The Masers Towards IRAS 20126+4104

We present MERLIN observations of OH, water and methanol masers towards the young high mass stellar object IRAS 20126+4104. Emission from the 1665-MHz OH, 22-GHz H_2O and 6.7-GHz CH_3OH masers is detected and all originates very close to the central source. The OH and methanol masers appear to trace part of the circumstellar disk around the central source. The positions and velocities of the OH and methanol masers are consistent with Keplerian rotation around a central mass of ~ 5 Msun. The water masers are offset from the OH and methanol masers and have significantly changed since they were last observed, but still appear to be associated to the outflow from the source. All the OH masers components are circularly polarised, in some cases reaching 100 percent while some OH components also have linear polarisation. We identify one Zeeman pair of OH masers and the splitting of this pair indicates a magnetic field of strength ~ 11 mG within ~ 0.5" (850 AU) of the central source. The OH and methanol maser emission suggest that the disk material is dense, n > 10^6 cm^-3, and warm, T > 125 K and the high abundance of methanol required by the maser emission is consistent with the evaporation of the mantles on dust grains in the disk as a result of heating or shocking of the disk materialComment: 9 pages, 7 figures and 6 table

Kinerja UMKM Tenant Inkubator Bisnis Universitas Muria Kudus Berdasarkan Implementasi E-marketing

Dengan berkembangnya kemajuan teknologi dan informasi membawa paradigma tersendiri bagi konsep pemasaran. Kini pemasaran bersinergi dengan pemanfaatan teknologi dan informasi dalam konsep Pemasaran Elektronik (E-Marketing). E-Marketing ini dapat mempermudah akses antara para pelaku pemasaran, yakni Perusahaan, pemasar, pelanggan dan mitra bisnis yang lainnya. E-Marketing dapat difungsikan guna memperkenalkan produk yang tidak hanya pada lokal daerah tapi juga skala nasional bahkan Internasional. E-Marketing juga berperan sebagai pembentuk nilai keunggulan bersaing.Objek penelitian ini adalah 25 UMKM sebagai tenant inkubator bisnis Universitas Muria Kudus. Sebanyak 8 buah UMKM bergerak pada jenis industri makanan dan minuman, 8 buah konveksi pakaian, dan masing-masing 3 buah UMKM pada konveksi bordir, konveksi jilbab, dan konveksi tas.Penelitian ini akan menilai kinerja UMKM tenant inkubator Universitas Muria Kudus berdasarkan implementasi E-Marketing. Sehingga akan nampak berapa UMKM yang telah melaksanakan E-Marketing, bagaimana pemanfaatan dan penggunaan media sosial dan uji beda sebelum dan sesudah kegiatan E-Marketing didayagunakan

Kajian Potensi Investasi Taman Budaya Sosrokartono Kabupaten Kudus

Kajian Potensi Investasi Taman Budaya Sosrokartono pada hakekatnya bertujuan untuk mengembangkan potensi budaya Kabupaten Kudus yang terdiri dari : sistem bahasa, sistem pengetahuan, sistem teknologi, sistem ekonomi, sistem sosial, sistem religi, dan sistem kesenian. Ketujuh sistem tersebut saling berkaitan merupakan satu kesatuan yang semata-tidak dapat dipisahkan. Analisi yang diguanakan adalah analisis SWOT yang berkolaborasi dengan analisis Balanced Scorecard. Mengacu pada tujuh sistem budaya tersebut dapat di identifikasi faktor internal dan eksternal yang terdiri dari : kekuatan/potensi, kelemahan, peluang, ancaman, yang dikolaborasikan dengan perspektif finance, operasional, customer, dan learning proces. Proses berikutnya adalah menentukan posisi strategis dan perencanaan strategis Taman Budaya Sosrokartono. Kesimpulan hasil kajian ini adalah adanya potensi investasi yang terdiri dari tujuh sistem budaya dan dapat direkomendasikan pembangunan sarana dan prasarana sesuai Peruntukanny

Comparative Gene Expression Profiling of Benign and Malignant Lesions Reveals Candidate Therapeutic Compounds for Leiomyosarcoma

Leiomyosarcoma (LMS) is a malignant, soft-tissue tumor for which few effective therapies exist. Previously, we showed that there are three molecular subtypes of LMS. Here, we analyzed genes differentially expressed in each of the three LMS subtypes as compared to benign leiomyomas and then used the Connectivity Map (cmap) to calculate enrichment scores for the 1309 cmap drugs in order to identify candidate molecules with the potential to induce a benign, leiomyoma-like phenotype in LMS cells. 11 drugs were selected and tested for their ability to inhibit the growth of three human LMS cell lines. We identified two drugs with in vitro efficacy against LMS, one of which had a strongly negative enrichment score (Cantharidin) and the other of which had a strongly positive enrichment score (MG-132). Given MG-132's strong inhibitory effect on LMS cell viability, we hypothesized that LMS cells may be sensitive to treatment with other proteasome inhibitors and demonstrated that bortezomib, a clinically-approved proteasome inhibitor not included in the original cmap screen, potently inhibited the viability of the LMS cell lines. These findings suggest that systematically linking LMS subtype-specific expression signatures with drug-associated expression profiles represents a promising approach for the identification of new drugs for LMS

Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the muscle-enriched cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P<0.005). Expression of the five markers was associated with improved disease-specific survival in a multivariate Cox regression analysis (P<0.04). In this analysis that combined gene expression profiling, aCGH and IHC, we characterized distinct molecular LMS subtypes, provided insight into their pathogenesis, and identified prognostic biomarkers

A Survey of OH Masers Towards High Mass Protostellar Objects

We present a survey of OH maser emission towards a sample of high mass protostellar objects made using the Nancay and GBT telescopes.OH maser emission was detected towards 63 objects with 36 new detections. There are 56 star-forming regions and 7 OH/IR candidates. There is no evidence that sources with OH masers have a different range of luminosities from the non-maser sources. The results of this survey are compared with previous water and class II methanol maser observations of the same objects. Some of the detected sources are only associated with OH masers and some sources are only associated with the 1720 MHz OH maser line. The velocity range of the maser emission suggests that the water maser sources may be divided into two groups. The detection rates and velocity range of the OH and Class II methanol masers support the idea that there is a spatial association of the OH and Class II methanol masers. The sources span a wide range in R, the ratio of the methanol maser peak flux to OH 1665 MHz maser peak flux, however there are only a few sources with intermediate values of R, 8<R<32, which has characterised previous samples. Sources which have masers of any species, OH, water or methanol, have redder [100um-12um] IRAS colours than those without masers. However, there is no evidence for different maser species tracing different stages in the evolution of these young high mass sources. Previous observations which have shown that the OH maser emission from similar sources traces the circumstellar disks around the objects. This combined with the sensitivity of the OH emission to the magnetic field, make the newly detected sources interesting candidates for future follow-up at high angular resolution.Comment: Accepted for publication in A&

VLBI study of maser kinematics in high-mass SFRs. I. G16.59-0.05

The present paper focuses on the high-mass star-forming region G16.59-0.05. Methods: Using the VLBA and the EVN arrays, we conducted phase-referenced observations of the three most powerful maser species in G16.59-0.05: H2O at 22.2 GHz (4 epochs), CH3OH at 6.7 GHz (3 epochs), and OH at 1.665 GHz (1 epoch). In addition, we performed high-resolution (> 0".1), high-sensitivity (< 0.1 mJy) VLA observations of the radio continuum emission from the star-forming region at 1.3 and 3.6 cm. Results: This is the first work to report accurate measurements of the "relative" proper motions of the 6.7 GHz CH3OH masers. The different spatial and 3-D velocity distribution clearly indicate that the 22 GHz water and 6.7 GHz methanol masers are tracing different kinematic environments. The bipolar distribution of 6.7 GHz maser l.o.s. velocities and the regular pattern of observed proper motions suggest that these masers are tracing rotation around a central mass of about 35 solar masses. The flattened spatial distribution of the 6.7 GHz masers, oriented NW-SE, suggests that they can originate in a disk/toroid rotating around the massive YSO which drives the 12CO(2-1) outflow, oriented NE-SW, observed on arcsec scale. The extended, radio continuum source observed close to the 6.7 GHz masers could be excited by a wide-angle wind emitted from the YSO associated with the methanol masers, and such a wind is proven to be sufficiently energetic to drive the NE-SW 12CO(2-1) outflow. The H2O masers distribute across a region offset about 0".5 to the NW of the CH3OH masers, in the same area where emission of high-density molecular tracers, typical of HMCs, was detected. We postulate that a distinct YSO, possibly in an earlier evolutionary phase than that exciting the methanol masers, is responsible for the excitation of the water masers and the HMC molecular lines. (Abridged)Comment: 20 pages, 8 figures, 3 tables, accepted by Astronomy and Astrophysic

Discrete Source Survey of 6 GHz OH emission from PNe & pPNe and first 6 GHz images of K 3-35

The aim of this study is to investigate the physical properties of molecular envelopes of planetary nebulae in their earliest stages of evolution. Using the 100m telescope at Effelsberg, we have undertaken a high sensitivity discrete source survey for the first excited state of OH maser emission (J=5/2, 2PI3/2 at 6GHz) in the direction of planetary and proto-planetary nebulae exhibiting 18cm OH emission (main and/or satellite lines), and we further validate our detections using the Nan\c{c}ay radio telescope at 1.6-1.7GHz and MERLIN interferometer at 1.6-1.7 and 6GHz. Two sources have been detected at 6035MHz (5cm), both of them are young (or very young) planetary nebulae. The first one is a confirmation of the detection of a weak 6035MHz line in Vy 2-2. The second one is a new detection, in K 3-35, which was already known to be an exceptional late type star because it exhibits 1720MHz OH emission. The detection of 6035MHz OH maser emission is confirmed by subsequent observations made with the MERLIN interferometer. These lines are very rarely found in evolved stars. The 1612MHz masers surround but are offset from the 1720 and 6035MHz masers which in turn lie close to a compact 22GHz continuum source embedded in the optical nebula.Comment: 9 pages, 7 figures, published in A&

Intermittent maser flare around the high mass young stellar object G353.273+0.641 I: data & overview

We have performed VLBI and single-dish monitoring of 22 GHz H$_{2}$O maser emission from the high mass young stellar object G353.273+0.641 with VERA (VLBI Exploration of Radio Astrometry) and Tomakamai 11-m radio telescope. Two maser flares have been detected, separated almost two years. Frequent VLBI monitoring has revealed that these flare activities have been accompanied by structural change of the prominent shock front traced by H2O maser alignments. We have detected only blue-shifted emissions and all maser features have been distributed within very small area of 200 $\times$ 200 au$^{2}$ in spite of wide velocity range (> 100 km s$^{-1}$). The light curve shows notably intermittent variation and suggests that the H$_{2}$O masers in G353.273+0.641 are excited by episodic radio jet. The time-scale of \sim2 yr and characteristic velocity of \sim500 km s$^{-1}$ also support this interpretation. Two isolated velocity components of C50 (-53 \pm 7 km s$^{-1}$) and C70 (-73 \pm 7 km s$^{-1}$) have shown synchronised linear acceleration of the flux weighted V_{\rmn{LSR}} values (\sim-5 km s$^{-1}$ yr$^{-1}$) during the flare phase. This can be converted to the lower-limit momentum rate of 1.1 \times 10$^{-3}$ M_{\sun} km s$^{-1}$ yr$^{-1}$. Maser properties are quite similar to that of IRAS 20126+4104 especially. This corroborates the previous suggestion that G353.273+0.641 is a candidate of high mass protostellar object. The possible pole-on geometry of disc-jet system can be suitable for direct imaging of the accretion disc in this case.Comment: 13 pages, 5 figures accepted for publication in MNRA