Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease A Mendelian Randomization Analysis

ObjectivesThe purpose of this study was to estimate the effect of long-term exposure to lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart disease (CHD).BackgroundLDL-C is causally related to the risk of CHD. However, the association between long-term exposure to lower LDL-C beginning early in life and the risk of CHD has not been reliably quantified.MethodsWe conducted a series of meta-analyses to estimate the effect of long-term exposure to lower LDL-C on the risk of CHD mediated by 9 polymorphisms in 6 different genes. We then combined these Mendelian randomization studies in a meta-analysis to obtain a more precise estimate of the effect of long-term exposure to lower LDL-C and compared it with the clinical benefit associated with the same magnitude of LDL-C reduction during treatment with a statin.ResultsAll 9 polymorphisms were associated with a highly consistent reduction in the risk of CHD per unit lower LDL-C, with no evidence of heterogeneity of effect (I2 = 0.0%). In a meta-analysis combining nonoverlapping data from 312,321 participants, naturally random allocation to long-term exposure to lower LDL-C was associated with a 54.5% (95% confidence interval: 48.8% to 59.5%) reduction in the risk of CHD for each mmol/l (38.7 mg/dl) lower LDL-C. This represents a 3-fold greater reduction in the risk of CHD per unit lower LDL-C than that observed during treatment with a statin started later in life (p = 8.43 × 10−19).ConclusionsProlonged exposure to lower LDL-C beginning early in life is associated with a substantially greater reduction in the risk of CHD than the current practice of lowering LDL-C beginning later in life

Computer modelling of compact 28/38 GHz dual-band antenna for millimeter-wave 5G applications

YesA four-element compact dual-band patch antenna having a common ground plane operating at 28/38 GHz is proposed for millimeter-wave communication systems in this paper. The multiple-input-multiple-output (MIMO) antenna geometry consists of a slotted ellipse enclosed within a hollow circle which is orthogonally rotated with a connected partial ground at the back. The overall size of the four elements MIMO antenna is 2.24λ × 2.24λ (at 27.12 GHz). The prototype of four-element MIMO resonator is designed and printed using Rogers RT Duroid 5880 with εr = 2.2 and loss tangent = 0.0009 and having a thickness of 0.8 mm. It covers dual-band having a fractional bandwidth of 15.7% (27.12–31.34 GHz) and 4.2% (37.21–38.81 GHz) for millimeter-wave applications with a gain of more than 4 dBi at both bands. The proposed antenna analysis in terms of MIMO diversity parameters (Envelope Correlation Coefficient (ECC) and Diversity Gain (DG)) is also carried out. The experimental result in terms of reflection coefficient, radiation pattern, gain and MIMO diversity parameter correlates very well with the simulated ones that show the potential of the proposed design for MIMO applications at millimeter-wave frequencies.This work is supported by the Moore4Medical Project, funded within ECSEL JU in collaboration with the EU H2020 Framework Programme (H2020/2014-2020) under Grant Agreement H2020-ECSEL-2019-IA-876190, and Fundação para a Ciência e Tecnologia (ECSEL/0006/2019). This work is also funded by the FCT/MEC through national funds and when applicable co-financed by the ERDF, under the PT2020 Partnership Agreement under the UID/EEA/50008/2020 Project

Smart android based home automation system using internet of things (IoT)

Recently, home automation system has getting significant attention because of the fast and advanced technology, making daily living more convenient. Almost everything has been digitalized and automated. The development of home automation will become easier and more popular because of the use of the Internet of Things (IoT). This paper described various interconnection systems of actuators, sensors to enable multiple home automation implementations. The system is known as HAS (Home automation system). It operates by connecting the robust Application Programming Interface (API), which is the key to a universal communication method. The HAS used devices, often implemented the actuators or sensors that have an upwards communication network followed by HAS (API). Most of the devices of the HAS (home automation system) used Raspberry Pi boards and ESP8285 chips. A smartphone application has been developed that allows users to control a wide range of home appliances and sensors from their smartphones. The application is user-friendly, adaptable, and beneficial for consumers and disabled people. It has the potential to be further extended via the use of various devices. The main objectives of this work are to make our home automation system, more secure and intelligent. HAS is a highly effective and efficient computational system that may be enhanced with a variety of devices and add-ons

Cell Nucleus-Targeting Zwitterionic Carbon Dots

An innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle has been developed for anticancer drug delivery and optical monitoring. The zwitterionic functional groups of the CDs introduced by a simple one-step synthesis using beta-alanine as a passivating and zwitterionic ligand allow cytoplasmic uptake and subsequent nuclear translocation of the CDs. Moreover, multicolor fluorescence improves the accuracy of the CDs as an optical code. The CD-based drug delivery system constructed by non-covalent grafting of doxorubicin, exhibits superior antitumor efficacy owing to enhanced nuclear delivery in vitro and tumor accumulation in vivo, resulting in highly effective tumor growth inhibition. Since the zwitterionic CDs are highly biocompatible and effectively translocated into the nucleus, it provides a compelling solution to a multifunctional nanoparticle for substantially enhanced nuclear uptake of drugs and optical monitoring of translocation.open

Kinetics of toluene methylation over silica modified HZSM-5 zeolites

334-340Kinetics of toluene alkylation with methanol over silica modified HZSM-5 catalyst under experimental conditions that are close to envisaged industrial conditions are studied. Of the several possible kinetic models tested and compared, a simple power law model is found satisfactory in predicting toluene conversions and p-xylene selectivities. However, further studies with a comprehensive experimental program, is suggested for investigating the numerous side reactions and to account for a large number of by-products observed. </span

EFFECT OF LONG-TERM EXPOSURE TO LOWER LOW-DENSILIPOPROTEIN CHOLESTEROL BEGINNING EARLY IN LIFE ON THE RISK OF CORONARY HEART DISEASE. A MENDELIAN RANDOMIZATION ANALYSIS

Translation articles: B.A. Ference, W. Yoo, I. Alesh, N. Mahajan, K.K. Mirowska, A. Mewada, J. Kahn, L. Afonso, K.A. Williams, J.M. Flack «Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease. A Mendelian Randomization Analysis» впервые опубликована в журнале J Am Coll Cardiol 2012; 60(25): 2631-9;doi:10.1016/j.jacc.2012.09.017 © 2012 by the AmericanCollegeofCardiology Foundatio