Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B

Background: HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials. We aimed to evaluate the predictive value of serum hyaluronate for the presence of extensive liver fibrosis and inflammation. Methods: 28 healthy volunteers and 65 patients with HBeAg negative chronic hepatitis B were enrolled. Liver biopsies scored according to Ishak system. Association of serum hyaloronate with liver fibrosis and inflammation were assessed, and cut off points for serum hyaluronate levels were identified by receiver operating characteristics (ROC) curves and their values for prediction of fibrosis and inflammation were assessed. Results: In patients with CHB serum hyaluronate had the most significant correlation and predictive values for the liver fibrosis and inflammation comparing to the other variables. At the cut off point of 126.4 ngm/ml it could discriminate extensive fibrosis from milder ones with sensitivity of 90.9% and specificity of 98.1%. With the same value it could discriminate extensive inflammation from their milder counterparts with sensitivity of 63.6% and specificity of 92.6%. Conclusion: Serum hyaluronate was the best predictor of extensive liver fibrosis and inflammation and it could discriminate subgroups of patients with chronic hepatitis B. It could be used as a non-invasive test to monitor these patients more closely with developing anti viral agents in clinical trials

Content validity of national post marriage educational program using mixed methods

Background: Although the validity of content of program is mostly conducted with qualitative methods, this study used both qualitative and quantitative methods for the validation of content of post marriage training program provid-ed for newly married couples. Content validity is a preliminary step of obtaining authorization required to install the program in country's health care system. Methods: This mixed methodological content validation study carried out in four steps with forming three expert panels. Altogether 24 expert panelists were involved in 3 qualitative and quantitative panels; 6 in the first item devel-opment one; 12 in the reduction kind, 4 of them were common with the first panel, and 10 executive experts in the last one organized to evaluate psychometric properties of CVR and CVI and Face validity of 57 educational objectives. Results: The raw data of post marriage program had been written by professional experts of Ministry of Health, using qualitative expert panel, the content was more developed by generating 3 topics and refining one topic and its respec-tive content. In the second panel, totally six other objectives were deleted, three for being out of agreement cut of point and three on experts' consensus. The validity of all items was above 0.8 and their content validity indices (0.8-1) were completely appropriate in quantitative assessment. Conclusion: This study provided a good evidence for validation and accreditation of national post marriage program planned for newly married couples in health centers of the country in the near future. © 2015, Iranian Journal of Public Health. All right reserved

Spring search algorithm for simultaneous placement of distributed generation and capacitors

Purpose. In this paper, for simultaneous placement of distributed generation (DG) and capacitors, a new approach based on Spring Search Algorithm (SSA), is presented. This method is contained two stages using two sensitive index Sv and Ss. Sv and Ss are calculated according to nominal voltageand network losses. In the first stage, candidate buses are determined for installation DG and capacitors according to Sv and Ss. Then in the second stage, placement and sizing of distributed generation and capacitors are specified using SSA. The spring search algorithm is among the optimization algorithms developed by the idea of laws of nature and the search factors are a set of objects. The proposed algorithm is tested on 33-bus and 69-bus radial distribution networks. The test results indicate good performance of the proposed methodЦель. В статье для одновременного размещения распределенной генерации и конденсаторов представлен новый подход, основанный на "пружинном" алгоритме поиска (Spring Search Algorithm, SSA). Данный метод состоит из двух этапов с использованием двух показателей чувствительности Sv и Ss. Показатели чувствительности Sv и Ss рассчитываются в соответствии с номинальным напряжением и потерями в сети. На первом этапе определяются шины-кандидаты для установки распределенной генерации и конденсаторов согласно Sv и Ss. Затем, на втором этапе размещение и калибровка распределенной генерации и конденсаторов выполняются с использованием алгоритма SSA. "Пружинный" алгоритм поиска входит в число алгоритмов оптимизации, разработанных на основе идей законов природы, а факторы поиска представляют собой набор объектов. Предлагаемый алгоритм тестируется на радиальных распределительных сетях с 33 и 69 шинами. Результаты тестирования показывают хорошую эффективность предложенного метода

Does knowledge of cancer diagnosis affect quality of life? A methodological challenge

BACKGROUND: As part of an assessment of quality of life in lung cancer patients an investigation was carried out to examine whether the knowledge of their diagnosis affected their quality of life. METHODS: Every patient in a defined geographical area with a potential diagnosis of lung cancer was interviewed at first consultation and after a definitive treatment has been given. Quality of life was assessed using three standard measures: the Nottingham Health Profile (NHP), the EORTC quality of life questionnaire (QLQ-C30) and its lung cancer supplementary questionnaire (QLQ-LC13). Comparison was made in quality of life scores between patients who knew their cancer diagnosis and those who did not. RESULTS: In all, 129 lung cancer patients were interviewed. Of these, 30 patients (23%) knew and 99 (78%) did not know their cancer diagnosis at the time of baseline assessment. The patient groups were similar in their characteristics except for age (P = 0.04) and cell type (P < 0.0001). Overall, there were no significant differences between these two groups with regard to their scores on the three instruments used. A major finding was that both group scored almost the same on emotional reactions (P = 0.8) and social isolation (P = 1.0) as measured by the NHP, and emotional (P = 0.7) and social functioning (P = 1.0) as measured by the EORTC QLQ-C30. In addition there were no significant differences in patients' symptom scores between those who knew their diagnosis and those who did not, nor did any consistent pattern emerge. The only significant difference was for sleep difficulties (P = 0.02). CONCLUSION: The findings suggest that the knowledge of cancer diagnosis does not affect the way in which patients respond to quality of life questionnaires

Risk factors of pelvic organ prolapse in Iranian women: a cross-sectional study

Background and aims: Pelvic organ prolapse (POP) is a common condition which affects on a large proportion of women. The objective of this study was to determine the risk factors of POP in Iranian women. Methods: This cross-sectional study was carried out to examine the role of demographic, anthropometric and clinical characteristics in POP disease in a sample of 365 females in Ilam, Iran. Examinations were performed according to Pelvic Organ Prolapse Quantification (POPQ) technique in dorsal lithotomic position. Then, the sample divided into two groups as with and without prolapse. Then, unilabiate and multivariate analyses were performed. Results: Totally, 365 women participated in this study. The prevalence of POP was 80.8. Univariate logistic regression analysis showed a significant differences between groups with and without POP based on age, maximum birth weight, BMI, pregnancy, delivery mode, delivery operative and delivery position. But after multivariate analysis, the most significant factors identified as risk factors for POP were age (OR= 1.12, 95 CI= 1.02-1.23, P= 0.02), normal vaginal delivery (NVD; OR= 6.18, 95 CI= 1.43-26.75, P= 0.01) and episiotomy (OR= 30, 95 CI= 5.69-158.11, P= 0.000). Conclusion: Findings of the study showed that several risk factors could collaborate in creating of POP. However; body mass index and number of pregnancies are modifiable factors. So, maternal care providers should educate women for maintaining the ideal weight and decreasing the number of pregnancy in order to prevent POP

Velocity-Based LOD Reduction in Virtual Reality: A Psychometric Approach

Virtual Reality headsets enable users to explore the environment by performing self-induced movements. The retinal velocity produced by such motion reduces the visual system's ability to resolve fine detail. We measured the impact of self-induced head rotations on the ability to detect quality changes of a realistic 3D model in an immersive virtual reality environment. We varied the Level-of-Detail (LOD) as a function of rotational head velocity with different degrees of severity. Using a psychophysical method, we asked 17 participants to identify which of the two presented intervals contained the higher quality model under two different maximum velocity conditions. After fitting psychometric functions to data relating the percentage of correct responses to the aggressiveness of LOD manipulations, we identified the threshold severity for which participants could reliably (75\%) detect the lower LOD model. Participants accepted an approximately four-fold LOD reduction even in the low maximum velocity condition without a significant impact on perceived quality, which suggests that there is considerable potential for optimisation when users are moving (increased range of perceptual uncertainty). Moreover, LOD could be degraded significantly more in the maximum head velocity condition, suggesting these effects are indeed speed dependent

Synthesis of Single-Phase Anatase TiO2 Nanoparticles by Hydrothermal Treatment

Pure anatase powders of titanium dioxide with a homogeneous nanosized particles distribution were prepared by a facile hydrothermal route using solution of acetic acid and tetraisopropyl orthotitanate as the precursors with a molar ratio of 1:1. The modified hydrolyzed alkoxide was treated at various temperatures under different autogenic pressures. Two different reactors were employed as autoclaves for heating and generation of high pressures during the synthesis and crystallization of TiO2 nanoparticles. The characteristics of TiO2 powders obtained under various synthesis conditions were verified using X-Ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FE-SEM). The results indicated that particles size of the formed TiO2 could be finely tuned by varying the experimental parameters of temperature, pressure and the amount of nitric acid in the peptization step. TiO2 nanoparticles with good dispersion and mean size of about 9 nm could be seen in FE-SEM image of sample synthesized under temperature of 160 °C for 12 h using more nitric acid in the peptization step. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3488