EFEKTIFITAS MODEL DIRECTLY OBSERVED TREATMENT INTAKE (DOTI) TERHADAP KEPATUHAN PERAWATAN DIRI PASIEN HIPERTENSI: ANALISIS STATEMENT DEVELOPMENT

Latar Belakang:    Hipertensi merupakan masalah kesehatan global dan perlu mendapatkan perhatian serius untuk mengatasinya. Salah satu pendekatan yang direkomendasikan adalah Directly Observed Treatment Intake (DOTI). DOTI merupakan suatu tindakan observasi langsung terhadap obat-obatan yang dilakukan sendiri oleh pasien secara mandiri. Tujuan:    Mengembangkan analisis statement development tentang efektifitas model intervensi DOTI terhadap kepatuhan pengobatan dan perawatan diri pasien hipertensi. Metode: Analisis statement ini menggunakan pendekatan yang dikembangkan oleh Walker dan Avant. Artikel-artikel pendukung diperoleh dari Proquest, CINHAL, SCOPUS dan Google Scholar yang dipublikasikan pada tahun 2000 sampai 2021. Informasi terkait DOTI diperoleh dari 4 halaman website. Konsep DOTI, kepatuhan, perawatan diri dan hipertensi diidentifikasi secara jelas. Hasil:   Tahap-tahap analisis statement development efektifitas model intervensi DOTI terhadap kepatuhan perawatan diri pasien hipertensi (Salgueiro et al., 2018)adalah: 1) Select the statement to be analyzed; 2) Simply the statement; 3) Classify the statement; 4) Examine concepts within the statement for definition and validity; 5) Specify relationships between concept by type, sign and symmetry; 6) Examine the logic; dan 7) Determine testability Kesimpulan:   Analisis statement adalah suatu proses menganalisis hubungan antar statement untuk menentukan dalam bentuk apa penyajiannya bagaimana hubungan antara konsep dalam statement. Kegunaannya adalah untuk membangan sebuah teori keperawatan diawali yang diawali dengan pengembangan konsep dari fenomena yang diamati. Konsep-konsep yang dikembangkan ini akan menghasilkan sebuah kerangka teori. Perlu pemahaman terkait karakteristik konsep-konsep yang dikembangkan. Selanjutnya perlu memahami hubungan atau keterkaitan antara konsep-konsep tersebut dengan statement development

I-mode studies at ASDEX Upgrade: L-I and I-H transitions, pedestal and confinement properties

The I-mode is a plasma regime obtained when the usual L-H power threshold is high, e.g. with unfavourable ion B ∇ direction. It is characterised by the development of a temperature pedestal while the density remains roughly as in the L-mode. This leads to a confinement improvement above the L-mode level which can sometimes reach H-mode values. This regime, already obtained in the ASDEX Upgrade tokamak about two decades ago, has been studied again since 2009 taking advantage of the development of new diagnostics and heating possibilities. The I-mode in ASDEX Upgrade has been achieved with different heating methods such as NBI, ECRH and ICRF. The I-mode properties, power threshold, pedestal characteristics and confinement, are independent of the heating method. The power required at the L-I transition exhibits an offset linear density dependence but, in contrast to the L-H threshold, depends weakly on the magnetic field. The L-I transition seems to be mainly determined by the edge pressure gradient and the comparison between ECRH and NBI induced L-I transitions suggests that the ion channel plays a key role. The I-mode often evolves gradually over a few confinement times until the transition to H-mode which offers a very interesting situation to study the transport reduction and its link with the pedestal formation. Exploratory discharges in which n = 2 magnetic perturbations have been applied indicate that these can lead to an increase of the I-mode power threshold by flattening the edge pressure at fixed heating input power: more heating power is necessary to restore the required edge pressure gradient. Finally, the confinement properties of the I-mode are discussed in detail.European Commission (EUROfusion 633053

Smart lanthanide antennas for sensing water

Two new families of lanthanide antennas are described. 8-Methoxy- 4,5-dihydrocyclopenta[de]quinolin-2(1H)-one phosphonates or carboxylates behave as selective antennas exhibiting Eu3+ luminescence in organic solvents, while quinolin-2(1H)-one analogues selectively sensitize the Tb3+ emission. These emissions are quenched by H2O addition. Based on this behaviour, the new lanthanide antennas can be used as highly sensitive water sensors.Spanish Ministerio de Economia y Competividad SAF2012-32209 FU2015-67284-RMinisterio de Ciencia e Innovacion/Agencia Estatal de Investigacion/European Regional Development Fund CTQ2017-85658-R CTQ2015-63997-C2Consejo Superior de Investigaciones Cientificas (CSIC) 201580E07

Effect of resonant magnetic perturbations on low collisionality discharges in MAST and a comparison with ASDEX Upgrade

Sustained ELM mitigation has been achieved on MAST and AUG using RMPs with a range of toroidal mode numbers over a wide region of low to medium collisionality discharges. The ELM energy loss and peak heat loads at the divertor targets have been reduced. The ELM mitigation phase is typically associated with a drop in plasma density and overall stored energy. In one particular scenario on MAST, by carefully adjusting the fuelling it has been possible to counteract the drop in density and to produce plasmas with mitigated ELMs, reduced peak divertor heat flux and with minimal degradation in pedestal height and confined energy. While the applied resonant magnetic perturbation field can be a good indicator for the onset of ELM mitigation on MAST and AUG there are some cases where this is not the case and which clearly emphasise the need to take into account the plasma response to the applied perturbations. The plasma response calculations show that the increase in ELM frequency is correlated with the size of the edge peeling-tearing like response of the plasma and the distortions of the plasma boundary in the X-point region.Comment: 31 pages, 28 figures. This is an author-created, un-copyedited version of an article submitted for publication in Nuclear Fusion. IoP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i

The effect of air pollution on children’s health: a comparative study between La Plata and Bahía Blanca, Buenos Aires Province, Argentina

We present the results of a study of outdoor air quality in two comparable regions of Buenos Aires province (Argentina), La Plata and Bahía Blanca, developed jointly by researchers of National University in both cities, and of the Hospital of Bahía Blanca, between 2009 and 2011. Both regions are characterized by a large petrochemical complex and a village with outstanding traffic. In this study, we measure levels of volatile organic compounds (VOCs), particulate matter suspended in air (PM) in air outdoor and affectation of respiratory system in children between 6 and 12 years. Also, analysis of the effect of the air pollution exposure was done thought the calculation of potentially increased life time cancer risk (LCR) in children. In both regions, including three areas: urban, industrial and residential (reference area), 20 VOCs were sampled by passive monitoring (3M 3500), and determined by GC/FID, comprising n-alkanes, cycloalkanes, aromatics, chlorinated compounds, terpenoids and ketones; particulate matter (PM10) was token using a low flow sampler MiniVol TAS, and spirometry were performed, using a portable spirometer. The collected data show higher levels of PM10 in Bahía Blanca, both in the industrial zone and urban areas, industrial area of Bahía Blanca with very bad air quality, associable with a 5% increased in mortality. The levels of total VOCs found in the residential area for both regions are comparable. Spirometry parameters of children living in industrial area evidence respiratory disease respect to urban and residential areas.Fil: Colman Lerner, Jorge Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Morales, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Aguilar, M.. Universidad Nacional de La Plata. Fundación Ciencias Exactas; ArgentinaFil: Giuliani, Daniela Silvana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orte, Marcos Agustín. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ditondo, J.. Hospital Interzonal General de Agudos “Dr. José Penna”; ArgentinaFil: Dodero, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Massolo, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Sanchez, Erica Yanina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Matamoros, N.. Universidad Nacional de La Plata. Facultad de Ingenieria; ArgentinaFil: Porta, A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentin

Unexpected role of communities colonizing dead coral substrate in the calcification of coral reefs

Global and local anthropogenic stressors such as climate change, acidification, overfishing, and pollution are expected to shift the benthic community composition of coral reefs from dominance by calcifying organisms to dominance by non-calcifying algae. These changes could reduce the ability of coral reef ecosystems to maintain positive net calcium carbonate accretion. However, relationships between community composition and calcification rates remain unclear. We performed field experiments to quantify the metabolic rates of the two most dominant coral reef substrate types, live coral and dead coral substrate colonized by a mixed algal assemblage, using a novel underwater respirometer. Our results revealed that calcification rates in the daytime were similar for the live coral and dead coral substrate communities. However, in the dark, while live corals continued to calcify at slower rates, the dead coral substrate communities exhibited carbonate dissolution. Daytime net photosynthesis of the dead coral substrate communities was up to five times as much as for live corals, which we hypothesize may have created favorable conditions for the precipitation of carbonate minerals. We conclude that: (1) calcification from dead coral substrate communities can contribute to coral reef community calcification during the day, and (2) dead coral substrate communities can also contribute to carbonate mineral dissolution at night, decreasing ecosystem calcification over a diel cycle. This provides evidence that reefs could shift from slow, long-term accretion of calcium carbonate to a state where large daily cycling of calcium carbonate occurs, but with little or no long-term accumulation of the carbonate minerals needed to sustain the reef against erosional forces

Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

The transient outward potassium current (Itof) is generated by the activation of KV4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by KV4.3/KChIP2, KV4.3/KChIP2/DPP6 and KV4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (KV4.3/KChIP2, KV4.3/KChIP2/DPP6 or KV4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreased the maximum peak of KV4.3/KChIP2, KV4.3/KChIP2/DPP6 and KV4.3/KChIP2/KCNE2 currents, slowing their time course of inactivation in a concentration-, voltage-, time- and use-dependent manner. IQM-266 produced an increase in the charge in KV4.3/KChIP2 channels that was intensified when DPP6 was present and abolished in the presence of KCNE2. IQM-266 induced an activation unblocking effect during the application of trains of pulses to cells expressing KV4.3/KChIP2 and KV4.3/KChIP2/KCNE2, but not in KV4.3/KChIP2/DPP6 channels. Overall, all these results are consistent with a preferential IQM-266 binding to an active closed state of Kv4.3/KChIP2 and Kv4.3/KChIP2/KCNE2 channels, whereas in the presence of DPP6, IQM-266 binds preferentially to an inactivated state. In conclusion, DPP6 and KCNE2 modify the pharmacological response of KV4.3/KChIP2 channels to IQM-266

A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging

We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane