鸡尾酒抗体D2-40/CD34-CK对淋巴结检出数量不足结直肠癌标本的临床病理评价

目的探讨鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色在淋巴结检出数量不足的结直肠癌(colorectal cancer,CRC)标本脉管侵犯评估中的应用及意义。方法收集133例淋巴结检出数量<12枚的CRC标本,分别行HE染色及鸡尾酒抗体双重免疫组化染色,比较两种方法在脉管侵犯筛查效果中的差异,并分析应用鸡尾酒抗体免疫组化染色证实的脉管侵犯与临床病理特征及患者总生存期(overall survival,OS)的关系。结果 (1)鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色及HE染色对脉管侵犯的检出率分别为42. 9%(57/133)和21. 8%(29/133),差异有显著性(P <0. 001)。(2)鸡尾酒抗体D2-40/CD34-CK双重免疫组化法证实的脉管侵犯与Dukes分期、浸润深度、临床分期、淋巴结转移、肿瘤出芽相关(P <0. 05)。(3)脉管侵犯、侵犯位置深度、程度及脉管侵犯灶数≤2个灶且癌栓细胞数量≥5. 5个与患者OS密切相关(P <0. 05)。结论鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色对脉管侵犯评估优于常规HE染色切片观察,与肿瘤分期、淋巴结转移及出芽情况密切相关,是患者预后的独立影响因素,可作为淋巴结检出数量不足CRC病例的补充检测指标。国家自然科学基金青年科学基金(81301787

中国心理学会会议论文集

以往研究发现,突然出现的刺激(abrupt onsets)对于注意和眼动均有捕捉效应(Theeuwes,1994;Yantis &amp; Jonides,1984,1990)。然而,这种捕捉效应究竟是新位置的明度变化还是新客体本身特异性造成,以往研究并没有得到一致的结论。本研究通过追踪被试的眼动轨迹和注视点来探索这种突现刺激对于眼动的捕捉是否主要源于明度变化。为此,我们在传统的刺激突现实验范式的占位刺激&nbsp;</p

2.7~1.6 ka BP塔克拉玛干沙漠腹地圆沙绿洲的演化[C]

汉及更早时代塔里木盆地绿洲的研究工作少见.沿塔克拉玛干沙漠腹地克里雅河现代绿洲尾闾达理雅博依以西的古河道,对圆沙古城遗址(38°52'N,81°35' E)所在的干三角洲进行了实地考察,发现陶石器残片、砍剁木及铜器小件等古人类活动遗迹点百余处,采集到能够反映古人类活动及自然环境变迁的14C年龄样品14个及沉积物光释光(OSL)年龄样品5个并进行了测定,结果表明：圆沙古城及其周围的绿洲至少约2.6 ka BP于春秋时代(公元前716～475年)就已存在；约2.2 ka BP,流经古城遗址的古河道曾发生断流,绿洲主体随克里雅河东迁至喀拉墩—带,成为史载西汉时期(公元前206～公元25年)塔里木丝路南道古国扜弥重要领地；约1.9 ka BP,克里雅河曾再次在圆沙古城一带发育绿洲,该绿洲属东汉(公元24～220年)扜弥国,约至1.6 ka BP与精绝和楼兰等塔里木盆地古绿洲同期废弃.圆沙等古绿洲的发育演变暗示,塔里木盆地铁器时代文明的开始可能与我国西部的2.8 ka BP冰进事件有关,而其约1.6kP的消亡则与塔里木盆地精绝和楼兰等古绿洲的衰退可能有相似的原因.应用地貌学和考古学对圆沙干三角洲的年代学分析,为汉代及之前塔里木盆地的绿洲演化与环境变迁研究提供了证据

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies