Prediction of virus-host protein-protein interactions mediated by short linear motifs

Table S4. Supplement information describing the previous files. (Supplement - Prediction of Virus-Host Protein-Protein interactions based on Short Linear Motifs.pdf) available at https://figshare.com/articles/Supplement_-_Prediction_of_Virus-Host_Protein-Protein_interactions_based_on_Short_Linear_Motifs/4667461 . (PDF 166 kb

Análisis del consumo de cerveza en el área metropolitana de Monterrey: Un modelo de respuesta censurada

This study analyses the effect of household income and socioeconomic composition on household expenditure on beer. Tobit models are used in order to capture the response on the magnitude of beer purchases as well as the behavior of non-purchasing households. The results indicate, without regard to income segment, that household income and education of the household manager determine beer consumption and have a greater effect on potential consumers.

Mean reversion in monetary aggregates in Chile.

In this paper we examine the statistical properties of the monetary aggregates in Chile in order to know if the time series display mean reverting behavior. For this purpose, we use techniques based on fractional integration. Monthly data of various Chilean monetary aggregates from January 1986 until August 2019 are used, and the results indicate very weak evidence of mean reversion. In fact, this property is only found in the case of the currency on circulation and M1 for some of the series examined; however, for M2 and M3 the results clearly show high persistence with orders of integration substantially higher than 1. Thus, shocks are expected to have a permanent nature in these cases. Another remarkable feature observed in the results is that the level of persistence in the series seems to grow with the amount of the monetary aggregate. In a multivariate context, performing a FCVAR model, evidence of cointegration is found among the monetary aggregates, finding a long run equilibrium relationship between them.pre-print395 K

Catalyst- and solvent-free synthesis of 2-fluoro-N- (3-methylsulfanyl-1H-1,2,4-triazol-5-yl)benzamide through a microwave-assisted Fries rearrangement : X-ray structural and theoretical studies

An efficient approach for the regioselective synthesis of (5-amino-3-methylsulfanyl- 1H-1,2,4-triazol-1-yl)(2-fluorophenyl)methanone, C10H9FN4OS, (3), from the N-acylation of 3-amino-5-methylsulfanyl-1H-1,2,4-triazole, (1), with 2-fluorobenzoyl chloride has been developed. Heterocyclic amide (3) was used successfully as a strategic intermediate for the preparation of 2-fluoro-N-(3- methylsulfanyl-1H-1,2,4-triazol-5-yl)benzamide, C10H9FN4OS, (4), through a microwave-assisted Fries rearrangement under catalyst- and solvent-free conditions. Theoretical studies of the prototropy process of (1) and the Fries rearrangement of (3) to provide (4), involving the formation of an intimate ion pair as the key step, were carried out by density functional theory (DFT) calculations. The crystallographic analysis of the intermolecular interactions and the energy frameworks based on the effects of the different molecular conformations of (3) and (4) are described

Estimation parameters and black box model of a brushless DC motor

El modelamiento de un proceso o una planta es de vital importancia para el diseño de su sistema de control, ya que permite predecir su dinámica y comportamiento ante diferentes circunstancias, entradas, perturbaciones y ruido. El objetivo principal de este trabajo es identificar qué modelo es mejor entre el matemático y el de caja negra para un motor específico de corriente continua sin escobillas de imanes permanentes. Para ello se presenta el modelo matemático de un motor de corriente continua sin escobillas PW16D del fabricante Golden Motor y se compara con su modelo de caja negra, ambos se obtienen a partir de datos experimentales. Dichos datos, el voltaje promedio aplicado y la velocidad angular, se adquieren mediante una tarjeta de adquisición y se importan al ordenador. Las constantes del modelo matemático se estiman mediante un ajuste de curvas basado en algoritmos de mínimos cuadrados no lineales y patrón de búsqueda mediante herramienta computacional. Para la estimación de constantes del modelo matemático mediante mínimos cuadrados no lineales y patrón de búsqueda se obtuvo una bondad de ajuste de 84,88% y 80,48% respectivamente. La bondad de ajuste obtenida por el modelo de caja negra fue de 87,72%. El modelo matemático presentó ligeramente menor bondad de ajuste, pero permite analizar el comportamiento de variables de interés como el consumo de corriente y el torque aplicado al motor. Debido a esto, se concluye que el modelo matemático obtenido mediante datos experimentales del motor sin escobillas PW16D es mejor que su modelo de caja negra.The modeling of a process or a plant is vital for the design of its control system, since it allows predicting its dynamic and behavior under different circumstances, inputs, disturbances and noise. The main objective of this work is to identify which model is best for a permanent magnet brushless DC specific motor. For this, the mathematical model of a DC motor brushless PW16D, manufactured by Golden Motor, is presented and compared with its black box model; both are derived from experimental data. These data, the average applied voltage and the angular velocity, are acquired by a data acquisition card and imported to the computer. The constants of the mathematical model are estimated by a curve fitting algorithm based on non-linear least squares and pattern search using computational tool. To estimate the mathematical model constants by non-linear least square and search pattern, a goodness of fit of 84.88% and 80.48% respectively was obtained. The goodness of fit obtained by the black box model was 87.72%. The mathematical model presented slightly lower goodness of fit, but allowed to analyze the behavior of variables of interest such as the power consumption and the torque applied to the motor. Because of this, it is concluded that the mathematical model obtained by experimental data of the brushless motor PW16D, is better than its black box model.

Removal of nutrients and pesticides from agricultural runoff using microalgae and cyanobacteria

The use of pesticides in agriculture has ensured the production of different crops. However, pesticides have become an emerging public health problem for Latin American countries due to their excessive use, inadequate application, toxic characteristics, and minimal residue control. The current project evaluates the ability of two strains of algae (Chlorella and Scenedesmus sp.) and one cyanobacteria (Hapalosyphon sp.) to remove excess pesticides and other nutrients present in runoff water from rice production. Different concentrations of wastewater and carbon sources (Na2CO3 and NaHCO3 ) were evaluated. According to the results, all three strains can be grown in wastewater without dilution (100%), with a biomass concentration comparable to a synthetic medium. All three strains significantly reduced the concentration of NO3 and PO4 (95 and 85%, respectively), with no difference between Na2CO3 or NaHCO3 . Finally, Chlorella sp. obtained the highest removal efficiency of the pesticide (Chlorpyrifos), followed by Scenedesmus and Hapalosyphon sp. (100, 75, and 50%, respectively). This work shows that it is possible to use this type of waste as an alternative source of nutrients to obtain biomass and metabolites of interest, such as lipids and carbohydrates, to produce biofuels

Abrazando mi historia de vida: la experiencia de vivir con cáncer siendo adolescente.

Objective.   To   explore   the   life   history   of   an   adolescent   who   experiences   cancer.   Materials and methods. This is a qualitative study based on single-case life history. In-depth interview was used, and the results were analyzed using a reduced version of Amedeo Giorgi’s method.  Results.  Two   central themes emerged from the data:  Diagnosis implications for the personal, social and, family life of a teenager suffering from cancer and family support as crucial in coping with the disease.  The support of the family was essential in overcoming cancer in an adolescent. Solid social support to the patient favored the processes of living, adapting, coping with and, overcoming cancer. Conclusions. The study allowed the researchers to understand an adolescent’s experience of living with osteosarcoma, revealing a particular world that has not been explored in depth.  Sometimes childhood cancer is considered a devastating disease, which has severe implications for the patient and his family forcing them to reorganize their family and social dynamics to adapt and fight against that disease.Objetivo. Explorar la experiencia de vida de un adolescente con cáncer. Materiales y métodos. Estudio cualitativo, con caso único, basado en historia de vida; la técnica utilizada fue la entrevista a profundidad y los resultados se examinaron con base en una versión simplificada de la propuesta de Amedeo Giorgi. Resultados. emergieron dos temas centrales: Diagnóstico: implicaciones para la vida personal, social y familiar de un adolescente con cáncer y el apoyo familiar como soporte indispensable para afrontar la enfermedad. Conclusiones. El estudio permitió comprender el significado que otorga un adolescente a la experiencia de vivir con osteosarcoma, revelando un mundo distinto y poco explorado. El apoyo de la familia, fue indispensable para la superación del cáncer en el adolescente, podría decirse, que un soporte social sólido en el paciente, favorece los procesos de afrontamiento y adaptación en la experiencia de vivir y sobreponerse a esta condición. En ocasiones el cáncer infantil se visualiza como una enfermedad devastadora, que tiene serias implicaciones para el paciente y su familia, obligándolos a reorganizar su dinámica familiar y social, para adaptarse y luchar contra la enfermedad.&nbsp

The Sensitivity of HAWC to High-Mass Dark Matter Annihilations

The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC will observe gamma rays and cosmic rays with an array of water Cherenkov detectors. The full HAWC array is scheduled to be operational in Spring 2015. In this paper, we study the HAWC sensitivity to the gamma-ray signatures of high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be sensitive to diverse searches for dark matter annihilation, including annihilation from extended dark matter sources, the diffuse gamma-ray emission from dark matter annihilation, and gamma-ray emission from non-luminous dark matter subhalos. Here we consider the HAWC sensitivity to a subset of these sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the Galactic center. We simulate the HAWC response to gamma rays from these sources in several well-motivated dark matter annihilation channels. If no gamma-ray excess is observed, we show the limits HAWC can place on the dark matter cross-section from these sources. In particular, in the case of dark matter annihilation into gauge bosons, HAWC will be able to detect a narrow range of dark matter masses to cross-sections below thermal. HAWC should also be sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The constraints placed by HAWC on the dark matter cross-section from known sources should be competitive with current limits in the mass range where HAWC has similar sensitivity. HAWC can additionally explore higher dark matter masses than are currently constrained.Comment: 15 pages, 4 figures, version to be published in PR

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro