Bose-Fermi mixtures in the molecular limit

We consider a Bose-Fermi mixture in the molecular limit of the attractive interaction between fermions and bosons. For a boson density smaller or equal to the fermion density, we show analytically how a T-matrix approach for the constituent bosons and fermions recovers the expected physical limit of a Fermi-Fermi mixture of molecules and atoms. In this limit, we derive simple expressions for the self-energies, the momentum distribution function, and the chemical potentials. By extending these equations to a trapped system, we determine how to tailor the experimental parameters of a Bose-Fermi mixture in order to enhance the 'indirect Pauli exclusion effect' on the boson momentum distribution function. For the homogeneous system, we present finally a Diffusion Monte Carlo simulation which confirms the occurrence of such a peculiar effect.Comment: 13 pages, 7 figures; final versio

Quantum Monte Carlo study of the indirect Pauli exclusion effect in Bose-Fermi mixtures

We study the momentum distributions of a three-dimensional resonant Bose-Fermi mixture in the molecular limit at zero temperature. For concentration of the bosons with respect to the fermions less or equal to one, each boson is bound to a fermion and the system is composed of fermionic molecules plus excess fermions. Not only the bosonic condensate fraction goes to zero, signaling a quantum phase transition towards a normal phase, but a finite region of low momenta is depleted, depending on the concentration. This phenomenon is named indirect Pauli exclusion effect and is demonstrated via Fixed-Node Diffusion Monte Carlo simulations and T-matrix calculations.Comment: 5 pages, 3 figures, published in EPJ ST volume entitled "Novel Quantum Phases and Mesoscopic Physics in Quantum Gases

Produção de clones de limeira ácida Tahiti (Citrus latifolia Tanaka) conduzidos com e sem irrigação

A base genética da produção nacional de lima ácida Tahiti é composta predominantemente pelos clones IAC-5 e Quebra-galho, como cultivares copa, e o limoeiro Cravo (Citrus limonia Osbeck), como porta-enxerto. Entretanto, existem novos materiais genéticos para a diversificação de copas e dados experimentais relatando o bom desempenho da limeira ácida Tahiti sobre outros porta-enxertos, notadamente o citrumeleiro Swingle [Citrus paradisi Macfad. cv. Duncan x Poncirus trifoliata (L.) Raf.], entretanto a baixa disponibilidade de informações sobre estes materiais genéticos impede a diversificação dos pomares tornando a cultura suscetível ao surgimento de novas pragas e doenças (STUCHI; CYRILLO, 1998; FIGUEIREDO et al., 2000; FIGUEIREDO et al., 2001; STUCHI et al., 2002; FIGUEIREDO et al., 2002). O presente trabalho teve por objetivo avaliar a produção de cinco clones da limeira ácida Tahiti sobre o citrumeleiro Swingle, conduzidas com e sem irrigação, em Bebedouro - SP.pdf 159

Shape-resonant superconductivity in nanofilms: from weak to strong coupling

Ultrathin superconductors of different materials are becoming a powerful platform to find mechanisms for enhancement of superconductivity, exploiting shape resonances in different superconducting properties. Here we evaluate the superconducting gap and its spatial profile, the multiple gap components, and the chemical potential, of generic superconducting nanofilms, considering the pairing attraction and its energy scale as tunable parameters, from weak to strong coupling, at fixed electron density. Superconducting properties are evaluated at mean field level as a function of the thickness of the nanofilm, in order to characterize the shape resonances in the superconducting gap. We find that the most pronounced shape resonances are generated for weakly coupled superconductors, while approaching the strong coupling regime the shape resonances are rounded by a mixing of the subbands due to the large energy gaps extending over large energy scales. Finally, we find that the spatial profile, transverse to the nanofilm, of the superconducting gap acquires a flat behavior in the shape resonance region, indicating that a robust and uniform multigap superconducting state can arise at resonance.Comment: 7 pages, 4 figures. Submitted to the Proceedings of the Superstripes 2016 conferenc

In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Here we report two antimicrobial peptides (AMPs), HG2 and HG4 identified from a rumen microbiome metagenomic dataset, with activity against multidrug-resistant (MDR) bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA) strains, a major hospital and community-acquired pathogen. We employed the classifier model design to analyse, visualise, and interpret AMP activities. This approach allowed in silico discrimination of promising lead AMP candidates for experimental evaluation. The lead AMPs, HG2 and HG4, are fast-acting and show anti-biofilm and anti-inflammatory activities in vitro and demonstrated little toxicity to human primary cell lines. The peptides were effective in vivo within a Galleria mellonella model of MRSA USA300 infection. In terms of mechanism of action, HG2 and HG4 appear to interact with the cytoplasmic membrane of target cells and may inhibit other cellular processes, whilst preferentially binding to bacterial lipids over human cell lipids. Therefore, these AMPs may offer additional therapeutic templates for MDR bacterial infections

In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Here we report two antimicrobial peptides (AMPs), HG2 and HG4 identified from a rumen microbiome metagenomic dataset, with activity against multidrug-resistant (MDR) bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA) strains, a major hospital and community-acquired pathogen. We employed the classifier model design to analyse, visualise, and interpret AMP activities. This approach allowed in silico discrimination of promising lead AMP candidates for experimental evaluation. The lead AMPs, HG2 and HG4, are fast-acting and show anti-biofilm and anti-inflammatory activities in vitro and demonstrated little toxicity to human primary cell lines. The peptides were effective in vivo within a Galleria mellonella model of MRSA USA300 infection. In terms of mechanism of action, HG2 and HG4 appear to interact with the cytoplasmic membrane of target cells and may inhibit other cellular processes, whilst preferentially binding to bacterial lipids over human cell lipids. Therefore, these AMPs may offer additional therapeutic templates for MDR bacterial infections

In silico identification of novel peptides with antibacterial activity against multidrug resistant Staphylococcus aureus

Herein we report the identification and characterisation of two linear antimicrobial peptides (AMPs), HG2 and HG4, with activity against a wide range of multidrug resistant (MDR) bacteria, especially methicillin resistant Staphylococcus aureus (MRSA) strains, a highly problematic group of Gram-positive bacteria in the hospital and community environment. To identify the novel AMPs presented here, we employed the classifier model design, a feature extraction method using molecular descriptors for amino acids for the analysis, visualization, and interpretation of AMP activities from a rumen metagenomic dataset. This allowed for the in silico discrimination of active and inactive peptides in order to define a small number of promising novel lead AMP test candidates for chemical synthesis and experimental evaluation. In vitro data suggest that the chosen AMPs are fast acting, show strong biofilm inhibition and dispersal activity and are efficacious in an in vivo model of MRSA USA300 infection, whilst showing little toxicity to human erythrocytes and human primary cell lines ex vivo. Observations from biophysical AMP-lipid-interactions and electron microscopy suggest that the newly identified peptides interact with the cell membrane and may be involved in the inhibition of other cellular processes. Amphiphilic conformations associated with membrane disruption are also observed in 3D molecular modelling of the peptides. HG2 and HG4 both preferentially bind to MRSA total lipids rather than with human cell lipids indicating that HG4 may form superior templates for safer therapeutic candidates for MDR bacterial infections