Research on the mechanism of Cx43 and AKAP95 involving in cell cycle

肺癌是严重危害人类健康的常见恶性肿瘤之一，近年来，肺癌致死率依然呈急剧上升的状态，当前也没有有效的治疗方法。Cx43是构成细胞间隙连接通道重要的膜蛋白，主要功能是允许不同细胞间的信息交流，研究表明Cx43的生物学作用并不局限于在细胞膜上形成间隙连接，它还存在于细胞内参与细胞周期的调控，且这一过程不依赖于细胞间隙连接通讯功能。AKAP95蛋白能锚定PKA于细胞核内，PKA与AKAP95蛋白连接形成复合物并接近其特异性底物，继而发挥其激酶活性。此外AKAP95蛋白也参与了细胞生理活动中许多过程，如参与细胞周期及细胞凋亡过程。PKA激酶在cAMP介导的细胞信号通路扮演重要角色，其活性依赖于cAMP，...Lung cancer is a common malignancywhich does a serious harm to human health, in recent years,the mortality rates of lung cancer still showed a sharp rise,currently there is no effective treatment.Cx43 is an important cell membrane protein which constitues gap junction channels,its main function is to allow the exchange of information between differernt cells,studies have shown that the biological ...学位：理学硕士院系专业：医学院_药理学学号：2452011115342

Elemental Detection and Multi-elemental Imaging Analysis of Porcelain Shards and Megaspores of Selaginella Sinensis via Laser Ionization Time-of-Flight Mass Spectrometry

在矿石、冶金、考古、半导体工业等领域，固体样品表面的直接元素分析具有十分重要的意义。目前，对固体的元素分析大多数采取溶液进样的形式，再利用原子吸收光谱法（Atomicabsorptionspectroscopy，AAS）、电感耦合等离子体质谱法（Inductivelycoupledplasmaatomicemissionspectrometry，ICP-MS）、电感耦合等离子体原子发射光谱法（Inductivelycoupledplasmaatomicemissionspectrometry，ICP-AES）和一系列方法实现固体样品的元素成分检测。通常，这些分析方法需要进行样品的消解，样品的消...Elemental directly analysis of solids plays an important role in mineral, metallurgy, geochemistry, archaeology, semiconductor industry and many other fields. Currently, the elemental determination of solids has beenconducted by solution-based analytical techniques, which are associated with the risk of sample contamination and require complicated time-consuming sample-preparation procedures. And ...学位：理学硕士院系专业：化学化工学院_分析化学学号：2052010015363

畜禽废水磷回收产物的磷素释放特性及肥效试验研究

以畜禽废水沼气发酵液为磷回收对象,采用曝气沉淀结晶法磷回收工艺,对回收产物进行水溶性磷连续浸提试验和玉米盆栽试验,考察畜禽废水磷回收产物的磷素动态释放情况、玉米盆栽的肥效以及磷素利用情况。浸提试验表明,磷回收产物经6次浸提,水溶性磷的释放量呈缓慢下降的趋势,第6次与第1次相比只下降了1.42%,总释放量占总磷的57.97%,证明磷回收产物（RPP）具有良好的缓释性,作为肥料使用时不易被水淋失。盆栽试验表明,用RPP以不同比例代替磷酸一铵作为肥料对玉米均能起到显著的增产作用,最佳的质量替代比例为40%;RPP较磷酸一铵的地上部分和地下部分磷素利用率分别高出19.14%和2.50%,显示其具有较高的磷吸收效率。因此,从畜禽废水沼气发酵液中回收得到的磷回收产物具有较高的肥效价值,是一种节约资源、保护环境、缓解磷资源危机的新型肥料

激光电离飞行时间质谱技术用于古代瓷片中元素的检测及元素成像分析

采用自制激光电离飞行时间质谱(LI-TOF-MS)及多元素成像体系,尝试分析了古瓷片中的多种元素。对一块北宋龙泉青瓷瓷片及一块仿古青瓷瓷片样品进行了表面元素分析,所得多元素半定量分析结果表明,这两种瓷片的胎体和釉面中所含元素的种类及含量存在差异;同时对一块明代青花瓷片进行表面多元素成像分析,获得Co,Mn,Fe,Ni,Ba,Ca,Mg,Na,Al,Si,P,K,Cu,Zn和Rb的元素成像图

添加晶种对沼气发酵液磷回收的影响研究

以畜禽养殖废水经厌氧消化处理后的沼气发酵液为研究对象,采用曝气吹脱调节pH的处理方式。晶种采用海泡石粉、沸石粉和凹凸棒石粉3种天然矿物材料。考察了不同pH条件、晶种添加量和不同初始磷负荷对磷回收的影响,并利用扫描电镜-能谱分析仪（SEM-EDX）对产物进行了表征分析。结果表明：3种晶种材料中,凹凸棒石粉对磷回收的促进效果最好。在pH从7.5到8.5之间海泡石粉、沸石粉和凹凸棒石粉均可将Rp（t）提高10%以上,8.5到9.5之间,添加海泡石粉和沸石粉对Rp（t）的提升幅度降低,添加凹凸棒石粉可以达到14%左右的提升幅度。海泡石粉和沸石粉添加量增大后Rp（t）有小幅的提升,但变化不规律,凹凸棒石粉的最佳添加量为0.92 g/L。初始PO43--P为90 mg/L时凹凸棒石粉对磷回收有最好的促进效果。添加凹凸棒石粉的产物在SEM图片上可看到明显有晶体覆盖,EDX图上出现了明显的强度较大的P组分峰,从微观的角度证实了添加凹凸棒石粉的促进作用

激光电离飞行时间质谱用于矿石表面元素成像

高功率密度激光电离飞行时间质谱法(Laser ionization time-of-flight mass spectrometry,LI-TOF-MS)是一种先进的固体元素直接分析法.与传统的固体分析方法相比,其样品前处理简单、分析速度快,而且消耗样品量少、无毒、绝对灵敏度高,已广泛应用于地质、环境等领域[1～3].与同类的固体直接分析法相比,激光电离飞行时间质谱法具有谱图干扰少,可同时分析金属和非金属元素以及多元素同

激光电离飞行时间质谱用于矿石表面元素成像

An elemental imaging system was developed based on the high irradiance laser ionization time-of-flight mass spectrometry(LI-TOF-MS), which could be applied to analyze all elements simultaneously and sensitively, including metals and non-metals. A stibnite sample was analyzed and elemental images of Sb, S, Si, Al, K, Ca, and Fe were subsequently acquired. Standardless semi-quantitation of detected elements on the stibnite surface was thus performed and the results indicate that the surface elemental imaging system associated with the LI-TOF-MS was a promising tool for elemental imaging Of solid surface and standardless elemental semi-quantitation

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies