Effective Universal Unrestricted Adversarial Attacks using a MOE Approach

Recent studies have shown that Deep Leaning models are susceptible to adversarial examples, which are data, in general images, intentionally modified to fool a machine learning classifier. In this paper, we present a multi-objective nested evolutionary algorithm to generate universal unrestricted adversarial examples in a black-box scenario. The unrestricted attacks are performed through the application of well-known image filters that are available in several image processing libraries, modern cameras, and mobile applications. The multi-objective optimization takes into account not only the attack success rate but also the detection rate. Experimental results showed that this approach is able to create a sequence of filters capable of generating very effective and undetectable attacks

17-jähriger Mann mit akuten Bauchschmerzen, Hämatochezie und Exanthem

Zusammenfassung: Ein 17-jähriger Patient stellte sich mit kolikartigen abdominellen Schmerzen und Diarrhö vor. Als weitere Symptome traten Petechien, Arthralgien und eine Hämatochezie auf. Sonographisch bestand eine auffällige Ileozökalregion. Endoskopisch fand sich eine Ileitis terminalis, und histologisch zeigte sich hier eine leukozytoklastische Vaskulitis mit IgA-Ablagerungen. Die Kasuistik zeigt exemplarisch die mehrzeitige klinische Manifestation der Purpura Schönlein-Henoch und deren Verlau

Patterns of the parasite communities in a fish assemblage of a river in the Brazilian Amazon region.

This paper characterizes the pattern of ectoparasite and endoparasite communities in an assemblage of 35 sympatric fish from different trophic levels in a tributary from the Amazon River system, northern Brazil. In detritivorous, carnivorous, omnivorous and piscivorous hosts, the species richness consisted of 82 ectoparasites and endoparasites, but protozoan ectoparasites such as Ichthyophthirius multifiliis, Piscinoodinium pillulare and Tripartiella sp. were dominant species predominated, such that they were present in 80% of the hosts. The taxon richness was in the following order: Monogenea > Nematoda > Digenea > Crustacea > Protozoa > Acanthocephala = Cestoda > Hirudinea. Among the hosts, the highest number of parasitic associations occurred in Satanoperca jurupari, Aequidens tetramerus, Hoplerythrinus unitaeniatus, Hoplosternum littorale, Cichlasoma amazonarum, Chaetobranchus flavescens, Squaliforma emarginata, Chaetobranchopsis orbicularis and Hoplias malabaricus. A weak positive correlation between ectoparasite abundance and length of the hosts was observed. Ectoparasite communities of detritivorous, carnivorous and omnivorous hosts were similar, but these differed from the communities of piscivorous hosts. Larval endoparasite species with low host specificity were the main determinants of the parasite infracommunity structure of the fish assemblage. Fish assemblage had few species of helminth that were specialist endoparasites, while many were parasites at the larval stage, infecting intermediate and paratenic hosts. Finally, carnivorous and omnivorous hosts harbored endoparasite communities that were more heterogeneous than those of detritivorous and piscivorous hosts. This result lends supports to the notion that the feeding habits of the host species are a significant factor in determining the endoparasites fauna

Fast-track referral for health interventions during pregnancy: study protocol of a randomised pragmatic experimental study to reduce low birth weight in Portugal (STOP LBW)

Introduction Low birth weight (LBW) is associated with a wide range of short-term and long-term consequences and is related to maternal psychosocial and behavioural determinants. The objective of this study is to estimate the effect of implementing fast-track referral for early intervention on psychosocial and behavioural risk factors—smoking, alcohol consumption, depression and physical violence—in reducing the incidence of LBW. Methods and analysis Parallel superiority pragmatic clinical trial randomised by clusters. Primary healthcare units (PHCU) located in Portugal will be randomised (1:1) to intervention or control groups. Pregnant women over 18 years of age attending these PHCU will be eligible to the study. Risk factors will be assessed through face-to-face interviews. In the intervention group, women who report at least one risk factor will have immediate access to referral services. The comparison group will be the local standard of care for these risk factors. We will use intention-to-treat analyses to compare intervention and control groups. We estimated a sample size of 2832 pregnant women to detect a 30% reduction in the incidence rate of LBW between the control and intervention groups. Secondary outcomes are the reduction of preterm births, reduction of the four risk factors and acceptance of the intervention. Ethics and dissemination The study was approved by the Ethics Committee of the Public Health Institute of the University of Porto (no CE20140). The findings will be disseminated to the public, the funders, health professionals, health managers and other researchers.This project was funded by the Calouste Gulbenkian Foundation under the Knowledge Challenge 'The Importance of the Right Weight at Birth'. Sponsor contact information: HB. ISPUP. [email protected]

Changes in muscular activity in different stable and unstable conditions on aquatic platforms

The present study aimed to analyse and compare the muscle activity of twelve participants (seven men and five women) (age 20.1 ± 0.9 years; height 170.5 ± 10 cm; body mass: 64.86 ± 8.3 kg) in two exercises, each with two variants: squat (dynamic and static) and plank (hands and elbows) in a stable environment on land and an unstable environment on an aquatic platform. The erector spinae, biceps femoris, rectus femoris, external oblique, and rectus abdominis muscles were evaluated using surface electromyography. The dynamic squat increases the recruitment of the biceps femoris and external oblique, while the static squat demands greater activation of the rectus femoris. The elbow plank exercise increases the recruitment of erector spinae muscles, and the hand plank exercise increases the recruitment of the erector spinae and external oblique. In conclusion, performing exercises in unstable conditions on an aquatic platform slightly increases muscle recruitment.info:eu-repo/semantics/publishedVersio

Shake-induced order in nanosphere systems

Self-assembled patterns obtained from a drying nanosphere suspension are investigated by computer simulations and simple experiments. Motivated by the earlier experimental results of Sasaki and Hane and Schope, we confirm that more ordered triangular lattice structures can be obtained whenever a moderate intensity random shaking is applied on the drying system. Computer simulations are realized on an improved version of a recently elaborated Burridge-Knopoff-type model. Experiments are made following the setup of Sasaki and Hane, using ultrasonic radiation as source for controlled shaking.Comment: 7 pages, 10 figure

Sobrevivência e crescimento inicial de espécies arbóreas em Integração Lavoura-Pecuária-Floresta no Amapá.

O sistema integração lavoura-pecuária-floresta (iLPF) está entre as estratégias do Plano ABC, visando aumentar a sustentabilidade das atividades agropecuárias. Esse estudo objetivou avaliar a sobrevivência e o crescimento inicial de espécies arbóreas em consórcio com espécies agrícolas em experimento conduzido no Campo Experimental do Cerrado da Embrapa Amapá, em Macapá, AP. Foram feitos seis tratamentos compostos de uma espécie arbórea nas linhas combinado com milho (Zea mays L.) ou sorgo (Sorghum bicolor) nas entrelinhas. A Gliricídia (Gliricidia sepium) e o Tachi-branco (Sclerolobium paniculatum) foram plantados em linhas simples, com um espaçamento de 2 m, com 12 m nas entrelinhas, e o Eucalipto (Eucalyptus urograndis) foi plantado em linhas duplas, com espaçamento de 2 m intercalado entre as linhas, com 10 m nas entrelinhas. Avaliou-se a sobrevivência e crescimento das arbóreas aos 30 dias, nove e 12 meses após o plantio. Observou-se a altura total, diâmetro à altura do colo (DAC) das plantas com altura igual ou inferior a 1,30 m e diâmetro à altura do peito (DAP) em plantas com altura superior a 1,30 m. As taxas de sobrevivência para as três espécies testadas foram: 88,1% para Tachi-branco, 99,8% para Gliricídia e 99,7% para Eucalipto. A altura média das árvores aos 12 meses foi 4,04 m, variando de 1,50 m a 5,74 m, sendo Tachi-branco o que apresentou o menor crescimento (1,50 m). O Eucalipto apresentou o maior desenvolvimento, com alturas médias de 3,03 m (9 meses) e 5,74 m (12 meses). Até nove meses a Gliricídia teve o maior aumento de diâmetro (2,35 cm ± 1,25 cm), sendo ultrapassada por eucalipto aos 12 meses (5,25 cm ± 1,04 cm). Apesar de ter o menor crescimento, o Tachi-branco é uma espécie nativa interessante para consórcios que não exijam rápido crescimento. O Eucalipto é uma espécie interessante devido seu rápido crescimento, pequeno diâmetro de copa e alta produtividade, no entanto o espaçamento utilizado pode restringir a agricultura rapidamente. A Gliricídia, devido sua alta capacidade de regeneração que permite poda periódica, adapta-se muito bem em consorciação com agricultura

Neoadjuvant Chemotherapy for Intrahepatic, Perihilar, and Distal Cholangiocarcinoma:a National Population-Based Comparative Cohort Study

IntroductionData supporting the utilization of neoadjuvant chemotherapy (NAC) in patients receiving resection for cholangiocarcinoma (CCA) remains uncertain. We aimed to determine whether NAC followed by resection improves long-term survival in intrahepatic (iCCA), perihilar (hCCA), and distal (dCCA) cholangiocarcinoma, analyzed separately.MethodsPatients undergoing surgery for iCCA, hCCA, and dCCA, receiving either none, NAC, or adjuvant chemotherapy (AC) from 2010 to 2016 were identified from the National Cancer Database (NCDB). Cox regression was performed to account for selection bias and to assess the impact of surgery alone (SA) versus either NAC or AC on overall survival (OS).ResultsThere were 9411 patients undergoing surgery for iCCA (n = 3772, 39.5%), hCCA (n = 1879, 20%), and dCCA (n = 3760, 40%). Of these, 10.6% (n = 399), 6.5% (n = 123), and 7.2% (n = 271) with iCCA, hCCA, and dCCA received NAC, respectively. On adjusted analyses, patients receiving NAC followed by surgery had significantly improved OS, compared to SA for iCCA (HR 0.75, CI95% 0.64-0.88, p < 0.001), hCCA (HR 0.72, CI95% 0.54-0.97, p = 0.033), and for dCCA (HR 0.65, CI95% 0.53-0.78, p < 0.001). However, sensitivity analyses demonstrated no differences in OS between NACs, followed by surgery or AC after surgery in iCCA (HR 1.19, CI95% 0.99-1.45, p = 0.068), hCCA (HR 0.83 CI95% 0.59-1.19, p = 0.311), and dCCA (HR 1.13 CI95% 0.91-1.41, p = 0.264).ConclusionsThis study associated NAC with increased OS for all CCA subtypes, even in patients with margin-negative and node-negative disease; however, no differences were found between NAC and AC. Our results highlight that a careful and interdisciplinary evaluation should be sought to consider NAC in CCA and warrant the need of larger studies to provide robust recommendation

Genetic diversity in Brazilian populations of Anastrepha obliqua (Macquart) based on mtDNA.

Anastrepha obliqua (Macquart), the West Indian fruit fly, is the second most polyphagous species within the genus in Brazil and therefore one of the most economically important pest species. It infests an extensive range of hosts, at least 60 species. Anastrepha obliqua ranges from northern Mexico to southern Brazil also including the Caribbean Islands. Methods: We sequenced a fragment of the mitochondrial gene COI to estimate population structure and genetic diversity of A. obliqua geographic collections in Brazil. Results: A total of 153 specimens from the Amazon Forest, Atlantic Rainforest, Cerrado, and Caatinga were analyzed. A total of 20 haplotypes were found. The highest diversity levels were observed in collections from the Amazon Forest. AMOVA and Fst tests showed evidence of genetic structure allowing us to delineate two groups of A. obliqua populations. The Mantel tests were not significant indicating a weak correlation between genetic and geographic distances. Mismatch distributions and Neutrality Tests suggest that the Caatinga, Cerrado and Atlantic Forest populations have experienced a recent population expansion. Conclusion: Populations in the Amazon Forest showed high genetic diversity when compared to the other biomes and the demographic parameters indicated a recent expansion of A. obliqua in Brazil

Parasitos em assembleia de peixes de diferentes níveis tróficos na bacia igarapé Fortaleza, estado do Amapá, Brasil.

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