Effect of ready-to-use-therapeutic food supplementation on the nutritional status, mortality and morbidity of children 6 to 60 months in Niger, a cluster randomized trial

Presented at the conference of the American Society of Tropical Medicine and Hygiene 200

Reducing wasting in young children with preventive supplementation: a cohort study in Niger

OBJECTIVE: To compare the incidence of wasting, stunting, and mortality among children aged 6 to 36 months who are receiving preventive supplementation with either ready-to-use supplementary foods (RUSFs) or ready-to-use therapeutic foods (RUTFs). SUBJECTS AND METHODS: Children aged 6 to 36 months in 12 villages of Maradi, Niger, (n = 1645) received a monthly distribution of RUSFs (247 kcal [3 spoons] per day) for 6 months or RUTFs (500-kcal sachet per day) for 4 months. We compared the incidence of wasting, stunting, and mortality among children who received preventive supplementation with RUSFs versus RUTFs. RESULTS: The effectiveness of RUSF supplementation depended on receipt of a previous preventive intervention. In villages in which a preventive supplementation program was previously implemented, the RUSF strategy was associated with a 46% (95% confidence interval [CI]: 6%-69%) and 59% (95% CI: 17%-80%) reduction in wasting and severe wasting, respectively. In contrast, in villages in which the previous intervention was not implemented, we found no difference in the incidence of wasting or severe wasting according to type of supplementation. Compared with the RUTF strategy, the RUSF strategy was associated with a 19% (95% CI: 0%-34%) reduction in stunting overall. CONCLUSION: We found that the relative performance of a 6-month RUSF supplementation strategy versus a 4-month RUTF strategy varied with receipt of a previous nutritional intervention. Contextual factors will continue to be important in determining the dose and duration of supplementation that will be most effective, acceptable, and sustainable for a given setting

Improving resilience to climate impacts in West Africa through improved availability, access and use of climate information: dialog with users

The stakeholder workshop on “Improving Resilience to Climate Impacts in West Africa Through Improved Availability, Access and Use of Climate Information: Dialogue With Users” was convened by the Centre Regional de Formation et d'Application en Agrométéorologie et Hydrologie Opérationnelle (AGRHYMET) in collaboration with the International Research Institute for Climate and Society (IRI) with funding and technical support from the United States Agency for International Development (USAID), the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS) and the United Nations Development Program (UNDP). Stakeholders from six Permanent Inter-state Committee for Drought Control in the Sahel (CILSS) countries were invited, in addition to representatives of five river basin organizations and the African Center of Meteorological Application for Development (ACMAD). The three-day meeting in Niamey, Niger (January 21-23, 2014) was attended by 40 participants and facilitators. It consisted of five components: • Introduction to AGRHYMET’s latest climate data, tools, and information products; • Training on the use of the tools for data analysis and visualization; • Engagement on the concept of climate risk management in the different sectors; • Soliciting feedback and needs from participants, to assess the value of the available tools and products to users, and inform improvements that are most relevant to stakeholders; and • Exploration of an Advisory Group for improving Climate Services provided by the AGRHYMET Center. The workshop introduced and solicited feedback on data, products and decision-support tools launched to support improved resilience to climate impacts, across sectors, initially targeting the agriculture, water and disaster risk management communities

The dynamics of measles in sub-Saharan Africa.

Although vaccination has almost eliminated measles in parts of the world, the disease remains a major killer in some high birth rate countries of the Sahel. On the basis of measles dynamics for industrialized countries, high birth rate regions should experience regular annual epidemics. Here, however, we show that measles epidemics in Niger are highly episodic, particularly in the capital Niamey. Models demonstrate that this variability arises from powerful seasonality in transmission-generating high amplitude epidemics-within the chaotic domain of deterministic dynamics. In practice, this leads to frequent stochastic fadeouts, interspersed with irregular, large epidemics. A metapopulation model illustrates how increased vaccine coverage, but still below the local elimination threshold, could lead to increasingly variable major outbreaks in highly seasonally forced contexts. Such erratic dynamics emphasize the importance both of control strategies that address build-up of susceptible individuals and efforts to mitigate the impact of large outbreaks when they occur

Field evaluation of two rapid diagnostic tests for Neisseria meningitidis serogroup A during the 2006 outbreak in Niger.

The Pastorex((R)) (BioRad) rapid agglutination test is one of the main rapid diagnostic tests (RDTs) for meningococcal disease currently in use in the "meningitis belt". Earlier evaluations, performed after heating and centrifugation of cerebrospinal fluid (CSF) samples, under good laboratory conditions, showed high sensitivity and specificity. However, during an epidemic, the test may be used without prior sample preparation. Recently a new, easy-to-use dipstick RDT for meningococcal disease detection on CSF was developed by the Centre de Recherche Médicale et Sanitaire in Niger and the Pasteur Institute in France. We estimate diagnostic accuracy in the field during the 2006 outbreak of Neisseria meningitidis serogroup A in Maradi, Niger, for the dipstick RDT and Pastorex((R)) on unprepared CSF, (a) by comparing each test's sensitivity and specificity with previously reported values; and (b) by comparing results for each test on paired samples, using McNemar's test. We also (c) estimate diagnostic accuracy of the dipstick RDT on diluted whole blood. We tested unprepared CSF and diluted whole blood from 126 patients with suspected meningococcal disease presenting at four health posts. (a) Pastorex((R)) sensitivity (69%; 95%CI 57-79) was significantly lower than found previously for prepared CSF samples [87% (81-91); or 88% (85-91)], as was specificity [81% (95%CI 68-91) vs 93% (90-95); or 93% (87-96)]. Sensitivity of the dipstick RDT [89% (95%CI 80-95)] was similar to previously reported values for ideal laboratory conditions [89% (84-93) and 94% (90-96)]. Specificity, at 62% (95%CI 48-75), was significantly lower than found previously [94% (92-96) and 97% (94-99)]. (b) McNemar's test for the dipstick RDT vs Pastorex((R)) was statistically significant (p<0.001). (c) The dipstick RDT did not perform satisfactorily on diluted whole blood (sensitivity 73%; specificity 57%).Sensitivity and specificity of Pastorex((R)) without prior CSF preparation were poorer than previously reported results from prepared samples; therefore we caution against using this test during an epidemic if sample preparation is not possible. For the dipstick RDT, sensitivity was similar to, while specificity was not as high as previously reported during a more stable context. Further studies are needed to evaluate its field performance, especially for different populations and other serogroups

Effectiveness of ready-to-use therapeutic food compared to a corn/soy-blend-based pre-mix for the treatment of childhood moderate acute malnutrition in Niger.

Standard nutritional treatment of moderate acute malnutrition (MAM) relies on fortified blended flours though their importance to treat this condition is a matter of discussion. With the newly introduced World Health Organization growth standards, more children at an early stage of malnutrition will be treated following the dietary protocols as for severe acute malnutrition, including ready-to-use therapeutic food (RUTF). We compared the effectiveness of RUTF and a corn/soy-blend (CSB)-based pre-mix for the treatment of MAM in the supplementary feeding programmes (SFPs) supported by Médecins Sans Frontières, located in the Zinder region (south of Niger). Children measuring 65 to <110 cm, newly admitted with MAM [weight-for-height (WHM%) between 70% and <80% of the NCHS median] were randomly allocated to receive either RUTF (Plumpy'Nut®, 1000 kcal day(-1)) or a CSB pre-mix (1231 kcal day(-1)). Other interventions were similar in both groups (e.g. weekly family ration and ration at discharge). Children were followed weekly up to recovery (WHM% ≥ 85% for 2 consecutive weeks). In total, 215 children were recruited in the RUTF group and 236 children in the CSB pre-mix group with an overall recovery rate of 79.1 and 64.4%, respectively (p < 0.001). There was no evidence for a difference between death, defaulter and non-responder rates. More transfers to the inpatient Therapeutic Feeding Centre (I-TFC) were observed in the CSB pre-mix group (19.1%) compared to the RUTF group (9.3%) (p = 0.003). The average weight gain up to discharge was 1.08 g kg(-1) day(-1) higher in the RUTF group [95% confidence interval: 0.46-1.70] and the length of stay was 2 weeks shorter in the RUTF group (p < 0.001). For the treatment of childhood MAM in Niger, RUTF resulted in a higher weight gain, a higher recovery rate, a shorter length of stay and a lower transfer rate to the I-TFC compared to a CSB pre-mix. This might have important implications on the efficacy and the quality of SFPs

Epidémies de Choléra en Afrique Sub-Saharienne: Revue documentaire de 2010 à 2016

Introduction: Cholera remains a major public health problem in many parts of the world and particularly in sub-Saharan African countries. The objective of this study is to review data on cholera epidemiology, risk, microbiological and disease control factors in sub-Saharan Africa from 2010 to 2016. Material and method: A literature review on cholera epidemics in sub-Saharan Africa from 2010 to 2016 was conducted using electronic databases from countries that have experienced epidemics. Annual cholera data for countries with outbreaks from 2010 to 2016 have been reported. Results: From 2010 through 2016, 35 of the 54 African countries have experienced cholera epidemics. An overall of 1268 outbreaks have been reported, of which 13.04% were recorded in Nigeria and 4.35% in Burundi. The number of cases reported was 801022 and 13232 deaths (overall CFR =1.65%). Vibrio cholerae O1 and O139 are the main etiological agents. The main risk factors are heavy rains, floods, contamination of water sources and lack ofsanitation. Conclusion: In addition to the suffering of patients, cholera outbreaks cause panic, disrupt economic and social structures and hinder the development of affected communities. Mobilization of the water, sanitation and hygiene sectors is essential to ensure the benefits of patient care and cholera vaccination.Introduction : Le choléra demeure un problème majeur de Santé Publique dans de nombreuses parties du monde et en particulier dans les pays d’Afrique subsaharienne. L’objectif de cette étude de faire une revue des donnéessur les épidémies de choléra, les facteurs de risques, microbiologiques et de lutte contre la maladie en Afrique sub-saharienne de 2010 à 2016. Materiels et méthode: Une revue de la littérature sur les épidémies de choléra en Afrique sub-saharienne de 2010 à 2016 a été conduite dans des banques de données ou bases de données et bibiothèques électroniques des pays ayant connu des épidémies. Les données annuelles de choléra dans les pays ayant connu des épidémies de 2010 à 2016 ont été rapportées. Résultats : Entre 2010 et 2016, 35 des 54 pays d'Afrique ont connu des épidémies de choléra. 1268 épisodes épidémiques ont été rapportés dont 13,04% au Nigeria et 4,35% au Burundi. Le nombre de cas notifiés était de 801022 dont 13232 décès (létalité globale =1,65%). Le Vibrio cholerae O1 et O139 sont les principaux agents étiologiques épidémiogènes. Les principaux facteurs de risques sont les pluies abondantes, les inondations, la contamination des sources d’eau et le manque d’assainissement. Conclusion : En dehors des souffrances éprouvées par les malades, les flambées de choléra provoquent la panique, désorganisent les structures économiques et sociales et freinent le développement des communautés touchées. Cependant, la mobilisation des secteurs de l’eau, de l’assainissement et de l’hygiène ainsi que le rensforcement des systemes de surveillance et riposte surtout au niveau transfrontalier sont des etapes essentielles pour la lutte contre les epidemies de cholera en Afrique subsaharienne

Unacceptably High Mortality Related to Measles Epidemics in Niger, Nigeria, and Chad

BACKGROUND: Despite the comprehensive World Health Organization (WHO)/United Nations Children's Fund (UNICEF) measles mortality–reduction strategy and the Measles Initiative, a partnership of international organizations supporting measles mortality reduction in Africa, certain high-burden countries continue to face recurrent epidemics. To our knowledge, few recent studies have documented measles mortality in sub-Saharan Africa. The objective of our study was to investigate measles mortality in three recent epidemics in Niamey (Niger), N'Djamena (Chad), and Adamawa State (Nigeria). METHODS AND FINDINGS: We conducted three exhaustive household retrospective mortality surveys in one neighbourhood of each of the three affected areas: Boukoki, Niamey, Niger (April 2004, n = 26,795); Moursal, N'Djamena, Chad (June 2005, n = 21,812); and Dong District, Adamawa State, Nigeria (April 2005, n = 16,249), where n is the total surveyed population in each of the respective areas. Study populations included all persons resident for at least 2 wk prior to the study, a duration encompassing the measles incubation period. Heads of households provided information on measles cases, clinical outcomes up to 30 d after rash onset, and health-seeking behaviour during the epidemic. Measles cases and deaths were ascertained using standard WHO surveillance-case definitions. Our main outcome measures were measles attack rates (ARs) and case fatality ratios (CFRs) by age group, and descriptions of measles complications and health-seeking behaviour. Measles ARs were the highest in children under 5 y old (under 5 y): 17.1% in Boukoki, 17.2% in Moursal, and 24.3% in Dong District. CFRs in under 5-y-olds were 4.6%, 4.0%, and 10.8% in Boukoki, Moursal, and Dong District, respectively. In all sites, more than half of measles cases in children aged under 5 y experienced acute respiratory infection and/or diarrhoea in the 30 d following rash onset. Of measles cases, it was reported that 85.7% (979/1,142) of patients visited a health-care facility within 30 d after rash onset in Boukoki, 73.5% (519/706) in Moursal, and 52.8% (603/1,142) in Dong District. CONCLUSIONS: Children in these countries still face unacceptably high mortality from a completely preventable disease. While the successes of measles mortality–reduction strategies and progress observed in measles control in other countries of the region are laudable and evident, they should not overshadow the need for intensive efforts in countries that have just begun implementation of the WHO/UNICEF comprehensive strategy