Thermal state of electronic assemblies applied to smart building equipped with QFN64 device subjected to natural convection

The performance and reliability of electronic components and assemblies strongly depend on their thermal state. The knowledge of the temperature distribution throughout the assembly is therefore an essential element to ensure their correct operation. This is the main objective of this work that examines the case of a conventional assembly equipped with a quad flat nonlead QFN64 subjected to free convection. This active electronic package is welded on a PCBwhich may be inclined by an angle varying between 0° and 90° (horizontal and vertical positions respectively) and generates during its operation a high power ranging from 0.1 to 1W.Thermoregulation of the assembly is ensured by natural convection, given its many well known advantages in this engineering field. Accurate relationships are proposed to determine the temperature on different areas of the device and the PCB. They are determined by means of a 3D numerical survey based on the finite volume method confirmed by measurements on an actual installation. These relationships allow reliability improvement of these electronicassemblies widely used in many engineering fields, as computing industry, mobile telephony, home automation, automotive, embarked electronics and smart building considered in this survey. The present survey complements a recent study which quantifies the natural convective heat transfer on the considered electronic assembly equipped with the QFN64 device, for thesame power range and angle of inclination

Enhancement of natural convection for improvement of Trombe wall performance. An experimental study

This experimental work shows that the natural convective heat transfer in the active enclosure of a conventional Trombe wall assembly is enhanced by the interposition of transparent and vertical partitions. Quantification of the average Nusselt number corresponding to both versions with and without partitions was carried out by means of a 1/5 scale assembly. The glass cover is maintained isothermal at cold temperature while the active wall generates a variable heat flux simulating the incident solar radiation. The distance between the two active and parallel walls is variable. Four ratios between this distance and the height of the wall are considered, associated with a wide range of Rayleigh number reaching 4.1×109. An error calculation is carried out for all the processed configurations, taking into account the experimental uncertainties of the measured physical parameters. The maximum error found on the average Nusselt number is low, of about 5%. Measurements made by means of an interstitial medium without partitions are consistent with the results of other work carried out by experimental and numerical approaches in specific ranges of Rayleigh number. This study reveals the partitions effectiveness, since the natural convective heat transfer's increase lies between 10.0% and 14.4% according to the considered configuration. Correlations are proposed in the present work in order to calculate the average natural convective Nusselt number for the conventional Trombe wall without partitions and for its improved version, for any aspect ratio and in the whole range of the considered Rayleigh number. They contribute to the optimization of the thermal design of this interesting assembly

Thermal state of electronic assemblies applied to smart building equipped with QFN64 device subjected to natural convection

The performance and reliability of electronic components and assemblies strongly depend on their thermal state. The knowledge of the temperature distribution throughout the assembly is therefore an essential element to ensure their correct operation. This is the main objective of this work that examines the case of a conventional assembly equipped with a quad flat nonlead QFN64 subjected to free convection. This active electronic package is welded on a PCBwhich may be inclined by an angle varying between 0° and 90° (horizontal and vertical positions respectively) and generates during its operation a high power ranging from 0.1 to 1W.Thermoregulation of the assembly is ensured by natural convection, given its many well known advantages in this engineering field. Accurate relationships are proposed to determine the temperature on different areas of the device and the PCB. They are determined by means of a 3D numerical survey based on the finite volume method confirmed by measurements on an actual installation. These relationships allow reliability improvement of these electronicassemblies widely used in many engineering fields, as computing industry, mobile telephony, home automation, automotive, embarked electronics and smart building considered in this survey. The present survey complements a recent study which quantifies the natural convective heat transfer on the considered electronic assembly equipped with the QFN64 device, for thesame power range and angle of inclination

Toxic Epidermal Necrolysis after Pemetrexed and Cisplatin for Non-Small Cell Lung Cancer in a Patient with Sharp Syndrome

Background: Pemetrexed is an antifolate drug approved for maintenance and second-line therapy, and, in combination with cisplatin, for first-line treatment of advanced nonsquamous non-small cell lung cancer. The side-effect profile includes fatigue, hematological and gastrointestinal toxicity, an increase in hepatic enzymes, sensory neuropathy, and pulmonary and cutaneous toxicity in various degrees. Case Report: We present the case of a 58-year-old woman with history of Sharp's syndrome and adenocarcinoma of the lung, who developed toxic epidermal necrolysis after the first cycle of pemetrexed, including erythema, bullae, extensive skin denudation, subsequent systemic inflammation and severe deterioration in general condition. The generalized skin lesions occurred primarily in the previous radiation field and responded to immunosuppressive treatment with prednisone. Conclusion: Although skin toxicity is a well-known side effect of pemetrexed, severe skin reactions after pemetrexed administration are rare. Caution should be applied in cases in which pemetrexed is given subsequent to radiation therapy, especially in patients with pre-existing skin diseases

Present status and future plans for Tore Supra

Tore Supra is a limiter tokamak with circular plasma cross-section. The superconducting toroidal magnet is a unique feature which allows very long pulse discharges. Tore Supra has ion cyclotron resonance heating and an electron cyclotron system is being installed. Noninductive currents are driven by lower hybrid and by the bootstrap effect. Highlights of previous results include long pulses lasting up to 2 minutes with 280 MJ coupled into the plasma and fully non-inductive discharges lasting up to 75 seconds. Tore Supra is presently in the middle of a major shutdown for the installation of a new toroidal pumped limiter. This will be actively cooled with capability for steady state operation at total power levels around 20 MW. Future plans include upgrades to the ion cyclotron heating and lower hybrid current drive systems and a new pellet injector

Cholesteatoma of the external ear canal: etiological factors, symptoms and clinical findings in a series of 48 cases

BACKGROUND: To evaluate symptoms, clinical findings, and etiological factors in external ear canal cholesteatoma (EECC). METHOD: Retrospective evaluation of clinical records of all consecutive patients with EECC in the period 1979 to 2005 in a tertiary referral centre. Main outcome measures were incidence rates, classification according to causes, symptoms, extensions in the ear canal including adjacent structures, and possible etiological factors. RESULTS: Forty-five patients were identified with 48 EECC. Overall incidence rate was 0.30 cases per year per 100,000 inhabitants. Twenty-five cases were primary, while 23 cases were secondary: postoperative (n = 9), postinflammatory (n = 5), postirradiatory (n = 7), and posttraumatic (n = 2). Primary EECC showed a right/left ratio of 12/13 and presented with otalgia (n = 15), itching (n = 5), occlusion (n = 4), hearing loss (n = 3), fullness (n = 2), and otorrhea (n = 1). Similar symptoms were found in secondary EECC, but less pronounced. In total the temporomandibular joint was exposed in 11 cases, while the mastoid and middle ear was invaded in six and three cases, respectively. In one primary case the facial nerve was exposed and in a posttraumatic case the atticus and antrum were invaded. In primary EECC 48% of cases reported mechanical trauma. CONCLUSION: EECC is a rare condition with inconsistent and silent symptoms, whereas the extent of destruction may be pronounced. Otalgia was the predominant symptom and often related to extension into nearby structures. Whereas the aetiology of secondary EECC can be explained, the origin of primary EECC remains uncertain; smoking and minor trauma of the ear canal may predispose

Prediction of High-Grade Vesicoureteral Reflux after Pediatric Urinary Tract Infection: External Validation Study of Procalcitonin-Based Decision Rule

BACKGROUND: Predicting vesico-ureteral reflux (VUR) 653 at the time of the first urinary tract infection (UTI) would make it possible to restrict cystography to high-risk children. We previously derived the following clinical decision rule for that purpose: cystography should be performed in cases with ureteral dilation and a serum procalcitonin level 650.17 ng/mL, or without ureteral dilatation when the serum procalcitonin level 650.63 ng/mL. The rule yielded a 86% sensitivity with a 46% specificity. We aimed to test its reproducibility. STUDY DESIGN: A secondary analysis of prospective series of children with a first UTI. The rule was applied, and predictive ability was calculated. RESULTS: The study included 413 patients (157 boys, VUR 653 in 11%) from eight centers in five countries. The rule offered a 46% specificity (95% CI, 41-52), not different from the one in the derivation study. However, the sensitivity significantly decreased to 64% (95%CI, 50-76), leading to a difference of 20% (95%CI, 17-36). In all, 16 (34%) patients among the 47 with VUR 653 were misdiagnosed by the rule. This lack of reproducibility might result primarily from a difference between derivation and validation populations regarding inflammatory parameters (CRP, PCT); the validation set samples may have been collected earlier than for the derivation one. CONCLUSIONS: The rule built to predict VUR 653 had a stable specificity (ie. 46%), but a decreased sensitivity (ie. 64%) because of the time variability of PCT measurement. Some refinement may be warranted

Proteomic Analysis of S-Acylated Proteins in Human B Cells Reveals Palmitoylation of the Immune Regulators CD20 and CD23

S-palmitoylation is a reversible post-translational modification important for controlling the membrane targeting and function of numerous membrane proteins with diverse roles in signalling, scaffolding, and trafficking. We sought to identify novel palmitoylated proteins in B lymphocytes using acyl-biotin exchange chemistry, coupled with differential analysis by liquid-chromatography tandem mass spectrometry. In total, we identified 57 novel palmitoylated protein candidates from human EBV-transformed lymphoid cells. Two of them, namely CD20 and CD23 (low affinity immunoglobulin epsilon Fc receptor), are immune regulators that are effective/potential therapeutic targets for haematological malignancies, autoimmune diseases and allergic disorders. Palmitoylation of CD20 and CD23 was confirmed by heterologous expression of alanine mutants coupled with bioorthogonal metabolic labeling. This study demonstrates a new subset of palmitoylated proteins in B cells, illustrating the ubiquitous role of protein palmitoylation in immune regulation