The LHC di-photon excess and Gauge Coupling Unification in Extra Z′Z^\prime Heterotic-String Derived Models

The di-photon excess observed at the LHC can be explained as a Standard Model singlet that is produced and decays by heavy vector-like colour triplets and electroweak doublets in one-loop diagrams. The characteristics of the required spectrum are well motivated in heterotic-string constructions that allow for a light $Z^\prime$. Anomaly cancellation of the $U(1)_{Z^\prime}$ symmetry requires the existence of the Standard Model singlet and vector-like states in the vicinity of the $U(1)_{Z^\prime}$ breaking scale. In this paper we show that the agreement with the gauge coupling data at one-loop is identical to the case of the Minimal Supersymmetric Standard Model, owing to cancellations between the additional states. We further show that effects arising from heavy thresholds may push the supersymmetric spectrum beyond the reach of the LHC, while maintaining the agreement with the gauge coupling data. We show that the string inspired model can indeed account for the observed signal and discuss the feasibility of obtaining viable scalar mass spectrum.Comment: 26 pages. 11 figures. Published versio

Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs

Introduction: The COVID-19 pandemic poses an unprecedented challenge for the rapid discovery of drugs against this life-threatening disease. Owing to the peculiar features of the metal centers that are currently used in medicinal chemistry, metallodrugs might offer an excellent opportunity to achieve this goal. Areas covered: Two main strategies for developing metal-based drugs against the SARS-CoV-2 are herein illustrated. Firstly, a few clinically approved metallodrugs could be evaluated in patients according to a ‘drug repurposing’ approach. To this respect, the gold drug auranofin seems a promising candidate, but some other clinically established metal compounds are worthy of a careful evaluation as well. On the other hand, libraries of inorganic compounds, featuring a large chemical diversity, should be screened to identify the most effective molecules. This second strategy might be assisted by a pathway-driven discovery approach arising from a preliminary knowledge of the mode of action, exploitable to inhibit the functional activities of the key viral proteins. Also, attention must be paid to selectivity and toxicity issues. Expert opinion: The medicinal inorganic chemistry community may offer a valuable contribution against COVID-19. The screening of metallodrugs’ libraries can expand the explored ‘chemical space’ and increase the chance of finding effective anti-COVID agents

Numerical and experimental investigation of the stability of a drop in a single-axis acoustic levitator

Acoustic levitation can be employed to hold liquid drops in midair, enabling novel applications in X-ray scattering of proteins, amorphous crystallization of solutions, or contactless mixing. Multiple studies have characterized the physical behavior of a levitated drop inside an acoustic field. Here, we present a numerical and experimental study on the acoustic levitation of water drops in a single-Axis acoustic levitator consisting of an ultrasonic transducer and an opposing reflector. Instead of modeling an abstract incident acoustic field, our model considers the shape of the drop as well as the real geometry of the levitator. We also use a high-speed camera to observe the disintegration and the undesired oscillations of the drops. Our results show that the insertion of a drop in the levitator provokes a shift in its resonant frequency that depends on the shape of the drop. Second, the levitation behavior depends on whether the levitator operates slightly below or above the resonance. Third, if the levitator is driven above the resonant frequency, it is possible to levitate with more strength and avoid disintegration of the drop. This research provides an insight on how to achieve more stable experiments that avoid the bursting and undesired oscillations of the levitated sample. We hope that it will facilitate numerous experiments involving acoustically levitated liquid drops.This work was supported by the São Paulo Research Foundation—FAPESP (Grant No. 2017/27078-0)

A Next-to-Leading-Order Study of Dihadron Production

The production of pairs of hadrons in hadronic collisions is studied using a next-to-leading-order Monte Carlo program based on the phase space slicing technique. Up-to-date fragmentation functions based on fits to LEP data are employed, together with several versions of current parton distribution functions. Good agreement is found with data for the dihadron mass distribution. A comparison is also made with data for the dihadron angular distribution. The scale dependence of the predictions and the dependence on the choices made for the fragmentation and parton distribution functions are also presented. The good agreement between theory and experiment is contrasted to the case for single $\pi^0$ production where significant deviations between theory and experiment have been observed.Comment: 22 pages, 15 figures; 3 references added, one figure modified for clarit

Study of the Bcl-2 Interactome by BiFC reveals differences in the activation mechanism of Bax and Bak

Evasion of apoptosis is one of the hallmarks of cancer cells. Proteins of the Bcl-2 family are key regulators of the intrinsic pathway of apoptosis, and alterations in some of these proteins are frequently found in cancer cells. Permeabilization of the outer mitochondrial membrane, regulated by pro- and antiapoptotic members of the Bcl-2 family of proteins, is essential for the release of apoptogenic factors leading to caspase activation, cell dismantlement, and death. Mitochondrial permeabilization depends on the formation of oligomers of the effector proteins Bax and Bak after an activation event mediated by BH3-only proteins and regulated by antiapoptotic members of the Bcl-2 family. In the present work, we have studied interactions between different members of the Bcl-2 family in living cells via the BiFC technique. Despite the limitations of this technique, present data suggest that native proteins of the Bcl-2 family acting inside living cells establish a complex network of interactions, which would fit nicely into “mixed” models recently proposed by others. Furthermore, our results point to differences in the regulation of Bax and Bak activation by proteins of the antiapoptotic and BH3-only subfamilies. We have also applied the BiFC technique to explore the different molecular models proposed for Bax and Bak oligomerization. Bax and Bak’s mutants lacking the BH3 domain were still able to associate and give BiFC signals, suggesting the existence of alternative surfaces of interaction between two Bax or Bak molecules. These results agree with the widely accepted symmetric model for the dimerization of these proteins and also suggest that other regions, different from the α6 helix, could be involved in the oligomerization of BH3-in groove dimers

Spectral Evidence of Aqueous Activity in Two Putative Martian Paleolakes

CRISM observations of putative paleolakes in Cankuzo and Luqa craters exhibit spectral features consistent with the activity of water. The spatial distributions suggest different formation scenarios for each site. In Cankuzo the distribution suggests postimpact alteration whereas in Luqa there are hints of possible formation of a layer of phyllosilicate materials

Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA–PEG nanoparticles

Chloro(triethylphosphine)gold(I), (Et(3)PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et(3)PAuCl exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines and is a promising anticancer drug candidate. We wondered whether Et(3)PAuCl encapsulation might lead to an improved pharmacological profile also considering the likely reduction of unwanted side-reactions that are responsible for adverse effects and for drug inactivation. Et(3)PAuCl was encapsulated in biocompatible PLGA–PEG nanoparticles (NPs) and the new formulation evaluated in colorectal HCT-116 cancer cells in comparison to the free gold complex. Notably, encapsulated Et(3)PAuCl (nano-Et(3)PAuCl hereafter) mostly retains the cellular properties of the free gold complex and elicits even greater cytotoxic effects in colorectal cancer (CRC) cells, mediated by apoptosis and autophagy. Moreover, a remarkable inhibition of two crucial signaling pathways, i.e. ERK and AKT, by nano-Et(3)PAuCl, was clearly documented. The implications of these findings are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10534-021-00313-0

Drivers of Small-Scale Fishers’ Acceptability across Mediterranean Marine Protected Areas at Different Stages of Establishment

The success of marine protected areas (MPAs) in achieving conservation and sustainable development goals hinges on, among other things, their social acceptability by local communities. Small-scale fishing communities represent a key stakeholder category within and around MPAs. Although many authors have examined the social acceptability of MPAs, relatively few studies have addressed this issue by considering how MPA acceptability is built and can be preserved. This study assessed the latent structure of MPA social acceptability and identified the individual and institutional variables driving stakeholders’ acceptability. Using questionnaire surveys, 124 small-scale fishers’ perceptions of MPAs and their social acceptability were explored in six Mediterranean MPAs (three were implemented, and three were designated). The results show that MPA acceptability is positively related to fishers’ age. The findings also highlight that the formal establishment of MPAs is not a sufficient condition for increasing MPA acceptability among fishers. Considerations about the possibility that MPA acceptability can be increased by building support and compliance emerged. MPA managers should implement successful long-term stakeholder engagement initiatives to increase commitment around conservation measures and to improve overall MPA effectiveness

Gynoecium size and ovule number are interconnected traits that impact seed yield

Angiosperms form the biggest group of land plants and display an astonishing diversity of floral structures. The development of the flowers greatly contributed to the evolutionary success of the angiosperms as they guarantee efficient reproduction with the help of either biotic or abiotic vectors. The female reproductive part of the flower is the gynoecium (also called pistil). Ovules arise from meristematic tissue within the gynoecium. Upon fertilization, these ovules develop into seeds while the gynoecium turns into a fruit. Gene regulatory networks involving transcription factors and hormonal communication regulate ovule primordium initiation, their spacing on the placenta, and ovule development. Ovule number and gynoecium size are usually correlated and several genetic factors that impact these traits have been identified. Understanding and fine-tuning the gene regulatory networks influencing ovule number and pistil length opens up strategies for crop yield improvement, which is pivotal in light of a rapidly growing world population. In this review, we present an overview of the current knowledge of the genes and hormones involved in determining ovule number and gynoecium size. We propose a model for the gene regulatory network that guides the developmental processes that determine seed yield

Altered endocannabinoid signalling after a high-fat diet in Apoe −/− mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance

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