The study on the association between polycyclic aromatic hydrocarbons exposure and adverse pregnancy outcomes and their mechanisms

目的通过流行病学调查，掌握闽南地区妊娠妇女妊娠结局情况，并探讨多环芳烃（polycyclicaromatichydrocarbons，PAHs）暴露对妊娠结局的影响，结合PAHs代谢酶活性及基因多态性分析，DNA损伤等指标，评价PAHs暴露对胎儿健康的危害。 方法利用问卷形式收集1106例孕妇流行病学资料，以了解环境因素对妊娠妇女妊娠结局的影响。采用气相色谱串联质谱（gaschromatograph-massspectrometer，GC-MS）技术测定206例孕妇外周静脉血、新生儿脐带血中PAHs含量；应用聚合酶链反应-限制性片段长度多态性（polymerasechainreaction-...Objective In order to investigate the effect of polycyclic aromatic hydrocarbons (PAHs) exposure on pregnancy outcomes, a questionnaire survey and the level of PAHs in serum of pregnant women and cord blood of newborn were analysis. To elucidate the mechanisms of PAHs exposure on pregnancy outcomes, the metabolic enzyme activity, gene polymorphism, and DNA damage were detected. Methods Using a ...学位：理学硕士院系专业：生命科学学院生物学系_动物学学号：2172009115203

Research on the microbial limit verification test of tacrolimus capsules

目的按2010版《中国药典》的要求探讨他克莫司胶囊微生物限度检测方法。方法选取5种具有代表性的微生物菌悬液,用常规法、稀释法、膜过滤法或其相结合的方法分别对他克莫司胶囊进行微生物验证试验。结果细菌总数用膜过滤法稀释1∶10,霉菌和酵母菌用膜过滤法稀释1∶1 000,检测后回收率均能达到70%以上。结论避免采用单一常规法或膜过滤法进行微生物限度检测,使实验科学合理,提高工作效率,更加规范性。Objective To research the microbial limit verification test of tacrolimus capsules according to the requirements of the 2010-edition Chinese Pharmacopoeia.Methods Five types of representative microbial bacterial suspension were selected and then microbial verification tests on tacrolimus capsules through the conventional method,the dilution method,the membrane filtration method or a combination of the above methods respectively were carried out.Results Both of the recovery rates were more than 70% when the total number of bacterial was detected by the membrane filtration method as per 1∶ 10 and when mould and yeast were detected by the membrane filtration method as per 1∶ 1 000.Conclusion Microbial limit test through the single conventional method or membrane filtration method is avoided so as to ensure scientific and reasonable experiment,improve work efficiency and achieve normalization

基于电阻层析成像技术的弹状流实验研究

在气液两相流研究中，相分布、相速度等流场特征信息对深入了解流动机理、提高模型计算精度有重要意义，但由于气液流动的复杂性与随机性，使得它们的准确测量较为困难。该研究基于快速电阻层析成像技术，首先对垂直向上气液管流中弹状流流型下多种工况的流动结构进行图像数据采集与重建；然后通过互相关算法得到轴向速度场分布，并与漂移流模型进行对比；再对按时序排列的横截面图像序列进行调整得到正确比例的空间三维图像；最后获得段塞长度、频率等特征信息。结果表明，快速电阻层析成像技术可以测得速度场分布、段塞长度、频率等特征信息，可用于优化与这些参数相关的理论模型和经验关系式，有助于提高气液两相流的模型计算精度

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies