Analisis Penguasaan Pemilikan Penggunaan Dan Pemanfaatan Tanah (P4t) Berbasis Bidang Menggunakan Sistem Informasi Geografis (Sig) (Studi Kasus : Kelurahan Tembalang Tahun 2015)

Tembalang merupakan wilayah yang memiliki perkembangan yang sangat dinamis, karena selain fungsinya sebagai kawasan pemukiman, Tembalang juga merupakan kawasan pendidikan. Pembangunan kampus Univesitas Diponegoro (UNDIP) yang dimulai sejak tahun 1990-an sampai dengan saat ini membuat banyak Perubahan bagi TembalangData yang digunakan dalam penelitian ini berupa peta administrasi Kelurahan Tembalang, citra GeoEye terkoreksi tahun 2013 dan sebaran persil BPN. Metode yang digunakan dalam penelitian ini adalah identifikasi pada obyek bidang tanah berupa poin penggunaan, pemanfaatan, pemilikan, dan penguasaan tanah.Penelitian ini dilakukan untuk mendapatkan hasil berupa peta yang akurat dan teliti mengenai sebaran bidang tanah lengkap dengan penggunaan, pemanfaatan, pemilikan, dan penguasaan tanah di Kelurahan Tembalang. Penggunaan tanah di Kelurahan Tembalang sebagian besar merupakan tanah kosong sudah diperuntukan dengan persentase 33,930%, pemanfaatan terbanyak adalah pemanfaatan campuran sebesar 29,68%, pemilikan tanah oleh negara sebesar 67,80% dan penguasaan tanah oleh negara sebesar 67,80%. Pola hubungan yang terjadi antara penguasaan, pemilikan, penggunaan, dan pemanfaatan tanah di Kelurahan Tembalang sebanyak 103 pola dengan pola yang mendominasi adalah pola penguasaan oleh negara dengan status kepemilikan tanah milik negara yang penggunaannya sebagai tanah kosong sudah diperuntukan dan dimanfaatkan sebagai pemanfaatan campuran dengan persentase 24,3454 % dan luas 93,045 Ha.Kata Kunci : Penguasaan, Pemilikan, Penggunaan, Pemanfaatan ABSTRACKTembalang is an area that has a very dynamic growth. It has a function not only for settlement area but also as an education area. The establishment of Diponegoro University (UNDIP) that started since 1990s until now, makes much changes for Tembalang.The data that is used in this study is a map of Tembalang, corrected GeoEye images from 2013 and BPN plot distribution. This study uses a method of identification of land area objects that are in the form of land use, utilization, ownership and authorization point.This study is being done to get a result that is in the form of accurate and precise maps about land area distribution with their land use, utilization,ownership and authorization at Tembalang. Land use at Tembalang district is mostly reserved barren land at 33,93%, the most use is mixed use at 29,68%, land ownership by the government at 67,80% and land authority by the government at 67,80%. The amount of correlation pattern that happens between land authority, land ownership, land use and utilization in Tembalang district is 103 pattern. With the dominating pattern which is authority by the government – land ownership by government – land use of reserved barren land – mixed use at 24,3454% and the area is 93,045 Hectare

Students’ independent work organization under performance appraisal rating system conditions

The leading learning method is the students’ independent work. And the teacher’s main task is to teach the students to think independently, to analyze, to choose the main idea in the information flow. Modular-rating technology of training allows not only to organize the students’ independent work in these areas, but also to predict both students and teachers activity. The educational process to teach how to work independently promotes the personality development and self-assertion, the formation of a competent person and a specialist able to move quickly and adapt to any situation.Рассмотрена самостоятельная работа студентов как ведущий метод обучения. Главная задача преподавателя – научить студентов самостоятельно мыслить, анализировать, выбирать основное в потоке информации. Модульно-рейтинговая технология обучения позволяет не только организовать самостоятельную работу студентов, но и спрогнозировать деятельность как студента, так и преподавателя. Обучение умению самостоятельно работать способствует развитию личности, формированию грамотного человека и специалиста, который может быстро адаптироваться к любой жизненной ситуации

Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro

A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers a broad-spectrum antiviral (BSA) to inhibit many SARS-CoV-2 variants and diverse human coronavirus strains with >99% reduction of the viral titer. We show that Cas13d-mediated coronavirus inhibition is dependent on the crRNA cellular spatial colocalization with Cas13d and target viral RNA. Cas13d can significantly enhance the therapeutic effects of diverse small molecule drugs against coronaviruses for prophylaxis or treatment purposes, and the best combination reduced viral titer by over four orders of magnitude. Using lipid nanoparticle-mediated RNA delivery, we demonstrate that the Cas13d system can effectively treat infection from multiple variants of coronavirus, including Omicron SARS-CoV-2, in human primary airway epithelium air-liquid interface (ALI) cultures. Our study establishes CRISPR-Cas13 as a BSA which is highly complementary to existing vaccination and antiviral treatment strategies

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Trapping Transient RNA Complexes by Chemically Reversible Acylation

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Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

Nanoparticles based on biocompatible methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (mPEG$_{113}$-b-P(D,L)LAn) copolymers as potential vehicles for the anticancer agent oxaliplatin were prepared by a nanoprecipitation technique. It was demonstrated that an increase in the hydrophobic PLA block length from 62 to 173 monomer units leads to an increase of the size of nanoparticles from 32 to 56 nm. Small-angle X-ray scattering studies confirmed the “core-corona” structure of mPEG$_{113}$-b-P(D,L)LAn nanoparticles and oxaliplatin loading. It was suggested that hydrophilic oxaliplatin is adsorbed on the core-corona interface of the nanoparticles during the nanoprecipitation process. The oxaliplatin loading content decreased from 3.8 to 1.5% wt./wt. (with initial loading of 5% wt./wt.) with increasing PLA block length. Thus, the highest loading content of the anticancer drug oxaliplatin with its encapsulation efficiency of 76% in mPEG$_{113}$-b-P(D,L)LAn nanoparticles can be achieved for block copolymer with short hydrophobic block