From quasiperiodicity to high-dimensional chaos without intermediate low-dimensional chaos

We study and characterize a direct route to high-dimensional chaos (i.e. not implying an intermediate low-dimensional attractor) of a system composed out of three coupled Lorenz oscillators. A geometric analysis of this medium-dimensional dynamical system is carried out through a variety of numerical quantitative and qualitative techniques, that ultimately lead to the reconstruction of the route. The main finding is that the transition is organized by a heteroclinic explosion. The observed scenario resembles the classical route to chaos via homoclinic explosion of the Lorenz model.Comment: 12 pages, 11 figures, 1 table. Extended version of [D. Pazo & M.A. Matias, EPL 72, 176-182 (2005)

Psicoterapia psicanalítica focada nas emoções

Este texto debruça-se sobre uma nova forma de fazer psicoterapia psicanalítica e psicanálise. A exploração das emoções como meio de mudança. Relato uma alteração na minha prática clínica em que a emoção passou a ser o foco da atenção. Uso um maior equilíbrio entre guiar e seguir o paciente, uma atenção aos marcadores e uso das intervenções para cada um desses marcadores como o desdobrar sistemático de uma evocação, focalização, ou o diálogo da cadeira vazia. São abordadas algumas dificuldades de integrar uma exploração mais eficaz da emoção num modelo psicanalítico praticado há muitos anos. Pequenas vinhetas clínicas ilustram a forma de explorar as emoções.This text is about a new way of doing psychoanalytic psychotherapy and psychoanalysis. The exploration of emotions as a means of change. I report a change in my clinical practice in which emotion has become the focus of attention. I use a greater balance between guiding and following the patient, an attention to the markers and use of interventions for each of these markers as the systematic evocation unfolding, focusing, or the empty-chair dialogue. I describe some difficulties of integrating a more effective exploration of the emotion in a psychoanalytic model practiced for many years. Small clinical vignettes illustrate how to explore emotions.info:eu-repo/semantics/acceptedVersio

Steady-State Visual Evoked Potentials Can Be Explained by Temporal Superposition of Transient Event-Related Responses

<p><b>Background:</b> One common criterion for classifying electrophysiological brain responses is based on the distinction between transient (i.e. event-related potentials, ERPs) and steady-state responses (SSRs). The generation of SSRs is usually attributed to the entrainment of a neural rhythm driven by the stimulus train. However, a more parsimonious account suggests that SSRs might result from the linear addition of the transient responses elicited by each stimulus. This study aimed to investigate this possibility.</p> <p><b>Methodology/Principal Findings::</b> We recorded brain potentials elicited by a checkerboard stimulus reversing at different rates. We modeled SSRs by sequentially shifting and linearly adding rate-specific ERPs. Our results show a strong resemblance between recorded and synthetic SSRs, supporting the superposition hypothesis. Furthermore, we did not find evidence of entrainment of a neural oscillation at the stimulation frequency.</p> <p><b>Conclusions/Significance:</b> This study provides evidence that visual SSRs can be explained as a superposition of transient ERPs. These findings have critical implications in our current understanding of brain oscillations. Contrary to the idea that neural networks can be tuned to a wide range of frequencies, our findings rather suggest that the oscillatory response of a given neural network is constrained within its natural frequency range.</p&gt

Balancing motherhood and drug addiction: The transition to parenthood of addicted mothers

This is a study about balancing motherhood and drug addiction, during the transition to parenthood. Few studies have dealt with the parental experience of drug-addicted mothers. The participants included 24 drug-addicted mothers, on methadone, with ages 25-42 and with children 1-32 months of age. Semi-structured interviews were conducted and analyzed according to Grounded Theory. The mothers' main concern was the ambivalence they felt towards pregnancy/motherhood and drug addiction, which was associated with strong feelings of guilt. Confronted with this ambivalence their maternal role becomes merely functional. They focus on providing the basic care to the child, but show little willingness to talk or play. Social support, especially from the partner seems to have a positive role.info:eu-repo/semantics/publishedVersio

Genetic diversity and structure of the commercially important native fish pacu (Piaractus mesopotamicus) from cultured and wild fish populations: relevance for broodstock management

Pacu (Piaractus mesopotamicus) is one of the most important Neotropical freshwater fish species produced by aquaculture in South America. This study is the first attempt to inquire about aquaculture stocks in Argentina regarding genetic diversity and structure. Neither genetic characterization nor pedigree records are available for pacu stocks in farms in Argentina. The presence of hybrids in both natural environment (Lower Paraná River) and farms has not been evaluated yet at the southern region of pacu distribution. Genetic characterization of pacu broodstocks, corresponding to 8 farms, and wild individuals from four areas at Lower Paraná River was performed. Pacu hybrids were not detected neither in wild nor in farm stocks analyzed. In general, similar levels of genetic diversity were observed between cultured and wild fish populations. Global genetic differentiation (Fst = 0.055) indicated a low level of structure and AMOVA showed that genetic variation was mostly within populations. Reduced contemporary effective population size (Ne) was observed, and probably reflects the bottleneck by founder effect in farmed fish populations. Moreover, kinship analysis showed that in fish farms, on average, 43.00% of the individuals were genetically related, whereas in wild population it was 36.40%. We recommend that broodstock management practices, such as using large Ne, single pair mating, precise records, and tagging of brood fish, should be implemented to avoid unintentional mismanagement.Fil: Del Pazo, F.. Universidad Nacional de Rosario; ArgentinaFil: Sánchez, Sebastián. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias. Instituto de Ictiología del Nordeste; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Posner, Victoria. Universidad Nacional de Rosario; ArgentinaFil: Sciara, Andrés A.. Universidad Nacional de Rosario; ArgentinaFil: Arranz, Silvia Eda. Universidad Nacional de Rosario; ArgentinaFil: Villanova, Gabriela V.. Universidad Nacional de Rosario; Argentin

First DNA barcode reference library for the identification of South American freshwater fish from the lower Paraná river

Valid fish species identification is essential for biodiversity conservation and fisheries management. Here, we provide a sequence reference library based on mitochondrial cytochrome c oxidase subunit I for a valid identification of 79 freshwater fish species from the Lower Paraná River. Neighbour-joining analysis based on K2P genetic distances formed non-overlapping clusters for almost all species with a ≥99% bootstrap support each. Identification was successful for 97.8% of species as the minimum genetic distance to the nearest neighbour exceeded the maximum intraspecific distance in all these cases. A barcoding gap of 2.5% was apparent for the whole data set with the exception of four cases. Withinspecies distances ranged from 0.00% to 7.59%, while interspecific distances varied between 4.06% and 19.98%, without considering Odontesthes species with a minimum genetic distance of 0%. Sequence library validation was performed by applying BOLDs BIN analysis tool, Poisson Tree Processes model and Automatic Barcode Gap Discovery, along with a reliable taxonomic assignment by experts. Exhaustive revision of vouchers was performed when a conflicting assignment was detected after sequence analysis and BIN discordance evaluation. Thus, the sequence library presented here can be confidently used as a benchmark for identification of half of the fish species recorded for the Lower Paraná River.Instituto de Limnología "Dr. Raul A. Ringuelet

Operacionalização psicodinâmica de diagnóstico (OPD-2) numa psicanálise

A investigação em psicoterapia psicanalítica é apontada como tendo um elevado nível de abstração, falta de clareza e de consenso entre os clínicos na operacionalização de constructos e na análise de resultados fiáveis. Um diagnóstico psicodinâmico rigoroso e fiável que permita uma homogeneização de critérios de avaliação aumenta a comunicação dentro da comunidade científica e aproxima a investigação à prática. O OPD2 – Operationalized Psychodynamic Diagnosis – objetiva operacionalizar os constructos psicanalíticos, através de entrevistas semiestruturadas, e formular um diagnóstico psicodinâmico multiaxial baseado em 5 eixos: experiência da doença e pré-requisitos para o tratamento (Eixo I); relações interpessoais (Eixo II); conflito (Eixo III); estrutura (Eixo IV); perturbações mentais e psicossomáticas (Eixo V). O OPD-2 foi aplicado neste estudo com o objetivo de testar a avaliação diagnóstica através de notas de sessões numa paciente seguida em psicanálise. A realização do diagnóstico multiaxial foi, de uma forma geral,Research on psychoanalytic psychotherapy is identified as having a high level of abstraction, lack of clarity and consensus among clinicians in the constructs operationalization and analysis of reliable results. A rigorous and reliable psychodynamic diagnosis that allows a homogenization of evaluation criteria, increases communication within the scientific community and approaches research to practice. The OPD2’s – Operationalized Psychodynamic Diagnosis – objective is to operationalize psychoanalytic constructs, through semi-structured interviews, to formulate a psychodynamic multi-axial diagnosis based on 5 axes: experience of the illness and prerequisites for the treatment (Axis I); interpersonal relationships (Axis II); conflict (Axis III); structure (Axis IV); mental and psychosomatic disorders (Axis V). The OPD-2 was applied in this study with the objective to test the diagnosis evaluation using sessions notes of one patient submitted to psychoanalysis. The realization of the multiaxial diagnosis was generally successful and changes in the focus formulated in the diagnosis were registered.info:eu-repo/semantics/acceptedVersio

NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial

Gemcitabine; Metastatic pancreatic ductal adenocarcinomaGemcitabina; Adenocarcinoma ductal de pàncrees metastàticGemcitabina; Adenocarcinoma ductal de páncreas metastásicoBackground Pancreatic ductal adenocarcinoma remains one of the most lethal malignancies, with few treatment options. NAPOLI 3 aimed to compare the efficacy and safety of NALIRIFOX versus nab-paclitaxel and gemcitabine as first-line therapy for metastatic pancreatic ductal adenocarcinoma (mPDAC). Methods NAPOLI 3 was a randomised, open-label, phase 3 study conducted at 187 community and academic sites in 18 countries worldwide across Europe, North America, South America, Asia, and Australia. Patients with mPDAC and Eastern Cooperative Oncology Group performance status score 0 or 1 were randomly assigned (1:1) to receive NALIRIFOX (liposomal irinotecan 50 mg/m2, oxaliplatin 60 mg/m2, leucovorin 400 mg/m2, and fluorouracil 2400 mg/m2, administered sequentially as a continuous intravenous infusion over 46 h) on days 1 and 15 of a 28-day cycle or nab-paclitaxel 125 mg/m2 and gemcitabine 1000 mg/m2, administered intravenously, on days 1, 8, and 15 of a 28-day cycle. Balanced block randomisation was stratified by geographical region, performance status, and liver metastases, managed through an interactive web response system. The primary endpoint was overall survival in the intention-to-treat population, evaluated when at least 543 events were observed across the two treatment groups. Safety was evaluated in all patients who received at least one dose of study treatment. This completed trial is registered with ClinicalTrials.gov, NCT04083235. Findings Between Feb 19, 2020 and Aug 17, 2021, 770 patients were randomly assigned (NALIRIFOX, 383; nab-paclitaxel–gemcitabine, 387; median follow-up 16·1 months [IQR 13·4–19·1]). Median overall survival was 11·1 months (95% CI 10·0–12·1) with NALIRIFOX versus 9·2 months (8·3–10·6) with nab-paclitaxel–gemcitabine (hazard ratio 0·83; 95% CI 0·70–0·99; p=0·036). Grade 3 or higher treatment-emergent adverse events occurred in 322 (87%) of 370 patients receiving NALIRIFOX and 326 (86%) of 379 patients receiving nab-paclitaxel–gemcitabine; treatment-related deaths occurred in six (2%) patients in the NALIRIFOX group and eight (2%) patients in the nab-paclitaxel–gemcitabine group. Interpretation Our findings support use of the NALIRIFOX regimen as a possible reference regimen for first-line treatment of mPDAC.Ipsen

Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report

Carcinomas of unknown primary origin account for 3-5% of all malignancies. The current literature suggests that metastatic dissemination is able to occur in the absence of primary tumor growth. In metastatic disease that is difficult to diagnose, the origin usually remains unknown even after an exhaustive evaluation of immunohistochemistry (IHC) markers. In the current study, a 49-year-old male presented with lymph nodes metastases of unknown origin. The exci- sional biopsy of an inguinal node revealed an adenocarcinoma growth pattern, but the IHC could not determine the primary origin. A gene profiling test was performed to complete the diagnosis and a salivary gland adenocarcinoma was diagnosed with 90% probability. Subsequently, the patient underwent appropriate chemotherapy for salivary gland adenocarcinoma, and exhibited an improved partial response. The present case study highlights the importance of an accurate diagnosis of the primary tumor and the use of all the current tools available in order to provide patients with the best treatment possibl