サッチャー保守党政権下のイギリス資本主義

Articledepartmental bulletin pape

Enhancing the German FL2 Classroom

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SBML Level 3: an extensible format for the exchange and reuse of biological models

Abstract Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edition of the Systems Biology Markup Language (SBML), a format designed for this purpose. A community of modelers and software authors developed SBML Level 3 over the past decade. Its modular form consists of a core suited to representing reaction‐based models and packages that extend the core with features suited to other model types including constraint‐based models, reaction‐diffusion models, logical network models, and rule‐based models. The format leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models. More recently, the rise of multiscale models of whole cells and organs, and new data sources such as single‐cell measurements and live imaging, has precipitated new ways of integrating data with models. We provide our perspectives on the challenges presented by these developments and how SBML Level 3 provides the foundation needed to support this evolution

SBML Level 3: an extensible format for the exchange and reuse of biological models

Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edition of the Systems Biology Markup Language (SBML), a format designed for this purpose. A community of modelers and software authors developed SBML Level 3 over the past decade. Its modular form consists of a core suited to representing reaction-based models and packages that extend the core with features suited to other model types including constraint-based models, reaction-diffusion models, logical network models, and rule-based models. The format leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models. More recently, the rise of multiscale models of whole cells and organs, and new data sources such as single-cell measurements and live imaging, has precipitated new ways of integrating data with models. We provide our perspectives on the challenges presented by these developments and how SBML Level 3 provides the foundation needed to support this evolution.journal articl

Long-Term Period in Restricted Three-body Problem

departmental bulletin pape

Annual Report of Clinical Activities by the Field of Clinical Psychology. (In the Academic Year 2006)

text紀要論文 / Departmental Bulletin Paperdepartmental bulletin pape

1200℃周辺の高温におけるCO2還元能測定システムの開発

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中国法意識スケーリング(1)

2000-06-30departmental bulletin pape

Stack Overflowのコード片へ加えられた変更に追従しないGitHubプロジェクトの変更パターン分類による考察

GitHubプロジェクトに再利用されているStack Overflowのコード片に変更が加えられた場合に再利用側の追従状況や追従の必要性について，その変更内容に対してパターン分類を実施することで考察を行う．journal articl

Structural study of monosubstituted β-cyclodextrins. crystal structures of phenylthio-β-cyclodextrin and phenylsulphinyl-β- cyclodextrin and spectroscopic study of related compounds in aqueous solution

The crystal structures of two monosubstituted β-cyclodextrins which have bulky hydrophobic groups instead of primary hydroxy groups were determined by X-ray diffraction. These compounds consist of the host (cyclodextrin moieties) and guest parts (hydrophobic groups), and have the ability to act as both host and guest at the same time. The crystal structures were solved by using Patterson maps, rotation functions, and trial-and-error methods combined with a rigid-body least-squares technique. The structures were refined by using a block-diagonal least-squares method to R values of 0.14 and 0.13. Hydrophobic groups are intermolecularly included in the cyclodextrin cavity of another molecule, and novel helical polymers are formed by repetition of this intermolecular inclusion. A spectroscopic study confirmed that this intermolecular inclusion occurs in aqueous solution