Preconditioning Kernel Matrices

The computational and storage complexity of kernel machines presents the primary barrier to their scaling to large, modern, datasets. A common way to tackle the scalability issue is to use the conjugate gradient algorithm, which relieves the constraints on both storage (the kernel matrix need not be stored) and computation (both stochastic gradients and parallelization can be used). Even so, conjugate gradient is not without its own issues: the conditioning of kernel matrices is often such that conjugate gradients will have poor convergence in practice. Preconditioning is a common approach to alleviating this issue. Here we propose preconditioned conjugate gradients for kernel machines, and develop a broad range of preconditioners particularly useful for kernel matrices. We describe a scalable approach to both solving kernel machines and learning their hyperparameters. We show this approach is exact in the limit of iterations and outperforms state-of-the-art approximations for a given computational budget

A Search for Biomolecules in Sagittarius B2 (LMH) with the ATCA

We have used the Australia Telescope Compact Array to conduct a search for the simplest amino acid, glycine (conformers I and II), and the simple chiral molecule propylene oxide at 3-mm in the Sgr B2 LMH. We searched 15 portions of spectrum between 85 and 91 GHz, each of 64 MHz bandwidth, and detected 58 emission features and 21 absorption features, giving a line density of 75 emission lines and 25 absorption lines per GHz stronger than the 5 sigma level of 110 mJy. Of these, 19 are transitions previously detected in the interstellar medium, and we have made tentative assignments of a further 23 features to molecular transitions. However, as many of these involve molecules not previously detected in the ISM, these assignments cannot be regarded with confidence. Given the median line width of 6.5 km/s in Sgr B2 LMH, we find that the spectra have reached a level where there is line confusion, with about 1/5 of the band being covered with lines. Although we did not confidently detect either glycine or propylene oxide, we can set 3 sigma upper limits for most transitions searched. We also show that if glycine is present in the Sgr B2 LMH at the level of N = 4 x 10^{14} cm^{-2} found by Kuan et al. (2003) in their reported detection of glycine, it should have been easily detected with the ATCA synthesized beam size of 17.0 x 3.4 arcsec^{2}, if it were confined to the scale of the LMH continuum source (< 5 arcsec). This thus puts a strong upper limit on any small-scale glycine emission in Sgr B2, for both of conformers I and II.Comment: 12 pages, 2 figures, 5 tables, accepted by MNRA

The influence of 'soft' fair work regulation on union recovery: a case of re-recognition in the Scottish voluntary social care sector

This longitudinal case study contributes to debates concerning how ‘soft’ and ‘hard’ forms of regulation can interact to contribute to the advancement of worker rights. More specifically, the article explores the contribution of Scotland’s ‘soft’ fair work (FW) programme and the UK’s ‘hard’ statutory recognition procedure to union re-recognition in a voluntary sector social care provider. In combination, ‘hard’ and ‘soft’ regulation are found to have added breadth to the pressures for re-recognition exerted by the union, bringing reputational and financial costs associated with derecognition to the employer. Concerns nevertheless arose regarding the depth of impact from this interaction due to union compromises on key issues in the final recognition agreement. Due to the specific public service context of the study, doubts are also expressed regarding the potential for unions in other hard to organise sectors to achieve similar outcomes

Supply chain regulation in Scottish social care: facilitators and barriers

Drawing on a study of a Scottish government initiative to ensure the provision of a living wage to social care workers, the paper sheds new light on the value of regulating domestic supply chains to enhance labour standards in supplier organisations, and the factors that facilitate and hinder such regulation. The study confirms that supply chains driven by monopsonistic purchasers tend to drive down employment conditions, while indicating that the studied initiative met with a good deal of success due to a combination of the government generated ‘soft’ regulation and support from care providers that reflected both value and pragmatic considerations. It also highlights the contradictory tensions that can arise between policy aspirations and business objectives and suggests that to be effective, initiatives to enhance labour standards in supply chains need to address adverse market dynamics

Mopra CO Observations of the Bubble HII Region RCW120

We use the Mopra radio telescope to test for expansion of the molecular gas associated with the bubble HII region RCW120. A ring, or bubble, morphology is common for Galactic HII regions, but the three-dimensional geometry of such objects is still unclear. Detected near- and far-side expansion of the associated molecular material would be consistent with a three-dimensional spherical object. We map the $J = 1\rightarrow 0$ transitions of $^{12}$CO, $^{13}$CO, C$^{18}$O, and C$^{17}$O, and detect emission from all isotopologues. We do not detect the $0_0\rightarrow 1_{-1} E$ masing lines of CH$_3$OH at 108.8939 GHz. The strongest CO emission is from the photodissociation region (PDR), and there is a deficit of emission toward the bubble interior. We find no evidence for expansion of the molecular material associated with RCW120 and therefore can make no claims about its geometry. The lack of detected expansion is roughly in agreement with models for the time-evolution of an HII region like RCW120, and is consistent with an expansion speed of $< 1.5\, {\rm km\, s^{-1}}$. Single-position CO spectra show signatures of expansion, which underscores the importance of mapped spectra for such work. Dust temperature enhancements outside the PDR of RCW120 coincide with a deficit of emission in CO, confirming that these temperature enhancements are due to holes in the RCW120 PDR. H$\alpha$ emission shows that RCW120 is leaking $\sim5\%$ of the ionizing photons into the interstellar medium (ISM) through PDR holes at the locations of the temperature enhancements. H-alpha emission also shows a diffuse "halo" from leaked photons not associated with discrete holes in the PDR. Overall $25\pm10\%$ of all ionizing photons are leaking into the nearby ISM.Comment: 35 pages, 14 figures. Accepted to Ap

Opioid modulation of GABA release in the rat inferior colliculus

Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information. While the majority of the recorded activities in the inferior colliculus are attributed to GABAergic and glutamatergic signalling, other neurotransmitter systems are expressed in this brain area including opiate peptides and their receptors which may play a modulatory role in neuronal communication.Results: Using a perfusion protocol we demonstrate that morphine can inhibit KCl-induced release of [H-3] GABA from rat inferior colliculus slices. DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)ol]-enkephalin) but not DADLE ([D-Ala2, D-Leu5]-enkephalin or U69593 has the same effect as morphine indicating that mu rather than delta or kappa opioid receptors mediate this action. [H-3]GABA release was diminished by 16%, and this was not altered by the protein kinase C inhibitor bisindolylmaleimide I. Immunostaining of inferior colliculus cryosections shows extensive staining for glutamic acid decarboxylase, more limited staining for mu opiate receptors and relatively few neurons co-stained for both proteins.Conclusion: The results suggest that mu-opioid receptor ligands can modify neurotransmitter release in a sub population of GABAergic neurons of the inferior colliculus. This could have important physiological implications in the processing of hearing information and/or other functions attributed to the inferior colliculus such as audiogenic seizures and aversive behaviour

A view of Large Magellanic Cloud HII regions N159, N132, and N166 through the 345 GHz window

We present results obtained towards the HII regions N159, N166, and N132 from the emission of several molecular lines in the 345 GHz window. Using ASTE we mapped a 2.4' $\times$ 2.4' region towards the molecular cloud N159-W in the $^{13}$CO J=3-2 line and observed several molecular lines at an IR peak very close to a massive young stellar object. $^{12}$CO and $^{13}$CO J=3-2 were observed towards two positions in N166 and one position in N132. The $^{13}$CO J=3-2 map of the N159-W cloud shows that the molecular peak is shifted southwest compared to the peak of the IR emission. Towards the IR peak we detected emission from HCN, HNC, HCO$^{+}$, C$_{2}$H J=4-3, CS J=7-6, and tentatively C$^{18}$O J=3-2. This is the first reported detection of these molecular lines in N159-W. The analysis of the C$_{2}$H line yields more evidence supporting that the chemistry involving this molecular species in compact and/or UCHII regions in the LMC should be similar to that in Galactic ones. A non-LTE study of the CO emission suggests the presence of both cool and warm gas in the analysed region. The same analysis for the CS, HCO$^{+}$, HCN, and HNC shows that it is very likely that their emissions arise mainly from warm gas with a density between $5 \times 10^5$ to some $10^6$ cm$^{-3}$. The obtained HCN/HNC abundance ratio greater than 1 is compatible with warm gas and with an star-forming scenario. From the analysis of the molecular lines observed towards N132 and N166 we propose that both regions should have similar physical conditions, with densities of about 10$^3$ cm$^{-3}$.Comment: accepted in MNRAS (October 5, 2015

Do managed clinical networks improve quality of diabetes care? : Evidence from a retrospective mixed methods evaluation

Peer reviewedPostprin