Tensor-Scalar Torsion

A theory of gravity with torsion is examined in which the torsion tensor is constructed from the exterior derivative of an antisymmetric rank two potential plus the dual of the gradient of a scalar field. Field equations for the theory are derived by demanding that the action be stationary under variations with respect to the metric, the antisymmetric potential, and the scalar field. A material action is introduced and the equations of motion are derived. The correct conservation law for rotational angular momentum plus spin is observed to hold in this theory.Comment: 10 pages, LaTeX, Mod. Phys. Lett. A accepte

Process intensification: Case study with a CHO-based monoclonal antibody production process

Standard platform technologies for cell culture processing provide simple and robust strategies to meet rapid timelines for early process development and ease of manufacturing. However, when there is a need to achieve high antibody titers due to high product demand, both culture media and feed strategies must be customized for specific cell lines. Two case studies will describe the strategies employed as part of a process intensification effort to overcome the limitations of a platform Phase III cell culture process. The first case study will demonstrate an intensified fed-batch process development effort performed to maximize production of a CHO-based monoclonal antibody, while maintaining product quality comparability with the original Phase III process. The second case study will describe the evaluation of a concentrated fed-batch process using alternating tangential flow filtration to retain the protein in the bioreactor, and achieve even higher titers in support of the high product demand forecast. These case studies will show that the intensified fed-batch process improved titers by 50%, and the concentrated fed-batch process improved titers by 100% relative to the fed-batch platform

Classical and quantum q-deformed physical systems

On the basis of the non-commutative q-calculus, we investigate a q-deformation of the classical Poisson bracket in order to formulate a generalized q-deformed dynamics in the classical regime. The obtained q-deformed Poisson bracket appears invariant under the action of the q-symplectic group of transformations. In this framework we introduce the q-deformed Hamilton's equations and we derive the evolution equation for some simple q-deformed mechanical systems governed by a scalar potential dependent only on the coordinate variable. It appears that the q-deformed Hamiltonian, which is the generator of the equation of motion, is generally not conserved in time but, in correspondence, a new constant of motion is generated. Finally, by following the standard canonical quantization rule, we compare the well known q-deformed Heisenberg algebra with the algebra generated by the q-deformed Poisson bracket.Comment: 9 pages, accepted for publication in "The European Physical Journal C

Inclusive Education Importance and Problems for Students Social Integration

The article relevance. Modern concepts of education development, recognition of the uniqueness and self-worth of human individuality have led to the search for ways to socialize individuals with disabilities, to the development of new pedagogical strategies aimed at developing ideas of independent life for this category of the population. The research purpose is to study the features and identify ways to improve the quality of inclusive education. Research methods: as a research method, we used a questionnaire survey as a method of collecting primary information, which allows us to identify various aspects related to the problems of formation and perception of inclusive education by participants in the educational process. Research results: the article describes the peculiarity of the current stage of inclusive education development, analyzes the social mechanisms for improving the quality of inclusive education. The novelty and originality of the research lies in the fact that for the first time the correspondence of the existing model of inclusive education to the needs of a significant part of the educational process subjects was investigated. It is shown that, from the point of view of educational services’ consumers, a significant obstacle to improving the quality of inclusive education is the orientation of the education system on results, and not the educational process. It is revealed that the main functions of an inclusive school are educational, career-oriented, educational, and integrative. It is shown that relationships with teachers are a significant factor of psychological stress in inclusive classes. It is found that inclusive classes are sufficiently distanced from interaction with the local community. It is shown that teachers lack the skills of teamwork and confident behavior of the teacher in the presence of another adult in the classroom. It is revealed that the inclusive school is currently characterized by a high level of internal unity, but is not focused on external relations with the local community.  It is shown that parents, unlike students, note the creation of an accessible environment only for certain categories of children with disabilities (including children with musculoskeletal disorders), but not for children with sensory disorders (vision and hearing). Practical significance: the data Obtained in this work can be used in psychological research, pedagogical Sciences, age psychology, as well as for further theoretical development of this issu

Minimal irreversible quantum mechanics. The decay of unstable states

Brownian motion is modelled by a harmonic oscillator (Brownian particle) interacting with a continuous set of uncoupled harmonic oscillators. The interaction is linear in the coordinates and the momenta. The model has an analytical solution that is used to study the time evolution of the reduced density operator. It is derived in a closed form, in the one-particle sector of the model. The irreversible behavior of the Brownian particle is described by a reduced density matrix.Comment: 39 pages, 2 figure

Measuring the Lyapunov exponent using quantum mechanics

We study the time evolution of two wave packets prepared at the same initial state, but evolving under slightly different Hamiltonians. For chaotic systems, we determine the circumstances that lead to an exponential decay with time of the wave packet overlap function. We show that for sufficiently weak perturbations, the exponential decay follows a Fermi golden rule, while by making the difference between the two Hamiltonians larger, the characteristic exponential decay time becomes the Lyapunov exponent of the classical system. We illustrate our theoretical findings by investigating numerically the overlap decay function of a two-dimensional dynamical system.Comment: 9 pages, 6 figure

Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response

© 2019 The Authors Objectives: PD-L1 expression on tumour cells can guide the use of anti-PD-1/PD-L1 immune modulators to treat patients with non-small cell lung cancer (NSCLC). Heterogeneity of PD-L1 expression both within and between tumour sites is a well-documented phenomenon that compromises its predictive power. Our aim was to better characterise the pattern and extent of PD-L1 heterogeneity with a view to optimising tumour sampling and improve its accuracy as a biomarker. Materials and methods: Expression of PD-L1 was assessed by immunochemistry using the SP263 clone in 107 resected primary NSCLCs and their nodal metastases. Intra-tumoural heterogeneity, defined as ‘small-scale’ (mm²), ‘medium-scale’ (cm²) and ‘large-scale’ (between tumour blocks), was assessed by digital imaging using a novel ‘squares method’. Inter-tumoural heterogeneity between the primary tumours and their nodal metastases and between N1 and N2 nodal stages was also assessed. Results: The majority of tumours demonstrated intra-tumoural heterogeneity (small-scale 78%, medium-scale 50%, large-scale 46%). Inter-tumoural heterogeneity between the primary and nodal metastases was present in 53% of cases and, in 17%, between N1 and N2 disease. These differences were occasionally sufficient to lead to discrepancy across the ≥1%, ≥25% and ≥50% cut-offs used to guide therapy. Conclusion: Heterogeneity of PD-L1 expression is common, variable in scale and extent, and carries significant implications for its accuracy as a predictive biomarker. Extensive sampling reduces, but cannot eliminate, this inaccuracy