Analisis Pengukuran Nilai Overall Equipment Effectiveness (Oee) pada Proses Packaging di Line 2 (Studi Kasus PT. Multi Bintang Indonesia. Tbk)

PT. Multi Bintang Indonesia Tbk bergerak dalam bidang industri pembuatan minuman, dimana Perusahaan tersebut berproduksi berdasarkan besarnya permintaan dari costumer yang merupakan kantor-kantor pemasaran yang telah tersebar berbagai daerah di Indonesia. Dalam tahap proses packaging di PT.MBI melalui dengan 3 line diantaranya racking line, canning line, bottling line. Penelitian ini bertujuan untuk mengetahui nilai overall equipment effectiveness (OEE) dan Losses yang paling berpengaruh dari six big Losses OEE yang terfokus pada peralatan atau mesin secara keseluruhan menjadi satu kesatuan yaitu pada lini Line 2, yang kemudian akan diketahui akar penyebab losses yang terjadi dari penelitian selama dilapangan. Dari hasil perhitungan overall equipment effectiveness (OEE) terdapat dua rasio yang masih kurang baik dan berada dibawah standar kelas dunia, adapun rasio tersebut yaitu avaibility sebesar 88,85% dari standar kelas dunia sebesar 90% dan performance ratio sebesar 78,51% dari standar kelas dunia sebesar 95%, sedangkan untuk quality ratio telah masuk standar kelas dunia yaitu sebesar 99,90%. Sehingga dengan demikian nilai OEE pada lini Line 2 masih berada dibawah standar kelas dunia. Pada penelitian ini hanya terdapat lima losses yang dapat diidentifikasi, dan adapun losses yang sangat berpengaruh yaitu pada Reduced Speed Losses, losses ini menyumbang nilai tingkat presentase losses terbesar yakni 19,12%, dari hasil penelitian losses ini terjadi karena adanya sistem pengawasan yang jelek (kurang baik) yang menyebabkan karyawan atau operator tidak melakukan pekerjaan sesuai ketentuan yang telah ditetapkan

Fabrication of Multi-Layered Bone Scaffolds using Femtosecond Pulsed Lasers

An IR femtosecond pulsed laser was used for micropatterning of biomineral containing chitosan membranes, aiming to enhance bone mineralization and angiogenesis. Pre and post irradiation materials have been characterized with XRD, SEM and spectroscopic techniques

Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues

Funding Information: We thank P. Asamaphan, A. Clark, and B. Kerscher for providing NIH overexpression cell lines, S. Yamasaki for the anti‐Mincle antibody, the staff of the University of Aberdeen animal facility for the care for our animals, and the Iain Fraser Cytometry Centre at the University of Aberdeen for their assistance. This work was supported by funding from the Wellcome Trust (102705, 217163), the Medical Research Council Centre for Medical Mycology, and the University of Exeter (MR/N006364/2).Peer reviewedPublisher PD

Targeted Inactivation of the IL-4 Receptor α Chain I4R Motif Promotes Allergic Airway Inflammation

The insulin/interleukin-4 (IL-4) receptor (I4R) motif mediates the association of insulin receptor substrate (IRS)-2 with the interleukin-4 (IL-4)Rα chain and transduces mitogenic signals in response to IL-4. Its physiological functions were analyzed in mice with a germline point mutation that changed the motif's effector tyrosine residue into phenylalanine (Y500F). The Y500F mutation abrogated IRS-2 phosphorylation and impaired IL-4–induced CD4+ T lymphocyte proliferation but left unperturbed Stat6 activation, up-regulation of IL-4-responsive gene products, and Th cell differentiation under Th2 polarizing conditions. However, in vivo the Y500F mutation was associated with increased allergen-induced IgE production, airway responsiveness, tissue eosinophilia, and mucus production. These results define an important role for the I4R motif in regulating allergic inflammation

Liquid racism and the Danish Prophet Muhammad cartoons

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Author.This article examines reactions to the October 2005 publication of the Prophet Muhammad cartoons in the Danish newspaper Jyllands-Posten. It does so by using the concept of ‘liquid racism’. While the controversy arose because it is considered blasphemous by many Muslims to create images of the Prophet Muhammad, the article argues that the meaning of the cartoons is multidimensional, that their analysis is significantly more complex than most commentators acknowledge, and that this complexity can best be addressed via the concept of liquid racism. The article examines the liquidity of the cartoons in relation to four readings. These see the cartoons as: (1) a criticism of Islamic fundamentalism; (2) blasphemous images; (3) Islamophobic and racist; and (4) satire and a defence of freedom of speech. Finally, the relationship between postmodernity and the rise of fundamentalism is discussed because the cartoons, reactions to them, and Islamic fundamentalism, all contain an important postmodern dimension.ESR

Physiologically engineered porous titanium/brushite scaffolds for critical-size bone defects: A design and manufacturing study

Repairing critical-size bone defects still represents a critical clinical challenge in the field of trauma surgery. This study focuses on a physiological design and manufacturing of porous composite scaffold (titanium Ti with 10 % mole iron doped brushite DCPD-Fe3+) which can mimic the biomechanical properties of natural cortical bone, specifically for the purpose of repairing critical-size defects. To achieve this, the principle of design of experiments (DOE) was applied for investigating the impact of sintering temperature, mineral ratio, and volume fraction of porosity on the mechanical properties of the fabricated scaffolds. The fabricated scaffolds had open porosity up to 60 %, with pore size approximately between 100 μm and 850 μm. The stiffness of the porous composite scaffolds varied between 3.30 GPa and 20.50 GPa, while the compressive strength ranged from approximately 130 MPa–165 MPa at sintering temperatures equal to or exceeding 1000 °C. Scaffolds with higher porosity and mineral content demonstrated lower stiffness values, resembling natural bone. Numerical simulation was employed by Ansys Workbench to investigate the stress and strain distribution of a critical size defect in mid-shaft femur which was designed to be replaced with the fabricated scaffold. The fabricated scaffolds showed flexible biomechanical behaviour at the bone/scaffold interface, generating lower stress levels and indicating a better match with the femoral shaft stiffness. The experimental and numerical findings demonstrated promising applications for manufacturing a patient-specific bone scaffold for critical and potentially large defects for reducing stress shielding and minimizing non-union risk

TACI and BAFF-R mediate isotype switching in B cells

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching

Haptic dokunma hisli ve kuvvet geri beslemeli arayüz sistem tasarımı

TÜBİTAK MAG01.07.2008“Haptic” cihaz, kullanıcı ile bilgisayar arasında üç boyutlu veri transferi sağlayan bir cihazdır. Bu cihaz kullanıcıya sanal ortamdaki bir nesneyi görmenin yanında, bu sanal nesneye dokunma olanağı da sağlar. Aynı zamanda bu cihaz ile gerçek bir nesneden veriler alınarak bu verilerin sanal ortamda kullanımı da gerçekleştirilebilir. Günümüzde sanal gerçeklik teknolojisinin gelişimine paralel olarak “haptic” cihazlarının kullanımı, sanayi, eğitim ve tıp alanlarında gittikçe artmaktadır. Bu teknolojinin değişik uygulama alanları, farklı bilim dallarına ait disiplinlerarası çalışmaları gerektirdiğinden, kendi içinde özgün çalışma konularını da yaratmaktadır (“haptic” arayüz tasarımı, serbest modelleme, sanal ortamda ameliyat eğitimi, vb.). Medikal uygulamalarda önemli bir potansiyele sahip bu teknoloji ile daha önceleri el işçiliği ile yapılmak zorunda kalınan karmaşık modifikasyonlar gerçekleştirilebilmektedir (beyin cerrahisinde hata kabul etmeyen, ustalık ve ameliyat öncesi uzun uğraşlar gerektiren operasyonlar). Bu örnek “haptic” cihazlar ile dijital ortamda gerçekleştirilebilecek olan uygulamalardan sadece bir tanesidir. Bu proje kapsamında, bahsedilen uygulama alanlarına yönelik 7 serbestlik dereceli bir “haptic” cihaz tasarlanıp üretilmiş ve cihazın kullanılabilirliğini göstermek için bir arayüz tasarlamıştır. Günümüze kadar tasarlanmış olan bütün “haptic” cihazlar maksimum 6 serbestlik derecesine sahiptirler. Tasarlanan 7 serbestlik dereceli “haptic” cihaz, bugüne kadar üretilmiş aynı uzuv uzunlukları ve eklem değişkenlerine sahip diğer “haptic” cihazlar ile karşılaştırıldığında yaklaşık %20 daha büyük bir çalışma hacmine ve daha esnek bir çalışma kabiliyetine sahiptir. Bu çalışma, Dünya’daki “haptic” cihazların geliştirilmesi ve Türkiye’deki “haptic” cihazların ve uygulama alanlarının yaygınlaşması açısından son derece önemlidir.Haptic devices are used to provide multi-modal data transfer between haptic users and computers in virtual reality applications. They enable humans to take force and tactile feedback from any virtual or remote objects. Haptic devices also facilitate the use of data collected from a real object in the virtual environment. Usage of the haptic devices increase more and more in industrial, educational and medical applications in parallel with development of virtual reality technology. As virtual reality technology requires interdisciplinary study with related to its application areas, it creates a lot of different specific working areas (Haptic interface design, freeform model, surgical operations in virtual environment etc.). Especially, some complex modifications which require hand-working can be performed with the system having great potential in medical applications (Brain surgery without error and operations which require great skill etc.). This is only one of the implementations of haptic devices in digital environment. Aim of this project is to design and manufacture a novel haptic device which serves the mentioned application areas and to improve an interface to implement the device. Most of the haptic devices in literature have maximum 6 DOF. The 7 DOF haptic device designed has about 20% extra working space and more flexible working capability compared to the other haptic devices with the similar link lengths and joint limitations. This project is important in terms of the development of haptic devices in the world as well as spreading of haptic devices and its applications in Turkey

MelLec Exacerbates the Pathogenesis of Aspergillus fumigatus-Induced Allergic Inflammation in Mice

ACKNOWLEDGMENTS We thank the staff of the University of Aberdeen animal facility for their support and care for our animals. We also would like to express gratitude to Linda Duncan and Ailsa Laird of the Ian Fraser Cytometry Centre at the University of Aberdeen for their technical support and advice. Funding was provided by the Wellcome Trust (102705, 097377) and the Medical Research Council Centre for Medical Mycology (MR/N006364/2). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. KT received a research fellowship from The Jikei University School of Medicine.Peer reviewedPublisher PD

Transcellular diapedesis is initiated by invasive podosomes

Producción CientíficaDiapedesis is critical for immune system function and inflammatory responses. This occurs by migration of blood leukocytes either directly through individual microvascular endothelial cells (the “transcellular” route) or between them (the “paracellular” route). Mechanisms for transcellular pore formation in endothelium remain unknown. Here we demonstrate that lymphocytes used podosomes and extended “invasive podosomes” to palpate the surface of, and ultimately form transcellular pores through, the endothelium. In lymphocytes, these structures were dependent on Src kinase and the actin regulatory protein WASP; inhibition of podosome formation selectively blocked the transcellular route of diapedesis. In endothelium, membrane fusion events dependent on the SNARE-containing membrane fusion complex and intracellular calcium were required for efficient transcellular pore formation in response to podosomes. These findings provide insights into basic mechanisms for leukocyte trafficking and the functions of podosomes