PP026—Medigenia: innovative cloud based solution for pharmacovigilance

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The study on the effect of the dislocation density on formation of a closed piecewise-continuous dislocation loop in aluminum

Mathematical model allowing carrying out studies on energy, scale and time characteristics of formation of closed dislocation loop and crystallographic shear zone as a whole, and forming of a dislocation loop for FCC-materials, has been developed. Using the mathematical model study on the effect of the dislocation density on the dynamics of formation of an elementary crystallographic slip bounded by a closed piecewise-continuous dislocation loop in aluminum has been carried out. It has been shown that with decrease in the density of dislocations in metal from 10−12 up to 4centerdot10−11 along different orientations of the expansion of the dislocation loop the maximum value of the dislocation velocity increases by 20-30% and the maximum value of the kinetic energy and the dislocation path increases by almost 2 times. It has been shown that in aluminum the area of elementary crystallographic slip, swept out by the dislocation loop, increases with a decrease in the dislocation density in metal. But, at the same time, regardless of the value of the dislocation density in metal the radius of the dislocation loop in the final configuration along the screw orientation is practically by an order of magnitude less than along the edge orientation

Dephosphorization of Manganese Ore Raw Materials

The dephosphorization of manganese ores and concentrates in a reducing atmosphere is thermodynamically analyzed. It is shown that phosphorus can completely pass to a gas phase in a closed reaction system in a wide temperature range (1273–2073 K) at the amounts of a reducing gas (CO) that exceed the stoichiometric minimum required for reduction reactions. The gaseous products of reduction is found to contain phosphorus in the form of mainly polyatomic “heavy” molecular oxides, which can decrease the real effect of dephosphorization as compared to that obtained by equilibrium calculations because of kinetic factors. A thermodynamic simulation of a flow reaction system shows that almost complete transition of phosphorus to light gaseous substances (PO, P2) is thermodynamically possible at the temperatures that are close to the technological operation temperatures. This transition is provided by the ratio of the rate of formation of volatile phosphorus-containing substances to the rate of their removal from reaction regions. Keywords: manganese ores, manganese concentrates, phosphorus, carbon monoxide, reductio

PP179—Identification of Drug–Drug Interactions Through a Digital Health Service

e74 Volume 35 Number 8S accounting for 21.2% and 16.2% of total AED consumption (DDD 163.7 and 125.2, respectively). In the same year, oxcarbazepine and lamotrigine were the most used new AEDs (10.91% and 10.79% of total; DDD 84.1 and 83.2, respectively), while gabapentin and pregabalin exhibited the higher incidence of use. The main indication of use was epileptic disorders for older AEDs and neuropathic pain for newer AEDs. A high number of patients treated with older AEDs, in particular carbamazepine, phenobarbital, and valproic acid, received coprescription at clinically relevant interaction risk. Among newer AEDs, lamotrigine showed a high annual rate of possible interaction. Conclusion: Significant differences were shown in the prescribing pattern of newer and older medications: older AEDs were mainly used in the treatment of epileptic disorders, while newer compounds were also preferred for conditions other than epilepsy, in particular neuropathic pain. The fall in the use of newer AEDs during 2007 agreed with revised reimbursement criteria for gabapentin and pregabalin. The coprescription should be evaluated with caution and avoided if possible. Drugs at risk of interactions should be replaced with others having same indication of use. Disclosure of Interest: None declared

Impact of potential inappropriate NSAIDs use in chronic pain

Abstract: Pain remains one of the main reasons for medical consultation worldwide: moderate- to severe-intensity pain occurs in 19% of adult Europeans, seriously affecting the quality of their social and working lives. Nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended for long-term use and a careful surveillance to monitor for toxicity and efficacy is critical. This study aims to assess: 1) the pattern of use of NSAIDs and opioids in a population covered by a cloud-based pharmacovigilance surveillance system; and 2) potential inappropriate use. A retrospective 18-months systematic analysis on patients\u2019 pain treatment was performed. The primary endpoint was evaluating the prevalence of NSAIDs and opioids use and the duration of therapy regimen. The secondary endpoint was to investigate the prevalence of NSAIDs taken for \ue02e21 consecutive days concomitant with drugs for peptic ulcer and gastroesophageal reflux disease (GORD) or antiplatelet drugs. The yearly cost for individual users of concomitant NSAIDs for more than 21 consecutive days and of GORD medications has been estimated. A total of 3,050 subjects with chronic pain were enrolled; 97% of them took NSAIDs for \ue02e21 consecutive days; about one-fourth of these users also received drugs for peptic ulcer and GORD (Anatomical Therapeutic Chemical code A02B). The yearly cost foran individual who uses NSAIDs for \ue02e21 consecutive days as well as concomitant GORD medications is 61.23 euros. In total, 238 subjects (8%) using NSAIDs for \ue02e21 days also received one antiplatelet agent. About 11% of subjects received opioids at least once and only 2% of them carried on the therapy for more than 90 consecutive days. In evaluating the escalation in dosage as a proxy of dependence risk, this study shows no dosage escalation in our cohort of chronic pain population - that is to say we show no risk of dependence. Keywords: pain therapy, economic impact, dependenc

Electrooptics of mm-scale polar domains in the ferroelectric nematic phase

The recent discovery of the ferroelectric nematic phase has opened the door to experimental investigation of one of the most searched liquid crystal phases in decades, with high expectations for future applications. However, at this moment, there are more questions than answers. In this work, we examine the formation and structure of large polar nematic domains of the ferroelectric nematic material RM734 in planar liquid crystals cells with different aligning agents and specifications. We observe that confining surfaces have a strong influence over the formation of different types of domains, resulting in various twisted structures of the nematic director. For those cells predominantly showing mm-scale domains, we investigate the optical and second harmonic generation switching behaviour under applications of electric fields with a special focus on in-plane fields perpendicular to the confinement media rubbing direction. In order to characterise the underlying structure, the polar optical switching behaviour is reproduced using a simplified model together with Berreman calculations