ATTRIBUTION OF MENTAL DISORDERS IN SUICIDE OCCURRENCE

The present study aimed to determine attribution of mental disorders in suicide occurrence. By a cross-sectional study, all suicide records (n = 5188), between 1993 and 2009 in Ilam province, were investigated. Multiple logistic regression analysis was adopted. Totally, 27.5 of the suicides occurred due to mental disorders. This was significantly higher in males (29.3), individuals born in 1996(44) and 1990s (30.3), those aged 30 years and above (33.2) and suicide attempters (28.3), respectively and separately. The risk of suicide due to mental disorders was observed for females (OR = 0.85, CI = 0.74-0.97), those born in 1994 (OR = 2.82, CI = 1.27-6.24), completed suicides (OR = 0.81, CI = 0.68-0.97) and the age group 25 to 29 years old (OR = 0.82, CI = 0.66-1.01). Suicide due to mental disorders was higher among males compared to females, the rate of which was directly proportional to attempted suicide and age. It is therefore recommended that health educations be seriously carried on targeted groups

Health outcomes attributed to PM10 due to dust storms in Ilam city, in Iran from 2012 to 2013

Background and Aim: In recent years, increasing dust storms originating from the Iran's neighbors in the west have led to social, economic, and health concerns. The aim of this study was to assess the acute health effects of dust and estimate the mortality rate associated with cardiovascular and pulmonary disorders, attributed to dust particles in Ilam city, by using WHO protocols. Material and Methods: In this study, concentrations of PM10, PM2.5, and PM1 were measured from March 2012 to Feb 2013. The measurement was performed using the Grimm aerosol spectrometer model 1.108. Air Quality Health Impact Assessment software (Air Q 2.2.3) was used for quantification of health outcomes attributed to PM10 in Ilam, Iran. Results: Using the model, the number of cumulative excess mortality, mortality due to cardiovascular and pulmonary diseases, and all admitted patients due to cardiovascular and pulmonary diseases attributed to PM10 in Ilam were 69.2, 42.5, 12.3, 80.3 and 208.7 cases respectively. The additional cases of disorders attributed to PM10 showed an increasing trend with concentrations of more than 100 µg/m3. This trend was more severe with concentrations of more than 200 µg/m3. Conclusion: The estimated rates of health outcomes attributed to PM10 associated with dust storms necessitate urgent regional measures to bring the problem of harmful particles under control. In addition, personal care and training are of great importance. © 2015, Kurdistan University of Medical Sciences. All rights reserved

Distribution of the most prevalent spa types among clinical isolates of methicillin-resistant and -susceptible Staphylococcus aureus around the world: A review

Background: Staphylococcus aureus, a leading cause of community-acquired and nosocomial infections, remains a major health problem worldwide. Molecular typing methods, such as spa typing, are vital for the control and, when typing can be made more timely, prevention of S. aureus spread around healthcare settings. The current study aims to review the literature to report the most common clinical spa types around the world, which is important for epidemiological surveys and nosocomial infection control policies. Methods: A search via PubMed, Google Scholar, Web of Science, Embase, the Cochrane library, and Scopus was conducted for original articles reporting the most prevalent spa types among S. aureus isolates. The search terms were "Staphylococcus aureus, spa typing." Results: The most prevalent spa types were t032, t008 and t002 in Europe; t037 and t002 in Asia; t008, t002, and t242 in America; t037, t084, and t064 in Africa; and t020 in Australia. In Europe, all the isolates related to spa type t032 were MRSA. In addition, spa type t037 in Africa and t037and t437 in Australia also consisted exclusively of MRSA isolates. Given the fact that more than 95 of the papers we studied originated in the past decade there was no option to study the dynamics of regional clone emergence. Conclusion: This review documents the presence of the most prevalent spa types in countries, continents and worldwide and shows big local differences in clonal distribution. © 2018 Asadollahi, Farahani, Mirzaii, Khoramrooz, van Belkum, Asadollahi, Dadashi and Darban-Sarokhalil

Numerical Investigation of Optimization of Injection Angle Effects on Fluidic Thrust Vectoring

A computational investigation was conducted to optimize the fluidic injection angle effects on thrust vectoring. Numerical simulation of fluidic injection for shock vector control, with a convergent-divergent nozzle concept was performed, using URANS approach with Spalart-Allmaras turbulence model. The fluidic injection angles from 60º to 120º were investigated at different aerodynamic and geometric conditions. The current investigation demonstrated that secondary injection angle is an essential parameter in fluidic thrust vectoring. Computational results indicated that, optimizing secondary injection angle would have positive impact on thrust vectoring performance. Furthermore, in most cases, decreasing expansion ratio of the nozzle with increasing NPR has negative impact on pitch thrust vector angle and thrust vectoring efficiency. That is, the highest pitch thrust vector angle is obtained by decreasing nozzle expansion ratio with increasing SPR in smaller fluidic injection angles. In addition, the current investigation attempted to initiate a database of optimized injection angles with different essential parameter effects on thrust vectoring, in order to guide the design and development of an efficient propulsion system

Optimization of Freestream Flow Effects on Thrust Shock Vector Control Nozzle

The present study attempted to utilize a computational investigation to optimize the external freestream flow influence on thrust-vector control. The external flow with different Mach numbers from 0.05 to 1.1 and with optimum injection angles from 60˚ to 120˚ were studied at variable flow conditions. Simulation of a converging-diverging nozzle with shock-vector control method was performed, using the unsteady Reynolds- averaged Navier-Stokes approach with Spalart-Allmaras turbulence model. This research established that freestream flow and fluidic-injection angle are the significant parameters on shock-vector control performance. Computational results indicate that, increasing freestream Mach number would decline the thrust vectoring effectiveness. Also, optimizing injection angle would reduce the negative effect of external freestream flow on thrust-vector control. Moreover, increasing secondary to primary total pressure ratios and decreasing nozzle pressure ratios at different freestream Mach number would decrease dynamic response of starting thrust-vector control. Additionally, to lead the improvement of the next generation of jet engine concepts, the current study aimed to originate a database of variable external flow with effective aerodynamic parameters, which have influence on fluidic thrust-vector control

MASH Test No. 3-10 of a Non-Proprietary, High-Tension, Cable Median Barrier for Use in 6H:1V V-Ditch (Test No. MWP-9)

The Midwest Pooled Fund Program has been developing a prototype design for a non-proprietary, high-tension, cable median barrier for use in a 6H:1V median V-ditch. This system incorporates four evenly spaced cables, Midwest Weak Posts (MWPs) spaced at 8 to 16 ft (2.4 to 4.9 m) intervals, and a bolted, tabbed bracket to attach the cables to each post. Full-scale crash testing was needed to evaluate the barrier’s safety performance. According to the Manual for Assessing Safety Hardware 2016 (MASH) testing matrix for cable barriers installed within a 6H:1V median V-ditch, a series of eight full-scale crash tests are required to evaluate the safety performance of a system. Several previous tests have failed due to the posts penetrating into the occupant compartment. In order to mitigate the floor pan tearing, a modified MWP was designed. Test no. MWP-9 was conducted on the modified barrier system, consisting of MWPs with 3⁄4-in. (19-mm) diameter weakening holes at the ground line. Additionally, a two-part cap with a single retainer bolt was added to the top of the posts. The cap shielded the free edges of the MWPs during the post-to-vehicle contact. This test was conducted according to MASH 2016 test designation no. 3-10 and utilized an 1100C small car impacting the barrier on level terrain. The vehicle was contained by the system. The two-piece cap mitigated the floor pan tearing. However, one cable (cable no. 3) snagged on the cap retainer bolt and caused two cables (cable nos. 3 and 4) to become interlocked with the left-side A-pillar on the impact side of the vehicle, which resulted in excessive A-pillar crush. Therefore, test no. MWP-9 was deemed unacceptable. However, the two-part cap demonstrated that a closed-section post should be capable of mitigating floor pan tearing

Association between plasma leptin/adiponectin ratios with the extent and severity of coronary artery disease

Background: Leptin can have a direct effect on endothelial and vascular smooth muscle cells and high level of leptin is involved in the pathogenesis of atherosclerosis. This study aimed to determine the relationship between leptin/adiponectin (L/A) ratio and the extent and severity of coronary artery disease (CAD). Methods: This case-control study was conducted in an educational hospital in Ilam, Iran from June 2014 to September 2015. Totally 300 participants including 150 patients with CAD (case group) and 150 healthy individuals (control group) were selected and their plasma leptin, adiponectin and leptin/adiponectin ratio was measured. The extent and severity of coronary artery disease were assayed based on the number of involved vessels and Gensini score (GS) and the relation between scores and L/A findings were compared between cases and controls. Results: Totally, 300 participants including 150 (42.7 male), mean age 59.5 ± 11.4 years as cases and 150 (50.7 male), mean age 59.8 ± 10.7 as controls were analyzed. Plasma level of leptin and L/A ratio were higher in cases compared to controls, but level of adiponectin was significantly lower in CAD patients than the control group. More number of involved coronary vessels was significantly correlated to higher level of plasma leptin, L/A ratio and lower level of adiponectin among case group. Moreover, adiponectin was negatively and leptin or L/A ratio were positively correlated with number of involved vessels. 7.3 of cases had only one involved vessel, 42.7 had two involved vessels, and 50 of total patients had involved vessels and the mean ± SD of GS in the case group was 23.6 ± 6.9. Conclusions: Plasma levels of leptin, and adiponectin can indicate the extent of coronary artery diseases but leptin may be a better marker of extent of CAD than either L/A ratio or adiponectin separately. © 2020, The Author(s)

FDG-PET/CT of COVID-19 and Other Lung Infections

While not conventionally used as the first-line modality, [18F]-2-fluoro-2-deoxy-D-glucose (FDG) - positron emission tomography/computed tomography (PET/CT) can identify infection and inflammation both earlier and with higher sensitivity than anatomic imaging modalities [including chest X-ray (CXR), computed tomography (CT), and magnetic resonance imaging (MRI)]. The extent of inflammation and, conversely, recovery within the lungs, can be roughly quantified on FDG-PET/CT using maximum standardized uptake value (SUVmax) values. The Coronavirus disease 2019 (COVID-19) pandemic has highlighted the value of FDG-PET/CT in diagnosis, elucidation of acute pulmonary and extrapulmonary manifestations, and long-term follow up. Similarly, many other pulmonary infectio

New Insights Into the Clinical and Molecular Spectrum of the Novel CYFIP2-Related Neurodevelopmental Disorder and Impairment of the WRC-Mediated Actin Dynamics

Purpose: A few de novo missense variants in the cytoplasmic FMRP-interacting protein 2 (CYFIP2) gene have recently been described as a novel cause of severe intellectual disability, seizures, and hypotonia in 18 individuals, with p.Arg87 substitutions in the majority. Methods: We assembled data from 19 newly identified and all 18 previously published individuals with CYFIP2 variants. By structural modeling and investigation of WAVE-regulatory complex (WRC)-mediated actin polymerization in six patient fibroblast lines we assessed the impact of CYFIP2 variants on the WRC. Results: Sixteen of 19 individuals harbor two previously described and 11 novel (likely) disease-associated missense variants. We report p.Asp724 as second mutational hotspot (4/19 cases). Genotype–phenotype correlation confirms a consistently severe phenotype in p.Arg87 patients but a more variable phenotype in p.Asp724 and other substitutions. Three individuals with milder phenotypes carry putative loss-of-function variants, which remain of unclear pathogenicity. Structural modeling predicted missense variants to disturb interactions within the WRC or impair CYFIP2 stability. Consistent with its role in WRC-mediated actin polymerization we substantiate aberrant regulation of the actin cytoskeleton in patient fibroblasts. Conclusion: Our study expands the clinical and molecular spectrum of CYFIP2-related neurodevelopmental disorder and provides evidence for aberrant WRC-mediated actin dynamics as contributing cellular pathomechanism