Anomalous crustal movements with low seismic efficiency - Campi Flegrei, Italy and some examples in Japan

Campi Flegrei is a unique volcanic region located near Naples, Italy. Anomalous crustal movements at Pozzuoli in Campi Flegrei have been documented since the Roman period. The movements were gradual and have continued to the present, occasionally accompanying swarms of local earthquakes and volcanic eruptions. Generally the movements proceed with low seismicity. After the 1538 eruption of Monte Nuovo, Pozzuoli had subsided monotonously, but it changed to uplift abruptly in 1969. The uplift accelerated in 1983 and 1984 reaching more than 2 m, and thereafter began to subside. Many discussions of this event have been published. In Japan, we have examples of deformations similar to those at Campi Flegrei, mainly in volcanic areas, and rarely in non-volcanic areas. The former includes Iwojima, Miyakejima and Aira caldera while the latter is represented by Cape Omaezaki. Iwojima is a volcano island, and its secular uplifts since the 18th century are recognized as an unusual event. Miyakejima volcano and Aira caldera exhibited anomalous movements with low seismicity after their eruptions. Cape Omaezaki is not situated in volcanic zone but near a subduction zone, and gradually and continuously subsides as a precursor to a large earthquake. In such cases as Campi Flegrei and the Japanese localities, we would question whether the deformations are accompanied by normal seismicity or low seismicity. To examine quantitatively the relationship between seismicity and related deformation, seismic efficiency is generally useful. The crustal deformations in all the regions cited above are characterized by exceptionally low seismic efficiencies. In the present paper, the deformations at Pozzuoli and Iwojima are mainly described and a comparative discussion among these and other localities in Japan is supplemented. It is concluded that such anomalous phenomena in volcanic areas are attributable to peculiar rheological aspects of the material composing the local upper crust, and the deformation in a non-volcanic area is of tectonic origin

P12.14: 4D/3D ultrasound‐guided embryo transfer

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49° Festival dei Popoli

Il Festival dei Popoli è la più antica e prestigiosa manfestazione intranazionale di documentaristica sociale ed antropologica in Italia. Al suo interno sono previste proiezioni; seminari; convegni; laboratori: ecc

WNT4 deficiency—a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: A Case Report

The pathways leading to female sexual determination in mammals are incompletely defined. Loss-of-function mutations in the WNT4 gene appear to cause developmental abnormalities of sexual differentiation in women and mice. We recruited six patients with different degrees of Müllerian abnormalities, with or without renal aberrations and a normal female 46,XX karyotype. A clear androgen excess was found only in one patient. This 19-year-old woman was affected by primary amenorrhoea, absence of Müllerian ducts derivatives, clinical (acne and hirsutism) and biochemical (repeatedly high levels of testosterone) signs of androgen excess. Direct sequencing of her WNT4 gene followed by functional studies in human ovarian cells (OVCAR3) was performed. This patient carried the novel R83C loss-of-function dominant negative mutation in her WNT4, confirming the role of WNT4 in the development and maintenance of the female phenotype in women. Our study can also help refine the phenotype of WNT4 deficiency in humans. In fact, it appears that at least in this limited casuistic small group of patients, the absence of a uterus (and not other Müllerian abnormalities) and the androgen excess are the pathognomonic signs of WNT4 defects, suggesting that this might be a clinical entity distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrom

BoolSurf: Boolean Operations on Surfaces

We port Boolean set operations between 2D shapes to surfaces of any genus, with any number of open boundaries. We combine shapes bounded by sets of freely intersecting loops, consisting of geodesic lines and cubic Bézier splines lying on a surface. We compute the arrangement of shapes directly on the surface and assign integer labels to the cells of such arrangement. Differently from the Euclidean case, some arrangements on a manifold may be inconsistent. We detect inconsistent arrangements and help the user to resolve them. Also, we extend to the manifold setting recent work on Boundary-Sampled Halfspaces, thus supporting operations more general than standard Booleans, which are well defined on inconsistent arrangements, too. Our implementation discretizes the input shapes into polylines at an arbitrary resolution, independent of the level of resolution of the underlying mesh. We resolve the arrangement inside each triangle of the mesh independently and combine the results to reconstruct both the boundaries and the interior of each cell in the arrangement. We reconstruct the control points of curves bounding cells, in order to free the result from discretization and provide an output in vector format. We support interactive usage, editing shapes consisting up to 100k line segments on meshes of up to 1M triangles

50° Festival dei Popoli

Il Festival dei Popoli è la più antica e prestigiosa manfestazione intranazionale di documentaristica sociale ed antropologica in Italia. Al suo interno sono previste proiezioni; seminari; convegni; laboratori: ecc

Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus

Young age is often characterized by high consumption of processed foods and fruit juices rich in fructose, which, besides inducing a tendency to become overweight, can promote alterations in brain function. The aim of this study was therefore to (a) clarify brain effects resulting from fructose consumption in juvenile age, a critical phase for brain development, and (b) verify whether these alterations can be rescued after removing fructose from the diet. Young rats were fed a fructose-rich or control diet for 3 weeks. Fructose-fed rats were then fed a control diet for a further 3 weeks. We evaluated mitochondrial bioenergetics by high-resolution respirometry in the hippocampus, a brain area that is critically involved in learning and memory. Glucose transporter-5, fructose and uric acid levels, oxidative status, and inflammatory and synaptic markers were investigated by Western blotting and spectrophotometric or enzyme-linked immunosorbent assays. A short-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, associated with an increased concentration of inflammatory markers and decreased Neurofilament-M and post-synaptic density protein 95. These alterations, except for increases in haptoglobin and nitrotyrosine, were recovered by returning to a control diet. Overall, our results point to the dangerous effects of excessive consumption of fructose in young age but also highlight the effect of partial recovery by switching back to a control diet

Vaginal lactoferrin in prevention of preterm birth in women with bacterial vaginosis

Objective: To evaluate use of vaginal lactoferrin in prevention of preterm birth (PTB) in women with first trimester bacterial vaginosis and prior spontaneous PTB.Methods: This is a retrospective cohort study of all consecutive singleton gestations with prior PTB, and first trimester diagnosis of bacterial vaginosis. Women who were found to have bacterial vaginosis were recommended lactoferrin 300 mg vaginal tablets daily for 21 days. The primary outcome was the incidence of PTB at less than 37 weeks of gestations. Outcomes were compared in women who received daily lactoferrin with those who did notResults: During the study period, 847 pregnant women with prior spontaneous PTB were screened for bacterial vaginosis. Of them, 193 were found to have bacterial vaginosis in the first trimester, with an overall incidence of 22.8%. Out of the 193 women, 125 met the inclusion criteria for the study and were analyzed. Sixty of the included women received vaginal lactoferrin, while 65 did not. Women who received supplementation with lactoferrin had a significantly lower rate of PTB < 37 weeks (25.0 versus 44.6%; p = .02), lower mean gestational age at delivery (37.7 ± 3.2 versus 35.9 ± 4.1 weeks; p = .01), and lower rate of admission for threatened PTL (45.0 versus 70.8%; p = .04). No between-group differences were noticed in the other outcomes, including chorioamnionitis, PPROM < 34 weeks, and neonatal outcomes. No cases of late miscarriage were reported in our cohort. No cases of adverse events were reported.Conclusion: Based on this small single-center retrospective study, supplementation with vaginal lactoferrin in women with first trimester bacterial vaginosis may be an option to reduce the risk of preterm delivery