Ecology of large felids and their prey in small reserves of the Yucatán Peninsula of Mexico

Jaguars and pumas are top-predator species in the Neotropics that are threatened by habitat destruction, illegal poaching of their body parts and their favored prey, and by the human-wildlife conflicts that arise when predators attack livestock. Much of the remaining felid habitat in the Americas is in protected nature reserves that are too small and isolated to support local populations. Surrounding forests therefore play a vital role in felid conservation. Successful long-term conservation of these two felids requires evidence-based knowledge of their biological and ecological requirements. We studied population distributions of jaguars and pumas and their prey in and between two small, private reserves of the Northern Yucatán Peninsula, Mexico, with areas of 25 and 43 km2. During 2 years of camera trapping (2015 and 2016), we detected 21 jaguars, from which we estimated an average space requirement of 28-45 km2/individual. Dietary niche overlap exceeded random expectation. The most frequently occurring prey items in jaguar and puma diets were collared peccary and deer. Jaguar also favored nine-banded armadillos and white-nosed coati, while puma favored canids. Both felids avoided ocellated turkey. Overall, diet of jaguars was less species-rich, but similar in niche breadth, to that of pumas. A fluid use of space by both species, in 2015 tending toward mutual attraction and in 2016 toward partial exclusion of pumas by jaguars, combined with the high dietary overlap, is consistent with a dominance hierarchy facilitating coexistence. Jaguars and pumas favor the same prey as the people in local communities who hunt, which likely will intensify human-wildlife impacts when prey become scarce. We conclude that even small reserves play an important role in increasing the continuity of habitat for prey and large felids, whose generalist habits suppress interspecific competition for increasingly limiting prey that are largely shared between them and humans.</p

Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas

State Council of Science and Technology of Jalisco, Mexico; University of Guadalajara [PS-2009-432

Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas

Estrogens are oncogenic hormones at a high level in breast, prostate, endometrial and lung cancer. Estrogens are synthesized by aromatase which has been used as a biomarker both in breast and lung cancer. Estrogen biological activities are executed by their classic receptors (ER? and ER?). ER? has been described as a cancer promoter and ER?, as a possible tumor suppressor. Both receptors are present at low levels in primary multiforme glioblastoma (GBM). The GBM frequency is 50 % higher in men than in women. The GBM patient survival period ranges from 7 to 18 months. The purpose of this pilot study was to evaluate aromatase and estrogen receptor expression, as well as 17Zapotitlán-estradiol concentration in astrocytoma patients biopsies to obtain a prognosis biomarker for these patients. We analyzed 36 biopsies of astrocytoma patients with a different grade (I-IV) of malignity. Aromatase and estrogen receptor mRNA expression were analyzed by semiquantitative RT-PCR, and the E2 levels, by ELISA. E2 concentration was higher in GBM, compared to grade II or III astrocytomas. The number of cells immunoreactive to aromatase and estrogen receptors decreased as the grade of tumor malignity increased. Aromatase mRNA expression was present in all biopsies, regardless of malignity grade or patient age or gender. The highest expression of aromatase mRNA in GBM patients was associated to the worst survival prognostic (6.28 months). In contrast lowest expression of ER? mRNA in astrocytoma patients had a worst prognosis. In conclusion, aromatase and ER? expression could be used as prognosis biomarkers for astrocytoma patients. Zapotitlán 2014 Springer Science+Business Media New York

MED-CORDEX initiative for Mediterranean Climate studies.

International audienceThe Mediterranean is expected to be one of the most prominent and vulnerable climate change “hot spots” of the 21st century, and the physical mechanisms underlying this finding are still not clear. Furthermore complex interactions and feedbacks involving ocean-atmosphere-land-biogeochemical processes play a prominent role in modulating the climate and environment of the Mediterranean region on a range of spatial and temporal scales. Therefore it is critical to provide robust climate change information for use in Vulnerability/Impact/Adaptation assessment studies considering the Mediterranean as a fully coupled environmental system. The Med-CORDEX initiative aims at coordinating the Mediterranean climate modeling community towards the development of fully coupled regional climate simulations, improving all relevant components of the system, from atmosphere and ocean dynamics to land surface, hydrology and biogeochemical processes. The primary goals of Med-CORDEX are to improve understanding of past climate variability and trends, and to provide more accurate and reliable future projections, assessing in a quantitative and robust way the added value of using high resolution and coupled regional climate models. The coordination activities and the scientific outcomes of Med-CORDEX can produce an important framework to foster the development of regional earth system models in several key regions worldwide