecosystem, suggesting that the species might not be exclusive to subantarctic forests, as previously thought. Tis constitutes the northernmost continental record for the species, extending its range ca. 400 km the previous known northern locality.Fil: San Pedro, Annia Rodríguez. Universidad de Chile; ChileFil: Barquez, Ruben Marcos. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Programa de Investigación de Biodiversidad Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Simonetti, Javier A.. Universidad de Chile; Chil

Estudio descriptivo de dimorfismo sexual en una poblacion de 15 a 50 anos de edad, en base a un analisis rugoscopico

94 p.En la actualidad la odontología forense ha hecho significativas contribuciones para la identificación humana, en casos donde no es posible aplicar los métodos tradicionales debido al estado en que quedan los cadáveres, cuando ya han desaparecido otros elementos identificativos, o por las propias limitaciones que conllevan otros métodos. Así la rugoscopía, aparece como una técnica identificatoria ideal en casos de necroidentificación, y por lo mismo su uso ha ganado importancia durante el siglo pasado. Al realizar una breve revisión bibliográfica se encontró que las rugas palatinas se han considerado específicas para grupos raciales (Kapali et al.; Shetty et al., 2005), lo que facilita la identificación de poblaciones, además presentar diferencias entre géneros. A pesar de lo anterior muchos estudios han dado lugar a considerar que estas formaciones anatómicas no expresan diferencias sustanciales entre sexos (Thomas, 1972; Kashima, 1990; Hinojal-Fonseca y Martínez Cordero, 2005; Nayak et al., 2007), aunque también existen otros que si plantean dimorfismo sexual (Mona et al., 1998; Shetty et al., 2005; Preethi et al. 2007; Lysell, 1955). El objetivo del estudio es determinar las diferencias morfológicas de las rugas palatinas en sujetos de sexo femenino y sexo masculino, demostrando los mejores indicadores de dimorfismo obtenido a partir de ellas con interés médico legal en una muestra de sujetos de 15 a 50 años. Para ello se analizaron 120 modelos de yeso del maxilar superior, de pacientes entre 15 y 50 años de edad, 60 hombres y 60 mujeres, clasificándose las rugas palatinas según forma, número, tamaño y posición. Los valores obtenidos dieron como resultado diferencias significativas entre ambos grupos en relación a la forma y al tamaño de las rugas palatinas, siendo las formas punto y recta las más prevalentes para mujeres y hombres respectivamente. En cuanto al tamaño, se observó que las rugas circulares resultaron significativamente de mayor tamaño en mujeres que en hombres, a diferencia de las rugas de tipo compuestas, las cuales resultaron de mayor tamaño en hombres que en mujeres

Control of PCNA deubiquitylation in yeast

El pdf del artículo es la versión post-print.Eukaryotes ubiquitylate the replication factor PCNA (proliferating-cell nuclear antigen) so that it tolerates DNA damage. Although, in the last few years, the understanding of the evolutionarily conserved mechanism of ubiquitylation of PCNA, and its crucial role in DNA damage tolerance, has progressed impressively, little is known about the deubiquitylation of this sliding clamp in most organisms. In the present review, we will discuss potential molecular mechanisms regulating PCNA deubiquitylation in yeast.Peer reviewe

Biomimetic Ca-P coatings Incorporating bisphosphonates produced on starch-based degradable biomaterials

In this study, sodium clodronate, a well-known therapeutic agent from the family of bisphosphonates (BPs), is incorporated in a biomimetic calcium phosphate (CaP) coating, previously formed on the surface of a starch-based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration applications. The effects on the resulting CaP coatings were evaluated in terms of morphology, chemistry, and structure. The dissolution of Ca and P from the coating and the release profiles of sodium clodronate was also assessed. As a preliminary approach, this first study also aimed at evaluating the effects of this BP on the viability of a human osteoblastic cell line since there is still little information available on the interaction between BPs and this type of cells. Sodium clodronate was successfully incorporated, at different doses, in the structure of a biomimetic CaP layer previously formed by a sodium silicate process. This type of BPs had a stimulatory effect on osteoblastic activity, particularly at the specific concentration of 0.32 mg/mL. It is foreseen that these coatings can, for instances, be produced on the surface of degradable polymers and then used for regulating the equilibrium on osteoblastic/osteoclastic activity, leading to a controlled regenerative effect at the interface between the biomaterial and bone

Experiencia y resultados preliminares en el uso de cilindros intersomáticos para la artrodesis lumbar

El dolor lumbar crónico es una patología que puede llegar a ser incapacitante y en la que a menudo fracasan los tratamientos conservadores. Como alternativa entre las cirugías que pretenden atajar este problema mediante una artrodesis está la fusión intersomática con cilindros, que presenta algunas ventajas respecto a otras técnicas de fijación. Esta técnica ha sido introducida recientemente en nuestro país. Se presentan los primeros resultados obtenidos tras esta cirugía en los primeros 16 pacientes operados. Desde 1997 a diciembre de 2000 se han implantado 11 cilindros BAK y 5 LIFEC. Diez pacientes tenían un seguimiento mínimo de 1 año y éstos constituyen la serie evaluada. Siete pacientes (70%) no presentaban dolor. Cuatro pacientes (40%) se habían incorporado a sus trabajos respectivos. Seis pacientes (60%) no precisaban tratamiento médico. Los buenos resultados obtenidos hasta el momento nos invitan a pensar que esta técnica, de menor agresividad y que no cierra la puerta a otros tipos de instrumentación, es una opción válida para el tratamiento del dolor lumbar crónico.Chronic low back pain is a medical cause of disability in which conservative management is often not effective. As an alternative, interbody fusion with cylinders offers several advantages as compared to other surgical methods of fusion. This technique has been recently introduced in our Country. The preliminary results of 16 patients managed in our Department are shown. From 1997 to December 2000, eleven BAK devices and 5 LIFEC have been implanted. Ten patients had a minimum follow-up of 1 year and these constitute the series evaluated. Seven patients (70%) were free of pain. Four patients (40%) returned to their previous job. Six patients (60%) did not need medical treatment. The good results with this technique encourage us and suggest that these devices are a valid option for the management of chronic low back pain

Prótesis unicondílea de rodilla: Valoración clínica preliminar

Los pacientes afectados de artrosis unicompartimetal de rodilla pueden ser tratados con diferentes métodos quirúrgicos. Los más habituales son la osteonomía tibial en jóvenes y la prótesis total de rodilla en ancianos. Una alternativa que va adquiriendo adeptos es la prótesis unicondílea. Tras un período inicial de gran euforia se pasó a otro de escepticismo, dando los resultados. El propósito del presente estudio es evaluar un nuevo diseño de prótesis de rodilla unicondílea (Alpina, IQL) a corto plazo siguiendo criterios clínicos y de calidad de vida. Se revisan 13 pacientes intervenidos entre Junio de 2000 a Marzo del 2002. Siete eran varones y seis mujeres. La edad media fue de 65 años (r=55-72ª). En doce casos la etiología fue artrosis y en uno necrosis del cóndilo interno. La evaluación clínica se realizó mediante el cuestionario sobre la calidad de vida SF-12. Todos los pacientes consiguieron una flexión de 110º y extensión completa. Sólo un paciente presentó molestias leves.Patients who have unicompartimental knee osteoarthritis can be manager by different surgical techniques. Young people are usually treated by tibial osteotomy and elderly people by total knee replacement. Unicondylar knee prosthesis is becoming an attractive recognized alternative. After a period of enthusiastic regarding this technique, scepticism took place based on the clinical results. The aim of this study is to evaluate, in firs instance, a new knee unicondylar knee prosthesis design (Alpine, IQL) following clinical criteria and quality of life. Thirteen patients, managed in between June 2000 and March 2002, are reviewed. Seven were males and six females. The mean age was 65 years (range 55-77 years). Osteoarthritis was the aetiology in twelve cases and necrosis of the medial condyle in one patient. The clinical evaluation was based on quality of life through a questionnaire SF-12. All patients improved a knee flexion of 110º and a complete extension. Only one patient had slight pain and had some limitation

Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue

The standard pathway for virus infection of eukaryotic cells requires disassembly of the viral shell to facilitate release of the viral genome into the host cell. Here we use mechanical fatigue, well below rupture strength, to induce stepwise disruption of individual human adenovirus particles under physiological conditions, and simultaneously monitor disassembly in real time. Our data show the sequence of dismantling events in individual mature (infectious) and immature (noninfectious) virions, starting with consecutive release of vertex structures followed by capsid cracking and core exposure. Further, our experiments demonstrate that vertex resilience depends inextricably on maturation, and establish the relevance of penton vacancies as seeding loci for virus shell disruption. The mechanical fatigue disruption route recapitulates the adenovirus disassembly pathway in vivo, as well as the stability differences between mature and immature virionsWe acknowledge funding by grants from the Ministry of Science and Innovation of Spain, PIB2010US-00233, FIS2011-29493, Consolider CSD2010-00024 and CAM project and the Comunidad de Madrid No. S2009/MAT-1467 to P. J. P.; BFU2010-16382/BMC to C.S.M.; and FIS2011-16090-E to C.S.M. and P.J.P. S.J.F acknowledges funding from the National Institutes of Health, USA (GM037705 and AI1058172). A.J.P.-B. holds a Juan de la Cierva postdoctoral contract from the Ministry of Science and Innovation of Spain; A.O.-E. and R.M.-C. are recipients of predoctoral fellowships from the Ministry of Education and the Instituto de Salud Carlos III of Spain, respectivel