625 research outputs found
Demographic characteristics of exploited tropical lutjanids: a comparative analysis
Demographic parameters from seven exploited coral reef lutjanid species were compared as a case study of the implications of intrafamily variation in life histories for
multispecies harvest management. Modal lengths varied by 4 cm among four species (Lutjanus fulviflamma, L. vitta, L. carponotatus, L. adetii), which were at least 6 cm smaller than the modal lengths of the largest species (L. gibbus, Symphorus nematophorus, Aprion virescens). Modal ages, indicating ages of full selection to fishing gear, were 10 years or less for all species, but maximum ages ranged from
12 (L. gibbus) to 36 years (S. nematophorus). Each species had a unique growth pattern, with differences in length-at-age and mean asymptotic fork length (L∞), but smaller species generally grew fast during the first 1–2 years of life and larger species grew more slowly over a longer period. Total mortality rates varied among species; L. gibbus had the highest mortality and L. fulviflamma, the
lowest mortality. The variability in life history strategies of these tropical lutjanids makes generalizations about lutjanid life histories difficult, but the fact that all seven had characteristics that would make them particularly vulnerable to fishing indicates that
harvest of tropical lutjanids should be managed with caution
Notional defined contribution pension schemes: Why does only Sweden distribute the survivor dividend?
The aim of this paper is to analyse the role of the survivor dividend in notional defined contribution (NDC) pension schemes. At present, this feature can only be found in the Swedish defined contribution scheme. We develop a model that endorses the idea that the survivor dividend has a strong basis for enabling the NDC scheme to achieve financial equilibrium and that not including the dividend is a non-transparent way of compensating for increases in longevity and/or legacy costs from old pension systems. We also find that the average effect of the dividend remains unchanged for any constant annual rate of population growth, that contribu-tors who reach retirement age always get a higher return than the scheme does, and that population growth enables cohorts with more years of contributions to benefit to a greater extent from the dividend effect
First bounds on the very high energy gamma-ray emission from Arp 220
Using the Major Atmospheric Gamma Imaging Cherenkov Telescope (MAGIC), we
have observed the nearest ultra-luminous infrared galaxy Arp 220 for about 15
hours. No significant signal was detected within the dedicated amount of
observation time. The first upper limits to the very high energy -ray
flux of Arp 220 are herein reported and compared with theoretical expectations.Comment: Accepted for publication in Ap
Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models
α-Synuclein (α-syn) is a small lipid-binding protein involved in vesicle trafficking whose function is poorly characterized. It is of great interest to human biology and medicine because α-syn dysfunction is associated with several neurodegenerative disorders, including Parkinson’s disease (PD). We previously created a yeast model of α-syn pathobiology, which established vesicle trafficking as a process that is particularly sensitive to α-syn expression. We also uncovered a core group of proteins with diverse activities related to α-syn toxicity that is conserved from yeast to mammalian neurons. Here, we report that a yeast strain expressing a somewhat higher level of α-syn also exhibits strong defects in mitochondrial function. Unlike our previous strain, genetic suppression of endoplasmic reticulum (ER)-to-Golgi trafficking alone does not suppress α-syn toxicity in this strain. In an effort to identify individual compounds that could simultaneously rescue these apparently disparate pathological effects of α-syn, we screened a library of 115,000 compounds. We identified a class of small molecules that reduced α-syn toxicity at micromolar concentrations in this higher toxicity strain. These compounds reduced the formation of α-syn foci, re-established ER-to-Golgi trafficking and ameliorated α-syn-mediated damage to mitochondria. They also corrected the toxicity of α-syn in nematode neurons and in primary rat neuronal midbrain cultures. Remarkably, the compounds also protected neurons against rotenone-induced toxicity, which has been used to model the mitochondrial defects associated with PD in humans. That single compounds are capable of rescuing the diverse toxicities of α-syn in yeast and neurons suggests that they are acting on deeply rooted biological processes that connect these toxicities and have been conserved for a billion years of eukaryotic evolution. Thus, it seems possible to develop novel therapeutic strategies to simultaneously target the multiple pathological features of PD.MGH/MIT Morris Udall Center of Excellence in Parkinson Disease Research (NS038372)Michael J. Fox Foundation for Parkinson's ResearchHoward Hughes Medical InstituteUnited States. National Institutes of Health (NS049221)American Parkinson Disease Association, Inc
Implementation of the Random Forest Method for the Imaging Atmospheric Cherenkov Telescope MAGIC
The paper describes an application of the tree classification method Random
Forest (RF), as used in the analysis of data from the ground-based gamma
telescope MAGIC. In such telescopes, cosmic gamma-rays are observed and have to
be discriminated against a dominating background of hadronic cosmic-ray
particles. We describe the application of RF for this gamma/hadron separation.
The RF method often shows superior performance in comparison with traditional
semi-empirical techniques. Critical issues of the method and its implementation
are discussed. An application of the RF method for estimation of a continuous
parameter from related variables, rather than discrete classes, is also
discussed.Comment: 16 pages, 8 figure
Constraints on the steady and pulsed very high energy gamma-ray emission from observations of PSR B1951+32/CTB 80 with the MAGIC Telescope
We report on very high energy gamma-observations with the MAGIC Telescope of
the pulsar PSR B1951+32 and its associated nebula, CTB 80. Our data constrain
the cutoff energy of the pulsar to be less than 32 GeV, assuming the pulsed
gamma-ray emission to be exponentially cut off. The upper limit on the flux of
pulsed gamma-ray emission above 75 GeV is 4.3*10^-11 photons cm^-2 sec^-1, and
the upper limit on the flux of steady emission above 140 GeV is 1.5*10^-11
photons cm^-2 sec^-1. We discuss our results in the framework of recent model
predictions and other studies.Comment: 7 pages, 7 figures, replaced with published versio
Discovery of Very High Energy gamma-rays from 1ES 1011+496 at z=0.212
We report on the discovery of Very High Energy (VHE) gamma-ray emission from
the BL Lacertae object 1ES1011+496. The observation was triggered by an optical
outburst in March 2007 and the source was observed with the MAGIC telescope
from March to May 2007. Observing for 18.7 hr we find an excess of 6.2 sigma
with an integrated flux above 200 GeV of (1.58 photons
cm s. The VHE gamma-ray flux is >40% higher than in March-April
2006 (reported elsewhere), indicating that the VHE emission state may be
related to the optical emission state. We have also determined the redshift of
1ES1011+496 based on an optical spectrum that reveals the absorption lines of
the host galaxy. The redshift of z=0.212 makes 1ES1011+496 the most distant
source observed to emit VHE gamma-rays up to date.Comment: 4 pages, 6 figures, minor changes to fit the ApJ versio
Systematic search for VHE gamma-ray emission from X-ray bright high-frequency BL Lac objects
All but three (M87, BL Lac and 3C 279) extragalactic sources detected so far
at very high energy (VHE) gamma-rays belong to the class of high-frequency
peaked BL Lac (HBL) objects. This suggested to us a systematic scan of
candidate sources with the MAGIC telescope, based on the compilation of X-ray
blazars by Donato et al. (2001). The observations took place from December 2004
to March 2006 and cover sources on the northern sky visible under small zenith
distances zd < 30 degrees at culmination. The sensitivity of the search was
planned for detecting X-ray bright F(1 keV) > 2 uJy) sources emitting at least
the same energy flux at 200 GeV as at 1 keV. In order to avoid strong gamma-ray
attenuation close to the energy threshold, the redshift of the sources was
constrained to values z<0.3. Of the fourteen sources observed, 1ES 1218+304 and
1ES 2344+514 have been detected in addition to the known bright TeV blazars Mrk
421 and Mrk 501. A marginal excess of 3.5 sigma from the position of 1ES
1011+496 was observed and has been confirmed as a source of VHE gamma-rays by a
second MAGIC observation triggered by a high optical state (Albert et al.
2007). For the remaining sources, we present here the 99% confidence level
upper limits on the integral flux above ~200 GeV. We characterize the sample of
HBLs (including all HBLs detected at VHE so far) by looking for correlations
between their multi-frequency spectral indices determined from simultaneous
optical, archival X-ray, and radio luminosities, finding that the VHE emitting
HBLs do not seem to constitute a unique subclass. The absorption corrected
gamma-ray luminosities at 200 GeV of the HBLs are generally not higher than
their X-ray luminosities at 1 keV.Comment: 15 pages, 7 figures, 5 tables, submitted to ApJ (revised version
Unfolding of differential energy spectra in the MAGIC experiment
The paper describes the different methods, used in the MAGIC experiment, to
unfold experimental energy distributions of cosmic ray particles (gamma-rays).
Questions and problems related to the unfolding are discussed. Various
procedures are proposed which can help to make the unfolding robust and
reliable. The different methods and procedures are implemented in the MAGIC
software and are used in most of the analyses.Comment: Submitted to NIM
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