A Comprehensive Study on RXTE & INTEGRAL Observations of the X-ray Pulsar 4U 1907+09

We analyse \emph{INTEGRAL} (between 2005 October and 2007 November) and \emph{RXTE} (between 2007 June and 2011 March) observations of the accretion powered pulsar 4U 1907+09. From \emph{INTEGRAL} IBIS-ISGRI and \emph{RXTE}-PCA observations, we update pulse period history of the source. We construct power spectrum density of pulse frequencies and find that fluctuations in the pulse frequency derivatives are consistent with the random walk model with a noise strength of $1.27\times10^{-21}$ Hz s$^{-2}$. From the X-ray spectral analysis of \emph{RXTE}-PCA observations, we find that Hydrogen column density is variable over the binary orbit, tending to increase just after the periastron passage. We also show that the X-ray spectrum gets hardened with decreasing X-ray flux. We discuss pulse-to-pulse variability of the source near dipping ingress and egress. We find that the source more likely undergoes in dipping states after apastron until periastron when the accretion from clumpy wind might dominate so that occasional transitions to temporary propeller state might occur.Comment: 19 pages, 8 figures, accepted for publication in MNRA

Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas

Background: The etiopathogenesis of prostate cancer (PC) is still not clear, but hormonal, genetic, and environmental factors are thought to play a role in the tumor pathogenesis. Astrocyte elevated gene-1(AEG-1) as a novel transmembrane protein is predominantly located in the perinuclear region and endoplasmic reticulum. It has been found that AEG-1 upregulation increases the invasive ability of glioma and prostate cancer. Basic fibroblast growth factor (bFGF), matrix metalloproteinase-9 (MMP-9), cyclooxygenases-2 (COX-2), and adenomatous polyposis coli (APC) are very important in tumor progression as well. Materials and Methods: This study included 97 radical prostatectomy specimens. IHC stains for bFGF, MMP-9, COX-2, APC, and AEG-1 were performed on the tissue microarray using standard procedures. For each patient, the age, Gleason score, tumor volume, lymphovascular invasion, lymph node metastasis, surgical margin, and the invasion of vesiculoseminalis areas were assessed. Analyses were performed using the statistical PASW (ver. 18). Results: Statistically significant positive relationships were found MMP-9 and COX-2 (r = 0.242 and P = 0.017), between MMP-9 and APC (r = 0.207 and P = 0.043), and between bFGF and AEG-1 (r = 0.295 and P = 0.004). However, the relationships between age and staining results and tumor volume and staining results were not found to be significant. Although a positive correlation was found between the Gleason score and tumor volume and the Gleason score and age (r = 0.415 and P = 0.0001; r = 0.246 and P = 0.015, respectively), we did not find a statistically significant relationship between other stains and other prognostic parameters (lymphovascular invasion, lymph node metastasis, surgical margin, or vesiculoseminalis invasion). Conclusion:The relationships we found between MMP-9 and COX-2, between MMP-9, and APC and between bFGF and AEG-1 as independent prognostic parameters could be helpful in the development of new therapeutic procedures.Keywords: Adenomatous polyposis coli, astrocyte elevated gene‑1, basic fibroblast growth factor, cyclooxygenases‑2, matrix metalloproteinase‑9, prognostic parameters, prostate adenocarcinomasNigerian Journal of Clinical Practice • Oct-Dec 2013 • Vol 16 • Issue

Recent Torque Reversal of 4U 1907+09

We present timing and spectral analysis of RXTE-PCA observations of the accretion powered pulsar 4U 1907+09 between June 2007 and August 2008. 4U 1907+09 had been in a spin-down episode with a spin-down rate of $-3.54\times10^{-14}$ Hz s$^{-1}$ before 1999. From RXTE observations after March 2001, the source showed a $\sim 60$% decrease in spin-down magnitude and INTEGRAL observations after March 2003 showed that source started to spin-up. We found that the source recently entered a new spin-down episode with a spin-down rate of $-3.59 \times 10^{-14}$ Hz s$^{-1}$. This spin-down rate is pretty close to the previous long term spin-down rate of the source measured before 1999. From the spectral analysis, we showed that Hydrogen column density varies with the orbital phase.Comment: Published in MNRA

Sympathetic skin response and R-R interval variation in chronic administration of salmon calcitonin

The distribution of calcitonin and CGRP-producing cells and pathways in the brain and other tissues suggests functions for the peptide in nociception, ingestive behaviour and modulation of the autonomic and endocrine systems. Sympathetic skin response (SSR), is a reliable indicator of autonomic dysfunctions. The heart rate variability termed as R-R interval variation (RRIV) is another simple and reliable test which can be used to determine vagal autonomic dysfunction. Twenty female patients with active osteoporosis aged between 46-58 and for a control group 20 age-matched healthy female volunteers with no history or evidence of any other disease were included in this study. The study results show that long term therapy with salmon calcitonin does not effect any SSR and RRIV parameters. It can be speculated that though human calcitonin and CGRP have discrete functions in the human autonomic nervous system, replacement therapy with salmon calcitonin does not interfere normal autonomic functions

Preparation and evaluation of multipurpose herbal mouthwash for oromucosal diseases

2-s2.0-85073387180Due to the many advantages of herbal sources in medication, in this study, it was aimed to prepare and evaluate an herbal mouthwash formulation that can be useful for the treatment of some oromucosal diseases. For this aim, extracts of Thymus vulgaris L. (Lamiaceae), Pelargonium sidoides DC. (Geraniaceae), Glycyrrhiza glabra L. (Leguminosae), Matricaria chamomilla L. (Compositae), Melissa officinalis L. (Lamiaceae) and Laurus nobilis L. (Lauraceae) were used to prepare two different formulations. Physical parameters, pH, density, stability, in vitro antimicrobial activity and in vitro cytotoxicity studies were used for evaluation of formulations. Between the investigated formulations, the formulation that contains extracts of Thymus vulgaris L. (Lamiaceae), Pelargonium sidoides DC. (Geraniaceae), and Glycyrrhiza glabra L. (Leguminosae), showed good antimicrobial activity with acceptable physical characteristics, pH, density, stability and no cytotoxicity on fibroblast cells. It has been promised in order to create an effective and safe herbal oral mouthwash having multipurpose use for oromucosal diseases and further studies will be planned in terms of long-term stability and clinical studies. © 2019, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved