The Impact Of Oral Health Education And Preventive Measures On Dental Caries And Periodontal Diseases

Oral problems, including dental caries, periodontal diseases, and tooth loss, are significant global public health concerns. This is due to the fact that inadequate oral health has extensive impacts on general health and quality of life. In improving oral health, especially in developing countries, there are obstacles that need to be addressed. It is crucial to enhance public health programs worldwide by implementing efficient preventative measures against diseases and simultaneously boosting oral health. Frequently, collective actions are employed for the purpose of oral health education. These actions often involve delivering lectures utilizing various materials such as flipcharts, videos, PowerPoint presentations, as well as implementing other activities like supervised teeth brushing and topical fluoride application. This paper aimed to review the impact of oral health education and preventive measures on dental caries and periodontal diseases

The Role of the Syk/Shp-1 Kinase-Phosphatase Equilibrium in B Cell Development and Signaling

Signal transduction from the BCR is regulated by the equilibrium between kinases (e.g., spleen tyrosine kinase [Syk]) and phosphatases (e.g., Shp-1). Previous studies showed that Syk-deficient B cells have a developmental block at the pro/pre-B cell stage, whereas a B cell-specific Shp-1 deficiency promoted B-1a cell development and led to autoimmunity. We generated B cell-specific Shp-1 and Syk double-knockout (DKO) mice and compared them to the single-knockout mice deficient for either Syk or Shp-1. Unlike Syk-deficient mice, the DKO mice can generate mature B cells, albeit at >20-fold reduced B cell numbers. The DKO B-2 cells are all Syk-negative, whereas the peritoneal B1 cells of the DKO mice still express Syk, indicating that they require this kinase for their proper development. The DKO B-2 cells cannot be stimulated via the BCR, whereas they are efficiently activated via TLR or CD40. We also found that in DKO pre-B cells, the kinase Zap70 is associated with the pre-BCR, suggesting that Zap70 is important to promote B cell maturation in the absence of Syk and SHP-1. Together, our data show that a properly balanced kinase/phosphatase equilibrium is crucial for normal B cell development and function

Effects of p38α/β inhibition on Acute Lymphoblastic Leukemia (ALL) proliferation and survival <em>in vivo</em>.

P38α/β has been described as a tumor suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However, p38α/β also regulates other cellular processes. Here, we describe a role of p38α/β as a regulator of ALL proliferation and survival in experimental ALL models. We also report first evidence that p38α/β phosphorylation is associated with the occurrence of relapses in TEL-AML1 positive leukemia. First, in vitro experiments show that p38α/β signaling is induced in a cyclical manner upon initiation of proliferation and remains activated during log-phase of cell growth. Next, we provide evidence that growth-permissive signals in the bone marrow activate p38α/β in a novel avian ALL model, in which therapeutic targeting can be tested. We further demonstrate that p38α/β inhibition by small molecules can suppress leukemic expansion and prolong survival of mice bearing ALL cell lines and primary cells. Knockdown of p38α strongly delays leukemogenesis in mice xenografted with cell lines. Finally, we show that in xenografted TEL-AML1 patients, ex vivo p38α/β phosphorylation is associated with an inferior long-term relapse-free survival. We propose p38α/β as a mediator of proliferation and survival in ALL and show first preclinical evidence for p38α/β inhibition as an adjunct approach to conventional therapies

Awareness level of parents toward antibiotics those are prescribed to their children in al-dammam city

Background: Misuse of antibiotics is worldwide problem and annoying pediatricians. This misuses result in the increase the prevalence of one of global health problem which is antibiotic Resistance. Many studies mentioned that misusing of antibiotics is related to antibiotic resistance. The main reason of antibiotics misuse is low public awareness towards antibiotics indications. Also, patient's knowledge and practice with the antibiotic like self-prescription is common in developing countries. The antibiotics prescribed from private pharmacies are given to parents and parents are responsible to give medications to their children. So, we need to increase parents' awareness toward antibiotics usage to decrease the incidence of antibiotic resistance. Objective: To evaluate the parents' level of awareness towards antibiotics those prescribed to their children in At Dammam city Saudi Arabia. Methods: Questionnaire based on cross-sectional study. Questionnaires filled by parents whom have children less than 12 years old in public places randomly in the period from October to November 2018. The questionnaires has two parts: the first part is containing social-demographic data. While the second part: LIP of parents towards antibiotics. Data entering and analysis by SPSS. Results: Questionnaires have been distributed to 450 parents, most in participants were aged 20-29 . years old, the vast majority of participants have misconception regarding the antibiotics indications and (40%) of participants chose that antibiotics use for fever, (22%) for cough and (21%) do not know. Regarding parents' attitude toward antibiotics, (71.3%) have used antibiotics for their children but fortunately, Majority of the participants believe that their children don't need to antibiotics every time when they are sick (70%). in addition, Most of the. participants believe that antibiotics may harm the children (60%) Conclusion: Level of awaraness of parents in Dammam city is moderately acceptable. We can expect antibiotics resistance to happen among new generation in Al-Dammam city if there is no enough campaigns to increase the awareness and to fill the gap

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism, and that targeting the IL7R pathway may suppress incurable drug-resistant leukemia forms

Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Early response to therapy, especially the measurement of minimal residual disease (MRD), remains the most reliable and strongest independent prognostic parameter. Intriguingly, little is known on the mechanisms sustaining MRD in that disease. Here, we summarize existing evidence on the influences of molecular genetics and clonal architecture of childhood ALL on disease persistence. Also, the impact of the leukemic niche on residual leukemia cells in the bone marrow and extramedullary compartments is reviewed. We further discuss existing in vivo models of minimal residual disease based on different cellular labelling strategies and engraftment of ALL cells in immunodeficient mouse strains. We finally draw some conclusions on potential strategies targeting residual ALL cells, with a focus on cellular and antibodybased immunotherapy