Lafora Disease Masquerading as Hepatic Dysfunction

Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence. We chronicle here an unusual case of an asymptomatic young male soccer player who presented with elevated liver enzymes. Neurological examination was unremarkable. The diagnostic workup for hepatitis, infectious etiologies, autoimmune disorders, hemochromatosis, Wilson\u27s disease, alpha-1 antitrypsin deficiency, and other related diseases was inconclusive. He subsequently underwent an uneventful percutaneous liver biopsy. Based on the pathognomonic histopathological findings, Lafora disease was considered the likely etiology. The present study is a unique illustration of this rare disorder initially manifesting with abnormal liver enzymes. It underscores the importance of clinical suspicion of Lafora disease in cases with unexplained hepatic dysfunction. Prompt liver biopsy and genetic testing should be performed to antedate the onset of symptoms in these patients

Inter-cell interference mitigation using adaptive reduced power subframes in heterogeneous networks

With the remarkable impact and fast growth of the mobile networks, the mobile base stations have been increased too, especially in the high population areas. These base stations will be overloaded by users, for that reason the small cells (like pico cells) were introduced. However, the inter-cell interference will be high in this type of Heterogeneous networks. There are many solutions to mitigate this interference like the inter-cell interference coordination (ICIC), and then the further enhanced ICIC (Fe-ICIC) where the almost blank subframes are used to give priority to the (victim users). But it could be a waste of bandwidth due to the unused subframes. For that reason, in this paper, we proposed an adaptive reduced power subframe that reduces its power ratio according to the user’s signal-to-interference-plus-noise ratio (SINR) in order to get a better throughput and to mitigate the intercell interference. When the user is far from the cell, the case will be considered as an edge user and will get a higher priority to be served first. The results show that the throughput of all users in the macro cells and pico cell will be improved when applying the proposed scheme in term of throughput for the users and the cells

When Shall Coronavirus Disease-19 Stop? Review of Literature

In December 2019, a new coronavirus, now labeled as severe acute respiratory syndrome coronavirus 2, induced an episode of acute atypical respiratory illness started in Wuhan, Province of Hubei, China. The illness triggered by this virus was called coronavirus disease-19 (COVID-19). The infection is spread within humans and has triggered a global pandemic. The amount of death tolls continues to increase and a growing number of countries have been driven to create social barriers and lock-ups. The shortage of tailored counseling remains an issue. Epidemiological researches have shown that elderly patients are more vulnerable to serious diseases, while children tend to have milder symptoms. Here, we checked the latest understanding of this disease and found a possible explanation of the potential sequel and the expectations for the future

Treatment of pre-school children under 6 years of age for schistosomiasis: safety, efficacy and acceptability of praziquantel

BackgroundThe World Health Organization (WHO) recommends praziquantel for the control and treatment of schistosomiasis, with no real alternative. Pre-school children are excluded from population treatment programs mainly due to paucity of safety data on this age group.Objectives: This study investigated safety, efficacy and acceptability of praziquantel for the treatment of S. haematobium and S. mansoni infections among pre-school children aged <6years. The study also investigated the burden of schistosomiasis in this age group.Methods: Pre-school children (n=188) from Sudan were included in the study. The children were treated with praziquantel tablets at a single dose of 40 mg/kg body weight. Adverse events were assessed at 24 hours and 7 days later, via questionnaire administration to parents and guardians.Efficacy of treatment was assessed at 1, 3 and 6 months by examining stool and urine samples for schistosome eggs. Acceptability was determined by the number of children spitting or vomiting during administration of the drug.Results: The burden of schistosomiasis among pre-school children aged <6 years was high (31.1%), and this was comparable to that observed among school children-aged 6 years (32%). Praziquantel treatment achieved high cure rates (egg negative) for both S. haematobium and S.mansoni infections when assessed at 1 month after treatment (89.6-92.1%) and remained high for S. haematobium (89.6-100%) up to 6 months. However, cure rate dropped from 90.5% at one month to 58.8% and 69.2% at 3 and 6 months among S. mansoni-treated children.  Praziquantel treatment decreased egg counts considerably with  post-treatment geometric mean egg reductions rates ranging from 96.4% to 99.4% at 1 month. Acceptability of praziquantel treatment was high, only for one child the dose had to be repeated after initial spitting. Treatment resolved haematuria and improved weight of the children. There were no drug-related adverse events in all the treated children duringfollow-up at 24 hours and 7 days.Conclusions: Praziquantel is safe, effective and acceptable among children aged <6 years. Preschool children represent a high risk group for schistosomiasis and should be included in population treatment programs.Keywords:Schistosomiasis,Praziquantel, Safety,Young Children

WS-PGRADE workflows for cloud-based distributed simulation

Modeling and Simulation (M&S) is used for systems analysis and decision making in existing or new systems. Modeling large and complex organizations produces large-scale simulations that are difficult or impossible to run on a single computer. Such experiment execution requires high computation. Distributed Simulation (DS) allows modeling of large systems as smaller submodels that execute on different nodes of a computer network and interoperate with each other in order to compose larger systems. Furthermore, cloud computing offers on-demand access to multiple compute resources. Consequently, being able to run DS on cloud resources allows for more experimentation with large-scale simulations in a cost-effective way. However, deploying DS and in fact Cloud-based DS presents significant technical challenges. This paper proposes a framework for deploying DS on the cloud in a transparent manner using the CloudSME Simulation Platform based on WS-PGRADE workflows. A healthcare case study is used to demonstrate our approach.Special thanks to Dr. Tamas Kiss and Mr Hannu Visti, Centre for Parallel Computing, University of Westminster for supporting in this study

A robust control design approach for altitude control and trajectory tracking of a quadrotor

Introduction. Unmanned aerial vehicles as quadcopters, twin rotors, fixed-wing crafts, and helicopters are being used in many applications these days. Control approaches applied on the quadrotor after decoupling the model or separate altitude control and trajectory tracking have been reported in the literature. A robust linear H∞ controller has been designed for both altitude control and circular trajectory tracking at the desired altitude. Problem. The ability of the quadrotor system to hover at a certain height and track any desired trajectory makes their use in many industrial applications in both military and civil applications. Once a controller has been designed, it may not be able to maintain the desired performance in practical scenarios, i.e. in presence of wind gusts. Originality. This work presents the control strategy to ensure both altitude control and trajectory tracking using a single controller. Purpose. However, there is a need for a single controller that ensures both altitude control and trajectory tracking. Novelty. This paper presents a robust H∞ control for altitude control and trajectory tracking for a six degree of freedom of unmanned aerial vehicles quadrotor. Methodology. Multi input multi output robust H∞ controller has been proposed for the quadrotor for altitude control and tracking the desired reference. For the controller validation, a simulation environment is developed in which a 3D trajectory is tracked by the proposed control methodology. Results. Simulation results depict that the controller is efficient enough to achieve the desired objective at minimal control efforts. Practical value. To verify that the proposed approach is able to ensure stability, altitude control, and trajectory tracking under practical situations, the performance of the proposed control is tested in presence of wind gusts. The ability of the controller to cater to the disturbances within fractions of seconds and maintaining both transient and steady-state performance proves the effectiveness of the controller.Вступ. Безпілотні літальні апарати, такі як квадрокоптери, двороторні апарати, апарати з нерухомими крилами та гелікоптери сьогодні використовуються у багатьох сферах застосування. У літературі повідомляється про підходи до керування, застосовані на квадрокоптері після від’єднання моделі або окремого контролю висоти та відстеження траєкторії. Надійний лінійний регулятор H∞ був розроблений як для контролю висоти, так і для відстеження кругової траєкторії на потрібній висоті. Проблема. Здатність квадрокоптерної системи зависати на певній висоті та відстежувати будь-яку бажану траєкторію робить їх застосування можливим у багатьох сферах як у військових, так і в цивільних цілях. Розроблений контролер може не підтримувати бажані характеристики у реальних умовах, тобто за наявності поривів вітру. Оригінальність. У цій роботі представлена стратегія керування, яка забезпечує як контроль висоти, так і відстеження траєкторії за допомогою одного контролера. Мета. Однак існує потреба в єдиному контролері, який забезпечує як контроль висоти, так і відстеження траєкторії. Новизна. У цій статті представлено надійний регулятор H∞ для контролю висоти та відстеження траєкторії для шести ступенів свободи безпілотних літальних апаратів. Методологія. Для квадрокоптера запропоновано багатовхідний багатовихідний надійний контролер H∞ для контролю висоти та відстеження бажаного курсу. Для перевірки контролера розробляється середовище моделювання, в якому тривимірна траєкторія відстежується за запропонованою методологією керування. Результати. Результати моделювання показують, що контролер є досить ефективним для досягнення бажаної мети при мінімальних зусиллях контролю. Практична цінність. Щоб переконатися, що запропонований підхід здатний забезпечити стабільність, контроль висоти та відстеження траєкторії в реальних ситуаціях, параметри запропонованого контролю перевіряються за наявності поривів вітру. Здатність контролера усувати порушення протягом кількох секунд і підтримувати як перехідні, так і стабільні показники доводить ефективність контролера

Effect of exogenous application of nicotinic acid on morpho-physiological characteristics of Hordeum vulgare L. under water stress

Abiotic stresses, such as high temperature and drought conditions, greatly influence the development of plants and the quality and quantity of products. Barley (Hordeum vulgare L.) crop production is largely impacted by drought, affecting growth, yield, and ultimately the productivity of the crop in hot arid/semi-arid conditions. The current pot experiment was directed to observe the outcome of nicotinic acid (NA) treatments on barley’s physiological, biochemical, and production attributes at two capacity levels, i.e., 100% normal range and withholding water stress. Randomized complete block design (RCBD) was used during the experimentation with the two-factor factorial arrangement. NA was applied exogenously by two different methods, i.e., foliar and soil application (fertigation). NA solution contained various application levels, such as T1 = control, foliar applications (T2 = 0.7368 gL−1, T3 = 1.477 gL−1, T4 = 2.2159 gL−1), and soil applications (T5 = 0.4924 gL−1, T6 = 0.9848 gL−1, and T7 = 1.4773 gL−1). Results depicted that, overall, foliar treatments showed better effects than control and soil treatments. Plant growth was preeminent under T4 treatment, such as plant height (71.07 cm), relative water content (84.0%), leaf water potential (39.73-MPa), leaf area index (36.53 cm2), biological yield (15.10 kgha−1), grain yield (14.40 kgha−1), harvest index (57.70%), catalase (1.54 mmolg−1FW−1), peroxidase (1.90 g−1FWmin−1), and superoxide dismutase (52.60 µgFW−1) were superior under T4 treatment. Soil plant analysis development (54.13 µgcm−2) value was also higher under T4 treatment and lowest under T7 treatment. In conclusion, NA-treated plants were more successful in maintaining growth attributes than non-treated plants; therefore, the NA foliar treatment at the rate of 2.2159 gL−1 is suggested to find economical crop yield under drought conditions. The present study would contribute significantly to improving the drought tolerance potential of barley through exogenous NA supply in water deficit areas

Two-phase flow regimes of condensing R-134a at low mass flux in rectangular microchannels

Qualitative two-phase flow regime data are obtained from high-speed visualization of condensing flows of R-134a at mass fluxes from 75 to 150 kg m−2 s−1 and quality from 0.1 to 0.8 in square microchannels (DH = 0.84 mm) cooled from a single side. Superheated R-134a is distributed into multiple parallel microchannels and then partially condensed, using a counterflow water loop, to the desired quality prior to the inlet of a visualization section. This experimental arrangement mitigates the potential for flow maldistribution. Despite very small heat duties, a low uncertainty in the quality in the visualization section is maintained by enforcing a large temperature difference on the water-side (ΔT > 10 K). For all conditions, annular or annular/wavy type flow were observed, with no distinct intermittent flow. Data are compared with flow macro and mini/microchannel maps, which are shown to over predict the occurrence of intermittent or wavy flow

Link between Technically Derived Energy Efficiency and Ecological Footprint: Empirical Evidence from the Asean Region

The sustainable environment has been a desired situation around the world for the last few decades. Environmental contaminations can be a consequence of various economic activities. Different socio-economic factors influence the environment positively or negatively. Many previous studies have resulted in the efficient allocation of inputs as an environment-friendly component. This paper investigates the effects of energy efficiency on ecological footprint in the ASEAN region using balanced panel data from 2001 to 2019. First, this paper technically derives the energy effi-ciency, using the stochastic frontier analysis (SFA) of the translog production type of single output and multiple inputs. Findings of the SFA show that the Philippines and Singapore have the highest energy efficiency (94%) and Laos has the lowest energy efficiency (85%) in the ASEAN region. The estimated average efficiency score of the ASEAN region was around 90%, ranging from 85% to 96%, indicating that there is still 10% room for improvement in energy efficiency. Second, this study employed the panel autoregressive distributed lag (ARDL) model to explore the short run and long run impact of technically derived energy efficiency on ecological footprint in the ASEAN region. Results of the panel ARDL model show that energy efficiency is a reducing factor of ecological footprint in the long run. Moreover, energy efficiency plays a significant role to control the environmental contaminations. In addition, results of this study also explored that urbanization is an increasing factor of ecological footprint, and investment in agriculture is also beneficial for the environment. Moreover, to obtain the directional nature of the associations between the ecological footprint and its independent variables, this paper has employed the paired-panel Granger causality test. The results of the paired wise panel Granger causality test also confirm that the energy efficiency, ur-banization, and investment in agriculture cause ecological footprint. Finally, this study recom-mends that efficient utilization of energy resources as well as investment in agriculture are neces-sary for sustainable environment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Funding: Project no. 132805 has been implemented with support provided from the National Research, Development, and Innovation Fund of Hungary, financed under the K_19 funding scheme and supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00095/18 and BO/8/20)