非小细胞肺癌肿瘤白细胞介素的表达模式对免疫治疗疗效和预后的作用

目的为了明确对免疫检查点阻断（ICB）治疗应答反应较差的非小细胞肺癌（NSCLC）患者与肿瘤组织白细胞介素（ILs）表达水平之间的潜在关联，探讨其在NSCLC患者肿瘤中的表达差异及其对患者ICB疗效和预后的影响。方法从既往研究数据中回顾性收集确诊为NSCLC且经过ICB治疗的61例患者，取得其ICB治疗前的肿瘤组织转录组测序及生存相关的数据，通过生物信息学方法，筛选出显著影响患者ICB治疗疗效与预后的ILs，以无进展生存期（PFS）评价疗效和总生存期（OS）评价患者的预后，使用Kaplan-Meier生存曲线和ROC曲线分析ILs对NSCLC患者ICB疗效和预后的预测作用及效能。结果通过单因素Cox回归分析，筛选出9个与NSCLC患者OS相关的ILs（P < 0.1），经过多因素Cox回归分析进一步筛选得到与NSCLC患者不良预后显著相关的ILs，结果提示IL-11、IL-17D和IL-36A高表达与NSCLC患者ICB治疗的不良预后相关（P < 0.05）。Kaplan-Meier生存曲线结果表明IL-17D高表达与NSCLC患者的PFS和OS显著负相关，高表达患者的中位PFS为3.1个月对比低表达患者6.5个月［95%CI为（1.178，3.655），P = 0.009］，中位OS高表达组对比低表达组为9.8个月对比21.8个月［95%CI（1.116，4.392），P = 0.018］，ROC曲线表明其预测性能较好［AUCPFS = 0.702，95%CI（0.562，0.842），P = 0.027；AUCOS = 0.684，95%CI（0.550，0.818），P = 0.014］。虽然IL-11和IL-36A不能很好地预测NSCLC患者的PFS和OS（P > 0.05），但当两者与IL-17D的表达模式联合时，发现上述3种ILs均为高表达的NSCLC患者，中位PFS与OS分别缩短至2.2个月（P = 0.003）和3.0个月（P < 0.001），ROC曲线表明其预测效能得到提升［AUCPFS = 0.748，95%CI（0.615，0.880），P = 0.007；AUCOS = 0.703，95%CI（0.573，0.833），P = 0.007］。结论IL-11、IL-17D和IL-36A高表达提示NSCLC患者疾病进展的风险较高，与患者不良的PFS和OS相关，可能为NSCLC的ICB辅助治疗提供新的策略

准噶尔盆地阜东斜坡区侏罗系层序地层和成藏条件分析

1、发现准噶尔盆地阜东斜坡区侏罗系层序边界多为不整合面和煤层，沉积层序具有明显的沉积旋回性。各沉积层序地层展布总体表现出南厚北薄、多沉积和沉降中心的特征。阜4-阜8井区和台40井西区始终处于沉降中心位置。层序II、III地层展布最为均一，地层厚度较小且变化不大。2、指出侏罗纪整体上处于温带至亚热带气候区并表现出气候变化旋回特征。3、利用TREEDIP(模式识别、精细树形对比)沉积学地层倾角处理成果(9口井)，进行了关键井骨架砂岩沉积构造类型及古水流解释。4、依据可信度较高的地震反射结构和外部形态，辅助于地震反射振幅和连续性等地震相参数，在侏罗系各层序中共识别出平行席状和亚平行席状地震相、前积地震相、亚平行～乱岗状地震相、充填地震相和透镜状地震相以及楔状地震相等类型。5、提出侏罗系沉积主要发育曲流河、三角洲、辫状河三角洲、深水浊积扇和湖泊沉积体系。6、提出侏罗系储层主要为河流、三角洲和滨浅湖环境下形成的中细粒岩屑砂岩和长石质岩屑砂岩，具备较低成分成熟度和中等结构成熟度的特点。7、提出彩南油田油气来自于昌吉凹陷侏罗系湖相泥岩及煤岩，储层为层序III河道砂体，为背斜油气藏。8、提出阜东斜坡区烃源岩主要分布在昌吉凹陷和博格达山前凹陷的石炭系．二叠系、三叠系和侏罗系中。9、阜东斜坡区侏罗系具有优越的油气成藏基本条件和丰富的油气资源量，存在背斜构造圈闭、地层不整合遮挡和透镜状砂体等多种类型圈闭。在油气成藏条件研究和地震资料特殊处理的基础上，在阜东斜坡区中西部三工河组已发现的六个透镜状泥包砂的岩性圈闭

变温超固相线液相烧结工艺对15Cr系高铬铸铁显微组织及性能的影响

为解决常规定温超固相线液相烧结出现的烧结温度窗口狭窄和产品力学性能对烧结温度波动敏感的问题，采用变温超固相线液相烧结工艺制备了粉末冶金高铬铸铁，研究了变温超固相线液相烧结的高温阶段工艺参数对15Cr系高铬铸铁显微组织和力学性能的影响，并与定温超固相线液相烧结制备的合金进行了对比。研究发现，变温超固相线液相烧结制备的合金由M7C3型碳化物、马氏体及少量奥氏体组成，通过高、低温两个阶段的烧结能够实现高效致密化和对显微组织的有效调控，制备出相对密度超过98.96%的高性能合金材料，烧结温度窗口相较于定温超固相线液相烧结扩展了15 ℃。在1225～1245 ℃、5～10 min的高温阶段窗口，随烧结温度升高与保温时间延长，合金显微组织逐渐粗化；当高温阶段烧结保温时间控制在10 min以内时，合金晶粒尺寸低于26.98 μm，组织粗化程度可接受。变温超固相线液相烧结高铬铸铁的硬度和冲击韧性优于定温超固相线液相烧结高铬铸铁，且冲击韧性在烧结窗口内保持稳定，平均值达12.10 J·cm−2。在1～3 J·cm−2冲击功下，变温超固相线液相烧结试样的抗冲击磨粒磨损性能优于定温超固相线液相烧结试样，随着冲击功提高，合金的抗冲击磨粒磨损性能提升从9.70%提高到19.83%

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

Determination of the number of ψ(3686) events taken at BESIII

The number of ψ(3686) events collected by the BESIII detector during the 2021 run period is determined to be (2259.3±11.1)×106 by counting inclusive ψ(3686) hadronic events. The uncertainty is systematic and the statistical uncertainty is negligible. Meanwhile, the numbers of ψ(3686) events collected during the 2009 and 2012 run periods are updated to be (107.7±0.6)×106 and (345.4±2.6)×106, respectively. Both numbers are consistent with the previous measurements within one standard deviation. The total number of ψ(3686) events in the three data samples is (2712.4±14.3)×10^