Implementasi Model Pembelajaran Kooperatif Teknik Tsts dengan Pendekatan Saintifik untuk Meningkatkan Kreativitas Berpikir dan Prestasi Belajar Ekonomi SMA N 1 Bobotsaritahun Ajaran 2014/2015

Tujuan penelitian ini adalah untuk meningkatkan kreativitas berpikir dan prestasi belajar ekonomi pada siswa kelas X-I SMA Negeri 1 Bobotsari tahun ajaran 2014/2015 melalui penerapan model pembelajaran kooperatif teknik two stay two stray dengan menggunakan pendekatan saintifik. Jenis penelitian ini adalah Penelitian Tindakan Kelas. Subjek Penelitian ini adalah siswa X-I SMA N 1 Bobotsari Tahun Ajaran 2014/2015. Teknik pengumpulan data yang digunakan yaitu (a) observasi, (b) wawancara, (c) tes, dan (d) dokumentasi. Prosedur penelitian meliputi (1) perencanaan tindakan; (2) pelaksanaan tindakan; (3) observasi; dan (4) refleksi. Berdasarkan hasil penelitian, dapat disimpulkan bahwa model pembelajaran kooperatif teknik two stay two stray dengan menggunakan pendekatan saintifik dapat meningkatkan kreativitas berpikir dan prestasi belajar. Sebelum diterapkan medel pembelajaran kooperatif teknik two stay two stray dengan menggunakan pendekatan saintifik nilai rata-rata kelas adalah 69,88 atau dengan presentase ketuntasan 32,36%. Sedangkan kreativitas berpikir siswa pada aspek berpikir lancar2,94%, berpikir luwes 0%, berpikir orisinil2,94%, elaborasi 2,94%, dan evaluasi0%. Pada siklus I nilai rata-rata kelas adalah 77 atau dengan presentase ketuntasan 70,59%. Sedangkan kreativitas berpikir siswa pada aspek berpikir lancar 47,05%, berpikir luwes 61,76%, berpikir orisinil 55,88%, elaborasi 52,95%, dan evaluasi 58,82%. Pada siklus II nilai rata-rata kelas adalah 81 atau dengan presentase ketuntasan 82,35%. Sedangkan kreativitas berpikir siswa pada aspek berpikir lancar 82,35%, berpikir luwes 73,53%, berpikir orisinil 79,41%, elaborasi 85,30%, dan evaluasi 70,58%

Analisis Pengaruh Experiential Marketing terhadap Word Of Mouth Sepeda Motor Yamaha (Studi Kasus pada Mahasiswa Universitas Sebelas Maret Tahun 2014)

Tujuan penelitian adalah untuk mengetahui: pengaruh antara variabel-variabel experiential marketing terhadap variabel customer satisfaction dan pengaruh antara variabel customer satisfaction terhadap variabel word of mouth. Metode penelitian yang digunakan adalah metode deskriptif kuantitatif. Populasi sebagai subyek dalam penelitian ini adalah mahasiswa Universitas Sebelas Maret Surakarta yang menggunakan sepeda motor Yamaha. Sampling yang digunakan dalam penelitian ini adalah quota sampling dan accidental sampling. Jumlah sampel pada penelitian ini adalah 100 responden. Teknik pengumpulan data yang digunakan adalah teknik kuesioner dengan skala likert. Teknik analisis data yang digunakan adalah Partial Least Square (PLS). Uji analisis PLS yang digunakan dalam penelitian ini meliputi: uji outer model berupa uji convergent validity, discriminant validity, dan composite reliability. Uji inner model dengan melihat R2. Pengujian hipotesis yang digunakan adalah analisis koefisien jalur untuk mengetahui hubungan antar variabel penelitian. Berdasarkan hasil penelitian dapat disimpulkan bahwa: variabel Sense, Think,Feel, Act dan Relate terhadap Customer Satisfaction berpengaruh positif dan signifikan dan variabel Customer Satisfaction terhadap Word of Mouth berpengaruh positif dan signifikan.Kata kunci: experiential marketing, word of mouthThe purpose of this research were analyzed and determined : The Influence of the experiential marketing variables toward customer satisfaction variable and the influence of customer satisfaction variable toward word of mouth variable. The method used is descriptive quantitative method . The population as subjects in this study were University students March Surakarta who use Yamaha motorcycles . Sampling used in this study is quota sampling and accidental sampling . The number of samples in this study was 100 respondents . The data collection technique used was a questionnaire with Likert scale technique . The data analysis technique used was Partial Least Square ( PLS ). PLS analysis test used in this study include : testing a model of the outer test convergent validity , discriminant validity , and composite reliability . Test to see the inner workings of the model R2 . Testing this hypothesis used was path coefficient analysis to determine the relationship between the study variables. Based on the results of this study concluded that : variable Sense, Think, Feel, Act and Relate on Customer Satisfaction positively and significantly and Customer Satisfaction of the Word of Mouth variables positively and significantly

Analisis Kualitas Pelayanan Pendidikan pada Smk Batik 1 Surakarta

Penelitian dilatarbelakangi oleh rendahnya tingkat kepuasan siswa atas kualitas pelayanan pendidikan. Tujuan penelitian adalah mengetahui: (1)Besarnya tingkat kepentingan atribut kualitas pelayanan pendidikan, (2)Besarnya tingkat kinerja atribut kualitas pelayanan pendidikan, (3)Besarnya tingkat kepuasan siswa, (4)Atribut pelayanan pendidikan yang perlu ditingkatkan, dan (5)Atribut pelayanan pendidikan yang perlu dipertahankan. Berdasarkan tujuan, penelitian ini termasuk dalam penelitian eksploratif, dan jika berdasarkan teknik pengumpulan datanya, maka penelitian ini termasuk dalam jenis penelitian kuantitatif. Populasinya berjumlah 504 siswa dan sampelnya berjumlah 223 siswa. Berdasarkan penelitian yang dilaksanakan, hasil skor total dari kinerja sebesar 24.107, sedangkan skor total dari kepentingan sebesar 27.569. Berdasarkan skor tersebut, dapat diperoleh tingkat kesesuaian total sebesar 87,44%. 87,44% < 100%, sehingga dikatakan bahwa kinerja yang diberikan SMK Batik 1 Surakarta belum mampu memenuhi harapan siswanya. Tingkat kesesuaian tiap dimensinya sebesar: (1)Empati skor kesesuaiannya 87,38%, (2)Bukti fisik skor kesesuaiannya 88,84%, (3)Keandalan skor kesesuaiannya 87,88%, (4) Daya tanggap skor kesesuaiannya 84,95%, dan (5)Jaminan skor kesesuaiannya 88,06%. Pemetaan dalam diagram Kartesius, diperoleh hasil bahwa: (1)Terdapat 7 atribut yang masuk dalam kuadran A, (2)Terdapat 15 atribut yang masuk dalam kuadran B, (3)Terdapat 12 atribut yang masuk dalam kuadran C, dan (4)Terdapat 1 atribut yang masuk dalam kuadran D. Kata kunci: Kepuasan, kualitas layanan pendidikanThe research is motivated by the low level of student satisfaction on the quality of educational services. The research objective was to determine: (1) The level of interest attributes of quality educational services, (2) The level of performance attributes of quality educational services, (3) The level of student satisfaction, (4) Attributes education services need to be improved, and (5) Attributes educational services need to be maintained. Based on the purpose, this study is included in exploratory research, and if based on data collection techniques, this research included in this type of quantitative research. And a population of 504 students and the sample totaled 223 students. Based on the research conducted, the results of the total score of the performance of 24 107, while the total score of the interests of 27 569. Based on these scores, can be obtained in total conformity level of 87.44%. 87.44% <100%, so it is said that the performance of a given SMK Batik 1 Surakarta has not been able to meet the expectations of their students. The suitability of each dimension of: (1) Empathy scores compliance 87.38%, (2) physical evidence compliance score of 88.84%, (3) Reliability scores compliance 87.88%, (4) Responsiveness compliance scores 84.95 %, and (5) guarantee compliance score of 88.06%. Mapping in the diagram Cartesian, showed that: (1) There are seven attributes that are included in quadrant A, (2) There are 15 attributes included in quadrant B, (3) There are 12 attributes included in quadrant C, and (4) There 1 attribute included in quadrant D

Vertébrés (crocodilians, poisons) du Miocène marin de l’Algarve occidentale

Karst fillings rich in fossils from carbonate series, Miocene in age, exposed on the coast of Algarve, yielded some thousands of teeth and other vertebrate remains. A crocodilian and more than fifty species of fishes (Selacians, Teleosteans) have been identified (see tableau 1). This fauna is consistent as a whole with a Burdigalian (maybe late) and/or Langhian age. It also indicates shallow waters, warmer than at present in the same region although not strictly tropical. This fauna shows more affinities with others of the same age from mediterranean region (i.e. Baleares) than with those from Lisbon

The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.

Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apoptotic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro-survival kinase, the protein kinase C (PKC) zeta. We show that light exposure induced PKC zeta activation. PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation. These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase-independent pathways

Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation.

PURPOSE: To evaluate whether anti-vascular endothelial growth factor (VEGF) neutralizing antibodies injected in the vitreous of rat eyes influence retinal microglia and macrophage activation. To dissociate the effect of anti-VEGF on microglia and macrophages subsequent to its antiangiogenic effect, we chose a model of acute intraocular inflammation. METHODS: Lewis rats were challenged with systemic lipopolysaccharide (LPS) injection and concomitantly received 5 µl of rat anti-VEGF-neutralizing antibody (1.5 mg/ml) in the vitreous. Rat immunoglobulin G (IgG) isotype was used as the control. The effect of anti-VEGF was evaluated at 24 and 48 h clinically (uveitis scores), biologically (cytokine multiplex analysis in ocular media), and histologically (inflammatory cell counts on eye sections). Microglia and macrophages were immunodetected with ionized calcium-binding adaptor molecule 1 (IBA1) staining and counted based on their differential shapes (round amoeboid or ramified dendritiform) on sections and flatmounted retinas using confocal imaging and automatic quantification. Activation of microglia was also evaluated with inducible nitric oxide synthase (iNOS) and IBA1 coimmunostaining. Coimmunolocalization of VEGF receptor 1 and 2 (VEGF-R1 and R2) with IBA1 was performed on eye sections with or without anti-VEGF treatment. RESULTS: Neutralizing rat anti-VEGF antibodies significantly decreased ocular VEGF levels but did not decrease the endotoxin-induced uveitis (EIU) clinical score or the number of infiltrating cells and cytokines in ocular media (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α, and monocyte chemoattractant protein [MCP]-1). Eyes treated with anti-VEGF showed a significantly decreased number of activated microglia and macrophages in the retina and the choroid and decreased iNOS-positive microglia. IBA1-positive cells expressed VEGF-R1 and R2 in the inflamed retina. CONCLUSIONS: Microglia and macrophages expressed VEGF receptors, and intravitreous anti-VEGF influenced the microglia and macrophage activation state. Taking into account that anti-VEGF drugs are repeatedly injected in the vitreous of patients with retinal diseases, part of their effects could result from unsuspected modulation of the microglia activation state. This should be further studied in other ocular pathogenic conditions and human pathology

Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action

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ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target