489 research outputs found
Development of advanced fabrication techniques for regeneratively cooled thrust chambers by the gas-pressure-bonding process Final report, 29 Jun. 1967 - 30 Apr. 1970
Production of regeneratively cooled rocket thrust chambers by removable tooling and subsequent hot isostatic pressing in gas autoclav
Microdevices and methods of manufacture
Illustrative embodiments of microdevices and methods of manufacturing such microdevices are disclosed. In at least one illustrative embodiment, one or more microdevices may be formed on a substrate, with each of the one or more microdevices comprising a body micromachined from a continuous film formed on the substrate, the continuous film having a controlled microstructure of cellulose nanocrystals (CNC)
Microdevices and Methods of Manufacture
Illustrative embodiments of microdevices and methods of manufacturing such microdevices are disclosed. In at least one illustrative embodiment, a method of manufacturing one or more microdevices may include forming a liquid dispersion containing cellulose nanocrystals (CNC), depositing the liquid dispersion containing the CNC on a substrate, drying the liquid dispersion containing the CNC to form a solid film on the substrate, where the liquid dispersion contains a sufficient concentration of CNC to form a continuous solid film having a controlled microstructure, and processing the solid film to form the one or more microdevices on the substrate
Vortex Reconnection as the Dissipative Scattering of Dipoles
We propose a phenomenological model of vortex tube reconnection at high
Reynolds numbers. The basic picture is that squeezed vortex lines, formed by
stretching in the region of closest approach between filaments, interact like
dipoles (monopole-antimonopole pairs) of a confining electrostatic theory. The
probability of dipole creation is found from a canonical ensemble spanned by
foldings of the vortex tubes, with temperature parameter estimated from the
typical energy variation taking place in the reconnection process. Vortex line
reshuffling by viscous diffusion is described in terms of directional
transitions of the dipoles. The model is used to fit with reasonable accuracy
experimental data established long ago on the symmetric collision of vortex
rings. We also study along similar lines the asymmetric case, related to the
reconnection of non-parallel vortex tubes.Comment: 8 pages, 3 postscript figure
Predicting the safety and efficacy of butter therapy to raise tumour pHe: an integrative modelling study
Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.\ud
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Methods: We apply and extend a previously developed mathematical model of blood and tumour buffering to examine the impact of oral administration of bicarbonate buffer in mice, and the potential impact in humans. We recapitulate the experimentally observed tumour pHe effect of buffer therapy, testing a model prediction in vivo in mice. We parameterise the model to humans to determine the translational safety and efficacy, and predict patient subgroups who could have enhanced treatment response, and the most promising combination or alternative buffer therapies.\ud
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Results: The model predicts a previously unseen potentially dangerous elevation in blood pHe resulting from bicarbonate therapy in mice, which is confirmed by our in vivo experiments. Simulations predict limited efficacy of bicarbonate, especially in humans with more aggressive cancers. We predict buffer therapy would be most effectual: in elderly patients or individuals with renal impairments; in combination with proton production inhibitors (such as dichloroacetate), renal glomular filtration rate inhibitors (such as non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors), or with an alternative buffer reagent possessing an optimal pK of 7.1–7.2.\ud
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Conclusion: Our mathematical model confirms bicarbonate acts as an effective agent to raise tumour pHe, but potentially induces metabolic alkalosis at the high doses necessary for tumour pHe normalisation. We predict use in elderly patients or in combination with proton production inhibitors or buffers with a pK of 7.1–7.2 is most promising
Flame front propagation IV: Random Noise and Pole-Dynamics in Unstable Front Propagation II
The current paper is a corrected version of our previous paper
arXiv:adap-org/9608001. Similarly to previous version we investigate the
problem of flame propagation. This problem is studied as an example of unstable
fronts that wrinkle on many scales. The analytic tool of pole expansion in the
complex plane is employed to address the interaction of the unstable growth
process with random initial conditions and perturbations. We argue that the
effect of random noise is immense and that it can never be neglected in
sufficiently large systems. We present simulations that lead to scaling laws
for the velocity and acceleration of the front as a function of the system size
and the level of noise, and analytic arguments that explain these results in
terms of the noisy pole dynamics.This version corrects some very critical
errors made in arXiv:adap-org/9608001 and makes more detailed description of
excess number of poles in system, number of poles that appear in the system in
unit of time, life time of pole. It allows us to understand more correctly
dependence of the system parameters on noise than in arXiv:adap-org/9608001Comment: 23 pages, 4 figures,revised, version accepted for publication in
journal "Combustion, Explosion and Shock Waves". arXiv admin note:
substantial text overlap with arXiv:nlin/0302021, arXiv:adap-org/9608001,
arXiv:nlin/030201
Non-linear model equation for three-dimensional Bunsen flames
The non linear description of laminar premixed flames has been very successful, because of the existence of model equations describing the dynamics of these flames. The Michelson Sivashinsky equation is the most well known of these equations, and has been used in different geometries, including three-dimensional quasi-planar and spherical flames. Another interesting model, usually known as the Frankel equation,which could in principle take into account large deviations of the flame front, has been used for the moment only for two-dimensional expanding and Bunsen flames. We report here for the first time numerical solutions of this equation for three-dimensional flames
Diffusion in Stationary Flow from Mesoscopic Non-equilibrium Thermodynamics
We analyze the diffusion of a Brownian particle in a fluid under stationary
flow. By using the scheme of non-equilibrium thermodynamics in phase space, we
obtain the Fokker-Planck equation which is compared with others derived from
kinetic theory and projector operator techniques. That equation exhibits
violation of the fluctuation dissipation-theorem. By implementing the
hydrodynamic regime described by the first moments of the non-equilibrium
distribution, we find relaxation equations for the diffusion current and
pressure tensor, allowing us to arrive at a complete description of the system
in the inertial and diffusion regimes. The simplicity and generality of the
method we propose, makes it applicable to more complex situations, often
encountered in problems of soft condensed matter, in which not only one but
more degrees of freedom are coupled to a non-equilibrium bath.Comment: 10 pages, accepted in Phys. Rev.
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