Muslim Feminists and Transnational Networking in Asia: Upholding the Origin and Diaspora

Globalization, with both its banes and boons, poses certain threats to the episteme of the religions across the globe. Islam is no exception in this connection especially when it comes to its practices and popular discourses on gender. The Muslim feminists, at a global level, should tend to secure a transcultural and diasporic identity while also maintaining their territorialized affiliations with their respective virtual centers. The ideal can be materialized through the notion of transnational networking while exploiting the modern means of communication. The authors, in this paper, tends to articulate that in face of the starkly exploding spirit of postmodernist simulacra characterizing the present-day world order, the Muslim feminists in Asia are supposed to uphold both their origin and diaspora on the parallel if they intend to sustain their essential identity as Muslims while also enjoying the citizenship of a world order which has become most globalized, challenging and kaleidoscopic today. Keywords: globalization, transnational networking, simulacra, diaspora, Islam, feminism, Othe

Genotoxic Effect of Atrazine, Arsenic, Cadmium and Nitrate, Individually and in Mixtures at Maximum Contaminant Levels on mammalian Breast Cell Lines

There is strong evidence that hormonally active agents (HAAs) such as Atrazine (ATZ), Cadmium (Cd), Arsenic (As) and Nitrate (NO3) have both estrogenic activity and carcinogenic potential. Atrazine has clastogenic effects and may also act as tumor promoter as it induces the aromatase enzyme. Arsenic and Cadmium have been implicated in the etiology of skin, lung, prostate and liver cancers. Nitrate in drinking water has been found to increase the risk of bladder cancer.This study examined the genotoxicity of the aforementioned HAAs alone and in mixtures using mammalian breast cell lines, MCF-7 and MCF-10A, which are estrogen receptorpositive (ER+) and estrogen receptor-negative (ER-), respectively. To study the clastogenic potential by whole cell and flow karyotype damage, cells were exposed to environmentally relevant concentrations of ATZ, Cd, As and NO3 for 4 and 7 days.Results indicated that all treatments induced whole cell clastogenicity in MCF-7 cells; except Cd and NO3 after 4 and 7 days as well as the 10% quaternary As mixture after 1 week. In MCF-10A cells, all treatments except the 10% mixture induced whole cell clastogenicity after 4 days, where flow karyotype damage was detected in all treatments except for the 10% mixture after 1 week. Estrogen caused whole cell damage but not flow karyotype damage in MCF-7. On the other hand, estrogen caused flow karyotype damage and not whole cell damage in MCF-10A cells, suggesting that estrogen receptor modulated the genotoxicity of estrogen. Cd caused flow karyotype damage but not whole cell damage in MCF-7 indicating that Cd’s gentoxicity is not related to its estrogenic activity.Keywords: HAAs, clastogenicity, flow-karyotype, genotoxicity, MCF-7, MCF-10

Antibiotic Resistance Bacteria in Tertiary Hospitals in Chittagong, Bangladesh

Nosocomial infections (HAI) are major cause for mortality and morbidity worldwide. In low income countries, data suggests 6.5% - 33% of patients have HAI with pneumonia being the most frequent..Antibiotic resistance is highly prevalent in developing countries due to self medication, easy availability and poor regulatory controls. Clinicians have been left with limited antibiotic drug options for the treatment of bacterial infections due to escalated rates of resistance. This comparative study aimed to identify microorganisms from hospital surfaces in two major tertiary care hospitals in Chittagong, Bangladesh. It also identifies antibiotic susceptibility of the samples to antibiotics commonly used in Bangladesh. Samples were collected by swabbing different environmental surface around patients in both hospitals. Identification of bacteria was done by culturing in nutrient media and various common biochemical techniques. Antibiotic sensitivity was determined by disk diffusion method. During the study, 27 samples were collected from different surfaces in different wards of the hospitals. The predominating organisms were Streptococcus, Staphylococcus, Bacillus, Pseudomonas and Serratia. The isolates of organisms showed high level of resistance to commonly used antibiotics especially a fourth generation cephalosporin, cefepime. In addition, antibiotic sensitivity tests showed small colonies or film of growth within zone of inhibition of some of the samples known as “satellite colonies”. The study identified bacterial isolates responsible for HAI in tertiary hospitals and their susceptibility to antibiotics. Further research is currently being conducted on understanding the satellite colonies some of the isolates from hospital surface swabs have exhibited

Effectiveness of interventions to screen and manage infections during pregnancy on reducing stillbirths: a review

<p>Abstract</p> <p>Background</p> <p>Infection is a well acknowledged cause of stillbirths and may account for about half of all perinatal deaths today, especially in developing countries. This review presents the impact of interventions targeting various important infections during pregnancy on stillbirth or perinatal mortality.</p> <p>Methods</p> <p>We undertook a systematic review including all relevant literature on interventions dealing with infections during pregnancy for assessment of effects on stillbirths or perinatal mortality. The quality of the evidence was assessed using the adapted Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach by Child Health Epidemiology Reference Group (CHERG). For the outcome of interest, namely stillbirth, we applied the rules developed by CHERG to recommend a final estimate for reduction in stillbirth for input to the Lives Saved Tool (LiST) model.</p> <p>Results</p> <p>A total of 25 studies were included in the review. A random-effects meta-analysis of observational studies of detection and treatment of syphilis during pregnancy showed a significant 80% reduction in stillbirths [Relative risk (RR) = 0.20; 95% confidence interval (CI): 0.12 - 0.34) that is recommended for inclusion in the LiST model. Our meta-analysis showed the malaria prevention interventions i.e. intermittent preventive treatment (IPTp) and insecticide-treated mosquito nets (ITNs) can reduce stillbirths by 22%, however results were not statistically significant (RR = 0.78; 95% CI: 0.59 – 1.03). For human immunodeficiency virus infection, a pooled analysis of 6 radomized controlled trials (RCTs) failed to show a statistically significant reduction in stillbirth with the use of antiretroviral in pregnancy compared to placebo (RR = 0.93; 95% CI: 0.45 – 1.92). Similarly, pooled analysis combining four studies for the treatment of bacterial vaginosis (3 for oral and 1 for vaginal antibiotic) failed to yield a significant impact on perinatal mortality (OR = 0.88; 95% CI: 0.50 – 1.55).</p> <p>Conclusions</p> <p>The clearest evidence of impact in stillbirth reduction was found for adequate prevention and treatment of syphilis infection and possibly malaria. At present, large gaps exist in the growing list of stillbirth risk factors, especially those that are infection related. Potential causes of stillbirths including HIV and TORCH infections need to be investigated further to help establish the role of prevention/treatment and its subsequent impact on stillbirth reduction.</p

Relative Convex Hull Determination from Convex Hulls in the Plane

A new algorithm for the determination of the relative convex hull in the plane of a simple polygon A with respect to another simple polygon B which contains A, is proposed. The relative convex hull is also known as geodesic convex hull, and the problem of its determination in the plane is equivalent to find the shortest curve among all Jordan curves lying in the difference set of B and A and encircling A. Algorithms solving this problem known from Computational Geometry are based on the triangulation or similar decomposition of that difference set. The algorithm presented here does not use such decomposition, but it supposes that A and B are given as ordered sequences of vertices. The algorithm is based on convex hull calculations of A and B and of smaller polygons and polylines, it produces the output list of vertices of the relative convex hull from the sequence of vertices of the convex hull of A.Comment: 15 pages, 4 figures, Conference paper published. We corrected two typing errors in Definition 2: $I_S$ has to be defined based on $O_S$, and $I_E$ has to be defined based on $O_E$ (not just using $O$). These errors appeared in the text of the original conference paper, which also contained the pseudocode of an algorithm where $I_S$ and $I_E$ appeared as correctly define

Developing standard pedestrian-equivalent factors: passenger car–equivalent approach for dealing with pedestrian diversity

Similar to vehicular traffic, pedestrians, despite having diverse capabilities and body sizes, can be classified as heterogeneous. The use of vehicular traffic resolves the diversity issue with a conversion of heterogeneous vehicle flow into an equivalent flow with the use of passenger car–equivalent (PCE) factors. Analysis of pedestrian flow has yet to incorporate pedestrian diversity analysis implicitly into the design of pedestrian facilities, although some form of adjustment has been suggested. This paper introduces the concept of PCE-type factors for mixed pedestrian traffic called standard pedestrian-equivalent (SPE) factors. Estimates of SPE factors are made relative to the average commuter. The equivalent total travel time approach for PCE estimation was adapted to consider the effects of the differences in physical and operational characteristics of pedestrians, particularly walking speed and body size. Microsimulation of pedestrians was employed to evaluate hypothetical pedestrian proportions so as to generate corresponding flow relationships. Walking speeds and body sizes were varied across different flow conditions, walkway widths, and proportions of other pedestrian types. The first part of this paper explores how the two pedestrian characteristics (walking speed and body size) influence estimated SPE factors. The second part is a case study in which field-collected data illustrate SPE factors calculated for older adults, obese pedestrians, and their combination. An application of SPE factors demonstrates the robustness of the methodology in bridging the gap between pedestrian compositions and planning practice

A fast and accurate energy source emulator for wireless sensor networks

The capability to either minimize energy consumption in battery-operated devices, or to adequately exploit energy harvesting from various ambient sources, is central to the development and engineering of energy-neutral wireless sensor networks. However, the design of effective networked embedded systems targeting unlimited lifetime poses several challenges at different architectural levels. In particular, the heterogeneity, the variability, and the unpredictability of many energy sources, combined to changes in energy required by powered devices, make it difficult to obtain reproducible testing conditions, thus prompting the need of novel solutions addressing these issues. This paper introduces a novel embedded hardware-software solution aimed at emulating a wide spectrum of energy sources usually exploited to power sensor networks motes. The proposed system consists of a modular architecture featuring small factor form, low power requirements, and limited cost. An extensive experimental characterization confirms the validity of the embedded emulator in terms of flexibility, accuracy, and latency while a case study about the emulation of a lithium battery shows that the hardware-software platform does not introduce any measurable reduction of the accuracy of the model. The presented solution represents therefore a convenient solution for testing large-scale testbeds under realistic energy supply scenarios for wireless sensor networks

Modified physical properties of Ni doped ZnO NPs as potential photocatalyst and antibacterial agents

Hazardous organic dyes, present in the effluents of industries, are continuously polluting the environment. Photodegradation of these dyes on catalyst surface under sunlight irradiation is economic, safe and suitable strategy to protect environment. Hence, the synthesis and applications of Zn1-xNixO (x = 0.00, 0.02, 0.04, 0.06) NPs are reported here. Effect of pH and dopant concentration was studied to modify the electrical, magnetic, antibacterial and photocatalytic properties of Ni doped ZnO NPs. The samples were characterized by Scanning electron microscopy (SEM), Powder X-ray diffraction (XRD), UV–Visible spectroscopy (UV–Vis.), Energy-dispersive X-ray spectroscopy (EDS) and Fourier-transform infrared spectroscopy (FTIR) to determine the morphology, crystallite structure, optical properties, elemental composition and functional group detection, respectively. LCR meter and VSM were used to evaluate the dielectric properties and magnetic properties of Ni doped ZnO NPs, respectively. XRD pattern confirmed the presence of hexagonal wurtzite geometry of ZnO NPs. The structural and morphological analysis showed the increase in crystallinity with little effect on shape of doped NPs by increasing the dopant concentration and slight increase of pH. It was observed that the Ni doped ZnO NPs possess good photocatalytic potential by 94% degradation of 20 ppm solution of methyl orange dye (MO) in just 80 min under sunlight. Moreover, the enhancement in antibacterial potential was also observed with increase in dopant concentration and decrease in crystallite size of doped ZnO NPs. Smaller size NPs were found more effective against gram negative bacterial strains. © 2023 The Author(s)King Saud University, KSUAuthors would like to extend their sincere appreciation to the Researchers Supporting Project number (RSP2023R123), King Saud University, Riyadh, Saudi Arabia

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interactions between epithelial and immune cells, as indicated by ligand–receptor expression profiles, and activated immune cells, including inflammatory macrophages expressing CCL2, CCL3, CCL20, CXCL1, CXCL3, CXCL10, IL8, IL1B and TNF. The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. Our data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19